TNF-alpha NF-kB signaling pathway (Mus musculus)

From WikiPathways

Revision as of 00:29, 2 March 2011 by MaintBot (Talk | contribs)
Jump to: navigation, search
EndosomeEndoplasmic reticulum(Protein-protein interaction)ERRecruitmentDeacetylationDemethylationProteolytic cleavageProteins in a complex interactionDesumoylationENCY ->NUInhibitionCY ->NUEnzyme complexDDeubiquitinationMitochondrionLigandPMAccession Number: NetPath 9; cellmap:9AcetylationGolgi apparatusTranslocationCY ->NUCytoplasmMolecular associationMolecule in the pathwayGlycosylationUbiquitinationCY ->NUControlPalmitoylationMethylationMTNUECGOReceptorSumoylationExtracellularReaction through unknown mechanisms/moleculesCY ->NUAutophosphorylationDephosphorylationPlasma membraneNucleusActivationPhosphorylationCYDdx3xG3bp2TxlnaCasp7CraddYwhazNr2c2RelTnfrsf1bRasal2Tnfrsf11aBcl3RelaMap3k7ip1Traf5Hsp90ab1Mtif2Birc2TankFancd2RPL30NfkbieGnb2l1Gene SymbolSmarcc1ChukCdc37Traf4Map2k5Gm4596RPL6NfkbiaCasp8ap2Traf3Polr1dKpna6Nfkb1Nfkb2FblRPS6KB1Ptk2Ppp2caPolr1aTnfYwhaeCommd1Smarce1Cul1Cdc34Faf1NfkbiaGeneCapn3Psmd13AlplHdac1Pdcd2Polr1eTraf4Hsp90aa1Tnip1Nkiras2Psmd7Traf1Pkn1GeneMcm5LrpprcFlnaIkbkgIkbkgRipk2Bag4Tbk1PrkacaRelbCasp2Map3k2Ripk1TnfTnfrsf1aMap3k1Nfkb1Peg3Ripk3Akt2Kpna3ChukPolr1cCflarRPS13IkbkeHdac6Pias32610301G19RikTnip2YwhagTifaTraf6Psmc3GeneRipk1YwhabGsk3bRpl4Casp3Map3k8Pfdn2NsmafGab1Csnk2bNlrp4eNfkbiaFbxw11Psmb5Map3k14CyldCASP10KPNA2FaddIqgap2Psmd6Psmc1TnfKcnq1Csnk2a2Akt1IkbkapTrpc4apBirc2RelaTnfMark2Gm2423Nkiras1Traf2Smarca4Eif4a3Map3k3PrkczGlg1IkbkbTnfrsf1aTnfrsf1bHdac2Map3k7ip3BCL7ACrebbpTraf1Cops3MCCPapolaTnfUsp11Map3k3RelbGtf2iMcm7Tnfrsf8Rps6ka5Ptpn11CSNK2A1Pebp1Usp2Wdr68DapSmarcc2RelaBirc3Ktn1Azi2Rnf216HIST3H3SrcTraipRps11Dpf2Zfand5Psmd3Cav1Rnf25TraddSKP1ATraf2SUMO1Actl6aCd3eapBirc3YwhahTraf2Ube2iGenePpp1r13lTnfNfkbizCasp8Stat1Polr1bMap3k7ip2RelTnfrsf1aPolr2hPsmc2Nfkb1NfkbibTraddSmarcb1Hspb1Psmd1Akap8PmlRelaGm10774Nr2c2Psmd12RPL8Tbk1Unc5clTnfrsf1bFkbp5Tnfaip3BtrcUBCH5B


Description

No description

Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 91% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
118927view14:51, 4 June 2021EgonwModified description
118924view11:15, 4 June 2021Mkutmonupdate description
118923view11:15, 4 June 2021Mkutmonupdate description
116715view09:56, 11 May 2021EweitzModified title
69201view18:24, 8 July 2013MaintBotUpdated to 2013 gpml schema
67701view11:51, 26 June 2013DdiglesOntology Term : 'tumor necrosis factor mediated signaling pathway' added !
