Glycerophospholipid biosynthetic pathway (Homo sapiens)

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R-CH2-CH2-OH(Long chain fatty alcohol)Biosynthesis pathwaysPhosphocholine(Choline-P)1,2-diacyl-sn-glycero-3-phosphocholine(PC, Lecithin)Glycerol-3-phosphate dehydrogenase (NAD+)EC 1.1.1.81,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(PG)Dihydroxyacetone phosphateSerineFatty acyl-CoAPhosphatidylinositol-4-phosphate(PIP)PIP2[4',5']GlycolysisCoA-SHCardiolipin(DPG, CL)triacyl-sn-glycerol(Triacylglycerol; TAG)Adenosine triphosphate(ATP)Cytidine diphosphate choline(CDP-choline)1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-phosphate)(PGP)Cytidine diphosphate ethanolamine(CDP-ethanolamine)Phosphorylethanolamine1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate(CDP-DAG, CMP-PA)1,2-diacyl-sn-glycero-3-phosphoserine(PS)Cytidine monophosphate(CMP)PiNADH + H+1D-myo-Inositol-1-PCTP1,2-diacyl-sn-glycerol(1,2-diacylglycerol; 1,2-DAG)sn-glycerol-3-phosphate(glycerol-3-P)2-acyl-sn-glycero-3-phosphate(Lysophosphatidic acid; LPA)3 (S-adenosyl-methionine)Fatty acid Metabolism1,2-diacyl-sn-glycero-3-phosphate(Phosphatidic acid; PA)InositolEthanolamineD-Glucose-6-P1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol)(PI)GlycerolNAD+(Coenzyme I)PPiAdenosine diphosphate(ADP)CholinePyrimidine MetabolismPIP3[3',4',5']1,2-diacyl-sn-glycero-3-phosphoethanolamine(PE)Glycerol-3-PPiCMPCMPATPADPCTPPPiEthanolamineATPADPATPADPATPADPATPADPGlycerol kinaseEC 2.7.1.30Acyl-CoA2-acylglycerol-3-phosphate O-acyltransferaseEC 2.3.1.52Glycerol-3-phosphate 2-O-acyltransferaseEC 2.3.1.198Acyl coenzyme A(Acyl-CoA)Coenzyme A(CoA-SH)Phosphatidate phosphataseEC 3.1.3.4Diacylglycerol O-acyltransferaseEC 2.3.1.20Acyl coenzyme A(Acyl-CoA)Coenzyme A(CoA-SH)Phosphatidate cytidylyltransferaseEC 2.7.7.41Cytidine triphosphate(CTP)PPiCDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferaseEC 2.7.8.5PhosphatidylglycerophosphataseEC 3.1.3.27H2OCardiolipin synthaseEC 2.7.8.-CDP-DAGCMPCDP-diacylglyreol-inositol 3-phosphatidyltransferaseEC 2.7.8.111-phosphatidylinositol 4-kinaseEC 2.7.1.671-phosphatidylinositol 4-phosphate 5-kinaseEC 2.7.1.68Phosphatidylinositol-4,5-bisphosphate 3-kinaseEC 2.7.1.153Choline kinaseEC 2.7.1.32Choline-phosphate cytidylyltransferaseEC 2.7.7.15Diacylglycerol cholinephosphotransferaseEC 2.7.8.2Ethanolamine kinaseEC 2.7.1.82Ethanolamine-phosphate cytidylyltransferaseEC 2.7.7.14EthanolaminephosphotransferaseEC 2.7.8.1L-serine-phosphatidylethanolamine phosphatidyltransferaseEC 2.7.8.29Phosphatidylethanolamine N-methyltransferaseEC 2.1.1.173 (S-adenosylhomocysteine)CMPGlycolysisGlycolysisDegradation pathwaysPathway originAlkyldihydroxyacetonephosphate synthase(Alkyl-DHAP synthase)EC 2.5.1.261-Alkenyl-2-acylglycerophosphocholine(Plasmenylcholine)1-Alkyldihydroxyacetone phosphate(Octanoyl DHAP)1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine(Plasmanylethanolamine)1-Alkyl-sn-glycerol 3-phosphate1-alkyl-2-acyl-sn-glycero-3-phosphocholine(Plasmanylcholine, Platelet Activating Factor, PAF)1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine(Platelet Activating Factor, PAF)1-alkyl-2-acyl-sn-glycerol 3-phosphate1-Acyl dihydroxyacetone phosphate(Acyl-DHAP)1-alkenyl-2-acylglycerophosphoethanolamine(Plasmenylethanolamine)Acylglycerone-phosphate reductase(1-alkyl-sn-glycerol-3-phosphate dehydrogenase)EC 1.1.1.101Acyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acyltransferaseEC 2.3.1.-1-alkyl-2-acyl-sn-glycero-3-phosphate phosphatase(Phosphatidate phosphatase)EC 3.1.3.4CDP-ethanolamine:1-alkyl-2-acyl-sn-glycerophosphoethanolamine transferase(Ethanolaminephosphotransferase)EC 2.7.8.11-alkyl-2-acyl-sn-glycerophoethanolamine desaturase(Plasmanylethanolamine desaturase)EC 1.14.99.19CDP-choline:1-alkyl-2-acyl-sn-glycerophosphocholine transferase(Diacylglycerol cholinephosphotransferase)EC 2.7.8.2Nitrogen group transferasaEC 2.6.-.-Coenzyme A(CoA-SH)R'-COOH1-alkyl-2-acyl-sn-glycerolNADPH + H+NADP(Coenzyme II)Acyl-CoACoA-SHPiCytidine diphosphate ethanolamine(CDP-ethanolamine)CMPO2 + NADH + H+2H2OCytochrome bCytidine 5'-diphosphocholine(CDP-choline)CMPCholineEthanolamine1-Alkyl-2-acetyl-sn-glycerol 3-phosphateAlkylglycerophosphate 2-O-acetyltransferaseEC 2.3.1.105H2OPiAcetyl-CoACoA-SHAlkylacetylglycerophosphataseEC 3.1.3.591-Alkyl-2-acetyl-sn-glycerol


Description

Glycerophospholipids or phosphoglycerides, in which the hydrophobic regions are composed of two fatty acids joined to glycerol; and sphingolipids, in which a single fatty acid is joined to a fatty amine, sphingosine, are glycerol-based phospholipids and the main component of biological membranes. The hydrophilic moieties in these amphipathic compounds may be as a simple as a single -OH at one end of the sterol ring system, or they may be more complex. Glycerophospholipds, as well as sphingolipids, contained polar or charged alcohols at their polar ends; some also contain phosphate groups.

In glycerophospholipids, two fatty acids are ester-linked to glycerol at C-1 and C-2, and a highly polar or charged (and therefore hydrophilic) head group is attached to C-3 through a phosphodiester bond. All glycerophospholipds are derivatives of phosphatidic acid and are named for their polar head groups (e.g., phosphatidylethanolamine and phosphatidylcholine). All have a negative charge on the phosphate group at pH 7.0. The head-goup alcohol may also contribute one or more charges at pH near 7.0. The fatty acids in glycerophospholipds can be any of a wide variety. They are different in different species, in different tissues of the same species, and in different types of glycerophospholipids in the same cell or tissue. In general, glycerophospholipids contain a saturated fatty acid at C-1 and an unsaturated fatty acid at C-2, and, in general terms, the fatty acyl groups are generally 16 or 18 carbons long.

