Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)

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1-498, 99112145, 14623, 24637838-42138-1435011964120, 121147, 14898, 99104, 105147, 148127-1307771131, 13211881, 82125, 12619, 206, 75575127, 129, 133-13727-29145, 14657-5930-3721, 221076595-97539492, 93124113-1157414-1614711-131895, 100140, 14473108-11161, 625611951, 5283-91149, 150122, 12325, 2643-467217101, 102116, 1178-105, 66-706095, 100103547647-4910679, 8014, 151clathrin sculpted monoamine transport vesicle lumensynaptic vesicleGolgi lumenstored secretory granulelate endosome lumenendosome lumencytosolendoplasmic reticulum lumenMCT substratesNaDC3sodium ionD-fructosesodium ionH+Zinc 2+Noradrenaline uptake transporterSGLT4GLUT6/8/10/12NH4+sodium ionsodium ionGLUT7/11galactose, glucosecompounds transported by GLUT9GLUT9GLUT5RHAGsodium ionCholineURAT1CarnitineMagT1/2MTP1:Hephaestin (copper complex)sodium ionChlorideDopaminesodium ionsodium ionSuccinateInositolH+hexoses transported by GLUT7/11MATE1/2glycineH+sodium ionL-ProlineL-Prolineinorganic sulfatesodium ionSMITChlorideZn++sodium ionsodium ioniron (ferrous)DCT1hZIP5OAT2/4ErgothioneineOCT1H+sodium ioniron (3+)SMIT2ligands of SLC6A14OCT3 substratessodium ionSodium dependent Serotonin transporterCopperNaDC1ZIP6/ZIP14OCT2 substratesCholine2-Oxoglutaratealpha-D-glucosesodium ionsodium ionSOATNoradrenaline uptake transportersodium ionGlycineOCT3 substratesMagnesiumClass I GLUTsCTL1-5Carnitine transportersalpha-D-glucoseH+NH4+NaS2D-fructoseCholineChloridealpha-D-glucosehCTR1ligands of SLC6A12 (BGT-1)SLC6A15InositolGABAinorganic sulfateSLC6A GABA transportersgalactose, glucosehexoses transported by SGLT4Zn++UreaH+NRAMP1sodium ionZinc 2+sodium ionChloridesodium ionSolute carrier family 13 member 5H+MCT substratessodium ionsodium ioniron (3+)sodium ionDopamineSLC6A6Noradrenalinesodium ionNH4+NH4+Zn++hZIP1-4UreaH+RHCGsodium ioniron (ferrous)Divalent metals transported by NRAMP1MagnesiumH+CarnitineChlorideZnT2GABAligands of SLC6A15sodium ionOCT1 substratesSuccinatesodium ionZnT1MATE substratesligands of SLC6A6SGLT2ChlorideZnT3Urea transportersZnT5hexoses transported by GLUT7/11PROTH+OAT1-3SGLT1Biogenic amines transported by VMAT1/2ZnT6NH4+H+ligands of SLC6A15Zn++SerotoninH+ChlorideH+NaS1ligands of SLC6A6sodium ionligands of SLC6A19Citrateligands of SLC6A14OAT2/4 sulfate conjugate substratesProton myo-inositol cotransportersodium ionsodium ionNoradrenaline uptake transporterfructose, galactose, glucoseZIP8H+Inositols transported by SMIT2Inositols transported by SMIT2(S)-LactateBiogenic amines transported by VMAT1/2Divalent metals transported by NRAMP1H+sodium ion(S)-LactateSodium dpendent Dopamine transporterNH4+Noradrenalinesodium ionsodium ionUrateORCTL2 substratessodium ionOAT1-3 substratesInositolZn++H+ETTChlorideChlorideChlorideOCT2 substratesOAT1-3 substratesligands of SLC6A12 (BGT-1)sodium ionSLC6A19H+compounds transported by GLUT9sodium ionOCT1 substratessodium ionZnT8ORCTL2GLUT2 tetramertaurolithocholate sulfate5-HydroxytryptamineUratesodium ionRHBGORCTL2 substratessodium ionChloridetaurolithocholate sulfateZn++OCT3OAT2/4 sulfate conjugate substratesVMAT1/2H+H+ZnT7ligands of SLC6A19sodium ionsodium ionCitrateDicarboxylates transported by NaDC1hexoses transported by SGLT4CholineZn++H+Copperfructose, galactose, glucosesodium ionsodium ionInositolMonocarboxylate transportersGLYTsodium ionSLC6A20SLC6A18Ergothioneinesodium ionZIP7Dicarboxylates transported by NaDC1Chloridesodium ion2-oxoglutarateNAT1sodium ionMATE substratesChloridealpha-D-glucoseCHTSLC6A12SLC6A14MTP1:Ceruloplasmin (copper complex)hZIP10sodium ionChloride5


