Mitotic G2-G2/M phases (Homo sapiens)

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5, 6292223244-68, 14, 151717, 1816219212633132089-12323031131325227, 2827, 28cytosolnucleoplasmphospho-Cdc25CADPCRS kinasephospho-Cdc2(Thr 14):Cyclin AWee1Mature centrosomes enriched in gamma-TURC complexesCdc25CADPCyclin A2:phospho-Cdc2(Thr 161)ADPphospho-G2/M transition proteinphosphorylated NuMAMyt1 kinaseCentrosome associated Plk1Cyclin A2:Cdk2 phosphorylated G2/M transition proteinphospho-G2/M transition proteinnuclear Cyclin B1:Cdc2 complexesPLK1Cdc25BH2OATPADPATPCDK11p58ATPcytoplasmic Cyclin B1:Cdc2 complexesNuMA homodimerATPphospho-NlpADPATPphospho-Myt1Cyclin B:Cdc2 complexgamma-tubulin complexATPNlp-depleted centrosomeCyclin AG2/M transition proteinsH2OCdc25phosphorylated nuclear Cyclin B1:Cdc2 substratesCdc2Cyclin A:phospho-Cdk2(Thr160):E2F1/E2F3 complexCyclin A1:phospho-Cdc2(Thr161)PLK1Crm1phospho-Wee1centrosome containing phosphorylated Nlpnuclear Cyclin B1:phospho-Cdc2 ( Thr 14) complexesADPCyclin B1:phospho-Cdc2(Thr 161, Thr 14, Tyr 15)ATPCyclin A:phospho-Cdk2(Thr160):phospho-E2F1/E2F2 complexCyclin A:phospho-Cdk2(Thr160) complexcentrosome-associated NuMAATPactive nuclear Cyclin B1:Cdc2 complexesADPADPATPCyclin B:phospho-Cdc2(Thr 14)ADPphospho-Cyclin B1(CRS):phospho-Cdc2 (Thr 161)ADPcentrosomeCyclin BADPCyclin B1:phospho-Cdc2 (Thr 14, Thr 161)Cyclin A1:Cdk2 phosphorylated G2/M transition proteinCyclin A:Cdc2Cdc25CATPNuMAPhospho-Cyclin B1 (CRS):phospho-Cdc2(Thr 161)ATPCyclin B2:phospho-Cdc2(Thr 161)CAKH2OCentrosomes containing recruited CDK11p58nuclear Cyclin B1:Cdc2 substratesphospho-cyclin B1(CRS):phosph-Cdc2(Thr 161)Cyclin A:phospho-Cdc2(Thr 14, Thr 161)OrthophosphateADPOrthophosphateADPOrthophosphatecNAP-1 depleted centrosomeG2/M transition proteinOrthophosphateCdc25ATPCyclin B2:phospho-Cdc2(Thr 14, Thr 161)Myt1 kinaseCyclin A:phospho-Cdc2(Thr 161, Thr 14, Tyr 15)ATPG2/M transition proteinsCyclin A:phospho-Cdc2(Thr 14)Cdc25BH2OCdc25ATPADPE2F1/E2F3centrosome-nucleated microtubulesCyclin B1:phospho-Cdc2(Thr 161, Thr 14, Tyr 15)Cyclin A:phospho-Cdc2(Thr 161)Cep250/C-Nap1NuMA-bound microtubulesCyclin B1:phospho-Cdc2(Thr 161)Cyclin B1:phospho-Cdc2(Thr 161)