Eukaryotic membranes contain significant amounts of two other types of glycerophospholipids: Plasmalogens and Alkylacylglycerophospholipids. Plasmalogens contain a hydrocarbon chain linked to glycerol C-1 via vinyl ether linkage whereas alkylacylglycerophospholipids the alkyl substituent at glycerol C-1 is attached via an ether linkage. About 20% of mammalian glycerophospholipids are plasmalogens, this percentage varies both from species to species and from tissue to tissue within a given organism. While plasmalogens comprise only about 0.8% of the phospholipids in human liver, they account for around 23% of those in human nervous tissue. The alkylacylglycerophospholipids are less abundant than the plasmalogens, e.g., about 59% of ethanolamine glycerophospholipids of human heart are plasmalogens, whereas only 3.6% are alkylacylglycerophospholipids. However, in bovine erythrocytes, 75% of the ethanolamine glycerophospholipids are of alkylacyl type.

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  1. Houtkooper RH, Vaz FM; ''Cardiolipin, the heart of mitochondrial metabolism.''; Cell Mol Life Sci, 2008 PubMed Europe PMC Scholia
  2. Cornell RB; ''Cholinephosphotransferase from mammalian sources.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  3. Insall RH, Weiner OD; ''PIP3, PIP2, and cell movement--similar messages, different meanings?''; Dev Cell, 2001 PubMed Europe PMC Scholia
  4. Santiago OM, Rosenberg LI, Monaco ME; ''Organization of the phosphoinositide cycle. Assessment of inositol transferase activity in purified plasma membranes.''; Biochem J, 1993 PubMed Europe PMC Scholia
  5. Yamashita S, Hosaka K; ''Choline kinase from yeast.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  6. Turkish A, Sturley SL; ''Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: "Many ways to skin ACAT or a DGAT".''; Am J Physiol Gastrointest Liver Physiol, 2007 PubMed Europe PMC Scholia
  7. Kawasaki K, Kuge O, Yamakawa Y, Nishijima M; ''Purification of phosphatidylglycerophosphate synthase from Chinese hamster ovary cells.''; Biochem J, 2001 PubMed Europe PMC Scholia
  8. Jambou R, El-Assaad F, Combes V, Grau GE; ''Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases.''; Int J Biochem Cell Biol, 2009 PubMed Europe PMC Scholia
  9. Kooijman EE, Burger KN; ''Biophysics and function of phosphatidic acid: a molecular perspective.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  10. Messner MC, Albert CJ, Hsu FF, Ford DA; ''Selective plasmenylcholine oxidation by hypochlorous acid: formation of lysophosphatidylcholine chlorohydrins.''; Chem Phys Lipids, 2006 PubMed Europe PMC Scholia
  11. Ansell GB, Metcalfe RF; ''Studies on the CDP-ethanolamine-1,2-diglyceride ethanolaminephosphotransferase of rat brain.''; J Neurochem, 1971 PubMed Europe PMC Scholia
  12. Li Z, Vance DE; ''Phosphatidylcholine and choline homeostasis.''; J Lipid Res, 2008 PubMed Europe PMC Scholia
  13. Farooqui AA, Yang HC, Horrocks LA; ''Plasmalogens, phospholipases A2 and signal transduction.''; Brain Res Brain Res Rev, 1995 PubMed Europe PMC Scholia
  14. Vance DE; ''Phosphatidylethanolamine N-methyltransferase: unexpected findings from curiosity-driven research.''; Eur J Med Res, 1996 PubMed Europe PMC Scholia
  15. Arthur G, Page L; ''Synthesis of phosphatidylethanolamine and ethanolamine plasmalogen by the CDP-ethanolamine and decarboxylase pathways in rat heart, kidney and liver.''; Biochem J, 1991 PubMed Europe PMC Scholia
  16. Haagsman HP, de Haas CG, Geelen MJ, van Golde LM; ''Regulation of triacylglycerol synthesis in the liver. Modulation of diacylglycerol acyltransferase activity in vitro.''; J Biol Chem, 1982 PubMed Europe PMC Scholia
  17. Heacock AM, Agranoff BW; ''CDP-diacylglycerol synthase from mammalian tissues.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  18. Shin JJ, Loewen CJ; ''Putting the pH into phosphatidic acid signaling.''; BMC Biol, 2011 PubMed Europe PMC Scholia
  19. Bleijerveld OB, Brouwers JF, Vaandrager AB, Helms JB, Houweling M; ''The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  20. Singh H, Beckman K, Poulos A; ''Exclusive localization in peroxisomes of dihydroxyacetone phosphate acyltransferase and alkyl-dihydroxyacetone phosphate synthase in rat liver.''; J Lipid Res, 1993 PubMed Europe PMC Scholia
  21. Lapetina EG, Crouch MF; ''The relationship between phospholipases A2 and C in signal transduction.''; Ann N Y Acad Sci, 1989 PubMed Europe PMC Scholia
  22. Agranoff BW, Hajra AK; ''The acyl dihydroxyacetone phosphate pathway for glycerolipid biosynthesis in mouse liver and Ehrlich ascites tumor cells.''; Proc Natl Acad Sci U S A, 1971 PubMed Europe PMC Scholia
  23. Kawasaki K, Nishijima M; ''Purification of phosphatidylglycerophosphate synthase from cultured mammalian cells.''; Methods Mol Biol, 2003 PubMed Europe PMC Scholia
  24. Gonzalvez F, Gottlieb E; ''Cardiolipin: setting the beat of apoptosis.''; Apoptosis, 2007 PubMed Europe PMC Scholia
  25. Tzagournis M; ''Triglycerides in clinical medicine. A review.''; Am J Clin Nutr, 1978 PubMed Europe PMC Scholia
  26. Garcia C, Montero M, Alvarez J, Sanchez Crespo M; ''Biosynthesis of platelet-activating factor (PAF) induced by chemotactic peptide is modulated at the lyso-PAF:acetyl-CoA acetyltransferase level by calcium transient and phosphatidic acid.''; J Biol Chem, 1993 PubMed Europe PMC Scholia
  27. Roberti R, Mancini A, Freysz L, Binaglia L; ''Reversibility of the reactions catalyzed by cholinephosphotransferase and ethanolaminephosphotransferase solubilized from rat-brain microsomes.''; Biochim Biophys Acta, 1992 PubMed Europe PMC Scholia
  28. McGee TP, Skinner HB, Bankaitis VA; ''Functional redundancy of CDP-ethanolamine and CDP-choline pathway enzymes in phospholipid biosynthesis: ethanolamine-dependent effects on steady-state membrane phospholipid composition in Saccharomyces cerevisiae.''; J Bacteriol, 1994 PubMed Europe PMC Scholia
  29. Nakagawa T, Harada N, Miyamoto A, Kawanishi Y, Yoshida M, Shono M, Mawatari K, Takahashi A, Sakaue H, Nakaya Y; ''Membrane topology of murine glycerol-3-phosphate acyltransferase 2.''; Biochem Biophys Res Commun, 2012 PubMed Europe PMC Scholia
  30. Kay JG, Grinstein S; ''Phosphatidylserine-mediated cellular signaling.''; Adv Exp Med Biol, 2013 PubMed Europe PMC Scholia
  31. Bleijerveld OB, Klein W, Vaandrager AB, Helms JB, Houweling M; ''Control of the CDPethanolamine pathway in mammalian cells: effect of CTP:phosphoethanolamine cytidylyltransferase overexpression and the amount of intracellular diacylglycerol.''; Biochem J, 2004 PubMed Europe PMC Scholia
