Histidine, purine, and pyrimidine superpathway (Saccharomyces cerevisiae)
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L-aspartate
CTP
NAD
phosphoribosyl-carboxy-aminoimidazole
NH3
reduced thioredoxin
H2O
2-oxoglutarate
oxidized thioredoxin
H2O
NAD
imidazole acetol-phosphate
phosphoribosylformiminoAICAR-phosphate
reduced acceptor
H2O
5-phospho-ribosyl-glycineamide
histidinal
H2O
reduced flavodoxin
phosphoribosyl-formamido-carboxamide
H+
H2O
H+
phosphoribosyl-AMP
AMP
UDP
H2O
H2O
UMP
H2O
orotidine-5âÂÂ-phosphate
NAD
5-phosphoribosylamine
HCO3
H2O
CO2
THF
phosphoribosyl-ATP
H2O
H+
deoxy-GTP
phosphoribulosylformimino-AICAR-P
5âÂÂ-phosphoribosyl-4-(N-
oxidized flavodoxin
CO2
fumerate
dihydroorotate
carbamoyl-L-aspartate
5âÂÂ-phosphoribosyl-5-aminoimidazole
H2O
sucinocarboxamide)-5-aminoimidazole
AMP
H2O
L-aspartate
D-erythro-imidazole-glycerol-phosphate
H2O
H2O
UTP
THF
H2O
5âÂÂ-phosphoribosyl-N-formylglycineamide
5-phosphoribosyl-n-formylglycineamidine
orotate
AMP
H2O
IMP
acceptor
carbamoyl-phosphate
histidinol
ADE17
ADP
ADP
ADP
RNR4
AICAR
L-glutamate
ADP
HIS1
PRS5
ATP
L-glycine
phosphate
ATP
ADE8
IMD4
PRPP
L-glutamine
ADE6
RNR1
PRS4
HIS5
GUK1
L-histidine
phosphate
L-glutamate
L-histidinol-phosphate
ADP
ATP
ribose-5-phosphate
GTP
ADE4
GUA1
ATP
pyrophosphate
L-glutamine
ADE5,7
L-glutamine
ATP
ADE16
xanthosine-5-phosphate
ADP
URA2
YNK1
L-glutamate
ATP
ADP
L-glutamate
ADP
NADH
HIS4
pyrophosphate
HIS3
URA2
2 ATP
PRS1
phosphate
ATP
ATP
NADH
PRS3
10-formyl-THF
ATP
L-glutamate
ADP
RNR2
pyrophosphate
YNK1
phosphate
HIS4
L-glutamine
pyrophosphate
NADH
ADE5,7
URA6
ATP
phosphate
ADE16
GMP
phosphate
GDP
URA1
IMD3
ATP
ATP
HIS4
URA5
2 ADP
L-glutamate
phosphate
phosphate
L-glutamine
ATP
URA7
ADP
HIS2
pyrophosphate
URA8
CDP
phosphate
RNR3
ADE17
ADE2
ATP
dGDP
phosphate
IMD2
URA3
ADE13
HIS4
URA4
URA10
ATP
L-glutamine
ATP
L-glutamate
10-formyl-THF
PRS2
HIS6
ADP
ADP
ADE1
Description
No description
Comments
GenMAPP remarks
Based on
http://pathway.yeastgenome.org/biocyc/
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Quality Tags
Ontology Terms
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Bibliography
''Histidine, purine, and pyrimidine superpathway''; YeastPathways,
History
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Revision
Action
Time
User
Comment
135544
view
20:00, 23 September 2024
Khanspers
Modified description
135448
view
21:58, 5 September 2024
Khanspers
Ontology Term : 'classic metabolic pathway' added !
135447
view
21:58, 5 September 2024
Khanspers
removed GenMAPP comments
135446
view
21:57, 5 September 2024
Khanspers
135445
view
21:56, 5 September 2024
Khanspers
lit ref
135314
view
00:05, 17 August 2024
Khanspers
interactions
122754
view
05:17, 10 May 2022
Egonw
Added identifiers to water nodes
117345
view
11:53, 20 May 2021
Eweitz
Modified title
107259
view
14:35, 17 September 2019
MaintBot
ChEBI identifier normalization
94664
view
13:18, 4 October 2017
DeSl
Changed ribose-5-P label to D-ribose-5-P
94663
view
13:17, 4 October 2017
DeSl
Connected all lines, changed all textlabels to metabolite nodes, connected all genes to the lines.
93079
view
09:22, 28 July 2017
Elisa
Fixed some of the unconnected interactions (left side of the pathway).