Description

Hexoses like glucose, galactose and fructose serve as basic fuel molecules for eukaryotic cells. Indeed, glucose is the main energy source for mammalian cells. These sugars are unable to diffuse across cellular membranes, and require transporter proteins for entry into and exit out of cells. Four gene families encode hexose transporter proteins (He et al, 2009). SLC2 family contains 14 genes and encode facilitative glucose transporters (GLUTs) (Uldry M and Thorens B, 2004). SLC5 family contains 12 genes and encode Na+/glucose symporters (Wright EM and Turk E, 2004). SLC37 family contains 4 members and encode sugar-phosphate/phosphate exchangers (Bartoloni L and Antonarakis SE, 2004). SLC45 family has 4 members and encode putative sugar/H+ symporters.

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  104. Morris ME, Felmlee MA.; ''Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid.''; PubMed Europe PMC Scholia
  105. Sun W, Wu RR, van Poelje PD, Erion MD.; ''Isolation of a family of organic anion transporters from human liver and kidney.''; PubMed Europe PMC Scholia
  106. Olivès B, Martial S, Mattei MG, Matassi G, Rousselet G, Ripoche P, Cartron JP, Bailly P.; ''Molecular characterization of a new urea transporter in the human kidney.''; PubMed Europe PMC Scholia
  107. Desouki MM, Geradts J, Milon B, Franklin RB, Costello LC.; ''hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands.''; PubMed Europe PMC Scholia
  108. Koepsell H, Endou H.; ''The SLC22 drug transporter family.''; PubMed Europe PMC Scholia
  109. Yamada R, Tokuhiro S, Chang X, Yamamoto K.; ''SLC22A4 and RUNX1: identification of RA susceptible genes.''; PubMed Europe PMC Scholia
  110. Wakida N, Tuyen DG, Adachi M, Miyoshi T, Nonoguchi H, Oka T, Ueda O, Tazawa M, Kurihara S, Yoneta Y, Shimada H, Oda T, Kikuchi Y, Matsuo H, Hosoyamada M, Endou H, Otagiri M, Tomita K, Kitamura K.; ''Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia.''; PubMed Europe PMC Scholia
  111. Lin X, Ma L, Fitzgerald RL, Ostlund RE.; ''Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells.''; PubMed Europe PMC Scholia
  112. Pajor AM.; ''Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney.''; PubMed Europe PMC Scholia
  113. Tanihara Y, Masuda S, Sato T, Katsura T, Ogawa O, Inui K.; ''Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.''; PubMed Europe PMC Scholia
  114. Gründemann D, Schechinger B, Rappold GA, Schömig E.; ''Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter.''; PubMed Europe PMC Scholia
  115. Küry S, Dréno B, Bézieau S, Giraudet S, Kharfi M, Kamoun R, Moisan JP.; ''Identification of SLC39A4, a gene involved in acrodermatitis enteropathica.''; PubMed Europe PMC Scholia
  116. Reid G, Wolff NA, Dautzenberg FM, Burckhardt G.; ''Cloning of a human renal p-aminohippurate transporter, hROAT1.''; PubMed Europe PMC Scholia
  117. Wang F, Kim BE, Petris MJ, Eide DJ.; ''The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.''; PubMed Europe PMC Scholia
  118. Besecker B, Bao S, Bohacova B, Papp A, Sadee W, Knoell DL.; ''The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia.''; PubMed Europe PMC Scholia
  119. Gaither LA, Eide DJ.; ''The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells.''; PubMed Europe PMC Scholia
  120. Veyhl M, Keller T, Gorboulev V, Vernaleken A, Koepsell H.; ''RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1.''; PubMed Europe PMC Scholia
  121. He L, Wang B, Hay EB, Nebert DW.; ''Discovery of ZIP transporters that participate in cadmium damage to testis and kidney.''; PubMed Europe PMC Scholia
  122. Goytain A, Quamme GA.; ''Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties.''; PubMed Europe PMC Scholia
