Metapathway biotransformation Phase I and II (Homo sapiens)

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Glutathione conjugationElectrophilesAcetylationAmino acid acyl transferasesMethyltransferasesAldo-keto reductasesGlutathione reductaseSulfationGlutathione peroxidasesCytochrome P450Glutathione transferasesNucleophilesSulfotransferasesFlavin monooxygenasesGlucuronosyltransferasesGlutathione synthetaseEpoxide hydrolasesMethylationReductionHydrolysisOxidationN-acetyltransferasesGlucuronidationAmino acid conjugationGSTM4BAATNAT13CYP1A1UGT1A5CYP8B1CHST8SULT1C2Substrate-CH3CYP2W1CYP2C19GSTK1GLYATSULT1C4CYP1B1Xenobiotic substrateEPHX2SULT1A3CYP3A5AKR1B1GSTA5CYP46A1UGT1A10KCNAB1NDST3CYP2U1HS3ST6NAT8GAL3ST3CYP27B1FMO2CYP2E1HS6ST3CYP4Z1GlucuronosyltransferaseCYP4F11AKR1C4SULT1C1FMO1CHST5MGST1NDST4CYP20A1GPX4AKR1C1UGT2A2SULT1A2CYP19A1FMO5CYP27C1Glutathione transferaseKCNAB2CYP1A2CHST10CYP26B1SULT1A1AKR1A1NAT6UGT2B28TPMTCYP2A13Aldo-keto reductaseUGT1A3CYP2C8CYP2R1CYP4X1SULT6B1CYP17A1HS3ST3B1CYP4F8CYP4B1CYP3A4NAT8LCHST12GPX2CHST13AKR7A3SULT1E1NDST1UGT1A9MGST3NAT10CYP2C9CHST11CHST1CYP39A1SULT1B1Substrate-AcMethyltransferaseSubstrate-NH2UGT1A8CHST4GSTP1NDST2Substrate-GlCHST3Flavin monooxygenaseCHST2AKR7A2CYP2A6HS3ST3A1Substrate-OHGSTA1CYP21A2UGT2B4HS2ST1GPX3CYP11B2HS3ST4NAT5GSTCDGSTM3CYP2C18GPX5HNMTCYP4F2NNMTGPX1HS3ST2CHST14CYP2F1FMO3HS6ST1SULT2B1CYP2D6CHST7CYP24A1AKR1B10CYP11B1CYP4F22GSTM5Substrate-SO3HSubstrate=OKCNAB3NAT9GSTO2GSTT2BMGST2UGT1A7GSTA4CYP4F12GSTO1NAT14AKR1D1UGT1A4NAT12Substrate-O-RUGT2B15CYP2S1HS3ST1N-acetyltransferaseGSRCYP4V2SulfotransferaseSULT2A1AKR1C3INMTCYP2J2COMTCYP7A1GAL3ST1CYP2A7EPHX1UGT2A1Substrate-SGGSTT1UGT2B7CYP26C1NAT11UGT2B17GAL3ST2CYP26A1FMO4Substrate-AaUGT1A6GLYATL1HS6ST2NAT2NAT1CHST6UGT1A1GSTM1SULT1A4CYP4F3HS3ST5GSTA2UGT2A3CYP3A43GSTA3CYP11A1UGT2B11Substrate-SHGLYATL2GSTT2CYP2B6CYP51A1CYP450GSTM2GAL3ST4CYP27A1GSTZ1AKR1C2SULT1C3GSSCYP3A7CHST9Amino acid acyltransferaseCYP7B1SULT4A1


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Oppermann UC, Maser E; ''Molecular and structural aspects of xenobiotic carbonyl metabolizing enzymes. Role of reductases and dehydrogenases in xenobiotic phase I reactions.''; Toxicology, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127768view11:08, 3 December 2023EgonwRemoved a weird char from an Pfam identifier
106643view21:04, 12 September 2019KhanspersModified description
105646view05:10, 10 August 2019KhanspersModified description
102200view07:26, 9 December 2018EgonwMmm... only the ENSG00000277656 link works.
102197view06:56, 9 December 2018EgonwUndo revision 102196 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
102196view06:55, 9 December 2018EgonwMapable ID.
102195view06:54, 9 December 2018EgonwReplaced an outdated Ensembl identifiers with the new one.