  32. De Matteis MA, Wilson C, D'Angelo G; ''Phosphatidylinositol-4-phosphate: The Golgi and beyond.''; Bioessays, 2013 PubMed Europe PMC Scholia
  33. Roberti R, Vecchini A, Freysz L, Masoom M, Binaglia L; ''An improved procedure for the purification of ethanolaminephosphotransferase. Reconstitution of the purified enzyme with lipids.''; Biochim Biophys Acta, 1989 PubMed Europe PMC Scholia
  34. Vance JE; ''Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids.''; J Lipid Res, 2008 PubMed Europe PMC Scholia
  35. Heilmeyer LM Jr, Vereb G Jr, Vereb G, Kakuk A, Szivák I; ''Mammalian phosphatidylinositol 4-kinases.''; IUBMB Life, 2003 PubMed Europe PMC Scholia
  36. Claypool SM, Koehler CM; ''The complexity of cardiolipin in health and disease.''; Trends Biochem Sci, 2012 PubMed Europe PMC Scholia
  37. Carrasco S, Mérida I; ''Diacylglycerol, when simplicity becomes complex.''; Trends Biochem Sci, 2007 PubMed Europe PMC Scholia
  38. El-Bassiouni EA, Piantadosi C, Snyder F; ''Metabolism of alkyldihydroxyacetone phosphate in rat brain.''; Biochim Biophys Acta, 1975 PubMed Europe PMC Scholia
  39. van den Bosch H, Aarsman AJ, van Schaik RH, Schalkwijk CG, Neijs FW, Sturk A; ''Structural and enzymological properties of cellular phospholipases A2.''; Biochem Soc Trans, 1990 PubMed Europe PMC Scholia
  40. McMaster CR, Bell RM; ''CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  41. Patil VA, Greenberg ML; ''Cardiolipin-mediated cellular signaling.''; Adv Exp Med Biol, 2013 PubMed Europe PMC Scholia
  42. Zimmerman GA, Elstad MR, Lorant DE, Mclntyre TM, Prescott SM, Topham MK, Weyrich AS, Whatley RE; ''Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions.''; Adv Exp Med Biol, 1996 PubMed Europe PMC Scholia
  43. Coleman R, Bell RM; ''Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities.''; J Biol Chem, 1977 PubMed Europe PMC Scholia
  44. Arthur G, Page L, Mock T, Choy PC; ''The catabolism of plasmenylcholine in the guinea pig heart.''; Biochem J, 1986 PubMed Europe PMC Scholia
  45. Kulikov VI, Muzya GI; ''The bioregulatory role of platelet-activating factor in intracellular processes and cell-cell interactions.''; Biochemistry (Mosc), 1998 PubMed Europe PMC Scholia
  46. Ishidate K; ''Choline/ethanolamine kinase from mammalian tissues.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  47. Hjelmstad RH, Morash SC, McMaster CR, Bell RM; ''Chimeric enzymes. Structure-function analysis of segments of sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases.''; J Biol Chem, 1994 PubMed Europe PMC Scholia
  48. Snyder F; ''CDP-choline:alkylacetylglycerol cholinephosphotransferase catalyzes the final step in the de novo synthesis of platelet-activating factor.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  49. Nagan N, Zoeller RA; ''Plasmalogens: biosynthesis and functions.''; Prog Lipid Res, 2001 PubMed Europe PMC Scholia
  50. Balla T; ''Phosphatidylinositol 4-kinases.''; Biochim Biophys Acta, 1998 PubMed Europe PMC Scholia
  51. Koltai M, Hosford D, Guinot P, Esanu A, Braquet P; ''Platelet activating factor (PAF). A review of its effects, antagonists and possible future clinical implications (Part I).''; Drugs, 1991 PubMed Europe PMC Scholia
  52. Brindley DN, Pilquil C, Sariahmetoglu M, Reue K; ''Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  53. Ishidate K, Matsuo R, Nakazawa Y; ''CDP-choline: 1,2-diacylglycerol cholinephosphotransferase from rat liver microsomes. II. Photoaffinity labeling by radioactive CDP-choline analogs.''; Biochim Biophys Acta, 1992 PubMed Europe PMC Scholia
  54. Cole LK, Vance JE, Vance DE; ''Phosphatidylcholine biosynthesis and lipoprotein metabolism.''; Biochim Biophys Acta, 2012 PubMed Europe PMC Scholia
  55. Gehrmann T, Heilmeyer LM Jr; ''Phosphatidylinositol 4-kinases.''; Eur J Biochem, 1998 PubMed Europe PMC Scholia
  56. Maurice A, Malgat M; ''Phosphatidylethanolamine: ceramide-ethanolaminephosphotransferase activity in synaptic plasma membrane vesicles. Influence of some cations and phospholipid environment on transferase activity. Further proof of its location.''; Int J Biochem, 1993 PubMed Europe PMC Scholia
  57. Han XL, Gross RW; ''Plasmenylcholine and phosphatidylcholine membrane bilayers possess distinct conformational motifs.''; Biochemistry, 1990 PubMed Europe PMC Scholia
  58. Diagne A, Fauvel J, Record M, Chap H, Douste-Blazy L; ''Studies on ether phospholipids. II. Comparative composition of various tissues from human, rat and guinea pig.''; Biochim Biophys Acta, 1984 PubMed Europe PMC Scholia
  59. Mackenzie CG, Reiss OK, Moritz E, Mackenzie JB; ''Metabolism of glycerol monoethers in cultured liver cells and implications for monoglyceride pathways.''; J Lipid Res, 1976 PubMed Europe PMC Scholia
  60. Siegel A, Baker RR; ''Activities of enzymes in platelet activating factor biosynthetic pathways in the gerbil model of cerebral ischemia.''; Biochem Cell Biol, 1996 PubMed Europe PMC Scholia
  61. Spencer DA; ''An update on PAF.''; Clin Exp Allergy, 1992 PubMed Europe PMC Scholia
  62. Clement JM, Kent C; ''CTP:phosphocholine cytidylyltransferase: insights into regulatory mechanisms and novel functions.''; Biochem Biophys Res Commun, 1999 PubMed Europe PMC Scholia
  63. Piantadosi C, Ishaq KS, Wykle RL, Snyder F; ''Synthesis and characterization of 1-O-alkyldihydroxyacetone phosphates and derivatives.''; Biochemistry, 1971 PubMed Europe PMC Scholia
  64. Polokoff MA, Bell RM; ''Solubilization, partial purification and characterization of rat liver microsomal diacylglycerol acyltransferase.''; Biochim Biophys Acta, 1980 PubMed Europe PMC Scholia
  65. Bru R, Blöchliger E, Luisi PL; ''sn-1,2-diacylglycerol cholinephosphotransferase from pig liver: mixed micellar assay and kinetic analysis of the partially pure enzyme.''; Arch Biochem Biophys, 1993 PubMed Europe PMC Scholia
  66. Coleman RA; ''Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  67. Henneberry AL, Wistow G, McMaster CR; ''Cloning, genomic organization, and characterization of a human cholinephosphotransferase.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  68. Edwards YH, Shaw MA; ''The isozymes of membrane-associated enzymes: acetylcholinesterase, succinate dehydrogenase, and glycerol-3-phosphate dehydrogenase.''; Isozymes Curr Top Biol Med Res, 1983 PubMed Europe PMC Scholia
  69. Whatley RE, Clay KL, Chilton FH, Triggiani M, Zimmerman GA, McIntyre TM, Prescott SM; ''Relative amounts of 1-O-alkyl- and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine in stimulated endothelial cells.''; Prostaglandins, 1992 PubMed Europe PMC Scholia
  70. Ford DA, Gross RW; ''Plasmenylethanolamine is the major storage depot for arachidonic acid in rabbit vascular smooth muscle and is rapidly hydrolyzed after angiotensin II stimulation.''; Proc Natl Acad Sci U S A, 1989 PubMed Europe PMC Scholia