93011
view
14:46, 24 July 2017
DeSl
Changed wrong CAS number (salt) for correct ChEBI ID
85638
view
16:11, 4 June 2016
Egonw
Fixed the CAS number.
71897
view
10:35, 22 October 2013
Mkutmon
changed AICAR from Unknown to Metabolite
70270
view
21:50, 15 July 2013
MaintBot
updated to 2013 schema
69872
view
18:00, 11 July 2013
Egonw
Marked a few DataNodes with CAS registry numbers as metabolites.
67670
view
11:47, 26 June 2013
Ddigles
Ontology Term : 'nucleotide metabolic pathway' added !
41803
view
04:48, 2 March 2011
MaintBot
Removed redundant pathway information and comments
21558
view
11:32, 14 November 2008
MaintBot
[[Pathway:Saccharomyces cerevisiae:Superpathway of Histidine Purine and Pyrimidine Biosynthesis]] moved to [[Pathway:WP416]]: Moved to stable identifier
12861
view
08:06, 17 May 2008
MaintBot
automated metabolite conversion
8948
view
14:13, 7 January 2008
MaintBot
Added to category $category
8946
view
14:13, 7 January 2008
M.Braymer
Uploaded new pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
10-formyl-THF
2800-34-2 (CAS)
2 ADP
58-64-0 (CAS)
2 ATP
1927-31-7 (CAS)
ADE13
GeneProduct
S000004351 (SGD)
ADE16
GeneProduct
S000004018 (SGD)
ADE17
GeneProduct
S000004727 (SGD)
ADE1
GeneProduct
S000000070 (SGD)
ADE2
GeneProduct
S000005654 (SGD)
ADE4
GeneProduct
S000004915 (SGD)
ADE5,7
GeneProduct
S000003203 (SGD)
ADE6
GeneProduct
S000003293 (SGD)
ADE8
GeneProduct
S000002816 (SGD)
ADP
58-64-0 (CAS)
AICAR
3031-94-5 (CAS)
ATP
1927-31-7 (CAS)
CDP
63-38-7 (CAS)
GDP
146-91-8 (CAS)
GMP
85-32-5 (CAS)
GTP
2564-35-4 (CAS)
GUA1
GeneProduct
S000004830 (SGD)
GUK1
GeneProduct
S000001550 (SGD)
HIS1
GeneProduct
S000000857 (SGD)
HIS2
GeneProduct
S000001921 (SGD)
HIS3
GeneProduct
S000005728 (SGD)
HIS4
GeneProduct
S000000535 (SGD)
HIS5
GeneProduct
S000001378 (SGD)
HIS6
GeneProduct
S000001282 (SGD)
IMD2
GeneProduct
S000001259 (SGD)
IMD3
GeneProduct
S000004424 (SGD)
IMD4
GeneProduct
S000004520 (SGD)
L-glutamate
56-86-0 (CAS)
L-glutamine
56-85-9 (CAS)
L-glycine
56-40-6 (CAS)
L-histidine
71-001 (CAS)
L-histidinol-phosphate
25679-93-0 (CAS)
NADH
53-84-9 (CAS)
PRPP
97-55-2 (CAS)
PRS1
GeneProduct
S000001664 (SGD)
PRS2
GeneProduct
S000000901 (SGD)
PRS3
GeneProduct
S000001003 (SGD)
PRS4
GeneProduct
S000000164 (SGD)
PRS5
GeneProduct
S000005422 (SGD)
RNR1
GeneProduct
S000000872 (SGD)
RNR2
GeneProduct
S000003563 (SGD)
RNR3
GeneProduct
S000001328 (SGD)
RNR4
GeneProduct
S000003412 (SGD)
URA10
GeneProduct
S000004884 (SGD)
URA1
GeneProduct
S000001699 (SGD)
URA2
GeneProduct
S000003666 (SGD)
URA3
GeneProduct
S000000747 (SGD)
URA4
GeneProduct
S000004412 (SGD)
URA5
GeneProduct
S000004574 (SGD)
URA6
GeneProduct
S000001507 (SGD)
URA7
GeneProduct
S000000135 (SGD)
URA8
GeneProduct
S000003864 (SGD)
YNK1
GeneProduct
S000001550 (SGD)
dGDP
102783-74-4 (CAS)
phosphate
14265-44-2 (CAS)
pyrophosphate
2466-09-3 (CAS)
ribose-5-phosphate
3615-55-2 (CAS)
xanthosine-5-phosphate
523-98-8 (CAS)
Annotated Interactions
No annotated interactions
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