Hepatocyte growth factor receptor signaling (Bos taurus)
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AKT Pathway
AP-1
Transcription
RAC1
pathway
RHO
pathway
Cytoplasm
Trancription
Actin
CDC42
pathway
Changes in Cytoskeleton
and Cell mobility
P
P
P
Transcription
of Cox2
Right Click for Comments
Extracellular
Anoikis
JUN
MAPK3
RAP1B
RAF1
MAPK1
GRB2
ELK1
RASA1
PTK2
ITGB1
SRC
PTEN
PTK2
HRAS
DOCK1
MAPK8
PIK3CA
PAK1
SRC
HGF
GAB1
MAP4K1
MAP2K2
PXN
FOS
PTPN11
ITGA1
RAPGEF1
RAP1A
SOS1
CRK
PTK2B
PXN
CRKL
STAT3
MAP2K1
Met
PTK2B
Description
No description
Comments
GenMAPP remarks
Converted to human by GenMAPP.org
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP313(r21339)
with a 86% conversion rate.
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Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011
PubMed
Europe PMC
Scholia
History
View all...
Compare
Revision
Action
Time
User
Comment
118734
view
10:48, 1 June 2021
DeSl
Converted 2 lines to GraphicalLine
118733
view
10:47, 1 June 2021
DeSl
Added states iso textlabel P
118732
view
10:46, 1 June 2021
DeSl
Converted ReceptorSquare to MIMbinding with lit ref
118731
view
10:43, 1 June 2021
DeSl
Added description from WP313
117607
view
11:38, 21 May 2021
Eweitz
Modified title
80800
view
15:26, 30 June 2015
Mkutmon
homology conversion
63315
view
21:05, 9 May 2013
MaintBot
Updated to 2013 gpml schema
40496
view
19:28, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33740
view
23:55, 8 December 2009
MaintBot
Automatic update of empty xrefs
32511
view
12:52, 17 August 2009
MaintBot
Fixed text labels
32199
view
12:37, 15 August 2009
MaintBot
Fixed text labels
31681
view
11:44, 14 August 2009
MaintBot
Fixed group labels
31209
view
19:36, 13 August 2009
MaintBot
Fixed text labels
30615
view
22:20, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
CRK
GeneProduct
512841 (Entrez Gene)
CRKL
GeneProduct
DOCK1
GeneProduct
537203 (Entrez Gene)
Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
ELK1
GeneProduct
786886 (Entrez Gene)
FOS
GeneProduct
280795 (Entrez Gene)
GAB1
GeneProduct
540085 (Entrez Gene)
GRB2
GeneProduct
535298 (Entrez Gene)
HGF
GeneProduct
282879 (Entrez Gene)
HRAS
GeneProduct
513012 (Entrez Gene)
ITGA1
GeneProduct
535951 (Entrez Gene)
ITGB1
GeneProduct
281876 (Entrez Gene)
JUN
GeneProduct
280831 (Entrez Gene)
MAP2K1
GeneProduct
533199 (Entrez Gene)
MAP2K2
GeneProduct
510434 (Entrez Gene)
MAP4K1
GeneProduct
522002 (Entrez Gene)
MAPK1
GeneProduct
327672 (Entrez Gene)
MAPK3
GeneProduct
531391 (Entrez Gene)
MAPK8
GeneProduct
539941 (Entrez Gene)
Met
GeneProduct
280855 (Entrez Gene)
PAK1
GeneProduct
533729 (Entrez Gene)
PIK3CA
GeneProduct
282306 (Entrez Gene)
PTEN
GeneProduct
540786 (Entrez Gene)
PTK2
GeneProduct
506270 (Entrez Gene)
PTK2B
GeneProduct
541008 (Entrez Gene)
PTPN11
GeneProduct
533590 (Entrez Gene)
PXN
GeneProduct
517456 (Entrez Gene)
RAF1
GeneProduct
521196 (Entrez Gene)
RAP1A
GeneProduct
282031 (Entrez Gene)
RAP1B
GeneProduct
327708 (Entrez Gene)
RAPGEF1
GeneProduct
520454 (Entrez Gene)
RASA1
GeneProduct
282032 (Entrez Gene)
SOS1
GeneProduct
537682 (Entrez Gene)
Son of sevenless homolog 1 (Drosophila) (predicted)
SRC
GeneProduct
535742 (Entrez Gene)
STAT3
GeneProduct
508541 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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DataNodes
Annotated Interactions
No annotated interactions