  71. Koynova R, Caffrey M; ''Phases and phase transitions of the hydrated phosphatidylethanolamines.''; Chem Phys Lipids, 1994 PubMed Europe PMC Scholia
  72. Alarcon DA, Nandi M, Carpena X, Fita I, Loewen PC; ''Structure of glycerol-3-phosphate dehydrogenase (GPD1) from Saccharomyces cerevisiae at 2.45 Å resolution.''; Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 PubMed Europe PMC Scholia
  73. Chicco AJ, Sparagna GC; ''Role of cardiolipin alterations in mitochondrial dysfunction and disease.''; Am J Physiol Cell Physiol, 2007 PubMed Europe PMC Scholia
  74. Fariss MW, Chan CB, Patel M, Van Houten B, Orrenius S; ''Role of mitochondria in toxic oxidative stress.''; Mol Interv, 2005 PubMed Europe PMC Scholia
  75. Schümperli M, Pellaux R, Panke S; ''Chemical and enzymatic routes to dihydroxyacetone phosphate.''; Appl Microbiol Biotechnol, 2007 PubMed Europe PMC Scholia
  76. de Vet EC, Ijlst L, Oostheim W, Dekker C, Moser HW, van Den Bosch H, Wanders RJ; ''Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities.''; J Lipid Res, 1999 PubMed Europe PMC Scholia
  77. Jones AR, Gillan L; ''Metabolism of glycerol 3-phosphate by mature boar spermatozoa.''; J Reprod Fertil, 1996 PubMed Europe PMC Scholia
  78. Snyder F; ''Metabolism of platelet activating factor and related ether lipids: enzymatic pathways, subcellular sites, regulation, and membrane processing.''; Prog Clin Biol Res, 1988 PubMed Europe PMC Scholia
  79. Nojima S; ''Platelet-activating factor (PAF): an introduction.''; Lipids, 1991 PubMed Europe PMC Scholia
  80. Delage E, Puyaubert J, Zachowski A, Ruelland E; ''Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: convergences and divergences among eukaryotic kingdoms.''; Prog Lipid Res, 2013 PubMed Europe PMC Scholia
  81. de Vet EC, van den Bosch H; ''Alkyl-dihydroxyacetonephosphate synthase.''; Cell Biochem Biophys, 2000 PubMed Europe PMC Scholia
  82. Axelrod J; ''Phospholipase A2 and G proteins.''; Trends Neurosci, 1995 PubMed Europe PMC Scholia
  83. Willier S, Butt E, Grunewald TG; ''Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays.''; Biol Cell, 2013 PubMed Europe PMC Scholia
  84. Tufano MA, Biancone L, Rossano F, Capasso C, Baroni A, De Martino A, Iorio EL, Silvestro L, Camussi G; ''Outer-membrane porins from gram-negative bacteria stimulate platelet-activating-factor biosynthesis by cultured human endothelial cells.''; Eur J Biochem, 1993 PubMed Europe PMC Scholia
  85. Lykidis A, Wang J, Karim MA, Jackowski S; ''Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  86. D'Angelo G, Vicinanza M, Di Campli A, De Matteis MA; ''The multiple roles of PtdIns(4)P -- not just the precursor of PtdIns(4,5)P2.''; J Cell Sci, 2008 PubMed Europe PMC Scholia
  87. Thomas JR, Dwek RA, Rademacher TW; ''Structure, biosynthesis, and function of glycosylphosphatidylinositols.''; Biochemistry, 1990 PubMed Europe PMC Scholia
  88. Vance DE, Walkey CJ, Agellon LB; ''Why has phosphatidylethanolamine N-methyltransferase survived in evolution?''; Biochem Soc Trans, 1998 PubMed Europe PMC Scholia
  89. Hoch FL; ''Cardiolipins and biomembrane function.''; Biochim Biophys Acta, 1992 PubMed Europe PMC Scholia
  90. Grimm MO, Kuchenbecker J, Rothhaar TL, Grösgen S, Hundsdörfer B, Burg VK, Friess P, Müller U, Grimm HS, Riemenschneider M, Hartmann T; ''Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease.''; J Neurochem, 2011 PubMed Europe PMC Scholia
  91. Zhang L, Mao YS, Janmey PA, Yin HL; ''Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton.''; Subcell Biochem, 2012 PubMed Europe PMC Scholia
  92. Das AK, Hajra AK; ''Estimation of acyldihydroxyacetone phosphate and lysophosphatidate in animal tissues.''; Biochim Biophys Acta, 1984 PubMed Europe PMC Scholia
  93. Gale SE, Frolov A, Han X, Bickel PE, Cao L, Bowcock A, Schaffer JE, Ory DS; ''A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  94. Koltai M, Hosford D, Guinot P, Esanu A, Braquet P; ''PAF. A review of its effects, antagonists and possible future clinical implications (Part II).''; Drugs, 1991 PubMed Europe PMC Scholia
  95. Shin J, Thompson DH; ''Direct synthesis of plasmenylcholine from allyl-substituted glycerols.''; J Org Chem, 2003 PubMed Europe PMC Scholia
  96. Snyder F; ''Metabolic processing of PAF.''; Clin Rev Allergy, 1994 PubMed Europe PMC Scholia
  97. Kume K, Shimizu T; ''cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC Scholia
  98. Vance DE; ''Physiological roles of phosphatidylethanolamine N-methyltransferase.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  99. Downes CP, Carter AN; ''Inositol lipids and phosphates.''; Curr Opin Cell Biol, 1990 PubMed Europe PMC Scholia
  100. Hjelmstad RH, Bell RM; ''The sn-1,2-diacylglycerol cholinephosphotransferase of Saccharomyces cerevisiae. Nucleotide sequence, transcriptional mapping, and gene product analysis of the CPT1 gene.''; J Biol Chem, 1990 PubMed Europe PMC Scholia
  101. Moolenaar WH; ''Lysophosphatidic acid, a multifunctional phospholipid messenger.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  102. Liteplo RG, Sribney M; ''The stimulation of rat liver microsomal CTP: phosphatidate cytidylyltransferase activity by guanosine triphosphate.''; Biochim Biophys Acta, 1980 PubMed Europe PMC Scholia
  103. Kent C; ''Eukaryotic phospholipid biosynthesis.''; Annu Rev Biochem, 1995 PubMed Europe PMC Scholia
  104. Xu YF, O K, Choy PC; ''Plasmenylcholine (1-O-alk-1'-enyl-2-acyl-sn-glycero-3-phosphocholine) biosynthesis in guinea-pig heart and liver: cholinephosphotransferase is a bifunctional enzyme for the synthesis of phosphatidylcholine and plasmenylcholine.''; Biochem J, 1994 PubMed Europe PMC Scholia
  105. Hsuan JJ, Minogue S, dos Santos M; ''Phosphoinositide 4- and 5-kinases and the cellular roles of phosphatidylinositol 4,5-bisphosphate.''; Adv Cancer Res, 1998 PubMed Europe PMC Scholia
  106. Lucken-Ardjomande Hasler S; ''Cholesterol, cardiolipin, and mitochondria permeabilisation.''; Anticancer Agents Med Chem, 2012 PubMed Europe PMC Scholia
  107. Tijburg LB, Vermeulen PS, van Golde LM; ''Ethanolamine-phosphate cytidylyltransferase.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  108. Schlame M, Greenberg ML; ''Cardiolipin synthase from yeast.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  109. Farese RV Jr, Cases S, Smith SJ; ''Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase.''; Curr Opin Lipidol, 2000 PubMed Europe PMC Scholia
  110. Kocsis MG, Weselake RJ; ''Phosphatidate phosphatases of mammals, yeast, and higher plants.''; Lipids, 1996 PubMed Europe PMC Scholia
