Amyotrophic lateral sclerosis (ALS) (Homo sapiens)

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Endoplasmic reticulum (ER)AstrocyteMitochondriatBidDNA damageAggregatesElevated glutamatelevelsMAPK Signaling PathwayNEFHPPP3CCReactive Oxygen Species (ROS)NEFLDNAMKK3NOS1NONEFMCYTCPPP3CBNOMKK6p38TNFalphaASK1DAXXCa2+PPP3CAPresynaptic neuronMicroglial cellMotor neuronNOL-ArginineONOO-EAAT2L-Glutamic acidL-Glutamic acidP53Neuron deathAPAF1CASP3CASP9ApoptosisActivationL-Glutamic acidsynaptic transmission, glutamatergicIncrease incytosolic Ca2+Ca2+Derlin-1Accumulation ofmisfolded proteinsER stressATP depletionFall in mitochondrialmembrane potentialIncreased ROSDisturbance ofmitochondrial respirationMitochondrialdysfunctionLow Ca2+ bufferingcapacityCa2+CASP1BIDSOD1TOM40_HUMANBIM-BCL-2 complexBIM-BCL-xl complexBAXBADproteasome complexUbiquitin proteosomedysfunctionApoptosisCASP12MAP3K5TNFalphaTNFRGRIA1NONOSOD1Activation


