Glycerophospholipid biosynthetic pathway (Homo sapiens)

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Biosynthesis pathwaysGlycolysis2-acyl-sn-glycero-3-phosphate(Lysophosphatidic acid; LPA)1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol)(PI)D-Glucose-6-PPIP2[4',5']CholinePIP3[3',4',5']InositolCardiolipin(DPG, CL)1,2-diacyl-sn-glycero-3-phosphate(Phosphatidic acid; PA)triacyl-sn-glycerol(Triacylglycerol; TAG)Adenosine triphosphate(ATP)Phosphatidylinositol-4-phosphate(PIP)Cytidine diphosphate ethanolamine(CDP-ethanolamine)GlycerolAdenosine diphosphate(ADP)Cytidine diphosphate choline(CDP-choline)1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(PG)Ethanolamine1,2-diacyl-sn-glycero-3-phosphoethanolamine(PE)1D-myo-Inositol-1-PDihydroxyacetone phosphate1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-phosphate)(PGP)PiGlycerol-3-phosphate dehydrogenase (NAD+)EC 1.1.1.83 (S-adenosyl-methionine)CTPNAD+(Coenzyme I)PPi1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate(CDP-DAG, CMP-PA)Glucose1,2-diacyl-sn-glycero-3-phosphoserine(PS)CoA-SHPyrimidine MetabolismSerinePhosphocholine(Choline-P)Fatty acid MetabolismPhosphorylethanolamineNADH + H+sn-glycerol-3-phosphate(glycerol-3-P)1,2-diacyl-sn-glycero-3-phosphocholine(PC, Lecithin)1,2-diacyl-sn-glycerol(1,2-diacylglycerol; 1,2-DAG)Cytidine monophosphate(CMP)Glycerol-3-PPiCMPCMPATPADPCTPPPiEthanolamineATPADPATPADPATPADPATPADPGlycerol kinaseEC 2.7.1.30Acyl-CoA2-acylglycerol-3-phosphate O-acyltransferaseEC 2.3.1.52Glycerol-3-phosphate 2-O-acyltransferaseEC 2.3.1.198Acyl coenzyme A(Acyl-CoA)Coenzyme A(CoA-SH)Phosphatidate phosphataseEC 3.1.3.4Diacylglycerol O-acyltransferaseEC 2.3.1.20Acyl coenzyme A(Acyl-CoA)Coenzyme A(CoA-SH)Phosphatidate cytidylyltransferaseEC 2.7.7.41Cytidine triphosphate(CTP)PPiCDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferaseEC 2.7.8.5PhosphatidylglycerophosphataseEC 3.1.3.27H2OCardiolipin synthaseEC 2.7.8.-CDP-DAGCMPCDP-diacylglyreol-inositol 3-phosphatidyltransferaseEC 2.7.8.111-phosphatidylinositol 4-kinaseEC 2.7.1.671-phosphatidylinositol 4-phosphate 5-kinaseEC 2.7.1.68Phosphatidylinositol-4,5-bisphosphate 3-kinaseEC 2.7.1.153Choline kinaseEC 2.7.1.32Choline-phosphate cytidylyltransferaseEC 2.7.7.15Diacylglycerol cholinephosphotransferaseEC 2.7.8.2Ethanolamine kinaseEC 2.7.1.82Ethanolamine-phosphate cytidylyltransferaseEC 2.7.7.14EthanolaminephosphotransferaseEC 2.7.8.1L-serine-phosphatidylethanolamine phosphatidyltransferaseEC 2.7.8.29Phosphatidylethanolamine N-methyltransferaseEC 2.1.1.173 (S-adenosylhomocysteine)CMPGlycolysisGlycolysisDegradation pathwaysPathway origin


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History

View all...
CompareRevisionActionTimeUserComment
126497view18:52, 10 May 2023KhanspersAdded lit ref and xref to Shark Liver Oil
124384view05:54, 24 October 2022EgonwTyped three metabolites
120261view13:40, 22 November 2021Conroy lipidsadded some DB crossrefs
117145view09:41, 18 May 2021EweitzModified title
113857view06:37, 2 December 2020EgonwReplaced a deleted PubMed identifier with the (working) duplicate
110695view13:58, 28 May 2020L DupuisUpdated Chebi identifiers
110693view13:50, 28 May 2020L DupuisCHeBi ID added for inorganic phosphate
107760view16:15, 1 November 2019DeSlOntology Term : 'phosphatidylcholine metabolic pathway' added !
107759view16:14, 1 November 2019DeSlOntology Term : 'phosphoinositide metabolic pathway' added !
107758view16:12, 1 November 2019DeSlOntology Term : 'PW:0001156' removed !
107757view16:11, 1 November 2019DeSlUpdated all curved lines for side metabolites to MIMconversion pointing to/away from anchor.
107756view15:48, 1 November 2019DeSlUpdated IDs for EC 2.7.1.153 (bottom right corner).
107755view09:55, 1 November 2019DeSlUpdated top half of PW, so side metabolites are connected to anchors.
107754view09:49, 1 November 2019DeSlAdded separate IDs for proteins under EC 2.3.1.15 .