  111. Lamers JM, Dekkers DH, Bezstarosti K, Meij JT, van Heugten HA; ''Occurrence and functions of the phosphatidylinositol cycle in the myocardium.''; Mol Cell Biochem, 1992 PubMed Europe PMC Scholia
  112. Graham TR, Burd CG; ''Coordination of Golgi functions by phosphatidylinositol 4-kinases.''; Trends Cell Biol, 2011 PubMed Europe PMC Scholia
  113. Kwiatkowska K; ''One lipid, multiple functions: how various pools of PI(4,5)P(2) are created in the plasma membrane.''; Cell Mol Life Sci, 2010 PubMed Europe PMC Scholia
  114. Gibellini F, Smith TK; ''The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine.''; IUBMB Life, 2010 PubMed Europe PMC Scholia
  115. Ramanadham S, Bohrer A, Mueller M, Jett P, Gross RW, Turk J; ''Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: prominence of plasmenylethanolamine molecular species.''; Biochemistry, 1993 PubMed Europe PMC Scholia
  116. Pagès C, Simon M, Valet P, Saulnier-Blache JS; ''Lysophosphatidic acid synthesis and release(1).''; Prostaglandins, 2001 PubMed Europe PMC Scholia
  117. Gamper N, Shapiro MS; ''Target-specific PIP(2) signalling: how might it work?''; J Physiol, 2007 PubMed Europe PMC Scholia
  118. Pagès C, Simon MF, Valet P, Saulnier-Blache JS; ''Lysophosphatidic acid synthesis and release.''; Prostaglandins Other Lipid Mediat, 2001 PubMed Europe PMC Scholia
  119. Roberti R, Binaglia L, Francescangeli E, Goracci G, Porcellati G; ''Enzymic synthesis of 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine through ethanolaminephosphotransferase activity in the neuronal and glial cells of rabbit in vitro.''; Lipids, 1975 PubMed Europe PMC Scholia
  120. Divecha N; ''Lipid kinases: charging PtdIns(4,5)P2 synthesis.''; Curr Biol, 2010 PubMed Europe PMC Scholia
  121. Gibbons GF, Islam K, Pease RJ; ''Mobilisation of triacylglycerol stores.''; Biochim Biophys Acta, 2000 PubMed Europe PMC Scholia
  122. Clayton EL, Minogue S, Waugh MG; ''Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases.''; Mol Neurobiol, 2013 PubMed Europe PMC Scholia
  123. Yost CC, Weyrich AS, Zimmerman GA; ''The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses.''; Biochimie, 2010 PubMed Europe PMC Scholia
  124. Holmsen H, Hindenes JO, Fukami M; ''Glycerophospholipid metabolism: back to the future.''; Thromb Res, 1992 PubMed Europe PMC Scholia
  125. Tijburg LB, Geelen MJ, Van Golde LM; ''Biosynthesis of phosphatidylethanolamine via the CDP-ethanolamine route is an important pathway in isolated rat hepatocytes.''; Biochem Biophys Res Commun, 1989 PubMed Europe PMC Scholia
  126. Detopoulou P, Nomikos T, Fragopoulou E, Antonopoulou S, Kotroyiannis I, Vassiliadou C, Panagiotakos DB, Chrysohoou C, Pitsavos C, Stefanadis C; ''Platelet activating factor (PAF) and activity of its biosynthetic and catabolic enzymes in blood and leukocytes of male patients with newly diagnosed heart failure.''; Clin Biochem, 2009 PubMed Europe PMC Scholia
  127. Kay JG, Grinstein S; ''Sensing phosphatidylserine in cellular membranes.''; Sensors (Basel), 2011 PubMed Europe PMC Scholia
  128. Schlame M, Hostetler KY; ''Cardiolipin synthase from mammalian mitochondria.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  129. Tijburg LB, Geelen MJ, van Golde LM; ''Regulation of the biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine in the liver.''; Biochim Biophys Acta, 1989 PubMed Europe PMC Scholia
  130. Jiang F, Kelly BL, Hagopian K, Greenberg ML; ''Purification and characterization of phosphatidylglycerolphosphate synthase from Schizosaccharomyces pombe.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  131. Schlame M, Ren M; ''The role of cardiolipin in the structural organization of mitochondrial membranes.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  132. Dircks LK, Sul HS; ''Mammalian mitochondrial glycerol-3-phosphate acyltransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  133. Hajra AK, Das AK; ''Lipid biosynthesis in peroxisomes.''; Ann N Y Acad Sci, 1996 PubMed Europe PMC Scholia
  134. Haagsman HP, de Haas CG, Geelen MJ, van Golde LM; ''Regulation of triacylglycerol synthesis in the liver: a decrease in diacylglycerol acyltransferase activity after treatment of isolated rat hepatocytes with glucagon.''; Biochim Biophys Acta, 1981 PubMed Europe PMC Scholia
  135. Sims SM, Panupinthu N, Lapierre DM, Pereverzev A, Dixon SJ; ''Lysophosphatidic acid: a potential mediator of osteoblast-osteoclast signaling in bone.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  136. McMaster CR, Bell RM; ''CDP-choline:1,2-diacylglycerol cholinephosphotransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  137. Ishii S, Shimizu T; ''Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice.''; Prog Lipid Res, 2000 PubMed Europe PMC Scholia
  138. MacDonald PM, McMurray WC; ''Partial purification and properties of mammalian phosphatidylglycerophosphatase.''; Biochim Biophys Acta, 1980 PubMed Europe PMC Scholia
  139. Vance DE, Li Z, Jacobs RL; ''Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  140. Hajra AK; ''Dihydroxyacetone phosphate acyltransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  141. Paradies G, Petrosillo G, Paradies V, Ruggiero FM; ''Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging.''; Free Radic Biol Med, 2010 PubMed Europe PMC Scholia
  142. Blank ML, Fitzgerald V, Lee TC, Snyder F; ''Evidence for biosynthesis of plasmenylcholine from plasmenylethanolamine in HL-60 cells.''; Biochim Biophys Acta, 1993 PubMed Europe PMC Scholia
  143. Bewley GC, Cook JL; ''Molecular structure, developmental regulation, and evolution of the gene encoding glycerol-3-phosphate dehydrogenase isozymes in Drosophila melanogaster.''; Prog Clin Biol Res, 1990 PubMed Europe PMC Scholia
  144. Czech MP; ''PIP2 and PIP3: complex roles at the cell surface.''; Cell, 2000 PubMed Europe PMC Scholia
  145. Takenawa T, Itoh T, Fukami K; ''Regulation of phosphatidylinositol 4,5-bisphosphate levels and its roles in cytoskeletal re-organization and malignant transformation.''; Chem Phys Lipids, 1999 PubMed Europe PMC Scholia
  146. Baker RR, Chang HY; ''Alkylglycerophosphate acetyltransferase and lyso platelet activating factor acetyltransferase, two key enzymes in the synthesis of platelet activating factor, are found in neuronal nuclei isolated from cerebral cortex.''; Biochim Biophys Acta, 1996 PubMed Europe PMC Scholia
  147. Sinha Roy S, Mukhopadhyay S, Mukherjee S, Das SK; ''Breast cancer is associated with an increase in the activity and expression of cholinephosphotransferase in rats.''; Life Sci, 2008 PubMed Europe PMC Scholia