98553view18:18, 16 September 2018AlexanderPicoupdated outdated ensembl
96892view13:47, 18 April 2018FehrhartAdded annotations for CYP450
96046view16:07, 15 February 2018DeSlModified description
96045view16:06, 15 February 2018DeSlOntology Term : 'phase II biotransformation pathway' added !
96044view16:06, 15 February 2018DeSlOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
96043view16:05, 15 February 2018DeSlModified title
96042view16:03, 15 February 2018DeSlModified title
96041view16:03, 15 February 2018DeSlAdded lit. ref
73516view23:21, 29 January 2014KhanspersModified title
68908view17:30, 8 July 2013MaintBotUpdated to 2013 gpml schema
67458view11:04, 26 June 2013DdiglesOntology Term : 'cellular detoxification pathway' added !
59107view22:20, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
44905view10:25, 6 October 2011MartijnVanIerselOntology Term : 'phase I biotransformation pathway' added !
41055view23:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
34448view18:21, 10 December 2009MaintBotAutomatic update of empty xrefs
33415view14:50, 30 November 2009MaintBotRemoved group label
33182view17:47, 5 November 2009KhanspersModified categories
29945view16:15, 14 June 2009Pieter GiesbertzSpecify description
29944view16:09, 14 June 2009Pieter Giesbertzminor changes
29942view12:30, 14 June 2009Pieter GiesbertzAdded aa acyltransferase genes
29941view12:17, 14 June 2009Pieter GiesbertzSpecify description
29940view12:03, 14 June 2009Pieter GiesbertzSpecify description
29939view19:30, 13 June 2009Pieter GiesbertzAdded biotransformation genes
29938view19:21, 13 June 2009Pieter GiesbertzSpecify description
29937view19:20, 13 June 2009Pieter GiesbertzSpecify description
29936view19:06, 13 June 2009Pieter GiesbertzSpecify description
29935view19:05, 13 June 2009Pieter GiesbertzSpecify description
29934view18:42, 13 June 2009Pieter GiesbertzSpecify description
29931view18:41, 13 June 2009Pieter GiesbertzSpecify description
29930view18:36, 13 June 2009Pieter GiesbertzSpecify description
29929view18:07, 13 June 2009Pieter GiesbertzSpecify description
29928view18:02, 13 June 2009Pieter GiesbertzAdded CYPs
29927view17:58, 13 June 2009Pieter GiesbertzSpecify description
29926view17:47, 13 June 2009Pieter GiesbertzSpecify description
29925view17:43, 13 June 2009Pieter GiesbertzSpecify description
29357view10:05, 29 April 2009Pieter GiesbertzSpecify description
29356view10:05, 29 April 2009Pieter GiesbertzSpecify description
29355view10:03, 29 April 2009Pieter GiesbertzAdded methyltransferases
29340view13:42, 27 April 2009Pieter GiesbertzAdded coloured association pathway
29324view08:23, 24 April 2009Pieter GiesbertzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKR1A1GeneProductENSG00000117448 (Ensembl Human)
AKR1B10GeneProductENSG00000198074 (Ensembl Human)
AKR1B1GeneProductENSG00000085662 (Ensembl Human)
AKR1C1GeneProductENSG00000187134 (Ensembl Human)
AKR1C2GeneProductENSG00000151632 (Ensembl Human)
AKR1C3GeneProductENSG00000196139 (Ensembl Human)
AKR1C4GeneProductENSG00000198610 (Ensembl Human)
AKR1D1GeneProductENSG00000122787 (Ensembl Human)
