TNF-alpha NF-kB signaling pathway (Pan troglodytes)

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CY ->NUCY ->NUAutophosphorylationPMCytoplasmDemethylationECSumoylation(Protein-protein interaction)RecruitmentMTReceptorDeubiquitinationCY ->NUReaction through unknown mechanisms/moleculesNucleusControlAccession Number: NetPath 9; cellmap:9AcetylationMolecular associationProteolytic cleavageNUMethylationCY ->NUEndosomeLigandEndoplasmic reticulumDPalmitoylationDesumoylationCY ->NUExtracellularENCYDephosphorylationGlycosylationGOPhosphorylationEnzyme complexActivationDeacetylationGolgi apparatusMitochondrionProteins in a complex interactionPlasma membraneInhibitionMolecule in the pathwayTranslocationUbiquitinationERBCL7ANFKBIBGAB1CDC34AKAP8TNIP2ALPLIKBKGTNFRSF1ANFKBIEPPP1R13LDDX3LRPPRCTNFRSF1ATANKFKBP5PDCD2TRADDUBE2IRIPK1CDC37MCM5CASP2GeneSMARCA4POLR1CLOC464259GeneNFKBIZCASP7LOC462950BTRCTNFRSF1BPTK2IKBKBPEG3CSNK2A1PSMD1RPL8RELANFKBIAUBE2D2POLR2HRELAYWHAZSUMO1SMARCC2G3BP2TRADDFADDMCM7TRAF2RPL30DAPKPNA3POLR1DNFKBIARELFBLCHUKPOLR1BNFKB2RPS6KB1TAB3IKBKAPNKIRAS1NFKB1PSMD6POLR1ENR2C2RELBTRAIPHIST3H3TRAF4ACTL6ANFKBIATRAF3PRKCZTNFMAP3K8GeneTXLNANR2C2SRCPSMC1RNF25COMMD1CUL1IKBKEWDR68PKN1GTF2IRASAL2AKT1YWHABRELBCYLDBIRC3YWHAQTBK1RPS11SKP1MARK2YWHAHCRADDYWHAECASP8TRAF6TNFRSF11APSMD7CSNK2BSTAT1KTN1EIF4A3BIRC2PIAS3BCL3USP11RNF216PSMC2PSMC3TNFFLNAFAF1CASP10NFKB1CREBBPCASP8AP2CFLARNFKB1BIRC2USP2TNIP1POLR1APSMD3KCNQ1TRPC4APRPS6KA5PPP2CAGSK3BCHUKFANCD2TRAF2PSMB5CAV1TRAF1PTPN11COPS3UNC5CLNKIRAS2IQGAP2PRKACASMARCB1PFDN2RPL6YWHAGLOC737497TNFRSF1BNSMAFRPL4RIPK1MAP3K7IP1NLRP4MAP3K3TRAF2KPNA2UBE2D3PBAG4RPS13RELMAP3K1HSPB1MAP3K2RELATNFRSF8AZI2PEBP1HSP90AA1PSMD13MAP3K3FBXW11PSMD12RELATNFRSF1BZFAND5RIPK3MCCCASP3TNFAIP3TRAF4MAP2K5GeneRIPK2TNFGNB2L1BIRC3PAPOLAPOLR2LTNFGene SymbolTNFLOC464047PMLTBK1MTIF2TRAF1SMARCE1TNFRSF1ASMARCC1DPF2GLG1CSNK2A2IKBKGMAP3K7IP2TIFATRAF5HDAC6KPNA6TNFMAP3K14AKT2CD3EAPCAPN3


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 81% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118010view11:31, 23 May 2021EweitzModified title
108150view10:36, 29 November 2019FehrhartOntology Term : 'cancer' added !
87790view11:14, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87789view11:14, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
69230view18:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
41534view01:57, 2 March 2011MaintBotRemoved redundant pathway information and comments
34270view21:54, 9 December 2009MaintBotAutomatic update of empty xrefs
33581view09:49, 1 December 2009MaintBotRemoved group label
31605view22:10, 13 August 2009MaintBotFixed text labels
30498view21:41, 29 July 2009MaintBotNew pathway

External references

DataNodes

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Annotated Interactions

No annotated interactions
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