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Bibliography

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  1. Bublik DR, Scolz M, Triolo G, Monte M, Schneider C.; ''Human GTSE-1 regulates p21(CIP1/WAF1) stability conferring resistance to paclitaxel treatment.''; PubMed Europe PMC Scholia
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  64. Pines J, Hunter T.; ''Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.''; PubMed Europe PMC Scholia
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  69. Bayliss R, Sardon T, Vernos I, Conti E.; ''Structural basis of Aurora-A activation by TPX2 at the mitotic spindle.''; PubMed Europe PMC Scholia
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  82. Liu XS, Li H, Song B, Liu X.; ''Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery.''; PubMed Europe PMC Scholia
  83. Takizawa CG, Morgan DO.; ''Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C.''; PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
114706view16:18, 25 January 2021ReactomeTeamReactome version 75
113151view11:21, 2 November 2020ReactomeTeamReactome version 74
112379view15:31, 9 October 2020ReactomeTeamReactome version 73
101750view12:30, 5 November 2018DeSlOntology Term : 'G2/M transition pathway' added !
101749view12:29, 5 November 2018DeSlOntology Term : 'G2 phase pathway' added !
101282view11:17, 1 November 2018ReactomeTeamreactome version 66
100819view20:47, 31 October 2018ReactomeTeamreactome version 65
100360view19:22, 31 October 2018ReactomeTeamreactome version 64
99905view16:06, 31 October 2018ReactomeTeamreactome version 63
99461view14:38, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
94019view13:51, 16 August 2017ReactomeTeamreactome version 61
93638view11:29, 9 August 2017ReactomeTeamreactome version 61
86753view09:25, 11 July 2016ReactomeTeamreactome version 56
83378view11:04, 18 November 2015ReactomeTeamVersion54
81553view13:05, 21 August 2015ReactomeTeamVersion53
77022view08:32, 17 July 2014ReactomeTeamFixed remaining interactions
76727view12:09, 16 July 2014ReactomeTeamFixed remaining interactions
75762view11:26, 10 June 2014ReactomeTeamReactome 48 Update
75112view14:06, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74759view08:50, 30 April 2014ReactomeTeamReactome46
44913view10:36, 6 October 2011MartijnVanIerselOntology Term : 'cell cycle pathway, mitotic' added !
42077view21:55, 4 March 2011MaintBotAutomatic update
39885view05:54, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
CAK ComplexREACT_5717 (Reactome)
CDK11p58 ProteinREACT_16059 (Reactome)
CRS kinase UnknownREACT_6373 (Reactome)
Cdc2 ProteinP06493 (UniProt)
Cdc25 UnknownREACT_3533 (Reactome)
Cdc25 ProteinREACT_6588 (Reactome)
Cdc25 ProteinREACT_9309 (Reactome)
Cdc25B ProteinP30305 (UniProt)
Cdc25C ProteinP30307 (UniProt)
Centrosome

associated Plk1

ComplexREACT_18209 (Reactome)
Centrosomes

containing recruited CDK11p58

ComplexREACT_17657 (Reactome)
Cep250/C-

Nap1

ProteinQ9BV73 (UniProt)
Crm1 ProteinO14980 (UniProt)
Cyclin A ProteinREACT_6541 (Reactome)
Cyclin A1:

phospho- Cdc2(Thr161)

ComplexREACT_4408 (Reactome)
Cyclin A1:Cdk2

phosphorylated G2/M transition protein

UnknownREACT_23084 (Reactome)
Cyclin A2:

phospho-Cdc2 (Thr 161)

ComplexREACT_4651 (Reactome)
Cyclin A2:Cdk2

phosphorylated G2/M transition protein

UnknownREACT_22726 (Reactome)
Cyclin A:Cdc2 ComplexREACT_6461 (Reactome)
Cyclin A:phospho-

Cdc2(Thr 14)

ComplexREACT_6613 (Reactome)
Cyclin A:phospho-

Cdc2(Thr 14, Thr 161)

ComplexREACT_6673 (Reactome)
Cyclin A:phospho-

Cdc2(Thr 161)

ComplexREACT_6644 (Reactome)
Cyclin A:phospho-

Cdc2(Thr 161, Thr 14, Tyr 15)

ComplexREACT_6620 (Reactome)
Cyclin A:phospho-

Cdk2(Thr160) complex

ComplexREACT_9292 (Reactome)
Cyclin A:phospho-

Cdk2(Thr160): E2F1/E2F3 complex

ComplexREACT_9177 (Reactome)
Cyclin A:phospho-

Cdk2(Thr160): phospho-E2F1/E2F2 complex

ComplexREACT_9267 (Reactome)
Cyclin B ProteinREACT_6593 (Reactome)
Cyclin B1:phospho-

Cdc2 (Thr 14, Thr 161)

ComplexREACT_6474 (Reactome)
Cyclin B1:phospho-

Cdc2(Thr 161)

