Serotonin receptor 4/6/7 and NR3C signaling (Homo sapiens)

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26, 53, 83, 87, 101...18, 20, 34, 50, 59...68, 10540, 861547, 5592, 1061, 1028, 80173612, 3015, 16, 28, 58, 66...7, 56, 90411469106131, 43, 46, 52, 60...21, 454, 9, 62, 6451, 673, 13, 19, 24, 63...38, 10478, 825, 6, 25, 32, 42...7629, 761133, 37, 49, 57, 71...2, 27, 35, 39, 9565, 7022, 7323, 44, 72, 98, 10048, 816194, 99RAP1AserotoninADCYMAPKAPK2ELK1Cyclic AMPGNASHTR7RPS6KA5PKAMAP2K2MAPK1HTR4BRAFMAP2K1EGR1SRFNR3C1HTR6RPS6KATF1ELK4MAPK3CREB1


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  1. Graf K, Xi XP, Yang D, Fleck E, Hsueh WA, Law RE; ''Mitogen-activated protein kinase activation is involved in platelet-derived growth factor-directed migration by vascular smooth muscle cells.''; Hypertension, 1997 PubMed Europe PMC Scholia
  2. Lum H, Roebuck KA; ''Oxidant stress and endothelial cell dysfunction.''; Am J Physiol Cell Physiol, 2001 PubMed Europe PMC Scholia
  3. Baker LP, Nielsen MD, Impey S, Metcalf MA, Poser SW, Chan G, Obrietan K, Hamblin MW, Storm DR; ''Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  4. Yang E, Lerner L, Besser D, Darnell JE Jr; ''Independent and cooperative activation of chromosomal c-fos promoter by STAT3.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  5. Barry OP, Mullan B, Sheehan D, Kazanietz MG, Shanahan F, Collins JK, O'Sullivan GC; ''Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  6. Rossant CJ, Pinnock RD, Hughes J, Hall MD, McNulty S; ''Corticotropin-releasing factor type 1 and type 2alpha receptors regulate phosphorylation of calcium/cyclic adenosine 3',5'-monophosphate response element-binding protein and activation of p42/p44 mitogen-activated protein kinase.''; Endocrinology, 1999 PubMed Europe PMC Scholia
  7. Hetman M, Hsuan SL, Habas A, Higgins MJ, Xia Z; ''ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  8. Paine E, Palmantier R, Akiyama SK, Olden K, Roberts JD; ''Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  9. Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill MA, Engel K, Kotlyarov A, Kraft R, Kostka S, Gaestel M, Nordheim A; ''MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  10. Mo Y, Ho W, Johnston K, Marmorstein R; ''Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex.''; J Mol Biol, 2001 PubMed Europe PMC Scholia
  11. Engel K, Schultz H, Martin F, Kotlyarov A, Plath K, Hahn M, Heinemann U, Gaestel M; ''Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  12. Tao J, Sanghera JS, Pelech SL, Wong G, Levy JG; ''Stimulation of stress-activated protein kinase and p38 HOG1 kinase in murine keratinocytes following photodynamic therapy with benzoporphyrin derivative.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  13. Gupta P, Prywes R; ''ATF1 phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  14. Guha M, O'Connell MA, Pawlinski R, Hollis A, McGovern P, Yan SF, Stern D, Mackman N; ''Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression.''; Blood, 2001 PubMed Europe PMC Scholia
  15. Singh RP, Tyagi AK, Zhao J, Agarwal R; ''Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis.''; Carcinogenesis, 2002 PubMed Europe PMC Scholia
  16. Yung Y, Yao Z, Aebersold DM, Hanoch T, Seger R; ''Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  17. Papin C, Eych�ne A, Brunet A, Pag�s G, Pouyss�gur J, Calothy G, Barnier JV; ''B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.''; Oncogene, 1995 PubMed Europe PMC Scholia
  18. Papin C, Denouel-Galy A, Laugier D, Calothy G, Eych�ne A; ''Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  19. Syu LJ, Guan KL, Saltiel AR; ''Inducible expression of a mutant form of MEK1 in Swiss 3T3 cells.''; J Cell Biochem, 1997 PubMed Europe PMC Scholia
  20. New L, Jiang Y, Han J; ''Regulation of PRAK subcellular location by p38 MAP kinases.''; Mol Biol Cell, 2003 PubMed Europe PMC Scholia
  21. Mitchell J, Bansal A; ''Dexamethasone increases G alpha q-11 expression and hormone-stimulated phospholipase C activity in UMR-106-01 cells.''; Am J Physiol, 1997 PubMed Europe PMC Scholia
  22. Morgan MA, Dolp O, Reuter CW; ''Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling.''; Blood, 2001 PubMed Europe PMC Scholia
  23. Zhou B, Zhang ZY; ''The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  24. Kapoor GS, Golden C, Atkins B, Mehta KD; ''pp90RSK- and protein kinase C-dependent pathway regulates p42/44MAPK-induced LDL receptor transcription in HepG2 cells.''; J Lipid Res, 2003 PubMed Europe PMC Scholia
  25. Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV; ''Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  26. Obara S, Yamada K, Yoshimura Y, Shimoyama M; ''Evidence for the endogenous GTP-dependent ADP-ribosylation of the alpha-subunit of the stimulatory guanyl-nucleotide-binding protein concomitant with an increase in basal adenylyl cyclase activity in chicken spleen cell membrane.''; Eur J Biochem, 1991 PubMed Europe PMC Scholia
  27. Gosmanov AR, Wong JA, Thomason DB; ''Duality of G protein-coupled mechanisms for beta-adrenergic activation of NKCC activity in skeletal muscle.''; Am J Physiol Cell Physiol, 2002 PubMed Europe PMC Scholia
  28. L�pez Bernal A, Rivera J, Europe-Finner GN, Phaneuf S, Asb�th G; ''Parturition: activation of stimulatory pathways or loss of uterine quiescence?''; Adv Exp Med Biol, 1995 PubMed Europe PMC Scholia
  29. Rolli M, Kotlyarov A, Sakamoto KM, Gaestel M, Neininger A; ''Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  30. Chrestensen CA, Schroeder MJ, Shabanowitz J, Hunt DF, Pelo JW, Worthington MT, Sturgill TW; ''MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  31. Schoenbaum G, Chiba AA, Gallagher M; ''Neural encoding in orbitofrontal cortex and basolateral amygdala during olfactory discrimination learning.''; J Neurosci, 1999 PubMed Europe PMC Scholia
  32. Chen DB, Westfall SD, Fong HW, Roberson MS, Davis JS; ''Prostaglandin F2alpha stimulates the Raf/MEK1/mitogen-activated protein kinase signaling cascade in bovine luteal cells.''; Endocrinology, 1998 PubMed Europe PMC Scholia
  33. Lee HJ, Mignacca RC, Sakamoto KM; ''Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  34. Ino H, Chiba T; ''Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo.''; J Neurosci, 2001 PubMed Europe PMC Scholia
  35. Huber-Lang MS, Younkin EM, Sarma JV, McGuire SR, Lu KT, Guo RF, Padgaonkar VA, Curnutte JT, Erickson R, Ward PA; ''Complement-induced impairment of innate immunity during sepsis.''; J Immunol, 2002 PubMed Europe PMC Scholia
  36. Jeon SH, Chae BC, Kim HA, Seo GY, Seo DW, Chun GT, Yie SW, Eom SH, Kim PH; ''The PKA/CREB pathway is closely involved in VEGF expression in mouse macrophages.''; Mol Cells, 2007 PubMed Europe PMC Scholia
  37. Tan Y, Rouse J, Zhang A, Cariati S, Cohen P, Comb MJ; ''FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.''; EMBO J, 1996 PubMed Europe PMC Scholia
  38. Prat AG, Ausiello DA, Cantiello HF; ''Vasopressin and protein kinase A activate G protein-sensitive epithelial Na+ channels.''; Am J Physiol, 1993 PubMed Europe PMC Scholia
  39. Wesselborg S, Bauer MK, Vogt M, Schmitz ML, Schulze-Osthoff K; ''Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  40. Shi CS, Leonardi A, Kyriakis J, Siebenlist U, Kehrl JH; ''TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related.''; J Immunol, 1999 PubMed Europe PMC Scholia
  41. Tanimura S, Nomura K, Ozaki K, Tsujimoto M, Kondo T, Kohno M; ''Prolonged nuclear retention of activated extracellular signal-regulated kinase 1/2 is required for hepatocyte growth factor-induced cell motility.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  42. Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ; ''Epigenetic programming by maternal behavior.''; Nat Neurosci, 2004 PubMed Europe PMC Scholia
  43. Pindon A, van Hecke G, van Gompel P, Lesage AS, Leysen JE, Jurzak M; ''Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins.''; Mol Pharmacol, 2002 PubMed Europe PMC Scholia
  44. Hindley A, Kolch W; ''Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases.''; J Cell Sci, 2002 PubMed Europe PMC Scholia
  45. Bading H; ''Transcription-dependent neuronal plasticity the nuclear calcium hypothesis.''; Eur J Biochem, 2000 PubMed Europe PMC Scholia
  46. Banihashemi B, Albert PR; ''Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.''; Mol Endocrinol, 2002 PubMed Europe PMC Scholia
  47. B�langer LF, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, Hugo P, Erikson R, Charron J; ''Mek2 is dispensable for mouse growth and development.''; Mol Cell Biol, 2003 PubMed Europe PMC Scholia
  48. Hannan RD, Luyken J, Rothblum LI; ''Regulation of rDNA transcription factors during cardiomyocyte hypertrophy induced by adrenergic agents.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  49. Venkatasubbarao K, Choudary A, Freeman JW; ''Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases.''; Cancer Res, 2005 PubMed Europe PMC Scholia
  50. Ebina T, Kawabe J, Katada T, Ohno S, Homcy CJ, Ishikawa Y; ''Conformation-dependent activation of type II adenylyl cyclase by protein kinase C.''; J Cell Biochem, 1997 PubMed Europe PMC Scholia
  51. Ryder JW, Fahlman R, Wallberg-Henriksson H, Alessi DR, Krook A, Zierath JR; ''Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  52. Casper-Lindley C, Dahlbeck D, Clark ET, Staskawicz BJ; ''Direct biochemical evidence for type III secretion-dependent translocation of the AvrBs2 effector protein into plant cells.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC Scholia
  53. Li QJ, Vaingankar S, Sladek FM, Martins-Green M; ''Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression.''; Blood, 2000 PubMed Europe PMC Scholia
  54. Chen KD, Chen LY, Huang HL, Lieu CH, Chang YN, Chang MD, Lai YK; ''Involvement of p38 mitogen-activated protein kinase signaling pathway in the rapid induction of the 78-kDa glucose-regulated protein in 9L rat brain tumor cells.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  55. Suzaki Y, Yoshizumi M, Kagami S, Koyama AH, Taketani Y, Houchi H, Tsuchiya K, Takeda E, Tamaki T; ''Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  56. Enarsson M, Erlandsson A, Larsson H, Forsberg-Nilsson K; ''Extracellular signal-regulated protein kinase signaling is uncoupled from initial differentiation of central nervous system stem cells to neurons.''; Mol Cancer Res, 2002 PubMed Europe PMC Scholia
  57. Chibalin AV, Lopina OD, Petukhov SP, Vasilets LA; ''Phosphorylation of the Na,K-ATPase by Ca,phospholipid-dependent and cAMP-dependent protein kinases. Mapping of the region phosphorylated by Ca,phospholipid-dependent protein kinase.''; J Bioenerg Biomembr, 1993 PubMed Europe PMC Scholia
  58. Chu CT, Levinthal DJ, Kulich SM, Chalovich EM, DeFranco DB; ''Oxidative neuronal injury. The dark side of ERK1/2.''; Eur J Biochem, 2004 PubMed Europe PMC Scholia
  59. Vasilevskaya IA, O'Dwyer PJ; ''Effects of geldanamycin on signaling through activator-protein 1 in hypoxic HT29 human colon adenocarcinoma cells.''; Cancer Res, 1999 PubMed Europe PMC Scholia
  60. Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P; ''Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.''; EMBO J, 1995 PubMed Europe PMC Scholia
  61. Berruti G; ''A novel rap1/B-Raf/14-3-3 theta protein complex is formed in vivo during the morphogenetic differentiation of postmeiotic male germ cells.''; Exp Cell Res, 2000 PubMed Europe PMC Scholia
  62. Peters EP, Wilderspin AF, Wood SP, Zvelebil MJ, Sezer O, Danchin A; ''A pyruvate-stimulated adenylate cyclase has a sequence related to the fes/fps oncogenes and to eukaryotic cyclases.''; Mol Microbiol, 1991 PubMed Europe PMC Scholia
  63. Yan Z, Yang DC, Jett M; ''Cholera toxin induces tumor necrosis factor alpha production in human monocytes.''; Mol Cell Biol Res Commun, 1999 PubMed Europe PMC Scholia
  64. Silverman E, Fr�din M, Gammeltoft S, Maller JL; ''Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells.''; Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  65. Vossler MR, Yao H, York RD, Pan MG, Rim CS, Stork PJ; ''cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway.''; Cell, 1997 PubMed Europe PMC Scholia
  66. Coxon PY, Rane MJ, Uriarte S, Powell DW, Singh S, Butt W, Chen Q, McLeish KR; ''MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils.''; Cell Signal, 2003 PubMed Europe PMC Scholia
  67. Soroka V, Kiryushko D, Novitskaya V, Ronn LC, Poulsen FM, Holm A, Bock E, Berezin V; ''Induction of neuronal differentiation by a peptide corresponding to the homophilic binding site of the second Ig module of the neural cell adhesion molecule.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  68. Hatakeyama M, Yumoto N, Yu X, Shirouzu M, Yokoyama S, Konagaya A; ''Transformation potency of ErbB heterodimer signaling is determined by B-Raf kinase.''; Oncogene, 2004 PubMed Europe PMC Scholia
  69. Gao X, Du Z, Patel TB; ''Copper and zinc inhibit Galphas function: a nucleotide-free state of Galphas induced by Cu2+ and Zn2+.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  70. Wall NR, Mohammad RM, Al-Katib AM; ''Mitogen-activated protein kinase is required for bryostatin 1-induced differentiation of the human acute lymphoblastic leukemia cell line Reh.''; Cell Growth Differ, 2001 PubMed Europe PMC Scholia
  71. Tokunou T, Ichiki T, Takeda K, Funakoshi Y, Iino N, Takeshita A; ''cAMP response element-binding protein mediates thrombin-induced proliferation of vascular smooth muscle cells.''; Arterioscler Thromb Vasc Biol, 2001 PubMed Europe PMC Scholia
  72. Dillon TJ, Karpitski V, Wetzel SA, Parker DC, Shaw AS, Stork PJ; ''Ectopic B-Raf expression enhances extracellular signal-regulated kinase (ERK) signaling in T cells and prevents antigen-presenting cell-induced anergy.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  73. Millan MJ, Lejeune F, De Nanteuil G, Gobert A; ''Selective blockade of neurokinin (NK)(1) receptors facilitates the activity of adrenergic pathways projecting to frontal cortex and dorsal hippocampus in rats.''; J Neurochem, 2001 PubMed Europe PMC Scholia
  74. Andrews MH, Kostaki A, Setiawan E, McCabe L, Owen D, Banjanin S, Matthews SG; ''Developmental regulation of the 5-HT7 serotonin receptor and transcription factor NGFI-A in the fetal guinea-pig limbic system: influence of GCs.''; J Physiol, 2004 PubMed Europe PMC Scholia
  75. Ravanti L, Heino J, L�pez-Ot�n C, K�h�ri VM; ''Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  76. Monno S, Newman MV, Cook M, Lowe WL Jr; ''Insulin-like growth factor I activates c-Jun N-terminal kinase in MCF-7 breast cancer cells.''; Endocrinology, 2000 PubMed Europe PMC Scholia
  77. Chung KC, Sung JY, Ahn W, Rhim H, Oh TH, Lee MG, Ahn YS; ''Intracellular calcium mobilization induces immediate early gene pip92 via Src and mitogen-activated protein kinase in immortalized hippocampal cells.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  78. Eblen ST, Slack JK, Weber MJ, Catling AD; ''Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes.''; Mol Cell Biol, 2002 PubMed Europe PMC Scholia
  79. Janknecht R, Hunter T; ''Convergence of MAP kinase pathways on the ternary complex factor Sap-1a.''; EMBO J, 1997 PubMed Europe PMC Scholia
  80. Lindecke A, Korte M, Zagrebelsky M, Horejschi V, Elvers M, Widera D, Pr�llage M, Pfeiffer J, Kaltschmidt B, Kaltschmidt C; ''Long-term depression activates transcription of immediate early transcription factor genes: involvement of serum response factor/Elk-1.''; Eur J Neurosci, 2006 PubMed Europe PMC Scholia
  81. Traub O, Monia BP, Dean NM, Berk BC; ''PKC-epsilon is required for mechano-sensitive activation of ERK1/2 in endothelial cells.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  82. Azuma N, Akasaka N, Kito H, Ikeda M, Gahtan V, Sasajima T, Sumpio BE; ''Role of p38 MAP kinase in endothelial cell alignment induced by fluid shear stress.''; Am J Physiol Heart Circ Physiol, 2001 PubMed Europe PMC Scholia
