TP53 network (Homo sapiens)

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345621Grown arrest and apoptosisReduces transcriptional activity but does not induce degradationApoptosisDifferent isoforms of the proteinGrown arrest and apoptosisBBC3BCL2TP73gammaTP63BAXOTX2TP53TP73 Delta Np73MDM2TP73deltaTNFSF10TP73alphaCDKN1ATP73betaATMDeltaNp63betaDelatNp63alphaTAp63betaTAp63alphaTAp63gammaTP73epsilonCDKN2ATP73SUMO-1GADD45AABL1BIDTP73zetaBOKIGFBP-3PMAIP1MYCDeltaNp63gamma


Description

P53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high level of sequence homology in its DNA binding domain. The complexity of the family has been enriched by the alternatively spliced forms of the genes. At present pathway, the alternatively spliced forms of p63 and p73 and how they interact with p53 are shown . However, little is known about the transcriptional regulation of p53 family members. Further studies will tell us whether the three genes of the family also share others regulatory activities.

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Bibliography

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  1. Shaul Y; ''c-Abl: activation and nuclear targets.''; Cell Death Differ, 2000 PubMed Europe PMC Scholia
  2. Bunt J, de Haas TG, Hasselt NE, Zwijnenburg DA, Koster J, Versteeg R, Kool M; ''Regulation of Cell Cycle Genes and Induction of Senescence by Overexpression of OTX2 in Medulloblastoma Cell Lines.''; Mol Cancer Res, 2010 PubMed Europe PMC Scholia
  3. Ishimoto O, Kawahara C, Enjo K, Obinata M, Nukiwa T, Ikawa S; ''Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73.''; Cancer Res, 2002 PubMed Europe PMC Scholia
  4. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dötsch V, Andrews NC, Caput D, McKeon F; ''p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.''; Mol Cell, 1998 PubMed Europe PMC Scholia
  5. Dohn M, Zhang S, Chen X; ''p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes.''; Oncogene, 2001 PubMed Europe PMC Scholia
  6. Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY, Lu H, Kharbanda S, Weichselbaum R, Kufe D; ''p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.''; Nature, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134847view19:05, 27 July 2024EweitzEconomize layout
134846view19:02, 27 July 2024EweitzUse gene symbol
134845view18:57, 27 July 2024EweitzClarify isoform-level interactions
134844view18:43, 27 July 2024EweitzClarify interactions visually and computationally
134843view18:30, 27 July 2024EweitzFix typo: "Grown arrest" -> "Growth arrest"
134842view18:28, 27 July 2024EweitzEconomize layout
134841view17:07, 27 July 2024EweitzRefine legend
134840view17:01, 27 July 2024EweitzEconomize layout
126403view19:23, 26 April 2023EgonwLicense is CCZero
116592view16:31, 8 May 2021EweitzModified title
106445view23:35, 28 August 2019KhanspersModified description
105494view05:49, 8 August 2019KhanspersModified description
95548view14:32, 22 December 2017DeSlCOnnected more unconencted lines, changed several lines to graphical lines.
95475view23:43, 17 December 2017AndraConnected lines
95435view05:30, 15 December 2017MaintBotfixed xref
71700view19:51, 17 October 2013MaintBotUpdated data sources
70104view18:54, 12 July 2013MaintBotupdated to 2013 schema
70032view01:57, 12 July 2013AlexanderPicoModified title
59109view22:22, 21 February 2013MaintBotUpdated Ensembl data source
48062view18:41, 1 May 2012KhanspersReplaced special characters
48060view18:14, 1 May 2012KhanspersPeriodical save, work in progress
45074view20:17, 6 October 2011KhanspersOntology Term : 'cancer' added !
45073view20:16, 6 October 2011KhanspersOntology Term : 'p53 signaling pathway' added !
41057view23:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
39274view22:33, 9 November 2010AlexanderPicoModified categories
39273view22:32, 9 November 2010AlexanderPicoconnected line from SUMO-1 to TP53
39272view22:30, 9 November 2010AlexanderPicospecified xref systems, e.g., Entrez, UniProt or Ensembl
39264view11:17, 8 November 2010GlendaPeriodical save, work in progress
39263view10:56, 8 November 2010GlendaPeriodical save, work in progress
39262view10:36, 8 November 2010GlendaPeriodical save, work in progress
39261view09:54, 8 November 2010GlendaPeriodical save, work in progress
39260view09:43, 8 November 2010GlendaPeriodical save, work in progress
39205view07:57, 28 October 2010GlendaPeriodical save, work in progress
39204view07:47, 28 October 2010GlendaPeriodical save, work in progress
39203view07:10, 28 October 2010GlendaModified description
39202view05:03, 28 October 2010GlendaModified description
39197view14:05, 27 October 2010GlendaPeriodical save, work in progress
39196view13:49, 27 October 2010GlendaPeriodical save, work in progress
39195view13:38, 27 October 2010GlendaPeriodical save, work in progress
39194view13:28, 27 October 2010GlendaPeriodical save, work in progress
39193view13:18, 27 October 2010GlendaPeriodical save, work in progress
39192view13:02, 27 October 2010GlendaPeriodical save, work in progress
39191view12:52, 27 October 2010GlendaPeriodical save, work in progress
39190view12:39, 27 October 2010GlendaPeriodical save, work in progress
39189view12:28, 27 October 2010GlendaPeriodical save, work in progress
39188view12:18, 27 October 2010GlendaPeriodical save, work in progress
39187view12:08, 27 October 2010GlendaPeriodical save, work in progress
39186view11:57, 27 October 2010GlendaPeriodical save, work in progress
39185view11:12, 27 October 2010GlendaPeriodical save, work in progress
39184view10:59, 27 October 2010GlendaPeriodical save, work in progress

External references

DataNodes

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NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)
ATMGeneProductENSG00000149311 (Ensembl)
BAXGeneProduct581 (Entrez Gene)
BBC3GeneProduct27113 (Entrez Gene)
BCL2GeneProductENSG00000171791 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
BOKGeneProduct666 (Entrez Gene)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CDKN2AGeneProduct1029 (Entrez Gene)
DelatNp63alphaProteinQ9H3D4 (Uniprot/TrEMBL)
DeltaNp63betaProteinQ9H3D4 (Uniprot/TrEMBL)
DeltaNp63gammaProteinQ9H3D4 (Uniprot/TrEMBL)
GADD45AGeneProduct1647 (Entrez Gene)
IGFBP-3GeneProductHs.146732 (UniGene)
MDM2GeneProductENSG00000135679 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
OTX2GeneProductENSG00000165588 (Ensembl)
PMAIP1GeneProduct5366 (Entrez Gene)
SUMO-1Protein7341 (Entrez Gene)
TAp63alphaProteinQ9H3D4 (Uniprot/TrEMBL)
TAp63betaProteinQ9H3D4 (Uniprot/TrEMBL)
TAp63gammaProteinQ9H3D4 (Uniprot/TrEMBL)
TNFSF10GeneProduct8743 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
TP63GeneProduct8626 (Entrez Gene)
TP73 Delta Np73ProteinO15350 (Uniprot/TrEMBL)
TP73GeneProduct7161 (Entrez Gene)
TP73alphaProteinO15350 (Uniprot/TrEMBL)
TP73betaProteinO15350 (Uniprot/TrEMBL)
TP73deltaProteinO15350 (Uniprot/TrEMBL)
TP73epsilonProteinO15350 (Uniprot/TrEMBL)
TP73gammaProteinO15350 (Uniprot/TrEMBL)
TP73zetaProteinO15350 (Uniprot/TrEMBL)

Annotated Interactions

No annotated interactions

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