107753view09:31, 1 November 2019DeSlChanged 2- to "1-" in 1-acyl-sn-glycero-3-phosphate (Lysophosphatidic acid; LPA) (reaction otherwise doesn't occure in humans.
107133view14:21, 17 September 2019MaintBotChEBI identifier normalization
106718view13:15, 17 September 2019MaintBotHMDB identifier normalization
106449view11:34, 29 August 2019DeSlUpdated LipidMaps ID for TAG.
105333view12:05, 31 July 2019EgonwThe class, not the reference lipid.
98235view12:32, 14 August 2018EgonwReplace a PubChem SID with a ChEBI ID.
98103view11:11, 20 July 2018DeSlOntology Term : 'glycerophospholipid metabolic pathway' added !
95594view14:18, 5 January 2018DeSlChanged part of the layout for readability of this pathway.
93096view15:17, 28 July 2017DeSlChanged all the PubChem Substance ID's (around 13) to more stereospecific IDs.
93077view08:52, 28 July 2017ElisaFixed unconnected lines and changed arrows in the legend from interactions to graphical elements
93029view16:02, 26 July 2017DeSlChanged hydrate ID from PubChem compounds to correct HMDB ID for D-glucose-6-P
92861view15:19, 10 July 2017EgonwFixed PubChem compound ID (was salt, now pure compound).
85647view17:10, 4 June 2016EgonwFixed the PubChem SID.
84117view10:00, 16 January 2016EgonwFixed a typo in the label.
83825view11:17, 14 December 2015EgonwRemoved data source info from identifiers.
76320view07:17, 2 July 2014Mkutmonadded chebi identifiers to metabolites annotated with GO terms
71989view11:13, 24 October 2013MkutmonChanged Unknown -> Metabolite for 3 (S-adenosyl-methionine) and 3 (S-adenosylhomocysteine)
71699view19:49, 17 October 2013MaintBotUpdated data sources
70448view22:31, 1 August 2013AmanzoPeriodical save, work in progress
70447view22:21, 1 August 2013AmanzoPeriodical save, work in progress
70404view16:13, 29 July 2013AmanzoWork in progress
70403view16:07, 29 July 2013AmanzoPeriodical save, work in progress
70390view16:04, 26 July 2013AmanzoPeriodical save, work in progress
70389view23:52, 25 July 2013AmanzoWork in progress
70388view23:42, 25 July 2013AmanzoPeriodical save, work in progress
70387view23:32, 25 July 2013AmanzoPeriodical save, work in progress
70384view17:34, 23 July 2013AmanzoWork in progress
70381view23:33, 21 July 2013AmanzoPeriodical save, work in progress
70380view23:22, 21 July 2013AmanzoPeriodical save, work in progress
70379view23:12, 21 July 2013AmanzoPeriodical save, work in progress
70378view23:02, 21 July 2013AmanzoPeriodical save, work in progress
70377view22:52, 21 July 2013AmanzoPeriodical save, work in progress
70376view22:42, 21 July 2013AmanzoPeriodical save, work in progress
70375view22:32, 21 July 2013AmanzoPeriodical save, work in progress
70374view22:21, 21 July 2013AmanzoPeriodical save, work in progress
70373view22:11, 21 July 2013AmanzoPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate (CDP-DAG, CMP-PA)MetaboliteLMGP13010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphate (Phosphatidic acid; PA)MetaboliteLMGP10010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol) (PI)MetaboliteLMGP06010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-phosphate) (PGP)
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) (PG)MetaboliteLMGP04010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphocholine (PC, Lecithin)MetaboliteLMGP01010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (PE)MetaboliteLMGP02010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphoserine (PS)MetaboliteLMGP03010000 (LIPID MAPS)
1,2-diacyl-sn-glycerol (1,2-diacylglycerol; 1,2-DAG)MetaboliteLMGL02010000 (LIPID MAPS)
1-phosphatidylinositol 4-kinase EC 2.7.1.67ProteinQ9BTU6 (Uniprot/TrEMBL)
1-phosphatidylinositol 4-phosphate 5-kinase EC 2.7.1.68ProteinQ99755 (Uniprot/TrEMBL)
1D-myo-Inositol-1-PMetaboliteCID 5288642 (PubChem-compound)
2-acyl-sn-glycero-3-phosphate (Lysophosphatidic acid; LPA)MetaboliteLMGP10050000 (LIPID MAPS)