  123. Peltekova VD, Wintle RF, Rubin LA, Amos CI, Huang Q, Gu X, Newman B, Van Oene M, Cescon D, Greenberg G, Griffiths AM, St George-Hyslop PH, Siminovitch KA.; ''Functional variants of OCTN cation transporter genes are associated with Crohn disease.''; PubMed Europe PMC Scholia
  124. Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J.; ''Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex.''; PubMed Europe PMC Scholia
  125. Matskevitch I, Wagner CA, Stegen C, Bröer S, Noll B, Risler T, Kwon HM, Handler JS, Waldegger S, Busch AE, Lang F.; ''Functional characterization of the Betaine/gamma-aminobutyric acid transporter BGT-1 expressed in Xenopus oocytes.''; PubMed Europe PMC Scholia
  126. Lee J, Peña MM, Nose Y, Thiele DJ.; ''Biochemical characterization of the human copper transporter Ctr1.''; PubMed Europe PMC Scholia
  127. Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, Robertson D.; ''Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency.''; PubMed Europe PMC Scholia
  128. Hosoyamada M, Sekine T, Kanai Y, Endou H.; ''Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney.''; PubMed Europe PMC Scholia
  129. Olives B, Neau P, Bailly P, Hediger MA, Rousselet G, Cartron JP, Ripoche P.; ''Cloning and functional expression of a urea transporter from human bone marrow cells.''; PubMed Europe PMC Scholia
  130. Han O, Kim EY.; ''Colocalization of ferroportin-1 with hephaestin on the basolateral membrane of human intestinal absorptive cells.''; PubMed Europe PMC Scholia
  131. Li M, Zhang Y, Bharadwaj U, Zhai QJ, Ahern CH, Fisher WE, Brunicardi FC, Logsdon CD, Chen C, Yao Q.; ''Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts.''; PubMed Europe PMC Scholia
  132. Kishi F.; ''Isolation and characterization of human Nramp cDNA.''; PubMed Europe PMC Scholia
  133. Kobayashi Y, Ohshiro N, Sakai R, Ohbayashi M, Kohyama N, Yamamoto T.; ''Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]).''; PubMed Europe PMC Scholia
  134. Tamai I, Ohashi R, Nezu J, Yabuuchi H, Oku A, Shimane M, Sai Y, Tsuji A.; ''Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2.''; PubMed Europe PMC Scholia
  135. Liu Z, Peng J, Mo R, Hui C, Huang CH.; ''Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
114951view16:47, 25 January 2021ReactomeTeamReactome version 75
113395view11:47, 2 November 2020ReactomeTeamReactome version 74
112600view15:57, 9 October 2020ReactomeTeamReactome version 73
101754view12:49, 5 November 2018EgonwCHEBI:29036 is the identifier for Cu2+
101516view11:38, 1 November 2018ReactomeTeamreactome version 66
101052view21:20, 31 October 2018ReactomeTeamreactome version 65
100583view19:53, 31 October 2018ReactomeTeamreactome version 64
100132view16:39, 31 October 2018ReactomeTeamreactome version 63
99682view15:08, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99274view12:45, 31 October 2018ReactomeTeamreactome version 62
94493view08:58, 14 September 2017MkutmonReactome release 61
86602view09:22, 11 July 2016ReactomeTeamreactome version 56
83132view10:06, 18 November 2015ReactomeTeamVersion54
81475view13:00, 21 August 2015ReactomeTeamVersion53
76949view08:22, 17 July 2014ReactomeTeamFixed remaining interactions
76654view12:02, 16 July 2014ReactomeTeamFixed remaining interactions
75983view10:04, 11 June 2014ReactomeTeamRe-fixing comment source
75686view11:01, 10 June 2014ReactomeTeamReactome 48 Update
75042view13:55, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74686view08:45, 30 April 2014ReactomeTeamReactome46
45063view20:02, 6 October 2011KhanspersOntology Term : 'metal ion transport pathway' added !
45062view20:01, 6 October 2011KhanspersOntology Term : 'sugar transport pathway' added !
42150view22:00, 4 March 2011MaintBotAutomatic update
39961view05:58, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(S)-Lactate Metabolite422 (ChEBI)
2-Oxoglutarate Metabolite30915 (ChEBI)
2-oxoglutarate Metabolite30915 (ChEBI)
5-Hydroxytryptamine Metabolite28790 (ChEBI)
Biogenic amines

