Insulin signaling (Canis familiaris)

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1Transcriptional Regulators & Immediate Early GenesMetabolic Regulationp90 Rsk KinasesPDK/Akt SignalingRas-MAPK SignalingVesicular TraffickingTor SignalingPI 3-Kinasep70 S6 KinasesInsulin Receptor SubstratesMEK/MAP KinasesTranslation RegulationGlucose TransportModulators of Insulin ActionPFKLGRB14LOC477681CBLPRKAA2IRS4MAP3K10MAP4K3PRKCDPIK3CBSOS1EIF4ELIPEGYS2RPS6KA4GSK3AEGR1MAPK7SGK2SH2B2FLOT1RPS6KA6MAPK3RPS6KA2IRS1INSRSOCS1SNAP23RAPGEF1RRADPTENCBLCFLOT2MAPK1JUNXBP1SNX26KIF3ATRIB3MAP4K1MAP3K8MAP3K2PIK3C2AMAP3K12RPS6KA5PIK3R3CBLBRPS6KB1MAPK12TBC1D4RAC2LOC476352RHOXF2PIK3CGGSK3BEHD2FOXO3ARAC1STXBP2PTPN1IGF1RMAP2K2MAP3K5MAP2K1AKT2MAPK8RAB4AMAP2K3STX4MAPK6STXBP3SOS2GAB1CAP1PRKCZHRASMAPK14SGK1PRKCBGYG1MAP3K7INPPL1MAPK9MAP4K5MAPK13GRB10IRS2MAPK11PIK3R1PRKAA1SORBS1FOSMAP4K2RPS6KB2TSC1MAP2K6MAP2K4SLC2A1SGK3TSC2VAMP2EHD1AKT1PRKCHRPS6KA3RHEBSTXBP1EIF4EBP1PIK3C3SRFMAP3K1ARF1MAP4K4MAP3K4MYO1CRPS6KA1MAP3K3PIK3CDMAPK10MAP3K9PTPN11PPP1R3ASHC2MAP3K11GYS1SLC2A4MAP2K5GRB2CYTH3RHOQELK1INPP4AMAP2K7RHOJPDPK1PFKMFOXO1SOCS3PIK3R4SHC1MAP3K14PRKCAPRKCIMINK1PRKCQMAPK8ARF6RAF1STXBP4MAP3K13MTORMAPK4ENPP1CRKSNAP25PIK3CAKIF5BMAP3K6IKBKBPTPRFPIK3R2


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP481(r28132) with a 90% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001 PubMed Europe PMC Scholia
  2. Bevan P; ''Insulin signalling.''; J Cell Sci, 2001 PubMed Europe PMC Scholia
  3. Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129527view01:16, 9 May 2024EweitzModified title
125471view13:29, 16 February 2023Mkutmonfix complexes
125470view13:28, 16 February 2023Mkutmonfix complexes and unconnected lines
125469view13:08, 16 February 2023EgonwRemoved the Last-Modified attribute
68506view21:50, 5 July 2013MaintBotUpdated to 2013 gpml schema
48159view18:56, 9 May 2012MaintBotUpdating from human to fix xrefs
40657view21:48, 1 March 2011MaintBotRemoved redundant pathway information and comments
33949view18:20, 9 December 2009MaintBotAutomatic update of empty xrefs
32535view13:01, 17 August 2009MaintBotFixed text labels
32222view12:46, 15 August 2009MaintBotFixed text labels
31718view11:54, 14 August 2009MaintBotFixed group labels
31233view19:45, 13 August 2009MaintBotFixed text labels
30654view22:34, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct490878 (Entrez Gene)
AKT2GeneProduct449021 (Entrez Gene)
ARF1GeneProduct474591 (Entrez Gene)
ARF6GeneProduct490679 (Entrez Gene)
CAP1GeneProduct475317 (Entrez Gene)
CBLGeneProduct
CBLBGeneProduct487965 (Entrez Gene)
CBLCGeneProduct612343 (Entrez Gene)
CRKGeneProduct
CYTH3GeneProduct609100 (Entrez Gene)
EGR1GeneProduct481528 (Entrez Gene)