  83. Saji M, Levine MA, Zeiger MA; ''An in vitro model of thyroid neoplasia: permanently transfected FRTL-5 cells with thyroglobulin promoter-cholera toxin A1 subunit minigene.''; Surgery, 1994 PubMed Europe PMC Scholia
  84. Bai XC, Lu D, Bai J, Zheng H, Ke ZY, Li XM, Luo SQ; ''Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB.''; Biochem Biophys Res Commun, 2004 PubMed Europe PMC Scholia
  85. Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G; ''Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).''; EMBO J, 2003 PubMed Europe PMC Scholia
  86. Sutcliffe JG; ''Open-system approaches to gene expression in the CNS.''; J Neurosci, 2001 PubMed Europe PMC Scholia
  87. Barberis L, Wary KK, Fiucci G, Liu F, Hirsch E, Brancaccio M, Altruda F, Tarone G, Giancotti FG; ''Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  88. Winzen R, Kracht M, Ritter B, Wilhelm A, Chen CY, Shyu AB, M�ller M, Gaestel M, Resch K, Holtmann H; ''The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.''; EMBO J, 1999 PubMed Europe PMC Scholia
  89. Bakovic M, Waite K, Vance DE; ''Oncogenic Ha-Ras transformation modulates the transcription of the CTP:phosphocholine cytidylyltransferase alpha gene via p42/44MAPK and transcription factor Sp3.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  90. Budnik LT, Brunswig-Spickenheier B, Mukhopadhyay AK; ''Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway?''; Mol Endocrinol, 2003 PubMed Europe PMC Scholia
  91. Duan WR, Ito M, Park Y, Maizels ET, Hunzicker-Dunn M, Jameson JL; ''GnRH regulates early growth response protein 1 transcription through multiple promoter elements.''; Mol Endocrinol, 2002 PubMed Europe PMC Scholia
  92. Sananbenesi F, Fischer A, Schrick C, Spiess J, Radulovic J; ''Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: interactions between Erk-1/2 and Elk-1.''; Mol Cell Neurosci, 2002 PubMed Europe PMC Scholia
  93. Hassler M, Richmond TJ; ''The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex.''; EMBO J, 2001 PubMed Europe PMC Scholia
  94. Russell DL, Doyle KM, Gonzales-Robayna I, Pipaon C, Richards JS; ''Egr-1 induction in rat granulosa cells by follicle-stimulating hormone and luteinizing hormone: combinatorial regulation by transcription factors cyclic adenosine 3',5'-monophosphate regulatory element binding protein, serum response factor, sp1,and early growth response factor-1.''; Mol Endocrinol, 2003 PubMed Europe PMC Scholia
  95. Waas WF, Dalby KN; ''Transient protein-protein interactions and a random-ordered kinetic mechanism for the phosphorylation of a transcription factor by extracellular-regulated protein kinase 2.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  96. Szyf M, Weaver IC, Champagne FA, Diorio J, Meaney MJ; ''Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat.''; Front Neuroendocrinol, 2005 PubMed Europe PMC Scholia
  97. Bourdon DM, Camden JM, Landon LA, Levy FO, Turner JT; ''Identification of the adenylyl cyclase-activating 5-hydroxytryptamine receptor subtypes expressed in the rat submandibular gland.''; Br J Pharmacol, 2000 PubMed Europe PMC Scholia
  98. Sanna B, Bueno OF, Dai YS, Wilkins BJ, Molkentin JD; ''Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth.''; Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  99. Ahmed I, Gesty-Palmer D, Drezner MK, Luttrell LM; ''Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.''; Mol Endocrinol, 2003 PubMed Europe PMC Scholia
  100. Chen JK, Heckert LL; ''Dmrt1 expression is regulated by follicle-stimulating hormone and phorbol esters in postnatal Sertoli cells.''; Endocrinology, 2001 PubMed Europe PMC Scholia
  101. Andressen KW, Norum JH, Levy FO, Krobert KA; ''Activation of adenylyl cyclase by endogenous G(s)-coupled receptors in human embryonic kidney 293 cells is attenuated by 5-HT(7) receptor expression.''; Mol Pharmacol, 2006 PubMed Europe PMC Scholia