41391view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
34428view23:23, 9 December 2009MaintBotAutomatic update of empty xrefs
32375view16:51, 15 August 2009MaintBotFixed text labels
32011view13:20, 14 August 2009MaintBotFixed group labels
31412view20:54, 13 August 2009MaintBotFixed text labels
30882view00:17, 30 July 2009MaintBotConverted from Homo sapiens
21197view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:WP246]]: Moved to stable identifier
8448view13:46, 7 January 2008MaintBot[[Pathway:Mouse:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:Mus musculus:TNF-alpha-NF-kB NetPath 9]]: Renaming species
7840view16:22, 18 December 2007MaintBotfixed category names
7308view12:42, 4 November 2007MaintBotAdded categories to GPML
6503view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:TNF-alpha-NF-kB_NetPath_9]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2610301G19RikGeneProduct219158 (Entrez Gene)
Actl6aGeneProduct56456 (Entrez Gene)
Akap8GeneProduct56399 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
Akt2GeneProduct11652 (Entrez Gene)
AlplGeneProduct11647 (Entrez Gene)
Azi2GeneProduct27215 (Entrez Gene)
BCL7AGeneProduct77045 (Entrez Gene)
Bag4GeneProduct67384 (Entrez Gene)
Bcl3GeneProduct12051 (Entrez Gene)
Birc2GeneProduct11797 (Entrez Gene)
Birc3GeneProduct11796 (Entrez Gene)
BtrcGeneProduct12234 (Entrez Gene)
CASP10GeneProduct
CSNK2A1GeneProduct12995 (Entrez Gene)
Capn3GeneProduct12335 (Entrez Gene)
Casp2GeneProduct12366 (Entrez Gene)
Casp3GeneProduct12367 (Entrez Gene)
Casp7GeneProduct12369 (Entrez Gene)
Casp8GeneProduct12370 (Entrez Gene)
Casp8ap2GeneProduct26885 (Entrez Gene)
Cav1GeneProduct12389 (Entrez Gene)
Cd3eapGeneProduct70333 (Entrez Gene)
Cdc34GeneProduct216150 (Entrez Gene)
Cdc37GeneProduct12539 (Entrez Gene)
CflarGeneProduct12633 (Entrez Gene)
ChukGeneProduct12675 (Entrez Gene)
Commd1GeneProduct17846 (Entrez Gene)
Cops3GeneProduct26572 (Entrez Gene)
CraddGeneProduct12905 (Entrez Gene)
CrebbpGeneProduct12914 (Entrez Gene)
Csnk2a2GeneProduct13000 (Entrez Gene)
Csnk2bGeneProduct13001 (Entrez Gene)
Cul1GeneProduct26965 (Entrez Gene)
CyldGeneProduct74256 (Entrez Gene)
DapGeneProduct223453 (Entrez Gene)
Ddx3xGeneProduct13205 (Entrez Gene)
Dpf2GeneProduct19708 (Entrez Gene)
Eif4a3GeneProduct192170 (Entrez Gene)
FaddGeneProduct14082 (Entrez Gene)
Faf1GeneProduct14084 (Entrez Gene)
Fancd2GeneProduct211651 (Entrez Gene)
FblGeneProduct14113 (Entrez Gene)
Fbxw11GeneProduct103583 (Entrez Gene)
Fkbp5GeneProduct14229 (Entrez Gene)
FlnaGeneProduct192176 (Entrez Gene)
G3bp2GeneProduct23881 (Entrez Gene)
