IL-2 signaling pathway (Pan troglodytes)

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NUDDMTNucleusTranslocationCY -> NUMethylationPlasma membraneCY -> NUCY -> NUPhosphorylationGlycosylationCY -> NUCY -> NUCytoplasmActivationCY -> NUEndosomeDemethylationDDeubiquitinationMolecular associationPM -> CYUbiquitinationPalmitolyationDSumoylationLigandGOERControlReactions through unknown mechanisms/moleculesReceptorDephosphorylationDExtracellularECInhibitionRecruitmentGene SymbolProteins in a complex interactionPMENMTCYEnzyme complexDAccession Number: NetPath 14DGolgi apparatusDCY -> PMPhosphorylationMitochondrionDDAutophosphorylationDNUProteolytic cleavageMolecule in the pathwayDesumoylationNucleusDeacetylation(Protein-protein interaction)Endoplasmic reticulumAcetylationCY -> NUCY -> NUDNFKB1STAT3SOS1MAPKAPK2SOCS3CISHAKT1ETS2GRB2CRKLIFNA1CBLLCKPRKCZSTAMIRS1ETS1SYKSHC1CHUKICAM1JAK3CD53STAT5AHSP90AA1GNB2L1PIK3CDCRKSTAT5BJAK2PIK3CANSEP1IL2RBMAPK3CREB1MKNK1FYNCRKIRS2VAV1MAPK1NR3C1EIF3S9PIK3CBRELASTAT1STAM2NMIITM2BRELAKRASIL2RGPIK3CGIL2JAK1EIF4EAKT1PTPN6RPS6KB1IL2STAT5BPTPN11MAP2K1TERTSHBLYNNSEP1PIK3R1MAPK3RAF1MAPK8NFKB1MAPK1MAPK9IL2FRAP1FOXO3AIL2MAPK14STAT5AIL2AKT1RAF1PIK3R2IL2RATERTSOCS1BCL2GAB2PLCB1MAP2K2PTK2B


Description

Interleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 receptor beta (CD122) and a common gamma chain (γc), which is shared by all members of this family of cytokines. Binding of IL-2 activates the Ras/MAPK, JAK/Stat and PI 3-kinase/Akt signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_14

Comments

GenMAPP notes 
NetPath 14 - IL-2 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP49(r20779) with a 84% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
118668view05:20, 1 June 2021EgonwModified description
118003view11:30, 23 May 2021EweitzModified title
111045view12:25, 3 July 2020L DupuisConverted interactions to graphical lines in legend
89842view12:14, 6 October 2016Mkutmonremove GenMAPP notes
89841view12:14, 6 October 2016MkutmonModified description
73860view00:59, 26 February 2014MaintBotupdated schema
67372view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
41581view02:00, 2 March 2011MaintBotRemoved redundant pathway information and comments
35783view06:20, 13 February 2010MaintBotAdded description
34309view22:08, 9 December 2009MaintBotAutomatic update of empty xrefs
31561view21:55, 13 August 2009MaintBotFixed text labels
30424view21:17, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct740898 (Entrez Gene)
BCL2GeneProduct738409 (Entrez Gene)
CBLGeneProduct451690 (Entrez Gene)
CD53GeneProduct745007 (Entrez Gene)
CHUKGeneProduct450673 (Entrez Gene)
CISHGeneProduct470819 (Entrez Gene)
CREB1GeneProduct459901 (Entrez Gene)
CRKGeneProduct747142 (Entrez Gene)
CRKLGeneProduct470146 (Entrez Gene)
EIF3S9GeneProduct
EIF4EGeneProduct468435 (Entrez Gene)
ETS1GeneProduct
ETS2GeneProduct473996 (Entrez Gene)
FOXO3AGeneProduct
FRAP1GeneProduct
FYNGeneProduct462944 (Entrez Gene)
GAB2GeneProduct748918 (Entrez Gene)
GNB2L1GeneProduct462344 (Entrez Gene)
GRB2GeneProduct737245 (Entrez Gene)
HSP90AA1GeneProduct743883 (Entrez Gene)
ICAM1GeneProduct450196 (Entrez Gene)
IFNA1GeneProduct
IL2GeneProduct461472 (Entrez Gene)
IL2RAGeneProduct450884 (Entrez Gene)
IL2RBGeneProduct470203 (Entrez Gene)
IL2RGGeneProduct465692 (Entrez Gene)
IRS1GeneProduct459985 (Entrez Gene)
IRS2GeneProduct452657 (Entrez Gene)
ITM2BGeneProduct452714 (Entrez Gene)
JAK1GeneProduct743373 (Entrez Gene)
JAK2GeneProduct464979 (Entrez Gene)
JAK3GeneProduct455848 (Entrez Gene)
KRASGeneProduct473387 (Entrez Gene)
LCKGeneProduct
LYNGeneProduct472771 (Entrez Gene)
MAP2K1GeneProduct450188 (Entrez Gene)
MAP2K2GeneProduct456390 (Entrez Gene)
MAPK14GeneProduct450161 (Entrez Gene)
MAPK1GeneProduct458680 (Entrez Gene)
MAPK3GeneProduct454037 (Entrez Gene)
MAPK8GeneProduct450445 (Entrez Gene)
MAPK9GeneProduct462336 (Entrez Gene)
MAPKAPK2GeneProduct744091 (Entrez Gene)
MKNK1GeneProduct469189 (Entrez Gene)
NFKB1GeneProduct461406 (Entrez Gene)
NMIGeneProduct470714 (Entrez Gene)
NR3C1GeneProduct471681 (Entrez Gene)
NSEP1GeneProduct
PIK3CAGeneProduct460858 (Entrez Gene)
PIK3CBGeneProduct471079 (Entrez Gene)
PIK3CDGeneProduct457922 (Entrez Gene)
PIK3CGGeneProduct463649 (Entrez Gene)
PIK3R1GeneProduct461836 (Entrez Gene)
PIK3R2GeneProduct455855 (Entrez Gene)
PLCB1GeneProduct469875 (Entrez Gene)
PRKCZGeneProduct743533 (Entrez Gene)
PTK2BGeneProduct464073 (Entrez Gene)
PTPN11GeneProduct748225 (Entrez Gene)
PTPN6GeneProduct748032 (Entrez Gene)
RAF1GeneProduct460182 (Entrez Gene)
RELAGeneProduct466665 (Entrez Gene)
RPS6KB1GeneProduct468426 (Entrez Gene)
SHBGeneProduct465107 (Entrez Gene)
SHC1GeneProduct457351 (Entrez Gene)
SOCS1GeneProduct737070 (Entrez Gene)
SOCS3GeneProduct454921 (Entrez Gene)
SOS1GeneProduct459171 (Entrez Gene)
STAM2GeneProduct459661 (Entrez Gene)
STAMGeneProduct466269 (Entrez Gene)
STAT1GeneProduct459834 (Entrez Gene)
STAT3GeneProduct454682 (Entrez Gene)
STAT5AGeneProduct454681 (Entrez Gene)
STAT5BGeneProduct454679 (Entrez Gene)
SYKGeneProduct464586 (Entrez Gene)
TERTGeneProduct471443 (Entrez Gene)
VAV1GeneProduct455647 (Entrez Gene)

Annotated Interactions

No annotated interactions
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