TNF-alpha NF-kB signaling pathway (Rattus norvegicus)

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CytoplasmExtracellularEnzyme complexECDeubiquitinationNUGlycosylationPhosphorylationReceptorInhibitionCYCY ->NUProteolytic cleavageEndoplasmic reticulumLigand(Protein-protein interaction)SumoylationAccession Number: NetPath 9; cellmap:9DCY ->NUGONucleusEndosomeRecruitmentCY ->NUControlProteins in a complex interactionPlasma membraneAcetylationDephosphorylationGolgi apparatusActivationMethylationDeacetylationERPalmitoylationENCY ->NUUbiquitinationMolecule in the pathwayTranslocationMolecular associationCY ->NUReaction through unknown mechanisms/moleculesPMMitochondrionAutophosphorylationDesumoylationMTDemethylationPmlSKP1ACav1HIST3H3Gnb2l1YwhahPebp1FlnaCasp8ap2IkbkgCraddPsmc2BtrcNr2c2Rps11SUMO1LrpprcDapAzi2TnfTifaPolr1eUsp2Traf4Rpl30RGD1309922RELBRelaMap3k8PrkacaSmarcc1CflarRnf216CASP10Polr1aPkn1SrcPsmd3Ptpn11Traf2Birc2RelaNkiras2TnfPfdn2NfkbieTRAF1Casp3Map3k2Kpna3Polr1cGene 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


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 85% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
117025view11:52, 16 May 2021EweitzModified title
69441view19:05, 8 July 2013MaintBotUpdated to 2013 gpml schema
67702view11:51, 26 June 2013DdiglesOntology Term : 'tumor necrosis factor mediated signaling pathway' added !
41766view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
34134view19:31, 9 December 2009MaintBotAutomatic update of empty xrefs
32438view17:16, 15 August 2009MaintBotFixed text labels
32108view13:47, 14 August 2009MaintBotFixed group labels
31458view21:14, 13 August 2009MaintBotFixed text labels
30990view00:56, 30 July 2009MaintBotConverted from Homo sapiens
21642view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:WP457]]: Moved to stable identifier
8450view13:46, 7 January 2008MaintBot[[Pathway:Rat:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:Rattus norvegicus:TNF-alpha-NF-kB NetPath 9]]: Renaming species
7841view16:22, 18 December 2007MaintBotfixed category names
7309view12:42, 4 November 2007MaintBotAdded categories to GPML
6603view22:20, 22 May 2007A.Pandeygpml file for [[Rat:TNF-alpha-NF-kB_NetPath_9]]

External references

DataNodes

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NameTypeDatabase referenceComment
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Zfand5GeneProduct293960 (Entrez Gene)

Annotated Interactions

No annotated interactions
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