Gab1GeneProduct14388 (Entrez Gene)
GeneGeneProduct
Gene SymbolGeneProduct
Glg1GeneProduct20340 (Entrez Gene)
Gm10774GeneProduct100043714 (Entrez Gene)
Gm2423GeneProduct100039786 (Entrez Gene)
Gm4596GeneProduct100043702 (Entrez Gene)
Gnb2l1GeneProduct14694 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene)
Gtf2iGeneProduct14886 (Entrez Gene)
HIST3H3GeneProduct
Hdac1GeneProduct433759 (Entrez Gene)
Hdac2GeneProduct15182 (Entrez Gene)
Hdac6GeneProduct15185 (Entrez Gene)
Hsp90aa1GeneProduct15519 (Entrez Gene)
Hsp90ab1GeneProduct15516 (Entrez Gene)
Hspb1GeneProduct15507 (Entrez Gene)
IkbkapGeneProduct230233 (Entrez Gene)
IkbkbGeneProduct16150 (Entrez Gene)
IkbkeGeneProduct56489 (Entrez Gene)
IkbkgGeneProduct16151 (Entrez Gene)
Iqgap2GeneProduct544963 (Entrez Gene)
KPNA2GeneProduct16647 (Entrez Gene)
Kcnq1GeneProduct16535 (Entrez Gene)
Kpna3GeneProduct16648 (Entrez Gene)
Kpna6GeneProduct16650 (Entrez Gene)
Ktn1GeneProduct16709 (Entrez Gene)
LrpprcGeneProduct72416 (Entrez Gene)
MCCGeneProduct328949 (Entrez Gene)
Map2k5GeneProduct23938 (Entrez Gene)
Map3k1GeneProduct26401 (Entrez Gene)
Map3k14GeneProduct53859 (Entrez Gene)
Map3k2GeneProduct26405 (Entrez Gene)
Map3k3GeneProduct26406 (Entrez Gene)
Map3k7ip1GeneProduct66513 (Entrez Gene)
Map3k7ip2GeneProduct68652 (Entrez Gene)
Map3k7ip3GeneProduct66724 (Entrez Gene)
Map3k8GeneProduct26410 (Entrez Gene)
Mark2GeneProduct13728 (Entrez Gene)
Mcm5GeneProduct17218 (Entrez Gene)
Mcm7GeneProduct17220 (Entrez Gene)
Mtif2GeneProduct76784 (Entrez Gene)
Nfkb1GeneProduct18033 (Entrez Gene)
Nfkb2GeneProduct18034 (Entrez Gene)
NfkbiaGeneProduct18035 (Entrez Gene)
NfkbibGeneProduct18036 (Entrez Gene)
NfkbieGeneProduct18037 (Entrez Gene)
NfkbizGeneProduct80859 (Entrez Gene)
Nkiras1GeneProduct69721 (Entrez Gene)
Nkiras2GeneProduct71966 (Entrez Gene)
Nlrp4eGeneProduct446099 (Entrez Gene)
Nr2c2GeneProduct22026 (Entrez Gene)
NsmafGeneProduct18201 (Entrez Gene)
PapolaGeneProduct18789 (Entrez Gene)
Pdcd2GeneProduct18567 (Entrez Gene)
Pebp1GeneProduct23980 (Entrez Gene)
Peg3GeneProduct18616 (Entrez Gene)
Pfdn2GeneProduct18637 (Entrez Gene)
Pias3GeneProduct229615 (Entrez Gene)
Pkn1GeneProduct320795 (Entrez Gene)
PmlGeneProduct18854 (Entrez Gene)
Polr1aGeneProduct20019 (Entrez Gene)
Polr1bGeneProduct20017 (Entrez Gene)
Polr1cGeneProduct20016 (Entrez Gene)
Polr1dGeneProduct20018 (Entrez Gene)
Polr1eGeneProduct64424 (Entrez Gene)
Polr2hGeneProduct245841 (Entrez Gene)
Ppp1r13lGeneProduct333654 (Entrez Gene)
Ppp2caGeneProduct19052 (Entrez Gene)
PrkacaGeneProduct18747 (Entrez Gene)
PrkczGeneProduct18762 (Entrez Gene)
Psmb5GeneProduct19173 (Entrez Gene)