EHD1GeneProduct
EHD2GeneProduct484417 (Entrez Gene)
EIF4EGeneProduct487870 (Entrez Gene)
EIF4EBP1GeneProduct475590 (Entrez Gene)
ELK1GeneProduct491860 (Entrez Gene)
ENPP1GeneProduct476153 (Entrez Gene)
FLOT1GeneProduct474831 (Entrez Gene)
FLOT2GeneProduct610963 (Entrez Gene)
FOSGeneProduct490792 (Entrez Gene)
FOXO1GeneProduct477295 (Entrez Gene)
FOXO3AGeneProduct
GAB1GeneProduct483808 (Entrez Gene)
GRB10GeneProduct
GRB14GeneProduct478770 (Entrez Gene)
GRB2GeneProduct483312 (Entrez Gene)
GSK3AGeneProduct484476 (Entrez Gene)
GSK3BGeneProduct478575 (Entrez Gene)
GYG1GeneProduct611614 (Entrez Gene)
GYS1GeneProduct
GYS2GeneProduct403737 (Entrez Gene)
HRASGeneProduct
IGF1RGeneProduct442951 (Entrez Gene)
IKBKBGeneProduct482839 (Entrez Gene)
INPP4AGeneProduct474563 (Entrez Gene)
INPPL1GeneProduct485209 (Entrez Gene)
INSRGeneProduct484990 (Entrez Gene)
IRS1GeneProduct486148 (Entrez Gene)
IRS2GeneProduct485548 (Entrez Gene)
IRS4GeneProduct492059 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
KIF3AGeneProduct474675 (Entrez Gene)
KIF5BGeneProduct477968 (Entrez Gene)
LIPEGeneProduct403607 (Entrez Gene)
LOC476352GeneProduct476352 (Entrez Gene)
LOC477681GeneProduct477681 (Entrez Gene)
MAP2K1GeneProduct478347 (Entrez Gene)
MAP2K2GeneProduct611939 (Entrez Gene)
MAP2K3GeneProduct489547 (Entrez Gene)
MAP2K4GeneProduct489508 (Entrez Gene)
MAP2K5GeneProduct
MAP2K6GeneProduct480454 (Entrez Gene)
MAP2K7GeneProduct485004 (Entrez Gene)
MAP3K10GeneProduct484504 (Entrez Gene)
MAP3K11GeneProduct483732 (Entrez Gene)
MAP3K12GeneProduct607170 (Entrez Gene)
MAP3K13GeneProduct
MAP3K14GeneProduct490926 (Entrez Gene)
MAP3K1GeneProduct478061 (Entrez Gene)
MAP3K2GeneProduct612902 (Entrez Gene)
MAP3K3GeneProduct480481 (Entrez Gene)
MAP3K4GeneProduct476262 (Entrez Gene)
MAP3K5GeneProduct476215 (Entrez Gene)
MAP3K6GeneProduct487345 (Entrez Gene)
MAP3K7GeneProduct474996 (Entrez Gene)
MAP3K8GeneProduct487085 (Entrez Gene)
MAP3K9GeneProduct490765 (Entrez Gene)
MAP4K1GeneProduct484527 (Entrez Gene)
MAP4K2GeneProduct483759 (Entrez Gene)
MAP4K3GeneProduct475734 (Entrez Gene)
MAP4K4GeneProduct481331 (Entrez Gene)
MAP4K5GeneProduct490685 (Entrez Gene)
MAPK10GeneProduct478464 (Entrez Gene)
MAPK11GeneProduct607019 (Entrez Gene)
MAPK12GeneProduct607023 (Entrez Gene)
MAPK13GeneProduct612821 (Entrez Gene)
MAPK14GeneProduct403856 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
MAPK4GeneProduct491690 (Entrez Gene)
MAPK6GeneProduct478311 (Entrez Gene)
MAPK7GeneProduct489532 (Entrez Gene)
MAPK8GeneProduct477746 (Entrez Gene)
MAPK9GeneProduct474652 (Entrez Gene)
MINK1GeneProduct
MTORGeneProduct478232 (Entrez Gene)
MYO1CGeneProduct480646 (Entrez Gene)
PDPK1GeneProduct479875 (Entrez Gene)
