TNF-alpha NF-kB signaling pathway (Gallus gallus)

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Endoplasmic reticulumGolgi apparatusReaction through unknown mechanisms/moleculesGOControlGlycosylationPalmitoylationUbiquitinationEnzyme complexDeubiquitinationERCY ->NUSumoylationCY ->NUMolecular associationAutophosphorylationActivationNucleusProteins in a complex interactionPhosphorylationMolecule in the pathwayDeacetylationCY ->NUCytoplasmCY ->NUExtracellular(Protein-protein interaction)MethylationInhibitionCY ->NUTranslocationCYDemethylationPMAcetylationENMTLigandDesumoylationNUEndosomeDReceptorMitochondrionProteolytic cleavageAccession Number: NetPath 9; cellmap:9Plasma membraneRecruitmentDephosphorylationECGLG1RELAMAP3K3MAP3K2CASP2TNFAIP3MAP3K7IP1NFKB1TNFRSF1BPOLR1EAKAP8PMLASE1MAP3K7IP2AZI2ZFAND5NKIRAS1TRAF2MAP3K1BIRC2RELBNFKBIANALP4GeneCDC37RASAL2RPL6NFKB1MARK2HIST3H3SMARCA4CUL1HSPB1BIRC2POLR2HMAP3K7IP3RELAPSMD13RPL4TRAF4CFLARUBCH5CPOLR1BTNFYWHAHMCM5COPS3SKP1ANFKBIAPSMC1COMMD1GeneCDC34TIFATNFRSF1AHDAC2POLR1APOLR1CRELBPTPN11TNIP2PDCD2PSMD3TRAF2KPNA2MCM7MCCPSMC3TBK1RCJMB04_19h23PEBP1RCJMB04_4j14EIF4A3PPP2CARELATNFRSF11ACAPN3CASP10TNFTNFWDR68Gene SymbolCAV1RIPK2RCJMB04_19h23PSMB5AKT1NFKBIECASP3TRAF5TANKSMARCC2PEG3IKBKGAKT2GAB1PSMD1RELTRAF6GeneTRADDYWHAESMARCB1KTN1NFKBIAMAP3K3YWHABGNB2L1PFDN2RIPK1CRADDTRAF2CSNK2A1FAF1FBLIKBKGCASP8RCJMB04_14f8PSMC2RCJMB04_2a4TRAIPRCJMB04_17i9TNFKPNA3CSNK2BSRCHSPCBRNF216BIRC3RELDAPRPS6KA5RCJMB04_11l21NKIRAS2TRADDHDAC1PSMD6RCJMB04_36h7RELAUSP11DBC1TNFBIRC3KCNQ1PIAS3GSK3BFKBP5TBK1HDAC6MTIF2BCL3PRKCZBCL7ARCJMB04_5e12SMARCC1TXLNASUMO1CASP8AP2NFKBIZMAP3K14CSNK2A2NR2C2NSMAFUBE2IFANCD2UNC5CLPRKACATRAF1RPL8FLNAIKBKETNFRSF8UBE2D2RNF25TRPC4APRPS13RIPK3CREBBPPSMD12GTF2INFKB1PSMD7BTRCRIPK1RCJMB04_17o18PPP1R13LNFKBIBPTK2YWHAQBAG4MAP3K8GeneDPF2TNFUSP2TRAF3FADDPOLR1DALPLTRAF4TNFRSF1APOLR2LPAPOLACYLDLRPPRCTNFRSF1BTRAF1TNFRSF1BRPL30ACTL6AIQGAP2RCJMB04_34f17IKBKBNR2C2NFKB2RPS11SMARCE1PKN1TNFRSF1AHSP90AA1TNIP1G3BP2CASP7


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 69% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118011view11:32, 23 May 2021EweitzModified title
108152view10:37, 29 November 2019FehrhartOntology Term : 'cancer' added !
87787view11:14, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87785view11:13, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68867view17:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
41006view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
33927view18:09, 9 December 2009MaintBotAutomatic update of empty xrefs
33485view15:08, 30 November 2009MaintBotRemoved group label
31535view21:45, 13 August 2009MaintBotFixed text labels
30380view21:02, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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AKAP8GeneProduct426167 (Entrez Gene)
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ASE1GeneProduct
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BCL3GeneProduct
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BIRC3GeneProduct
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CASP8AP2GeneProduct421810 (Entrez Gene)
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FBLGeneProduct
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FLNAGeneProduct
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NALP4GeneProduct
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NFKBIAGeneProduct396093 (Entrez Gene)
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TNFGeneProduct
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TNFRSF11AGeneProduct769909 (Entrez Gene)
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YWHAQGeneProduct421932 (Entrez Gene)
ZFAND5GeneProduct427254 (Entrez Gene)

Annotated Interactions

No annotated interactions
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