ComplexREACT_3166 (Reactome)
Cyclin B1:phospho-

Cdc2(Thr 161, Thr 14, Tyr 15)

ComplexREACT_6566 (Reactome)
Cyclin B1:phospho-

Cdc2(Thr 161, Thr 14, Tyr 15)

ComplexREACT_6704 (Reactome)
Cyclin B1:phospho-Cdc2

(Thr 161)

ComplexREACT_6540 (Reactome)
Cyclin B2:phospho-

Cdc2(Thr 14, Thr 161)

ComplexREACT_6445 (Reactome)
Cyclin B2:phospho-

Cdc2(Thr 161)

ComplexREACT_4066 (Reactome)
Cyclin B:Cdc2

complex

ComplexREACT_6447 (Reactome)
Cyclin B:phospho-

Cdc2(Thr 14)

ComplexREACT_6524 (Reactome)
E2F1/E2F3 UnknownREACT_9082 (Reactome)
G2/M transition

protein

UnknownREACT_2998 (Reactome)
G2/M transition

proteins

UnknownREACT_22572 (Reactome)
G2/M transition

proteins

UnknownREACT_23060 (Reactome)
H2O Metabolite15377 (ChEBI)
Mature

centrosomes enriched in gamma-TURC complexes

ComplexREACT_15605 (Reactome)
Myt1 kinase ProteinQ99640 (UniProt)
Nlp-depleted

centrosome

ComplexREACT_18075 (Reactome)
NuMA ProteinQ14980 (UniProt)
NuMA

homodimer

ComplexREACT_15940 (Reactome)
NuMA-bound

microtubules

ComplexREACT_18043 (Reactome)
Orthophosphate Metabolite18367 (ChEBI)
PLK1 ProteinP53350 (UniProt)
Phospho-Cyclin B1

(CRS):phospho- Cdc2(Thr 161)

ComplexREACT_6578 (Reactome)
Wee1 ProteinP30291 (UniProt)
active nuclear

Cyclin B1:Cdc2 complexes

UnknownREACT_6519 (Reactome)
cNAP-1 depleted

centrosome

ComplexREACT_17186 (Reactome)
centrosome ComplexREACT_15979 (Reactome)
centrosome

containing phosphorylated Nlp

ComplexREACT_17093 (Reactome)
centrosome-

associated NuMA

ComplexREACT_15920 (Reactome)
centrosome-

nucleated microtubules

ComplexREACT_16122 (Reactome)
cytoplasmic Cyclin

B1:Cdc2 complexes

ComplexREACT_6372 (Reactome)
gamma-tubulin

complex

ComplexREACT_15704 (Reactome) A current model of the arrangement of subunits within the  TuRC postulates that 6-7 TuSC subcomplexes are held together by  the other Grip proteins, which together form the cap subunits(Reviewed in Wiese and Zheng, 2006).
nuclear Cyclin B1:

Cdc2 complexes

ComplexREACT_6641 (Reactome)
nuclear Cyclin B1:

Cdc2 substrates

UnknownREACT_6526 (Reactome)
nuclear Cyclin B1:

phospho-Cdc2 ( Thr 14) complexes

ComplexREACT_6390 (Reactome)
phospho-Cdc2(Thr

14):Cyclin A

ComplexREACT_6681 (Reactome)
phospho-Cdc25C ProteinP30307 (UniProt)
phospho-Cyclin B1

(CRS):phospho-Cdc2 (Thr 161)

ComplexREACT_6646 (Reactome)
phospho-G2/M

transition protein

UnknownREACT_4658 (Reactome)
phospho-G2/M

transition protein

UnknownREACT_3843 (Reactome)
phospho-Myt1 ProteinQ99640 (UniProt)
phospho-Nlp ProteinQ9Y2I6 (UniProt)
phospho-Wee1 ProteinP30291 (UniProt)
phospho-cyclin B1

(CRS):phosph-Cdc2 (Thr 161)

ComplexREACT_6436 (Reactome)
phosphorylated

NuMA

ProteinQ14980 (UniProt)
phosphorylated

nuclear Cyclin B1: Cdc2 substrates

UnknownREACT_8297 (Reactome)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1859"
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