DNA replication (Mus musculus)

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1-3Mcm10Mcm4Orc complexMcm5Orc5Cdt1Orc complexMcm4Mcm6Degraded by proteasome in cytosolOrc2Phosphorylated Orc1DNA polymerase alpha:primase: origin complexOrc5Cdc6Orc5p70Cdc6DNA polymerase alpha:primase: origin complex2. Activation of the pre-replicative complexRFC36RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerOrc4Orc3Mcm10RFC40Cdc6Cdc6RNA PrimerOrc complex4. Switching of origins to post-replicative stateMcm7RNA primer-DNA primer:origin duplex:PCNAOrc complexp180Mcm2Mcm6Ubiquitinated Orc1Cdt1Degraded byproteasomein cytosolOrc3GemininUbiquitinated Cdc6RFC383. DNA replication initiationRNA primer-DNA primerMcm 4,6,7 trimer forms andassociates with the replication fork1. Assembly of the pre-replicative complexp49Orc2Mcm5RFC140Mcm2Mcm3Orc2Phosphorylation ofMcm 2-7 complexOrc4UbiquitinOrc2Orc complexPhosphorylated Cdc6Cdt1Pre-replicative complexp58Mcm3Orc15. Leading/lagging strand synthesisRNA primer-DNA primerCdt1Orc3PrimaseMcm7RFC Heteropentamer:RNA primer-DNA primerOriginPre-replicative complexRFC37Processive complexDNAPolymerase ACdt1UbiquitinOrc3GmnnPola2Orc1lRfc3UbcPrim2Rfc1ADPATPRfc4Pold4Rpa3RPA4Rfc2UTPADPRpa1PoleCTPATPGTPCdt1Uba52Pole2Mcm10Mcm7Prim1Rfc5Pold1Mcm3Orc4lDbf4Orc2lMcm6dUTPATPCdc45lCdc6Pold3Orc5ldCTPdGTPMcm2dATPOrc3lPcnaCdc7Mcm4Mcm5Orc6lPold2Pola1ATPCdk2Rpa2


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [wikipedia:DNA_replication|Wikipedia]

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 72% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  3. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117872view10:19, 23 May 2021EweitzModified title
107197view14:28, 17 September 2019MaintBotChEBI identifier normalization
106854view13:33, 17 September 2019MaintBotHMDB identifier normalization
69148view18:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
67160view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41336view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35196view15:36, 11 February 2010ThomasModified description
35195view15:35, 11 February 2010Thomasadded literature
34403view23:03, 9 December 2009MaintBotAutomatic update of empty xrefs
32866view17:56, 16 September 2009MaintBotAdded xrefs
32350view13:38, 15 August 2009MaintBotFixed text labels
31975view13:09, 14 August 2009MaintBotFixed group labels
31398view20:48, 13 August 2009MaintBotFixed text labels
30825view23:59, 29 July 2009MaintBotConverted from Homo sapiens
20997view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:DNA replication Reactome]] moved to [[Pathway:WP150]]: Moved to stable identifier
7992view13:46, 7 January 2008MaintBot[[Pathway:Mouse:DNA replication Reactome]] moved to [[Pathway:Mus musculus:DNA replication Reactome]]: Renaming species
7620view16:04, 18 December 2007MaintBotfixed category names
7210view12:33, 4 November 2007MaintBotAdded categories to GPML
19418view22:18, 22 May 2007D.Korengpml file for [[Mouse:DNA_replication_Reactome]]
6430view22:18, 22 May 2007Kdahlquistgpml file for [[Mouse:DNA_replication_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteHMDB01341 (HMDB)
ATPMetaboliteHMDB01532 (HMDB)
CTPMetaboliteHMDB00998 (HMDB)
Cdc45lGeneProduct12544 (Entrez Gene)
Cdc6GeneProduct23834 (Entrez Gene)
Cdc7GeneProduct12545 (Entrez Gene)
Cdk2GeneProduct12566 (Entrez Gene)
Cdt1GeneProduct67177 (Entrez Gene)
Dbf4GeneProduct27214 (Entrez Gene)
GTPMetaboliteHMDB01440 (HMDB)
GmnnGeneProduct57441 (Entrez Gene)
Mcm10GeneProduct70024 (Entrez Gene)
Mcm2GeneProduct17216 (Entrez Gene)
Mcm3GeneProduct17215 (Entrez Gene)
Mcm4GeneProduct17217 (Entrez Gene)
Mcm5GeneProduct17218 (Entrez Gene)
Mcm6GeneProduct17219 (Entrez Gene)
Mcm7GeneProduct17220 (Entrez Gene)
Orc1lGeneProduct18392 (Entrez Gene)
Orc2lGeneProduct18393 (Entrez Gene)
Orc3lGeneProduct50793 (Entrez Gene)
Orc4lGeneProduct26428 (Entrez Gene)
Orc5lGeneProduct26429 (Entrez Gene)
Orc6lGeneProduct56452 (Entrez Gene)
PcnaGeneProduct18538 (Entrez Gene)
Pola1GeneProduct18968 (Entrez Gene)
Pola2GeneProduct18969 (Entrez Gene)
Pold1GeneProduct18971 (Entrez Gene)
Pold2GeneProduct18972 (Entrez Gene)
Pold3GeneProduct67967 (Entrez Gene)
Pold4GeneProduct69745 (Entrez Gene)
PoleGeneProduct18973 (Entrez Gene)
Pole2GeneProduct18974 (Entrez Gene)
Prim1GeneProduct19075 (Entrez Gene)
Prim2GeneProduct19076 (Entrez Gene)
RPA4GeneProduct
Rfc1GeneProduct19687 (Entrez Gene)
Rfc2GeneProduct19718 (Entrez Gene)
Rfc3GeneProduct69263 (Entrez Gene)
Rfc4GeneProduct106344 (Entrez Gene)
Rfc5GeneProduct72151 (Entrez Gene)
Rpa1GeneProduct68275 (Entrez Gene)
Rpa2GeneProduct19891 (Entrez Gene)
Rpa3GeneProduct68240 (Entrez Gene)
UTPMetabolite17625 (ChEBI)
Uba52GeneProduct22186 (Entrez Gene)
UbcGeneProduct22190 (Entrez Gene)
dATPMetaboliteHMDB01532 (HMDB)
dCTPMetaboliteHMDB00998 (HMDB)
dGTPMetaboliteHMDB01440 (HMDB)
dUTPMetabolite17625 (ChEBI)

Annotated Interactions

No annotated interactions
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