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Flomen R, Makoff A; ''Increased RNA editing in EAAT2 pre-mRNA from amyotrophic lateral sclerosis patients: involvement of a cryptic polyadenylation site.''; Neurosci Lett, 2011 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128125view13:18, 27 January 2024EweitzOntology Term : 'astrocyte' added !
128124view13:18, 27 January 2024EweitzOntology Term : 'neuron' added !
128123view13:17, 27 January 2024EweitzOntology Term : 'microglial cell' added !
128122view13:16, 27 January 2024EweitzRemove excessive padding
128121view13:15, 27 January 2024EweitzEconomize legend position
128120view13:14, 27 January 2024EweitzRefine layout, standardize case
113794view09:07, 24 November 2020Finterlysmall graphical update
113792view08:56, 24 November 2020Finterlymake pathways clickable
113789view17:09, 23 November 2020FinterlySmall graphical update and fixed links
109207view21:31, 26 February 2020KhanspersAdded mutation states
108062view13:19, 27 November 2019FehrhartOntology Term : 'amyotrophic lateral sclerosis' added !
106714view13:15, 17 September 2019MaintBotHMDB identifier normalization
105880view04:52, 16 August 2019KhanspersModified description
105527view06:00, 9 August 2019KhanspersModified description
96316view09:07, 8 March 2018Mkutmonremove old WP category
96258view16:25, 2 March 2018EgonwOntology Term : 'disease pathway' added !
96111view11:20, 18 February 2018EgonwReplaced mim-conversion with arrow for things that are not conversions.
96110view11:13, 18 February 2018EgonwMade a number of labels readable (again)
96105view14:38, 16 February 2018DeSlChanged MIMconversion to arrow between gene and metabolite
85186view14:39, 23 April 2016EgonwReplaced a mim-conversion with Arrow.
85057view10:52, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
85049view10:22, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
84415view21:47, 23 February 2016AlexanderPicoQuick edit to datanode annotation or property
79862view12:17, 21 April 2015Mkutmonfixed linkout to wikipedia for ROS
75221view21:48, 9 May 2014Khansperschnaged DNA from gene product to label
72245view20:53, 29 October 2013Khansperschanged pathway node xrefs from GO to WP
72040view13:49, 24 October 2013SusanConnected lines
71227view21:29, 15 October 2013MaintBotUpdated UniProt/TrEMBL data source
71226view21:21, 15 October 2013MaintBotUpdated KEGG xrefs
70574view18:04, 14 August 2013MaintBotFixed xref for p53
70573view17:59, 14 August 2013MaintBotFixed Wikipedia link for ROS
70572view15:05, 13 August 2013MetalmephistoAttempting to add ID for ROS
70571view15:00, 13 August 2013MetalmephistoChanged Metabolite ID
64563view17:47, 29 May 2013Khanspersadded lit ref
64292view04:22, 23 May 2013Khanspersadded pathway node
64291view04:09, 23 May 2013KhanspersModified description
64290view04:00, 23 May 2013Khanspersfinal draft
64289view03:56, 23 May 2013Khansperswork in progress
64288view03:52, 23 May 2013Khansperswork in progress
64271view20:45, 22 May 2013KhanspersPeriodical save, work in progress
64270view20:44, 22 May 2013KhanspersSpecify description
64269view20:35, 22 May 2013KhanspersPeriodical save, work in progress
64260view19:21, 22 May 2013KhanspersSpecify description
64259view19:17, 22 May 2013Khansperswork in progress
64256view19:09, 22 May 2013KhanspersPeriodical save, work in progress
64201view21:40, 21 May 2013Khansperswork in progress
64200view21:32, 21 May 2013Khansperswork in progress
64199view21:25, 21 May 2013KhanspersPeriodical save, work in progress
64198view21:15, 21 May 2013KhanspersPeriodical save, work in progress
64197view21:04, 21 May 2013KhanspersPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APAF1GeneProduct317 (Entrez Gene)
ASK1GeneProduct4217 (Entrez Gene)
ApoptosisPathwayWP254 (WikiPathways)
BADGeneProduct572 (Entrez Gene)
BAXGeneProduct581 (Entrez Gene)
BIDGeneProduct637 (Entrez Gene)
BIM-BCL-2 complexProteinGO:0097141 (GeneOntology)
BIM-BCL-xl complexProteinGO:0097140 (GeneOntology)
CASP12GeneProductENSG00000204403 (Ensembl)
CASP1GeneProduct834 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CYTCProteinP01034 (Uniprot/TrEMBL)
Ca2+MetaboliteC00076 (Kegg Compound)
Ca2+MetaboliteHMDB00464 (HMDB)
DAXXGeneProduct1616 (Entrez Gene)
DNAGeneProduct
Derlin-1Protein79139 (Entrez Gene)
EAAT2ProteinP43004 (Uniprot/TrEMBL)
GRIA1Protein2890 (Entrez Gene)
L-ArginineMetaboliteHMDB00517 (HMDB)
L-Glutamic acidMetaboliteHMDB00148 (HMDB)
MAP3K5GeneProductENSG00000197442 (Ensembl)
MAPK Signaling PathwayPathwayWP382 (WikiPathways)
MKK3GeneProduct5605 (Entrez Gene)
MKK6GeneProduct5608 (Entrez Gene)
NEFHGeneProduct4744 (Entrez Gene)
NEFLGeneProduct4747 (Entrez Gene)
NEFMGeneProduct4741 (Entrez Gene)
NOMetaboliteHMDB03378 (HMDB)
NOS1GeneProduct4842 (Entrez Gene)
ONOO-MetaboliteHMDB02179 (HMDB)
P53ProteinP53 (Uniprot/TrEMBL)
PPP3CAGeneProduct5530 (Entrez Gene)
PPP3CBGeneProduct5532 (Entrez Gene)
PPP3CCGeneProduct5533 (Entrez Gene)
Reactive Oxygen Species (ROS)Metabolite
SOD1GeneProduct6647 (Entrez Gene)
TNFRGeneProduct7132 (Entrez Gene)
TNFalphaGeneProduct7124 (Entrez Gene)
TOM40_HUMANProteinO96008 (Uniprot/TrEMBL)
p38GeneProduct1432 (Entrez Gene)
proteasome complexProteinGO:0000502 (GeneOntology)
synaptic

transmission,

glutamatergic		PathwayGO:0035249 (GeneOntology)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2447"
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