  148. Nakanishi K, Yasugi E, Morita H, Dohi T, Oshima M; ''Plasmenylethanolamine in human intestinal mucosa detected by an improved method for analysis of phospholipid.''; Biochem Mol Biol Int, 1994 PubMed Europe PMC Scholia
  149. de Vet EC, Hilkes YH, Fraaije MW, van den Bosch H; ''Alkyl-dihydroxyacetonephosphate synthase. Presence and role of flavin adenine dinucleotide.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  150. Leventis PA, Grinstein S; ''The distribution and function of phosphatidylserine in cellular membranes.''; Annu Rev Biophys, 2010 PubMed Europe PMC Scholia
  151. Thompson DH, Shin J, Boomer J, Kim JM; ''Preparation of plasmenylcholine lipids and plasmenyl-type liposome dispersions.''; Methods Enzymol, 2004 PubMed Europe PMC Scholia
  152. Zhao Y, Natarajan V; ''Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  153. Murakami M, Lambeau G; ''Emerging roles of secreted phospholipase A(2) enzymes: an update.''; Biochimie, 2013 PubMed Europe PMC Scholia
  154. Nikawa J, Yamashita S; ''Molecular cloning of the gene encoding CDPdiacylglycerol-inositol 3-phosphatidyl transferase in Saccharomyces cerevisiae.''; Eur J Biochem, 1984 PubMed Europe PMC Scholia
  155. Rooney SA; ''Lung surfactant.''; Environ Health Perspect, 1984 PubMed Europe PMC Scholia
  156. Reue K, Brindley DN; ''Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.''; J Lipid Res, 2008 PubMed Europe PMC Scholia
  157. Kashiwada M, Lu P, Rothman PB; ''PIP3 pathway in regulatory T cells and autoimmunity.''; Immunol Res, 2007 PubMed Europe PMC Scholia
  158. Hirasawa K, Nishizuka Y; ''Phosphatidylinositol turnover in receptor mechanism and signal transduction.''; Annu Rev Pharmacol Toxicol, 1985 PubMed Europe PMC Scholia
  159. Snyder F, Fitzgerald V, Blank ML; ''Biosynthesis of platelet-activating factor and enzyme inhibitors.''; Adv Exp Med Biol, 1996 PubMed Europe PMC Scholia
  160. Wright MM, McMaster CR; ''PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1).''; Lipids, 2002 PubMed Europe PMC Scholia
  161. Talmud PJ; ''Genetic determinants of plasma triglycerides: impact of rare and common mutations.''; Curr Atheroscler Rep, 2001 PubMed Europe PMC Scholia
  162. Clark JD, Schievella AR, Nalefski EA, Lin LL; ''Cytosolic phospholipase A2.''; J Lipid Mediat Cell Signal, 1995 PubMed Europe PMC Scholia
  163. Vance JE, Steenbergen R; ''Metabolism and functions of phosphatidylserine.''; Prog Lipid Res, 2005 PubMed Europe PMC Scholia
  164. Thompson RJ; ''The biosynthesis of cytidine diphosphate diacylglycerol in the mammalian cerebral cortex.''; Biochem Soc Trans, 1977 PubMed Europe PMC Scholia
  165. Lee TC, Qian CG, Snyder F; ''Biosynthesis of choline plasmalogens in neonatal rat myocytes.''; Arch Biochem Biophys, 1991 PubMed Europe PMC Scholia
  166. Wykle RL, Schremmer JM; ''Biosynthesis of plasmalogens by the microsomal fraction of fischer R-3259 sarcoma. Influence of specific 2-acyl chains on the desaturation of 1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine.''; Biochemistry, 1979 PubMed Europe PMC Scholia
  167. Taguchi T, Arai H; ''[Emerging roles of intracellular phosphatidylserine (PS) in membrane traffic].''; Seikagaku, 2012 PubMed Europe PMC Scholia
  168. Waugh MG; ''Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer.''; Cancer Lett, 2012 PubMed Europe PMC Scholia
  169. Antonsson B; ''Phosphatidylinositol synthase from mammalian tissues.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  170. Snyder F, Lee TC; ''1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphatase.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  171. de Vet EC, Ijlst L, Oostheim W, Wanders RJ, van den Bosch H; ''Alkyl-dihydroxyacetonephosphate synthase. Fate in peroxisome biogenesis disorders and identification of the point mutation underlying a single enzyme deficiency.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  172. Hajra AK, Datta SC, Ghosh MK; ''Acyl/alkyldihydroxyacetone phosphate reductase from guinea pig liver peroxisomes.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  173. Goñi FM, Alonso A; ''Structure and functional properties of diacylglycerols in membranes.''; Prog Lipid Res, 1999 PubMed Europe PMC Scholia
  174. Rudkowska I, Roynette CE, Demonty I, Vanstone CA, Jew S, Jones PJ; ''Diacylglycerol: efficacy and mechanism of action of an anti-obesity agent.''; Obes Res, 2005 PubMed Europe PMC Scholia
  175. Webber KO, Hajra AK; ''Dihydroxyacetone phosphate acyltransferase.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  176. Carman GM; ''Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  177. Xu FY, O K, Choy PC; ''Biosynthesis of plasmenylethanolamine (1-O-alk-1'-enyl-2-acyl-sn-glycero-3-phosphoethanolamine) in the guinea pig heart.''; J Lipid Res, 1997 PubMed Europe PMC Scholia
  178. Fagone P, Jackowski S; ''Phosphatidylcholine and the CDP-choline cycle.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  179. Secades JJ, Lorenzo JL; ''Citicoline: pharmacological and clinical review, 2006 update.''; Methods Find Exp Clin Pharmacol, 2006 PubMed Europe PMC Scholia
  180. Hullin-Matsuda F, Kawasaki K, Delton-Vandenbroucke I, Xu Y, Nishijima M, Lagarde M, Schlame M, Kobayashi T; ''De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate.''; J Lipid Res, 2007 PubMed Europe PMC Scholia
  181. Debeer LJ, Declercq PE, Mannaerts GP; ''Glycerol-3-phosphate content and triacylglycerol synthesis in isolated hepatocytes from fed and starved rats.''; FEBS Lett, 1981 PubMed Europe PMC Scholia
  182. Schlegel RA, Williamson P; ''P.S. to PS (phosphatidylserine)--pertinent proteins in apoptotic cell clearance.''; Sci STKE, 2007 PubMed Europe PMC Scholia
  183. Ellis JM, Paul DS, Depetrillo MA, Singh BP, Malarkey DE, Coleman RA; ''Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer.''; Toxicol Pathol, 2012 PubMed Europe PMC Scholia
  184. Carman GM, Han GS; ''Roles of phosphatidate phosphatase enzymes in lipid metabolism.''; Trends Biochem Sci, 2006 PubMed Europe PMC Scholia
  185. Nieto ML, Velasco S, Sanchez Crespo M; ''Modulation of acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PAF) acetyltransferase in human polymorphonuclears. The role of cyclic AMP-dependent and phospholipid sensitive, calcium-dependent protein kinases.''; J Biol Chem, 1988 PubMed Europe PMC Scholia
  186. Chao W, Olson MS; ''Platelet-activating factor: receptors and signal transduction.''; Biochem J, 1993 PubMed Europe PMC Scholia
  187. Sukumaran S, Barnes RI, Garg A, Agarwal AK; ''Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3.''; J Mol Endocrinol, 2009 PubMed Europe PMC Scholia
  188. Giudici ML, Hinchliffe KA, Irvine RF; ''Phosphatidylinositol phosphate kinases.''; J Endocrinol Invest, 2004 PubMed Europe PMC Scholia