AKR7A2GeneProductENSG00000053371 (Ensembl Human)
AKR7A3GeneProductENSG00000162482 (Ensembl Human)
Aldo-keto reductaseGeneProduct
Amino acid acyltransferaseGeneProduct
BAATGeneProductENSG00000136881 (Ensembl Human)
CHST10GeneProductENSG00000115526 (Ensembl Human)
CHST11GeneProductENSG00000171310 (Ensembl Human)
CHST12GeneProductENSG00000136213 (Ensembl Human)
CHST13GeneProductENSG00000180767 (Ensembl Human)
CHST14GeneProduct113189 (Entrez Gene)
CHST1GeneProductENSG00000175264 (Ensembl Human)
CHST2GeneProductENSG00000175040 (Ensembl Human)
CHST3GeneProductENSG00000122863 (Ensembl Human)
CHST4GeneProductENSG00000140835 (Ensembl Human)
CHST5GeneProductENSG00000135702 (Ensembl Human)
CHST6GeneProductENSG00000183196 (Ensembl Human)
CHST7GeneProductENSG00000147119 (Ensembl Human)
CHST8GeneProductENSG00000124302 (Ensembl Human)
CHST9GeneProduct83539 (Entrez Gene)
COMTGeneProductENSG00000093010 (Ensembl Human)
CYP11A1GeneProductENSG00000140459 (Ensembl Human)
CYP11B1GeneProductENSG00000160882 (Ensembl Human)
CYP11B2GeneProductENSG00000179142 (Ensembl Human)
CYP17A1GeneProductENSG00000148795 (Ensembl Human)
CYP19A1GeneProductENSG00000137869 (Ensembl Human)
CYP1A1GeneProductENSG00000140465 (Ensembl Human)
CYP1A2GeneProductENSG00000140505 (Ensembl Human)
CYP1B1GeneProductENSG00000138061 (Ensembl Human)
CYP20A1GeneProductENSG00000119004 (Ensembl Human)
CYP21A2GeneProduct1589 (Entrez Gene)
CYP24A1GeneProductENSG00000019186 (Ensembl Human)
CYP26A1GeneProductENSG00000095596 (Ensembl Human)
CYP26B1GeneProductENSG00000003137 (Ensembl Human)
CYP26C1GeneProductENSG00000187553 (Ensembl Human)
CYP27A1GeneProductENSG00000135929 (Ensembl Human)
CYP27B1GeneProductENSG00000111012 (Ensembl Human)
CYP27C1GeneProductENSG00000186684 (Ensembl Human)
CYP2A13GeneProductENSG00000197838 (Ensembl Human)
CYP2A6GeneProductENSG00000213052 (Ensembl Human)
CYP2A7GeneProductENSG00000198077 (Ensembl Human)
CYP2B6GeneProductENSG00000197408 (Ensembl Human)
CYP2C18GeneProductENSG00000108242 (Ensembl Human)
CYP2C19GeneProductENSG00000165841 (Ensembl Human)
CYP2C8GeneProductENSG00000138115 (Ensembl Human)
CYP2C9GeneProductENSG00000138109 (Ensembl Human)
CYP2D6GeneProductENSG00000100197 (Ensembl Human)
CYP2E1GeneProductENSG00000130649 (Ensembl Human)
CYP2F1GeneProductENSG00000197446 (Ensembl Human)
CYP2J2GeneProductENSG00000134716 (Ensembl Human)
CYP2R1GeneProductENSG00000186104 (Ensembl Human)
CYP2S1GeneProductENSG00000167600 (Ensembl Human)
CYP2U1GeneProductENSG00000155016 (Ensembl Human)
CYP2W1GeneProductENSG00000073067 (Ensembl Human)
CYP39A1GeneProductENSG00000146233 (Ensembl Human)
CYP3A43GeneProductENSG00000021461 (Ensembl Human)
CYP3A4GeneProductENSG00000160868 (Ensembl Human)
CYP3A5GeneProductENSG00000106258 (Ensembl Human)
CYP3A7GeneProductENSG00000160870 (Ensembl Human)
CYP450GeneProduct
CYP46A1GeneProductENSG00000036530 (Ensembl Human)
CYP4B1GeneProductENSG00000142973 (Ensembl Human)
CYP4F11GeneProductENSG00000171903 (Ensembl Human)
CYP4F12GeneProductENSG00000186204 (Ensembl Human)
CYP4F22GeneProductENSG00000171954 (Ensembl Human)
CYP4F2GeneProductENSG00000186115 (Ensembl Human)
