DNA replication (Danio rerio)

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1, 2Phosphorylated Orc1DNA polymerase alpha: primase: origin complexMcm7Orc complexOriginCTPMcm 4,6,7 trimer forms and associatesCdt1Orc5Ubiquitinated Orc1Orc complexOrc5Orc3Pre-replicative complexCdc6Phosphorylation of Mcm 2-7 complexOrc3Orc4Degraded by proteasome in cytosolCdc6Orc33. DNA replication initiationGemininOrc5p58Mcm4Cdt1PrimasedUTPMcm2dCTPMcm5Orc2Cdt1GTPPhosphorylated Cdc6Cdt1Orc3Mcm6Orc2ADPRFC Heteropentamer:RNA primer-DNA primerPre-replicative complexCdt1UbiquitinRFC37RNA primer-DNA primerCdc6Mcm4Mcm2Mcm51. Assembly of the pre-replicative complexMcm7Orc4ATPOrc2Mcm3RFC Heteropentamer:RNA primer-DNA primer:ATPATPdATPRNA primer-DNA primer:origin duplex:PCNAADP5. Leading/lagging strand synthesisaDNA PolymeraseUTPCdc6Mcm34. Switching of origins to post-replicative stateRFC140Mcm6RFC36Ubiquitinated Cdc6PCNA homotrimerRFC40RNA primer-DNA primerp49Orc1Ubiquitinp180p70dGTPRFC38Mcm10HOMOLOGY MAPPDegraded by proteasome in cytosolOrc complexOrc ComplexATPwith the replication forkProcessive complex2. Activation of the pre-replicative complexOrc2DNA polymerase alpha: primase: origin complexOrc complexRNA Primermcm4mcm2zgc:110810CDT1MCM10rpa1zgc:56598pcnarfc3orc6lmcm5MCM6pold2MCM7zgc:110727POLAPOLD1POLD3POLErfc5RFC1prim1rfc4ASKPOLE2rpa2POLD4RPA4orc1lCDC6zgc:77827zgc:77841zgc:85772zgc:56264ORC2Lorc3lgmnnmcm3zgc:101602zgc:56310UBCUBA52


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116856view10:52, 14 May 2021EweitzModified title
91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASKGeneProduct
CDC6GeneProduct
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
ORC2LGeneProduct
POLAGeneProduct
POLD1GeneProduct556456 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
RFC1GeneProduct
RPA4GeneProduct
UBA52GeneProduct641289 (Entrez Gene)
UBCGeneProduct
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1lGeneProduct335020 (Entrez Gene)
orc3lGeneProduct334315 (Entrez Gene)
orc6lGeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProduct368733 (Entrez Gene)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

Annotated Interactions

No annotated interactions
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