Glucocorticoid and mineralcorticoid metabolism (Mus musculus)

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CHOGlucuronides3CH311b,17a 21-Trihydroxy-5b=OOH=O-OHCC2HOOHOCCProgesterone Degradation3C=O*HOHblue=O23B-OH-delta-Steroid DhPregnane 3,20-dioneOHGlucocorticoidsHOOHTo Androgen Synthesisand Metabolism3a,11b,21-Trihydroxy-20-Oxo-5b-Pregnan-18-alUrocortisoneHOSubstrates inUrocortisol=O11-DeoxycorticosteroneCHC11b, 21-Dihydroxy-3,20-5b-Pregnan-18-al=OOH11-DeoxycortisolHO=OCH2Steroid HormoneSignalingHOCHOC3COHFrom Cholersterol Biosynthesis*CHC*CHCHO5b-Pregnane-3,20-dioneHOHOhave strucutures shownOH3Cyp21a1CortisolHsd3b1Cyp17a1Hsd3b1CortisoneProgesteroneHsd11b1Cyp11b220b-Hydroxysteroid DhCyp11b2Aldosterone17-a-HydroxyprogesteroneHsd3b318-HydroxycorticosteronePregnenoloneCyp17a1CortisolHsd3b13a-Hydroxysteroid DhHsd3b6CortoloneCyp11a1Pregnanediol3alpha-Hydroxy-5beta-pregnane-20-oneCorticosteroneHsd3b5Metabolite3-Oxo-5b-Steroid DhCortisone beta-reductaseHsd11b2Akr1c2117alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trioneCholesterolHsd3b4Hsd3b2(R)20-hydroxysteroid Dh17a-Hydroxypregnenolone


Description

No description

Comments

GenMAPP remarks 
Adapted from http://au.expasy.org/tools/pathways/

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
128039view21:32, 21 January 2024EweitzConnect interactions, refine to mim-catalysis
128038view20:32, 21 January 2024EweitzUpgrade pathway representations
118582view13:40, 28 May 2021EweitzModified title
114020view15:19, 17 December 2020NhungPConnecting lines
112996view15:18, 29 October 2020DeSlModified description
112995view15:16, 29 October 2020DeSlChanged title, removed structural drawings
106899view13:37, 17 September 2019MaintBotHMDB identifier normalization
71740view20:18, 17 October 2013MaintBotAutomated update of data sources
71325view17:17, 17 October 2013MaintBotAutomated update of data sources
69138view18:16, 8 July 2013MaintBotUpdated to 2013 gpml schema
67283view10:31, 26 June 2013Christine ChichesterOntology Term : 'C21-steroid hormone biosynthetic pathway' added !
62838view04:59, 3 May 2013MaintBotUpdated UniProt data source
41327view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
33388view14:43, 30 November 2009MaintBotRemoved group label
32963view21:54, 28 September 2009MaintBotPeriodical save, work in progress
32962view21:23, 28 September 2009MaintBotAdded metabolites and connectors
32961view21:10, 28 September 2009MaintBotadded metabolites and connectors
32960view21:05, 28 September 2009MaintBotPeriodical save, work in progress
32959view20:55, 28 September 2009MaintBotPeriodical save, work in progress
21720view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Glucocorticoid Mineralocorticoid Metabolism]] moved to [[Pathway:WP495]]: Moved to stable identifier
8080view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Glucocorticoid Mineralocorticoid Metabolism]] moved to [[Pathway:Mus musculus:Glucocorticoid Mineralocorticoid Metabolism]]: Renaming species
7662view16:08, 18 December 2007MaintBotfixed category names
7361view12:42, 4 November 2007MaintBotAdded categories to GPML
7108view13:20, 10 October 2007MichielSpecify description
7107view13:19, 10 October 2007MichielSpecify description
7106view13:17, 10 October 2007Michieltest
7105view13:15, 10 October 2007Michieltest
7101view12:57, 10 October 2007MichielTest
19472view22:19, 22 May 2007M.Liebermangpml file for [[Mouse:Glucocorticoid_Mineralocorticoid_Metabolism]]
6450view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:Glucocorticoid_Mineralocorticoid_Metabolism]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(R)20-hydroxysteroid DhGeneProduct
17-a-HydroxyprogesteroneMetabolite
17a-HydroxypregnenoloneMetaboliteHMDB00363 (HMDB)
17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trioneMetaboliteHMDB06758 (HMDB)
18-HydroxycorticosteroneMetaboliteHMDB00319 (HMDB)
20b-Hydroxysteroid DhGeneProduct
3-Oxo-5b-Steroid DhGeneProduct
3a-Hydroxysteroid DhGeneProduct
3alpha-Hydroxy-5beta-pregnane-20-oneMetaboliteHMDB06759 (HMDB)
Akr1c21GeneProduct77337 (Entrez Gene) SP, mouse EST: AW611181, rat SP: DIDH RAT
AldosteroneMetaboliteHMDB00037 (HMDB)
CholesterolMetaboliteHMDB00067 (HMDB)
CorticosteroneMetaboliteHMDB01547 (HMDB)
CortisolMetaboliteHMDB00063 (HMDB)
Cortisone beta-reductaseGeneProduct
CortisoneMetaboliteHMDB02802 (HMDB)
CortoloneMetaboliteHMDB03128 (HMDB)
Cyp11a1GeneProduct13070 (Entrez Gene)
Cyp11b2GeneProduct13072 (Entrez Gene) EC number: 1.14.15.5
Cyp17a1GeneProduct13074 (Entrez Gene)
Cyp21a1GeneProduct13079 (Entrez Gene)
Hsd11b1GeneProduct15483 (Entrez Gene)
Hsd11b2GeneProduct15484 (Entrez Gene)
Hsd3b1GeneProduct15492 (Entrez Gene)
Hsd3b2GeneProduct15493 (Entrez Gene)
Hsd3b3GeneProduct15494 (Entrez Gene)
Hsd3b4GeneProduct15495 (Entrez Gene)
Hsd3b5GeneProduct15496 (Entrez Gene)
Hsd3b6GeneProduct15497 (Entrez Gene)
MetaboliteMetabolite
PregnanediolMetaboliteHMDB04025 (HMDB)
PregnenoloneMetaboliteHMDB00253 (HMDB)
ProgesteroneMetaboliteHMDB01830 (HMDB)

Annotated Interactions

No annotated interactions
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