2-acylglycerol-3-phosphate O-acyltransferase EC 2.3.1.52ProteinEC 2.3.1.52 (Enzyme Nomenclature)
3 (S-adenosyl-methionine)CID 34756 (PubChem-compound)
3 (S-adenosylhomocysteine)CID 439155 (PubChem-compound)
ADPMetaboliteCID 6022 (PubChem-compound)
ATPMetaboliteCID 5957 (PubChem-compound)
Acyl coenzyme A (Acyl-CoA)MetaboliteSID 3342 (PubChem-substance)
Acyl-CoAMetaboliteSID 3342 (PubChem-substance)
Adenosine diphosphate (ADP)MetaboliteCID 6022 (PubChem-compound)
Adenosine triphosphate (ATP)MetaboliteCID 5957 (PubChem-compound)
CDP-DAGMetaboliteLMGP13010000 (LIPID MAPS)
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EC 2.7.8.5ProteinQ32NB8 (Uniprot/TrEMBL)
CDP-diacylglyreol-inositol 3-phosphatidyltransferase EC 2.7.8.11ProteinO14735 (Uniprot/TrEMBL)
CMPMetaboliteCID 6131 (PubChem-compound)
CTPMetaboliteCID 6176 (PubChem-compound)
Cardiolipin (DPG, CL)MetaboliteLMPG12010000 (LIPID MAPS)
Cardiolipin synthase EC 2.7.8.-ProteinQ9UJA2 (Uniprot/TrEMBL)
Choline kinase EC 2.7.1.32ProteinQ9Y259 (Uniprot/TrEMBL)
Choline-phosphate cytidylyltransferase EC 2.7.7.15ProteinQ9Y259 (Uniprot/TrEMBL)
CholineMetaboliteCID 305 (PubChem-substance)
CoA-SHMetaboliteCID 6816 (PubChem-compound)
Coenzyme A (CoA-SH)MetaboliteCID 6816 (PubChem-compound)
Cytidine diphosphate choline (CDP-choline)MetaboliteCID 25202509 (PubChem-compound)
Cytidine diphosphate ethanolamine (CDP-ethanolamine)MetaboliteCID 123727 (PubChem-compound)
Cytidine monophosphate (CMP)MetaboliteCID 6131 (PubChem-compound)
Cytidine triphosphate (CTP)MetaboliteCID 6176 (PubChem-compound)
D-Glucose-6-PMetaboliteCID 44134741 (PubChem-compound)
Diacylglycerol O-acyltransferase EC 2.3.1.20ProteinQ86VF5 (Uniprot/TrEMBL)
Diacylglycerol cholinephosphotransferase EC 2.7.8.2ProteinQ8WUD6 (Uniprot/TrEMBL)
Dihydroxyacetone phosphateMetaboliteCID 668 (PubChem-compound)
Ethanolamine kinase EC 2.7.1.82ProteinQ9Y259 (Uniprot/TrEMBL)
Ethanolamine-phosphate cytidylyltransferase EC 2.7.7.14ProteinQ99447 (Uniprot/TrEMBL)
EthanolamineMetaboliteCID 700 (PubChem-compound)
Ethanolaminephosphotransferase EC 2.7.8.1ProteinQ9Y6K0 (Uniprot/TrEMBL)
Fatty acid MetabolismPathway00071 (KEGG Pathway)
GlucoseMetabolite
Glycerol kinase EC 2.7.1.30ProteinP32189 (Uniprot/TrEMBL)
Glycerol-3-PMetaboliteCID 7048686 (PubChem-compound)
Glycerol-3-phosphate 2-O-acyltransferase EC 2.3.1.198ProteinO80437 (Uniprot/TrEMBL)
Glycerol-3-phosphate dehydrogenase (NAD+) EC 1.1.1.8ProteinP21695 (Uniprot/TrEMBL)
GlycerolMetaboliteCID 753 (PubChem-compound)
GlycolysisPathway00010 (KEGG Pathway)
H2O
InositolMetaboliteCID 892 (PubChem-compound)
L-serine-phosphatidylethanolamine phosphatidyltransferase EC 2.7.8.29ProteinP48651 (Uniprot/TrEMBL)
NAD+ (Coenzyme I)MetaboliteCID 5892 (PubChem-compound)
NADH + H+MetaboliteCID 439153 (PubChem-compound)
PIP2[4',5']MetaboliteLMGP08010003 (LIPID MAPS)
PIP3[3',4',5']MetaboliteLMGP09010001 (LIPID MAPS)
PPiMetabolite
Phosphatidate cytidylyltransferase EC 2.7.7.41ProteinO95674 (Uniprot/TrEMBL)
Phosphatidate phosphatase EC 3.1.3.4ProteinQ14693 (Uniprot/TrEMBL)
Phosphatidylethanolamine N-methyltransferase EC 2.1.1.17ProteinQ9UBM1 (Uniprot/TrEMBL)
Phosphatidylglycerophosphatase EC 3.1.3.27ProteinQ8WUK0 (Uniprot/TrEMBL)
Phosphatidylinositol-4,5-bisphosphate 3-kinase EC 2.7.1.153ProteinQ42338 (Uniprot/TrEMBL)
Phosphatidylinositol-4-phosphate (PIP)MetaboliteLMGP07010003 (LIPID MAPS)
Phosphocholine (Choline-P)MetaboliteCID 1014 (PubChem-compound)
PhosphorylethanolamineMetaboliteCID 1015 (PubChem-compound)
PiMetabolite
Pyrimidine MetabolismPathway00240 (KEGG Pathway)
SerineMetaboliteCID 5951 (PubChem-compound)
sn-glycerol-3-phosphate (glycerol-3-P)MetaboliteCID 7048686 (PubChem-compound)
triacyl-sn-glycerol (Triacylglycerol; TAG)MetaboliteLMGL03010000 (LIPID MAPS)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2533"
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