transported by VMAT1/2

MetaboliteREACT_20722 (Reactome)
Biogenic amines

transported by VMAT1/2

MetaboliteREACT_21050 (Reactome)
CHT ProteinQ9GZV3 (UniProt)
CTL1-5 UnknownREACT_20955 (Reactome)
Carnitine Metabolite17126 (ChEBI)
Carnitine transporters UnknownREACT_22929 (Reactome)
Chloride Metabolite17996 (ChEBI)
Choline Metabolite15354 (ChEBI)
Citrate Metabolite30769 (ChEBI)
Class I GLUTs UnknownREACT_20111 (Reactome)
Copper Metabolite28694 (ChEBI)
D-fructose Metabolite15824 (ChEBI)
DCT1 ProteinP49281 (UniProt)
Dicarboxylates

transported by NaDC1

MetaboliteREACT_20685 (Reactome)
Dicarboxylates

transported by NaDC1

MetaboliteREACT_21161 (Reactome)
Divalent metals

transported by NRAMP1

MetaboliteREACT_20962 (Reactome)
Divalent metals

transported by NRAMP1

MetaboliteREACT_21144 (Reactome)
Dopamine Metabolite18243 (ChEBI)
ETT ProteinQ9H015 (UniProt)
Ergothioneine Metabolite4828 (ChEBI)
GABA Metabolite16865 (ChEBI)
GLUT2 tetramer ComplexREACT_8747 (Reactome)
GLUT5 ProteinP22732 (UniProt)
GLUT6/8/10/1

2

UnknownREACT_20110 (Reactome)
GLUT7/11 UnknownREACT_19472 (Reactome)
GLUT9 ProteinQ9NRM0 (UniProt)
GLYT UnknownREACT_21204 (Reactome)
Glycine Metabolite15428 (ChEBI)
H+ Metabolite15378 (ChEBI)
Inositol Metabolite17268 (ChEBI)
Inositols transported

by SMIT2

MetaboliteREACT_19525 (Reactome)
Inositols transported

by SMIT2

MetaboliteREACT_19739 (Reactome)
L-Proline Metabolite17203 (ChEBI)
MATE substrates MetaboliteREACT_20849 (Reactome)
MATE substrates MetaboliteREACT_21070 (Reactome)
MATE1/2 UnknownREACT_20810 (Reactome)
MCT substrates MetaboliteREACT_20996 (Reactome)
MCT substrates MetaboliteREACT_21125 (Reactome)
MTP1:Ceruloplasmin

(copper complex)

ComplexREACT_24142 (Reactome)
MTP1:Hephaestin

(copper complex)

ComplexREACT_24553 (Reactome)
MagT1/2 UnknownREACT_20757 (Reactome)
Magnesium Metabolite18420 (ChEBI)
Monocarboxylate

transporters

UnknownREACT_21092 (Reactome)
NAT1 ProteinP23975 (UniProt)
NH4+ Metabolite28938 (ChEBI)
NRAMP1 ProteinP49279 (UniProt)
NaDC1 ProteinQ13183 (UniProt)
NaDC3 ProteinQ8WWT9 (UniProt)
NaS1 ProteinQ9BZW2 (UniProt)
NaS2 ProteinQ9UKG4 (UniProt)
Noradrenaline Metabolite18357 (ChEBI)
Noradrenaline uptake

transporter

ProteinO15244 (UniProt)
OAT1-3 UnknownREACT_22994 (Reactome)
OAT1-3 substrates MetaboliteREACT_22453 (Reactome)
OAT1-3 substrates MetaboliteREACT_23252 (Reactome)
OAT2/4 UnknownREACT_23320 (Reactome)
OAT2/4 sulfate

conjugate substrates

MetaboliteREACT_22525 (Reactome)
OAT2/4 sulfate

conjugate substrates

MetaboliteREACT_23389 (Reactome)
OCT1 ProteinO15245 (UniProt)
OCT1 substrates MetaboliteREACT_22807 (Reactome)
OCT1 substrates MetaboliteREACT_23354 (Reactome)
OCT2 substrates MetaboliteREACT_22491 (Reactome)
OCT2 substrates MetaboliteREACT_23290 (Reactome)
OCT3 ProteinO75751 (UniProt)
OCT3 substrates MetaboliteREACT_22507 (Reactome)
OCT3 substrates MetaboliteREACT_22750 (Reactome)
ORCTL2 ProteinQ96BI1 (UniProt)
ORCTL2 substrates MetaboliteREACT_22882 (Reactome)
ORCTL2 substrates MetaboliteREACT_23364 (Reactome)
PROT ProteinQ99884 (UniProt)
Proton myo-inositol

cotransporter

ProteinQ96QE2 (UniProt)
RHAG ProteinQ02094 (UniProt)
RHBG ProteinQ9H310 (UniProt)
RHCG ProteinQ9UBD6 (UniProt)
SGLT1 ProteinP13866 (UniProt)
SGLT2 ProteinP31639 (UniProt)
SGLT4 ProteinQ2M3M2 (UniProt)
SLC6A GABA