CYP4F3GeneProductENSG00000186529 (Ensembl Human)
CYP4F8GeneProductENSG00000186526 (Ensembl Human)
CYP4V2GeneProductENSG00000145476 (Ensembl Human)
CYP4X1GeneProductENSG00000186377 (Ensembl Human)
CYP4Z1GeneProductENSG00000186160 (Ensembl Human)
CYP51A1GeneProductENSG00000001630 (Ensembl Human)
CYP7A1GeneProductENSG00000167910 (Ensembl Human)
CYP7B1GeneProductENSG00000172817 (Ensembl Human)
CYP8B1GeneProductENSG00000180432 (Ensembl Human)
EPHX1GeneProductENSG00000143819 (Ensembl Human)
EPHX2GeneProductENSG00000120915 (Ensembl Human)
FMO1GeneProductENSG00000010932 (Ensembl Human)
FMO2GeneProductENSG00000094963 (Ensembl Human)
FMO3GeneProductENSG00000007933 (Ensembl Human)
FMO4GeneProductENSG00000076258 (Ensembl Human)
FMO5GeneProductENSG00000131781 (Ensembl Human)
Flavin monooxygenaseGeneProduct
GAL3ST1GeneProductENSG00000128242 (Ensembl Human)
GAL3ST2GeneProductENSG00000154252 (Ensembl Human)
GAL3ST3GeneProductENSG00000175229 (Ensembl Human)
GAL3ST4GeneProductENSG00000197093 (Ensembl Human)
GLYATGeneProductENSG00000149124 (Ensembl Human)
GLYATL1GeneProductENSG00000166840 (Ensembl Human)
GLYATL2GeneProductENSG00000156689 (Ensembl Human)
GPX1GeneProductENSG00000197582 (Ensembl Human)
GPX2GeneProductENSG00000176153 (Ensembl Human)
GPX3GeneProductENSG00000211445 (Ensembl Human)
GPX4GeneProductENSG00000167468 (Ensembl Human)
GPX5GeneProductENSG00000079782 (Ensembl Human)
GSRGeneProductENSG00000104687 (Ensembl Human)
GSSGeneProductENSG00000100983 (Ensembl Human)
GSTA1GeneProductENSG00000187919 (Ensembl Human)
GSTA2GeneProductENSG00000096087 (Ensembl Human)
GSTA3GeneProductENSG00000174156 (Ensembl Human)
GSTA4GeneProductENSG00000170899 (Ensembl Human)
GSTA5GeneProductENSG00000182793 (Ensembl Human)
GSTCDGeneProductENSG00000138780 (Ensembl Human)
GSTK1GeneProductENSG00000197448 (Ensembl Human)
GSTM1GeneProductENSG00000134184 (Ensembl Human)
GSTM2GeneProductENSG00000213366 (Ensembl Human)
GSTM3GeneProductENSG00000134202 (Ensembl Human)
GSTM4GeneProductENSG00000168765 (Ensembl Human)
GSTM5GeneProductENSG00000134201 (Ensembl Human)
GSTO1GeneProductENSG00000148834 (Ensembl Human)
GSTO2GeneProductENSG00000065621 (Ensembl Human)
GSTP1GeneProductENSG00000084207 (Ensembl Human)
GSTT1GeneProductENSG00000184674 (Ensembl Human)
GSTT2BGeneProductENSG00000133433 (Ensembl Human)
GSTT2GeneProductENSG00000099984 (Ensembl Human)
GSTZ1GeneProductENSG00000100577 (Ensembl Human)
GlucuronosyltransferaseGeneProduct
Glutathione transferaseGeneProduct
HNMTGeneProductENSG00000150540 (Ensembl Human)
HS2ST1GeneProductENSG00000153936 (Ensembl Human)
HS3ST1GeneProductENSG00000002587 (Ensembl Human)
HS3ST2GeneProductENSG00000122254 (Ensembl Human)
HS3ST3A1GeneProductENSG00000153976 (Ensembl Human)
HS3ST3B1GeneProductENSG00000125430 (Ensembl Human)
HS3ST4GeneProductENSG00000182601 (Ensembl Human)
HS3ST5GeneProductENSG00000175818 (Ensembl Human)
HS3ST6GeneProductENSG00000162040 (Ensembl Human)
HS6ST1GeneProductENSG00000136720 (Ensembl Human)
HS6ST2GeneProductENSG00000171004 (Ensembl Human)
HS6ST3GeneProductENSG00000185352 (Ensembl Human)
INMTGeneProductENSG00000011177 (Ensembl Human)
KCNAB1GeneProductENSG00000169282 (Ensembl Human)
KCNAB2GeneProductENSG00000069424 (Ensembl Human)
KCNAB3GeneProductENSG00000170049 (Ensembl Human)
MGST1GeneProductENSG00000008394 (Ensembl Human)
MGST2GeneProductENSG00000085871 (Ensembl Human)
MGST3GeneProductENSG00000143198 (Ensembl Human)
MethyltransferaseGeneProduct
N-acetyltransferaseGeneProduct
NAT10GeneProductENSG00000135372 (Ensembl Human)
NAT11GeneProductENSG00000110583 (Ensembl Human)
NAT12GeneProductENSG00000139977 (Ensembl Human)
NAT13GeneProductENSG00000121579 (Ensembl Human)
NAT14GeneProductENSG00000090971 (Ensembl Human)
NAT1GeneProductENSG00000171428 (Ensembl Human)
NAT2GeneProductENSG00000156006 (Ensembl Human)
NAT5GeneProductENSG00000173418 (Ensembl Human)
NAT6GeneProductENSG00000214699 (Ensembl Human)
NAT8GeneProductENSG00000144035 (Ensembl Human)
NAT8LGeneProductENSG00000185818 (Ensembl Human)
NAT9GeneProductENSG00000109065 (Ensembl Human)
NDST1GeneProductENSG00000070614 (Ensembl Human)
NDST2GeneProductENSG00000166507 (Ensembl Human)
NDST3GeneProductENSG00000164100 (Ensembl Human)
NDST4GeneProductENSG00000138653 (Ensembl Human)
NNMTGeneProductENSG00000166741 (Ensembl Human)
SULT1A1GeneProductENSG00000196502 (Ensembl Human)
SULT1A2GeneProductENSG00000197165 (Ensembl Human)
SULT1A3GeneProductENSG00000213599 (Ensembl Human)
SULT1A4GeneProductENSG00000213648 (Ensembl Human)
SULT1B1GeneProductENSG00000173597 (Ensembl Human)
SULT1C1GeneProductENSG00000198203 (Ensembl Human)
SULT1C2GeneProductENSG00000198075 (Ensembl Human)
SULT1C3GeneProductENSG00000196228 (Ensembl Human)
SULT1C4GeneProduct27233 (Entrez Gene)
SULT1E1GeneProductENSG00000109193 (Ensembl Human)
SULT2A1GeneProductENSG00000105398 (Ensembl Human)
SULT2B1GeneProductENSG00000088002 (Ensembl Human)
SULT4A1GeneProductENSG00000130540 (Ensembl Human)
SULT6B1GeneProductENSG00000138068 (Ensembl Human)
Substrate-AaMetabolite
Substrate-AcMetabolite
Substrate-CH3Metabolite
Substrate-GlMetabolite
Substrate-NH2Metabolite
Substrate-O-RMetabolite
Substrate-OHMetabolite
Substrate-SGMetabolite
Substrate-SHMetabolite
Substrate-SO3HMetabolite
Substrate=OMetabolite
SulfotransferaseGeneProduct
TPMTGeneProductENSG00000137364 (Ensembl Human)
UGT1A10GeneProduct54575 (Entrez Gene)
UGT1A1GeneProduct54658 (Entrez Gene)
UGT1A3GeneProduct54659 (Entrez Gene)
UGT1A4GeneProduct54657 (Entrez Gene)
UGT1A5GeneProduct54579 (Entrez Gene)
UGT1A6GeneProduct54578 (Entrez Gene)
UGT1A7GeneProduct54577 (Entrez Gene)
UGT1A8GeneProductENSG00000167165 (Ensembl Human)
UGT1A9GeneProduct54600 (Entrez Gene)
UGT2A1GeneProductENSG00000173610 (Ensembl Human)
UGT2A2GeneProduct574537 (Entrez Gene)
UGT2A3GeneProductENSG00000135220 (Ensembl Human)
UGT2B11GeneProductENSG00000213759 (Ensembl Human)
UGT2B15GeneProductENSG00000197592 (Ensembl Human)
UGT2B17GeneProductENSG00000197888 (Ensembl Human)
UGT2B28GeneProductENSG00000135226 (Ensembl Human)
UGT2B4GeneProductENSG00000156096 (Ensembl Human)
UGT2B7GeneProductENSG00000171234 (Ensembl Human)
Xenobiotic substrateMetabolite

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP702"
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