Psmc1GeneProduct19179 (Entrez Gene)
Psmc2GeneProduct19181 (Entrez Gene)
Psmc3GeneProduct19182 (Entrez Gene)
Psmd12GeneProduct66997 (Entrez Gene)
Psmd13GeneProduct23997 (Entrez Gene)
Psmd1GeneProduct70247 (Entrez Gene)
Psmd3GeneProduct22123 (Entrez Gene)
Psmd6GeneProduct66413 (Entrez Gene)
Psmd7GeneProduct17463 (Entrez Gene)
Ptk2GeneProduct14083 (Entrez Gene)
Ptpn11GeneProduct19247 (Entrez Gene)
RPL30GeneProduct19946 (Entrez Gene)
RPL6GeneProduct19988 (Entrez Gene)
RPL8GeneProduct26961 (Entrez Gene)
RPS13GeneProduct68052 (Entrez Gene)
RPS6KB1GeneProduct72508 (Entrez Gene)
Rasal2GeneProduct226525 (Entrez Gene)
RelGeneProduct19696 (Entrez Gene)
RelaGeneProduct19697 (Entrez Gene)
RelbGeneProduct19698 (Entrez Gene)
Ripk1GeneProduct19766 (Entrez Gene)
Ripk2GeneProduct192656 (Entrez Gene)
Ripk3GeneProduct56532 (Entrez Gene)
Rnf216GeneProduct108086 (Entrez Gene)
Rnf25GeneProduct57751 (Entrez Gene)
Rpl4GeneProduct67891 (Entrez Gene)
Rps11GeneProduct27207 (Entrez Gene)
Rps6ka5GeneProduct73086 (Entrez Gene)
SKP1AGeneProduct21402 (Entrez Gene)
SUMO1GeneProduct22218 (Entrez Gene)
Smarca4GeneProduct20586 (Entrez Gene)
Smarcb1GeneProduct20587 (Entrez Gene)
Smarcc1GeneProduct20588 (Entrez Gene)
Smarcc2GeneProduct68094 (Entrez Gene)
Smarce1GeneProduct57376 (Entrez Gene)
SrcGeneProduct20779 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
TankGeneProduct21353 (Entrez Gene)
Tbk1GeneProduct56480 (Entrez Gene)
TifaGeneProduct211550 (Entrez Gene)
TnfGeneProduct21926 (Entrez Gene)
Tnfaip3GeneProduct21929 (Entrez Gene)
Tnfrsf11aGeneProduct21934 (Entrez Gene)
Tnfrsf1aGeneProduct21937 (Entrez Gene)
Tnfrsf1bGeneProduct21938 (Entrez Gene)
Tnfrsf8GeneProduct21941 (Entrez Gene)
Tnip1GeneProduct57783 (Entrez Gene)
Tnip2GeneProduct231130 (Entrez Gene)
TraddGeneProduct71609 (Entrez Gene)
Traf1GeneProduct22029 (Entrez Gene)
Traf2GeneProduct22030 (Entrez Gene)
Traf3GeneProduct22031 (Entrez Gene)
Traf4GeneProduct22032 (Entrez Gene)
Traf5GeneProduct22033 (Entrez Gene)
Traf6GeneProduct22034 (Entrez Gene)
TraipGeneProduct22036 (Entrez Gene)
Trpc4apGeneProduct56407 (Entrez Gene)
TxlnaGeneProduct109658 (Entrez Gene)
UBCH5BGeneProduct
Ube2iGeneProduct22196 (Entrez Gene)
Unc5clGeneProduct76589 (Entrez Gene)
Usp11GeneProduct236733 (Entrez Gene)
Usp2GeneProduct53376 (Entrez Gene)
Wdr68GeneProduct71833 (Entrez Gene)
YwhabGeneProduct54401 (Entrez Gene)
YwhaeGeneProduct22627 (Entrez Gene)
YwhagGeneProduct22628 (Entrez Gene)
YwhahGeneProduct22629 (Entrez Gene)
YwhazGeneProduct22631 (Entrez Gene)
Zfand5GeneProduct22682 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools