From WikiPathways
RFC36 Cdt1 Pre-replicative complex Cdt1 Ubiquitin Orc2 Processive complex Orc3 Orc3 Orc complex Mcm6 Mcm4 Cdc6 DNA polymerase alpha: primase: origin complex Mcm5 Orc3 RNA primer-DNA primer Orc3 Phosphorylated Cdc6 Degraded by proteasome in cytosol RNA primer-DNA primer Orc2 Orc4 Mcm 4,6,7 trimer forms and associates with the replication fork Mcm6 Orc1 3. DNA replication initiation Mcm7 Mcm4 RFC40 RFC37 Ubiquitinated Cdc6 Degraded by proteasome in cytosol Cdc6 Mcm7 Primase Cdc6 RFC140 5. Leading/lagging strand synthesis Cdt1 Orc5 p49 RNA primer-DNA primer: origin duplex:PCNA Mcm10 DNA polymerase alpha: primase: origin complex DNA Polymerase A Cdt1 Orc5 p70 Orc complex Mcm3 1. Assembly of the pre-replicative complex Cdt1 Orc complex Mcm5 RFC Heteropentamer: RNA primer-DNA primer Mcm2 2. Activation of the pre-replicative complex Orc2 Ubiquitin Ubiquitinated Orc1 p180 Mcm2 RNA Primer Orc complex Phosphorylated Orc1 Mcm10 Orc4 Mcm3 Orc5 RFC38 Geminin 4. Switching of origins to post-replicative state RFC Heteropentamer: RNA primer-DNA primer PCNA homotrimer Phosphorylation of Mcm 2-7 complex Cdc6 Orc2 p58 Pre-replicative complex Orc complex Origin AgaP_AGAP004957 AgaP_AGAP003093 AgaP_AGAP004275 AgaP_AGAP005144 AgaP_AGAP008332 UTP AgaP_AGAP008910 ATP AgaP_AGAP008723 AgaP_AGAP009047 ATP ADP AgaP_AGAP010220 AgaP_AGAP004614 GMNN dCTP RPA3 POLD1 AgaP_AGAP006065 AgaP_AGAP004615 dUTP AgaP_AGAP004579 AgaP_AGAP011246 AgaP_AGAP001290 CTP AgaP_AGAP000978 AgaP_AGAP004408 CDC7 AgaP_AGAP007927 AgaP_AGAP007477 RPA4 ATP POLD3 dATP AgaP_AGAP007063 AgaP_AGAP010406 AgaP_AGAP010219 AgaP_AGAP004956 AgaP_AGAP000474 AgaP_AGAP005800 dGTP AgaP_AGAP001135 AgaP_AGAP006387 ASK POLD4 GTP ADP AgaP_AGAP005176 AgaP_AGAP005321 AgaP_AGAP001971 AgaP_AGAP011961 ATP AgaP_AGAP001929 AgaP_AGAP004392 AgaP_AGAP001421
Description
DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.
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