transporters

UnknownREACT_20690 (Reactome)
SLC6A12 ProteinP48065 (UniProt)
SLC6A14 ProteinQ9UN76 (UniProt)
SLC6A15 ProteinQ9H2J7 (UniProt)
SLC6A18 ProteinQ96N87 (UniProt)
SLC6A19 ProteinQ695T7 (UniProt)
SLC6A20 ProteinQ9NP91 (UniProt)
SLC6A6 ProteinP31641 (UniProt)
SMIT ProteinP53794 (UniProt)
SMIT2 ProteinQ8WWX8 (UniProt)
SOAT ProteinQ3KNW5 (UniProt)
Serotonin Metabolite28790 (ChEBI)
Sodium dependent

Serotonin transporter

UnknownREACT_15766 (Reactome)
Sodium dpendent

Dopamine transporter

ProteinQ01959 (UniProt)
Solute carrier family

13 member 5

ProteinQ86YT5 (UniProt)
Succinate Metabolite15741 (ChEBI)
URAT1 ProteinQ96S37 (UniProt)
Urate Metabolite17775 (ChEBI)
Urea Metabolite16199 (ChEBI)
Urea transporters UnknownREACT_20946 (Reactome)
VMAT1/

2

UnknownREACT_21239 (Reactome)
ZIP6/ZIP14 UnknownREACT_21222 (Reactome)
ZIP7 ProteinQ92504 (UniProt)
ZIP8 ProteinQ9C0K1 (UniProt)
Zinc 2+ Metabolite29105 (ChEBI)
Zn++ Metabolite29105 (ChEBI)
ZnT1 ProteinQ9Y6M5 (UniProt)
ZnT2 ProteinQ9BRI3 (UniProt)
ZnT3 ProteinQ99726 (UniProt)
ZnT5 ProteinQ8TAD4 (UniProt)
ZnT6 ProteinQ6NXT4 (UniProt)
ZnT7 ProteinQ8NEW0 (UniProt)
ZnT8 ProteinQ8IWU4 (UniProt)
alpha-D-glucose Metabolite17925 (ChEBI)
compounds

transported by GLUT9

MetaboliteREACT_19454 (Reactome)
compounds

transported by GLUT9

MetaboliteREACT_19915 (Reactome)
fructose, galactose,

glucose

MetaboliteREACT_9596 (Reactome)
fructose, galactose,

glucose

MetaboliteREACT_9838 (Reactome)
galactose, glucose MetaboliteREACT_9575 (Reactome)
galactose, glucose MetaboliteREACT_9887 (Reactome)
glycine Metabolite15428 (ChEBI)
hCTR1 ProteinO15431 (UniProt)
hZIP1-4 UnknownREACT_20986 (Reactome)
hZIP10 ProteinQ9ULF5 (UniProt)
hZIP5 ProteinQ6ZMH5 (UniProt)
hexoses transported

by GLUT7/11

MetaboliteREACT_19505 (Reactome)
hexoses transported

by GLUT7/11

MetaboliteREACT_20174 (Reactome)
hexoses transported

by SGLT4

MetaboliteREACT_19903 (Reactome)
hexoses transported

by SGLT4

MetaboliteREACT_19933 (Reactome)
inorganic sulfate Metabolite16189 (ChEBI)
iron (3+) Metabolite29034 (ChEBI)
iron (ferrous) Metabolite18248 (ChEBI)
ligands of SLC6A12

(BGT-1)

MetaboliteREACT_14225 (Reactome)
ligands of SLC6A12

(BGT-1)

MetaboliteREACT_14644 (Reactome)
ligands of SLC6A14 MetaboliteREACT_15161 (Reactome)
ligands of SLC6A14 MetaboliteREACT_15206 (Reactome)
ligands of SLC6A15 MetaboliteREACT_13883 (Reactome)
ligands of SLC6A15 MetaboliteREACT_14097 (Reactome)
ligands of SLC6A19 MetaboliteREACT_15160 (Reactome)
ligands of SLC6A19 MetaboliteREACT_15227 (Reactome)
ligands of SLC6A6 MetaboliteREACT_14486 (Reactome)
ligands of SLC6A6 MetaboliteREACT_14671 (Reactome)
sodium ion Metabolite29101 (ChEBI)
taurolithocholate

sulfate

Metabolite17864 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1935"
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