  102. Pomerance M, Abdullah HB, Kamerji S, Correze C, Blondeau JP; ''Thyroid-stimulating hormone and cyclic AMP activate p38 mitogen-activated protein kinase cascade. Involvement of protein kinase A, rac1, and reactive oxygen species.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  103. Sung JY, Shin SW, Ahn YS, Chung KC; ''Basic fibroblast growth factor-induced activation of novel CREB kinase during the differentiation of immortalized hippocampal cells.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  104. Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouyss�gur J; ''Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry.''; EMBO J, 1999 PubMed Europe PMC Scholia
  105. Morrison PF, Morishige GM, Beagles KE, Heyes MP; ''Quinolinic acid is extruded from the brain by a probenecid-sensitive carrier system: a quantitative analysis.''; J Neurochem, 1999 PubMed Europe PMC Scholia
  106. Krump E, Sanghera JS, Pelech SL, Furuya W, Grinstein S; ''Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils.''; J Biol Chem, 1997 PubMed Europe PMC Scholia

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70102view18:49, 12 July 2013MaintBotupdated to 2013 schema
49544view10:12, 20 July 2012AndraWp tidy
46089view02:26, 15 December 2011AllanKuchinskyupdated HGNC IDs
45037view18:51, 6 October 2011ThomasOntology Term : 'neuron' added !
45028view18:45, 6 October 2011ThomasOntology Term : 'serotonin signaling pathway' added !
41156view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
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30231view21:22, 16 July 2009ArukePeriodical save, work in progress
30230view21:12, 16 July 2009ArukePeriodical save, work in progress
30229view21:01, 16 July 2009ArukePeriodical save, work in progress
30228view20:51, 16 July 2009ArukePeriodical save, work in progress
30227view20:41, 16 July 2009ArukePeriodical save, work in progress
30226view20:31, 16 July 2009ArukePeriodical save, work in progress
30225view17:24, 16 July 2009ArukeUpdated all nodes
30224view17:16, 16 July 2009ArukePeriodical save, work in progress
30223view17:06, 16 July 2009ArukePeriodical save, work in progress
30222view16:55, 16 July 2009ArukeNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCYGeneProductAdenylate cyclase
ATF1GeneProduct466 (Entrez Gene) activating transcription factor 1
BRAFGeneProduct673 (Entrez Gene) v-raf murine sarcoma viral oncogene homolog B1
CREB1GeneProduct1385 (Entrez Gene) cAMP response element-binding protein 1
Cyclic AMPMetabolite60-92-4 (CAS)
EGR1GeneProduct1958 (Entrez Gene) early growth response protein
ELK1GeneProduct2002 (Entrez Gene) ELK1, member of ETS oncogene family
ELK4GeneProduct2005 (Entrez Gene) ETS domain-containing protein Elk-4 (SRF accessory protein 1)
GNASGeneProduct2778 (Entrez Gene) GNAS (guanine nucleotide binding protein, alpha stimulating)
HTR4GeneProduct3360 (Entrez Gene) 5 hydroxytryptamine (serotonin) receptor 4
HTR6GeneProduct3362 (Entrez Gene) 5-hydroxytryptamine (serotonin) receptor 6
HTR7GeneProduct3363 (Entrez Gene) 5-hydroxytryptamine (serotonin) receptor 7
MAP2K1GeneProduct5604 (Entrez Gene) mitogen activated protein kinase kinase 1
MAP2K2GeneProduct5605 (Entrez Gene) mitogen activated protein kinase kinase 2
MAPK1GeneProduct6871 (HUGO) mitogen activated protein kinase 1
MAPK3GeneProduct5595 (Entrez Gene) mitogen activated protein kinase 3
MAPKAPK2GeneProduct9261 (Entrez Gene) MAP kinase-activated protein kinase 2
NR3C1GeneProduct2908 (Entrez Gene) nuclear receptor, subfamily 3, group C, member 1
PKAGeneProductcAMP-dependent protein kinase, protein kinase A
RAP1AGeneProduct5906 (Entrez Gene) RAS-related protein-1a
RPS6KGeneProductribosomal protein S6 kinase
RPS6KA5GeneProduct9252 (Entrez Gene) ribosomal protein S6 kinase, polypeptide 5
SRFGeneProduct6722 (Entrez Gene) serum response factor
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions

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