Nanoparticle triggered regulated necrosis (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Andón FT, Fadeel B; ''Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials.''; Acc Chem Res, 2012 PubMed Europe PMC Scholia
2. Ma YH, Huang CP, Tsai JS, Shen MY, Li YK, Lin LY; ''Water-soluble germanium nanoparticles cause necrotic cell death and the damage can be attenuated by blocking the transduction of necrotic signaling pathway.''; Toxicol Lett, 2011 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	119820	view	10:33, 28 August 2021	Egonw	Made a few pathways clickable
	110691	view	13:47, 28 May 2020	Laurent	Added missing DataNode types - added ID to Ge NP
	106661	view	21:20, 12 September 2019	Khanspers	Modified description
	106207	view	12:10, 16 August 2019	MaintBot	HMDB identifier normalization
	105662	view	05:17, 10 August 2019	Khanspers	Modified description
	102135	view	09:25, 2 December 2018	Egonw	Fixed the Uniprot ID of TNF.
	102134	view	09:24, 2 December 2018	Egonw	Replaced Wikipedia with Wikidata identifiers.
	97539	view	14:33, 24 May 2018	Egonw	Fixed a character encoding issue.
	97519	view	13:52, 24 May 2018	Timverbruggen	increase mappings
	97510	view	13:39, 24 May 2018	Timverbruggen	increased mapping
	92316	view	08:50, 20 May 2017	Egonw	Ontology Term : 'nanomaterial response pathway' added !
	86006	view	00:51, 24 June 2016	Khanspers	changed look of pathway nodes
	86000	view	00:30, 24 June 2016	Khanspers	Connected interactions, updated xrefs, assigned node types
	85999	view	00:22, 24 June 2016	Khanspers	connected lines, changed gene nodes to pathway nodes where appropriate
	85026	view	14:21, 6 April 2016	Mkutmon	remove special characters and add graphical annotations instead
	81068	view	18:23, 19 July 2015	Egonw	Typed ceramide as metabolite.
	81067	view	18:22, 19 July 2015	Egonw	Use a ChEBI identifier instead of a Wikipedia one.
	77901	view	14:47, 28 October 2014	Bart Smeets	Modified description
	77900	view	14:47, 28 October 2014	Bart Smeets	Modified description
	77667	view	12:01, 5 October 2014	Egonw	Replaced 'Uniprot-SwissProt' by 'Uniprot-TrEMBL'.
	74182	view	09:32, 3 April 2014	Bart Smeets	Added wiki entries
	74143	view	10:31, 1 April 2014	Bart Smeets	Expanded description of nanoparticles in pathway, added corresponding literature references.
	73826	view	15:05, 25 February 2014	Bart Smeets	Fixed some wikipedia entries
	73825	view	15:01, 25 February 2014	Bart Smeets	Added a few GeneIDs
	71447	view	19:13, 17 October 2013	MaintBot	Updated data sources
	70991	view	20:50, 21 September 2013	Egonw	Added a few identifiers.
	68057	view	13:10, 29 June 2013	Egonw	Completed the pathway as given in the figure.
	68054	view	13:04, 29 June 2013	Egonw	Periodical save, work in progress
	66148	view	08:19, 15 June 2013	Egonw	Added the literature ref again.
	65706	view	12:26, 11 June 2013	Egonw	Added the caspase 8 identifier, and widened the Necroptosis box.
	65603	view	16:18, 10 June 2013	Egonw	More content of the pathway.
	65457	view	10:27, 8 June 2013	Egonw	Ontology Term : 'necrosis pathway' added !
	65447	view	08:02, 8 June 2013	Egonw	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
Arachidonic acid	Metabolite	HMDB01043 (HMDB)
CASP8	GeneProduct	ENSG00000064012 (Ensembl)
Calcium	Metabolite	HMDB00464 (HMDB)
Calpains
Ceramide
FADD	GeneProduct	ENSG00000168040 (Ensembl)
Iron	Metabolite	HMDB00692 (HMDB)
Nec-1
Necroptosis	Pathway
PARP1	GeneProduct	ENSG00000143799 (Ensembl)
RIPK1	GeneProduct	ENSG00000137275 (Ensembl)
RIPK3	GeneProduct	ENSG00000129465 (Ensembl)
ROS	Metabolite	CHEBI:26523 (ChEBI)
SMases	Protein
TRADD	GeneProduct	ENSG00000102871 (Ensembl)
cPLA₂
lipoxygenase
pH ↓

Annotated Interactions

No annotated interactions