Statin pathway (Mus musculus)

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1LDLVLDLFree FATissuesPlasmaLiver cellTriglyceridesHDLCell MembraneIDLPhospholipidApoc2ApoeLplPltpApoc1CholesterolAbca1LipcDgat1CetpScarb1Acetyl-CoALcatApoa4Apoc3HmgcrCholesterol EsterCholesterolLdlrLrp1Cyp7a1MttpStatinSoat1Apoa1Cholic acid


Description

What are statins? See Wikipedia at: http://en.wikipedia.org/wiki/Statin More about this pathway and statins: https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway

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Quality Tags

Ontology Terms

 

Bibliography

  1. Chen H, Ikeda U, Shimpo M, Shimada K; ''Direct effects of statins on cells primarily involved in atherosclerosis.''; Hypertens Res, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134146view19:55, 5 July 2024EweitzEconomize layout
134145view19:44, 5 July 2024EweitzEconomize layout
134144view19:32, 5 July 2024EweitzEconomize layout
134140view12:40, 3 July 2024EweitzStandardize font size
134139view12:39, 3 July 2024EweitzEase nomenclature, standardize case
127970view15:30, 20 January 2024EweitzIncrease node font size, standardize case
127969view15:25, 20 January 2024EweitzOntology Term : 'hepatocyte' added !
117947view10:46, 23 May 2021EweitzModified title
107192view14:28, 17 September 2019MaintBotChEBI identifier normalization
106833view13:31, 17 September 2019MaintBotHMDB identifier normalization
103264view07:46, 20 February 2019EgonwMore specific ChEBI identifier.
102612view19:50, 11 January 2019KhanspersOntology Term : 'cardiovascular system disease' added !
102611view19:50, 11 January 2019KhanspersOntology Term : 'hypercholesterolemia pathway' added !
102294view19:17, 17 December 2018KhanspersModified description
102291view19:14, 17 December 2018KhanspersModified description
73346view19:53, 22 January 2014EgonwAdded ChEBI identifiers to three metabolite classes.
69109view18:13, 8 July 2013MaintBotUpdated to 2013 gpml schema
67656view11:45, 26 June 2013DdiglesOntology Term : 'statin drug pathway' added !
53530view19:14, 8 November 2012EgonwUpdated the CHEBI id format (see http://www.pathvisio.org/ticket/1439)
53452view17:29, 7 November 2012AndraAdded entrez gene identifier of Cetp after RDF tidy
50199view14:21, 9 August 2012Mkutmonadded new shape forms, added xref for statin and cholesterol ester
41296view00:23, 2 March 2011MaintBotRemoved redundant pathway information and comments
38714view19:31, 23 September 2010AlexanderPico
35542view14:19, 12 February 2010Thomasremoved genmapp remark
35540view14:18, 12 February 2010ThomasModified description
35537view14:16, 12 February 2010Thomasadded literature, fixed title
33728view23:21, 8 December 2009KhanspersAdded connectors and metabolites
33727view23:12, 8 December 2009KhanspersPeriodical save, work in progress
29016view05:30, 27 March 2009AlexanderPicoReverted to version '04:29, 14 November 2008' by AlexanderPico
29015view05:30, 27 March 2009AlexanderPicoReverted to version '06:05, 14 November 2008' by AlexanderPico
22540view13:05, 14 November 2008TestUserSoap test - 1226667890445
22538view13:05, 14 November 2008TestUserSoap test - 1226667859184
20671view11:29, 14 November 2008MaintBot[[Pathway:Mus musculus:Statin Pathway PharmGKB]] moved to [[Pathway:WP1]]: Moved to stable identifier
11887view18:21, 8 May 2008KhanspersChanged contact info
8404view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Statin Pathway PharmGKB]] moved to [[Pathway:Mus musculus:Statin Pathway PharmGKB]]: Renaming species
7819view16:20, 18 December 2007MaintBotfixed category names
7396view12:42, 4 November 2007MaintBotAdded categories to GPML
19544view22:19, 22 May 2007BruceConklingpml file for [[Mouse:Statin_Pathway_PharmGKB]]
6496view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:Statin_Pathway_PharmGKB]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Abca1GeneProduct11303 (Entrez Gene)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
Apoa1GeneProduct11806 (Entrez Gene)
Apoa4GeneProduct11808 (Entrez Gene)
Apoc1GeneProduct11812 (Entrez Gene)
Apoc2GeneProduct11813 (Entrez Gene)
Apoc3GeneProduct11814 (Entrez Gene)
ApoeGeneProduct11816 (Entrez Gene)
CetpGeneProduct1071 (Entrez Gene)
Cholesterol EsterMetabolite17002 (ChEBI)
CholesterolMetaboliteHMDB00067 (HMDB)
Cholic acidMetaboliteHMDB00619 (HMDB)
Cyp7a1GeneProduct13122 (Entrez Gene)
Dgat1GeneProduct13350 (Entrez Gene)
HmgcrGeneProduct15357 (Entrez Gene)
LcatGeneProduct16816 (Entrez Gene)
LdlrGeneProduct16835 (Entrez Gene)
LipcGeneProduct15450 (Entrez Gene)
LplGeneProduct16956 (Entrez Gene)
Lrp1GeneProduct16971 (Entrez Gene)
MttpGeneProduct17777 (Entrez Gene)
PltpGeneProduct18830 (Entrez Gene)
Scarb1GeneProduct20778 (Entrez Gene)
Soat1GeneProduct20652 (Entrez Gene)
StatinMetabolite35664 (ChEBI)

Annotated Interactions

No annotated interactions

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