TNF-alpha NF-kB signaling pathway (Gallus gallus)

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Enzyme complexCY ->NUReaction through unknown mechanisms/moleculesProteins in a complex interactionDemethylationCY ->NUEndosomeDephosphorylationActivationMitochondrionAccession Number: NetPath 9; cellmap:9Endoplasmic reticulumCY ->NUUbiquitinationECERMolecular associationPalmitoylationAutophosphorylationCY ->NUNucleusCY ->NUDeacetylationCYGOMethylationENDeubiquitinationGlycosylationPMMTCytoplasmAcetylationRecruitmentTranslocation(Protein-protein interaction)DReceptorDesumoylationSumoylationInhibitionProteolytic cleavagePhosphorylationGolgi apparatusControlPlasma membraneExtracellularMolecule in the pathwayLigandNURCJMB04_2a4CUL1NR2C2CSNK2BRPS13NFKBIZTXLNAPSMD13RELTNFRSF8CASP10PIAS3RASAL2TRAF1RELAPRKACAGAB1EIF4A3BAG4RCJMB04_4j14RIPK2ASE1TRAF4PSMC2SMARCC2MARK2NFKB1RIPK1TBK1YWHAEMAP3K3TNFTRAF1RIPK3CDC34FKBP5NFKBIATNFRSF11ARCJMB04_19h23CSNK2A2YWHABCOPS3BCL7APRKCZTNFALPLGeneUNC5CLTNIP1LRPPRCNFKB1MAP3K7IP2TNFRCJMB04_11l21TRADDUSP11PTPN11TNFRSF1ARELAMAP3K7IP3SMARCA4FANCD2RNF25TNFAIP3CASP8AP2POLR1BRPL8IKBKEHSPCBTNFRSF1BCASP3HDAC2CAV1TANKDPF2PTK2MAP3K7IP1CASP2GNB2L1RCJMB04_5e12PMLMAP3K2NFKB1BCL3SRCRELACASP8RELAHIST3H3UBE2D2IKBKGGTF2ITNFRSF1BCSNK2A1NFKBIARPS11KPNA2NFKBIEG3BP2TRAIPKCNQ1COMMD1HDAC1MAP3K14AKT1PEG3POLR1EIKBKBTNFRSF1AMTIF2Gene SymbolAZI2TNFHDAC6GenePSMD1PSMC3WDR68GeneGSK3BRPL4NALP4FBLTRAF4MAP3K8TNFRSF1AYWHAHPPP2CABIRC2PFDN2IQGAP2TNFRELBUBCH5CMAP3K1SMARCE1PSMD12FLNAACTL6ASUMO1PSMC1PSMD6MCM5RELRELBBTRCAKAP8SMARCB1TRAF2NFKBIARPL6RCJMB04_17o18TIFAPDCD2RCJMB04_36h7TBK1TRAF6TRADDTRPC4APTNFRSF1BCREBBPNFKB2SMARCC1PPP1R13LZFAND5TRAF3AKT2KTN1MAP3K3RCJMB04_19h23PEBP1UBE2IPOLR2LNFKBIBRCJMB04_17i9FAF1RPL30TNFPSMB5MCM7IKBKGGLG1NKIRAS1BIRC2POLR1ARNF216FADDDAPYWHAQSKP1ACYLDCAPN3KPNA3POLR2HPSMD7POLR1DPSMD3PAPOLACFLARDBC1RCJMB04_34f17CRADDGeneMCCNSMAFPKN1CASP7TRAF5NKIRAS2POLR1CRPS6KA5BIRC3HSPB1HSP90AA1TRAF2TNIP2RIPK1RCJMB04_14f8USP2TRAF2CDC37NR2C2BIRC3


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 69% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118011view11:32, 23 May 2021EweitzModified title
108152view10:37, 29 November 2019FehrhartOntology Term : 'cancer' added !
87787view11:14, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87785view11:13, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68867view17:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
41006view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
33927view18:09, 9 December 2009MaintBotAutomatic update of empty xrefs
33485view15:08, 30 November 2009MaintBotRemoved group label
31535view21:45, 13 August 2009MaintBotFixed text labels
30380view21:02, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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ASE1GeneProduct
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BCL3GeneProduct
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CASP8AP2GeneProduct421810 (Entrez Gene)
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FBLGeneProduct
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FLNAGeneProduct
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NALP4GeneProduct
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RCJMB04_19h23GeneProduct423669 (Entrez Gene)
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ZFAND5GeneProduct427254 (Entrez Gene)

Annotated Interactions

No annotated interactions
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