  189. Rüdiger M, Kolleck I, Putz G, Wauer RR, Stevens P, Rüstow B; ''Plasmalogens effectively reduce the surface tension of surfactant-like phospholipid mixtures.''; Am J Physiol, 1998 PubMed Europe PMC Scholia
  190. van Heusden GP, van den Bosch H; ''The influence of exogenous and of membrane-bound phosphatidate concentration on the activity of CTP: phosphatidate cytidylyltransferase and phosphatidate phosphohydrolase.''; Eur J Biochem, 1978 PubMed Europe PMC Scholia
  191. Arienti G, Goracci G, Porcellati G; ''Glycerophospholipid metabolism in neuronal and glial cell-enriched fractions.''; Neurochem Res, 1981 PubMed Europe PMC Scholia
  192. Sorger D, Daum G; ''Triacylglycerol biosynthesis in yeast.''; Appl Microbiol Biotechnol, 2003 PubMed Europe PMC Scholia
  193. Longmuir KJ, Johnston JM; ''Changes in CTP:phosphatidate cytidylyltransferase activity during rabbit lung development.''; Biochim Biophys Acta, 1980 PubMed Europe PMC Scholia
  194. Horibata Y, Hirabayashi Y; ''Identification and characterization of human ethanolaminephosphotransferase1.''; J Lipid Res, 2007 PubMed Europe PMC Scholia
  195. Large WA, Saleh SN, Albert AP; ''Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle.''; Cell Calcium, 2009 PubMed Europe PMC Scholia
  196. Lacal JC; ''Choline kinase: a novel target for antitumor drugs.''; IDrugs, 2001 PubMed Europe PMC Scholia
  197. Sinha RK, Subrahmanyam G; ''Type II phosphatidylinositol 4-kinase(s) in cell signaling cascades.''; Indian J Biochem Biophys, 2007 PubMed Europe PMC Scholia
  198. Tsuboi K, Ikematsu N, Uyama T, Deutsch DG, Tokumura A, Ueda N; ''Biosynthetic pathways of bioactive N-acylethanolamines in brain.''; CNS Neurol Disord Drug Targets, 2013 PubMed Europe PMC Scholia
  199. Muzia TI, Kulikov VN; ''[1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine: acetylhydrolase is associated primarily with low density lipoproteins in human blood].''; Biokhimiia, 1991 PubMed Europe PMC Scholia
  200. Quest AF, Ghosh S, Xie WQ, Bell RM; ''DAG second messengers: molecular switches and growth control.''; Adv Exp Med Biol, 1997 PubMed Europe PMC Scholia
  201. Berdichevets IN, Tyazhelova TV, Shimshilashvili KhR, Rogaev EI; ''Lysophosphatidic acid is a lipid mediator with wide range of biological activities. Biosynthetic pathways and mechanism of action.''; Biochemistry (Mosc), 2010 PubMed Europe PMC Scholia
  202. Klingenberg M; ''Cardiolipin and mitochondrial carriers.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  203. Zhang Y, Du G; ''Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  204. Lake BD; ''Histochemical demonstration of cytosolic alpha-glycerophosphate dehydrogenase (EC 1.1.1.8) and mitochondrial alpha-glycerophosphate dehydrogenase (EC 1.1.99.5).''; J Neurol Sci, 1987 PubMed Europe PMC Scholia
  205. Honda Z, Ishii S, Shimizu T; ''Platelet-activating factor receptor.''; J Biochem, 2002 PubMed Europe PMC Scholia
  206. Ward KB, Pattabiraman N; ''Comparative anatomy of phospholipase A2 structures.''; Adv Exp Med Biol, 1990 PubMed Europe PMC Scholia
  207. Brown AJ, Glish GL, McBay EH, Snyder F; ''Alkyldihydroxyacetonephosphate synthase mechanism: 18O studies of fatty acid release from acyldihydroxyacetone phosphate.''; Biochemistry, 1985 PubMed Europe PMC Scholia
  208. Leonardi R, Frank MW, Jackson PD, Rock CO, Jackowski S; ''Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  209. Nikawa J, Yamashita S; ''Yeast mutant defective in synthesis of phosphatidylinositol. Isolation and characterization of a CDPdiacylglycerol--inositol 3-phosphatidyltransferase Km mutant.''; Eur J Biochem, 1982 PubMed Europe PMC Scholia
  210. Ridgway ND; ''The role of phosphatidylcholine and choline metabolites to cell proliferation and survival.''; Crit Rev Biochem Mol Biol, 2013 PubMed Europe PMC Scholia
  211. Thompson DH, Inerowicz HD, Grove J, Sarna T; ''Structural characterization of plasmenylcholine photooxidation products.''; Photochem Photobiol, 2003 PubMed Europe PMC Scholia
  212. Favrelière S, Barrier L, Durand G, Chalon S, Tallineau C; ''Chronic dietary n-3 polyunsaturated fatty acids deficiency affects the fatty acid composition of plasmenylethanolamine and phosphatidylethanolamine differently in rat frontal cortex, striatum, and cerebellum.''; Lipids, 1998 PubMed Europe PMC Scholia
  213. Paltauf F; ''Isolation of soluble proteins capable of stimulating aerobic plasmalogen biosynthesis.''; Eur J Biochem, 1978 PubMed Europe PMC Scholia
  214. Kawasaki K, Nishijima M; ''[Biosynthesis and function of phosphatidylglycerol and cardiolipin in animal cells].''; Tanpakushitsu Kakusan Koso, 1999 PubMed Europe PMC Scholia
  215. Zammit VA, Buckett LK, Turnbull AV, Wure H, Proven A; ''Diacylglycerol acyltransferases: Potential roles as pharmacological targets.''; Pharmacol Ther, 2008 PubMed Europe PMC Scholia
  216. Schug ZT, Gottlieb E; ''Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  217. Rock CO, Snyder F; ''Biosynthesis of 1-alkyl-sn-glycero-3-phosphate via adenosine triphosphate:1-alkyl-sn-glycerol phosphotransferase.''; J Biol Chem, 1974 PubMed Europe PMC Scholia
  218. Holmsen H, Hindenes JO, Fukami M; ''Glycerophospholipid metabolism: back to the future.''; Thromb Res, 1992 PubMed Europe PMC Scholia
  219. Arenth PM, Russell KC, Ricker JH, Zafonte RD; ''CDP-choline as a biological supplement during neurorecovery: a focused review.''; PM R, 2011 PubMed Europe PMC Scholia
  220. Jackowski S, Fagone P; ''CTP: Phosphocholine cytidylyltransferase: paving the way from gene to membrane.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  221. Shenker BJ, Ali H, Boesze-Battaglia K; ''PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases.''; Curr Pharm Des, 2011 PubMed Europe PMC Scholia
  222. Suh BC, Hille B; ''Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate.''; Curr Opin Neurobiol, 2005 PubMed Europe PMC Scholia
  223. Henneberry AL, McMaster CR; ''Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine.''; Biochem J, 1999 PubMed Europe PMC Scholia
  224. Das AK, Milam JE, Reddy RC, Hajra AK; ''Facile syntheses of acyl dihydroxyacetone phosphates and lysophosphatidic acids having different acyl groups.''; J Lipid Res, 2006 PubMed Europe PMC Scholia
  225. Qiu Q, Liu G, Li W, Shi Q, Zhu F, Lu G; ''Glycerol-3-phosphate acyltransferase 4 gene is involved in mouse spermatogenesis.''; Acta Biochim Biophys Sin (Shanghai), 2009 PubMed Europe PMC Scholia
  226. Hajra AK, Das AK; ''Lipid biosynthesis in peroxisomes.''; Ann N Y Acad Sci, 1996 PubMed Europe PMC Scholia
