TNF-alpha NF-kB signaling pathway (Mus musculus)

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ECCY ->NUENDeubiquitinationGlycosylationInhibitionMolecular associationNUPMGOSumoylationRecruitmentAcetylationGolgi apparatusTranslocationUbiquitinationEndosomeEnzyme complexCY ->NUERDemethylationPhosphorylationPalmitoylationDesumoylationEndoplasmic reticulumNucleusReceptorMolecule in the pathwayMTMitochondrionMethylationDProteins in a complex interactionAccession Number: NetPath 9; cellmap:9Proteolytic cleavageAutophosphorylationCY ->NUCYCY ->NUActivationDephosphorylationReaction through unknown mechanisms/moleculesControl(Protein-protein interaction)Plasma membraneExtracellularLigandCytoplasmDeacetylationCY ->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 SymbolTraf1Psmd12Fbxw11Tnfrsf11aSmarca4PrkczTraf5TifaTraf2Gtf2iCflarMap3k8TnfRasal2Hdac2Psmc1Polr1dSmarcc2Ripk1SrcTrpc4ap


Description

No description

Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 91% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118927view14:51, 4 June 2021EgonwModified description
118924view11:15, 4 June 2021Mkutmonupdate description
118923view11:15, 4 June 2021Mkutmonupdate description
116715view09:56, 11 May 2021EweitzModified title
69201view18:24, 8 July 2013MaintBotUpdated to 2013 gpml schema
67701view11:51, 26 June 2013DdiglesOntology Term : 'tumor necrosis factor mediated signaling pathway' added !
41391view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
34428view23:23, 9 December 2009MaintBotAutomatic update of empty xrefs
32375view16:51, 15 August 2009MaintBotFixed text labels
32011view13:20, 14 August 2009MaintBotFixed group labels
31412view20:54, 13 August 2009MaintBotFixed text labels
30882view00:17, 30 July 2009MaintBotConverted from Homo sapiens
21197view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:WP246]]: Moved to stable identifier
8448view13:46, 7 January 2008MaintBot[[Pathway:Mouse:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:Mus musculus:TNF-alpha-NF-kB NetPath 9]]: Renaming species
7840view16:22, 18 December 2007MaintBotfixed category names
7308view12:42, 4 November 2007MaintBotAdded categories to GPML
6503view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:TNF-alpha-NF-kB_NetPath_9]]

External references

DataNodes

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NameTypeDatabase referenceComment
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Annotated Interactions

No annotated interactions
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