PFKLGeneProduct487797 (Entrez Gene)
PFKMGeneProduct403849 (Entrez Gene)
PIK3C2AGeneProduct485399 (Entrez Gene)
PIK3C3GeneProduct490477 (Entrez Gene)
PIK3CAGeneProduct488084 (Entrez Gene)
PIK3CBGeneProduct477085 (Entrez Gene)
PIK3CDGeneProduct489644 (Entrez Gene)
PIK3CGGeneProduct483266 (Entrez Gene)
PIK3R1GeneProduct487235 (Entrez Gene)
PIK3R2GeneProduct609956 (Entrez Gene)
PIK3R3GeneProduct482512 (Entrez Gene)
PIK3R4GeneProduct477064 (Entrez Gene)
PPP1R3AGeneProduct482411 (Entrez Gene)
PRKAA1GeneProduct479351 (Entrez Gene)
PRKAA2GeneProduct489571 (Entrez Gene)
PRKCAGeneProduct490904 (Entrez Gene)
PRKCBGeneProduct489968 (Entrez Gene)
PRKCDGeneProduct494005 (Entrez Gene)
PRKCHGeneProduct490722 (Entrez Gene)
PRKCIGeneProduct478686 (Entrez Gene)
PRKCQGeneProduct478013 (Entrez Gene)
PRKCZGeneProduct479577 (Entrez Gene)
PTENGeneProduct403832 (Entrez Gene)
PTPN11GeneProduct477488 (Entrez Gene)
PTPN1GeneProduct477263 (Entrez Gene)
PTPRFGeneProduct475389 (Entrez Gene)
RAB4AGeneProduct479210 (Entrez Gene)
RAC1GeneProduct403955 (Entrez Gene)
RAC2GeneProduct481271 (Entrez Gene)
RAF1GeneProduct484648 (Entrez Gene)
RAPGEF1GeneProduct491286 (Entrez Gene)
RHEBGeneProduct475545 (Entrez Gene)
RHOJGeneProduct612985 (Entrez Gene)
RHOQGeneProduct474579 (Entrez Gene)
RHOXF2GeneProduct611154 (Entrez Gene)
RPS6KA1GeneProduct487353 (Entrez Gene)
RPS6KA2GeneProduct612448 (Entrez Gene)
RPS6KA3GeneProduct491768 (Entrez Gene)
RPS6KA4GeneProduct612105 (Entrez Gene)
RPS6KA5GeneProduct490831 (Entrez Gene)
RPS6KA6GeneProduct491989 (Entrez Gene)
RPS6KB1GeneProduct480580 (Entrez Gene)
RPS6KB2GeneProduct610499 (Entrez Gene)
RRADGeneProduct611304 (Entrez Gene)
SGK1GeneProduct403647 (Entrez Gene)
SGK2GeneProduct
SGK3GeneProduct486981 (Entrez Gene)
SH2B2GeneProduct489820 (Entrez Gene)
SHC1GeneProduct490439 (Entrez Gene)
SHC2GeneProduct611955 (Entrez Gene)
SLC2A1GeneProduct482437 (Entrez Gene)
SLC2A4GeneProduct403673 (Entrez Gene)
SNAP23GeneProduct478268 (Entrez Gene)
SNAP25GeneProduct477158 (Entrez Gene)
SNX26GeneProduct484573 (Entrez Gene)
SOCS1GeneProduct490006 (Entrez Gene)
SOCS3GeneProduct442949 (Entrez Gene)
SORBS1GeneProduct
SOS1GeneProduct483042 (Entrez Gene)
SOS2GeneProduct490682 (Entrez Gene)
SRFGeneProduct612861 (Entrez Gene)
STX4GeneProduct489919 (Entrez Gene)
STXBP1GeneProduct
STXBP2GeneProduct403880 (Entrez Gene)
STXBP3GeneProduct490128 (Entrez Gene)
STXBP4GeneProduct491094 (Entrez Gene)
TBC1D4GeneProduct485494 (Entrez Gene)
TRIB3GeneProduct485819 (Entrez Gene)
TSC1GeneProduct480688 (Entrez Gene)
TSC2GeneProduct479883 (Entrez Gene)
VAMP2GeneProduct479491 (Entrez Gene)
XBP1GeneProduct

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1085"
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