  227. Glaser KB, Mobilio D, Chang JY, Senko N; ''Phospholipase A2 enzymes: regulation and inhibition.''; Trends Pharmacol Sci, 1993 PubMed Europe PMC Scholia
  228. Brown A, Snyder F; ''Alkyldihydroxyacetonephosphate synthase.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  229. Waku K, Sugiura T, Nakagawa Y; ''Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages.''; Adv Prostaglandin Thromboxane Leukot Res, 1985 PubMed Europe PMC Scholia
  230. Salamon RS, Backer JM; ''Phosphatidylinositol-3,4,5-trisphosphate: Tool of choice for class I PI 3-kinases.''; Bioessays, 2013 PubMed Europe PMC Scholia
  231. Rabert U, Völkl A, Debuch H; ''Distribution of alkylglycerone-phosphate synthase in subcellular fractions of rat liver.''; Biol Chem Hoppe Seyler, 1986 PubMed Europe PMC Scholia
  232. Hosaka K, Schiele U, Numa S; ''Diacylglycerol acyltransferase from rat liver microsomes. Separation and acyl-donor specificity.''; Eur J Biochem, 1977 PubMed Europe PMC Scholia
  233. Vance JE; ''Molecular and cell biology of phosphatidylserine and phosphatidylethanolamine metabolism.''; Prog Nucleic Acid Res Mol Biol, 2003 PubMed Europe PMC Scholia
  234. Yamashita S, Hosaka K, Miki Y, Numa S; ''Glycerolipid acyltransferases from rat liver: 1-acylglycerophosphate acyltransferase, 1-acylglycerophosphorylcholine acyltransferase, and diacylglycerol acyltransferase.''; Methods Enzymol, 1981 PubMed Europe PMC Scholia
  235. Shindou H, Hishikawa D, Nakanishi H, Harayama T, Ishii S, Taguchi R, Shimizu T; ''A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  236. Carman GM, Kelley MJ; ''CDPdiacylglycerol synthase from yeast.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  237. Yang CY, Frohman MA; ''Mitochondria: signaling with phosphatidic acid.''; Int J Biochem Cell Biol, 2012 PubMed Europe PMC Scholia
  238. Verheij HM, Slotboom AJ, de Haas GH; ''Structure and function of phospholipase A2.''; Rev Physiol Biochem Pharmacol, 1981 PubMed Europe PMC Scholia
  239. Biermann J, Just WW, Wanders RJ, Van Den Bosch H; ''Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes.''; Eur J Biochem, 1999 PubMed Europe PMC Scholia
  240. André A, Tessier C, Brétillon L, Sébédio JL, Chardigny JM; ''In situ hybridization of dihydroxyacetone phosphate acyltransferase, the regulating enzyme involved in plasmalogen biosynthesis.''; Brain Res Mol Brain Res, 2005 PubMed Europe PMC Scholia
  241. Mrá�ek T, Drahota Z, Houštěk J; ''The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  242. Mavis RD, Vang MJ; ''Optimal assay and subcellular location of phosphatidylglycerol synthesis in lung.''; Biochim Biophys Acta, 1981 PubMed Europe PMC Scholia
  243. Mancini A, Roberti R, Binaglia L, el Missiri A, Freysz L; ''Factors affecting the stability of detergent-solubilized cholinephosphotransferase and ethanolaminephosphotransferase.''; Membr Biochem, 1993 PubMed Europe PMC Scholia
  244. van den Bosch H, de Vet EC; ''Alkyl-dihydroxyacetonephosphate synthase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  245. Dobrowsky RT, Ballas LM; ''Peroxisomal dihydroxyacetone phosphate acyltransferase. Effect of acetaldehyde on the intact and solubilized activity.''; J Biol Chem, 1987 PubMed Europe PMC Scholia
  246. Scherer M, Schmitz G; ''Metabolism, function and mass spectrometric analysis of bis(monoacylglycero)phosphate and cardiolipin.''; Chem Phys Lipids, 2011 PubMed Europe PMC Scholia
  247. Ohtsuka J, Nagata K, Lee WC, Ono Y, Fukuda R, Ohta A, Tanokura M; ''Crystallization and preliminary X-ray analysis of CTP:phosphoethanolamine cytidylyltransferase (ECT) from Saccharomyces cerevisiae.''; Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 PubMed Europe PMC Scholia
  248. Blank ML, Lee YJ, Cress EA, Snyder F; ''Stimulation of the de novo pathway for the biosynthesis of platelet-activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production.''; J Biol Chem, 1988 PubMed Europe PMC Scholia
  249. Nakashima A, Hosaka K, Nikawa J; ''Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  250. Kumaran D, Bonanno JB, Burley SK, Swaminathan S; ''Crystal structure of phosphatidylglycerophosphatase (PGPase), a putative membrane-bound lipid phosphatase, reveals a novel binuclear metal binding site and two "proton wires".''; Proteins, 2006 PubMed Europe PMC Scholia
  251. Wright MM, McMaster CR; ''PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1).''; Lipids, 2002 PubMed Europe PMC Scholia
  252. Frentzen M; ''Phosphatidylglycerol and sulfoquinovosyldiacylglycerol: anionic membrane lipids and phosphate regulation.''; Curr Opin Plant Biol, 2004 PubMed Europe PMC Scholia
  253. Huang CL; ''Complex roles of PIP2 in the regulation of ion channels and transporters.''; Am J Physiol Renal Physiol, 2007 PubMed Europe PMC Scholia
  254. Tie A, Bakovic M; ''Alternative splicing of CTP:phosphoethanolamine cytidylyltransferase produces two isoforms that differ in catalytic properties.''; J Lipid Res, 2007 PubMed Europe PMC Scholia
  255. Chang J, Musser JH, McGregor H; ''Phospholipase A2: function and pharmacological regulation.''; Biochem Pharmacol, 1987 PubMed Europe PMC Scholia
  256. Moolenaar WH, van Meeteren LA, Giepmans BN; ''The ins and outs of lysophosphatidic acid signaling.''; Bioessays, 2004 PubMed Europe PMC Scholia
  257. Saulnier-Blache JS; ''[Lysophosphatidic acid: a "bioactive" phospholipid].''; Med Sci (Paris), 2004 PubMed Europe PMC Scholia
  258. Claypool SM; ''Cardiolipin, a critical determinant of mitochondrial carrier protein assembly and function.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  259. Baker RR; ''Lipid acetylation reactions and the metabolism of platelet-activating factor.''; Neurochem Res, 2000 PubMed Europe PMC Scholia
  260. Stremmel W, Ehehalt R, Staffer S, Stoffels S, Mohr A, Karner M, Braun A; ''Mucosal protection by phosphatidylcholine.''; Dig Dis, 2012 PubMed Europe PMC Scholia
  261. Secades JJ, Frontera G; ''CDP-choline: pharmacological and clinical review.''; Methods Find Exp Clin Pharmacol, 1995 PubMed Europe PMC Scholia
  262. Downes P, Michell RH; ''Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: lipids in search of a function.''; Cell Calcium, 1982 PubMed Europe PMC Scholia
  263. Ide H, Miller JC, Weinhold PA; ''Ethanolaminephosphotransferase in rat lung: selectivity for endogenous and exogenous diacylglycerol.''; Biochim Biophys Acta, 1988 PubMed Europe PMC Scholia
  264. Kent C; ''CTP:phosphocholine cytidylyltransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  265. Yin H, Zhu M; ''Free radical oxidation of cardiolipin: chemical mechanisms, detection and implication in apoptosis, mitochondrial dysfunction and human diseases.''; Free Radic Res, 2012 PubMed Europe PMC Scholia
  266. Aoki J, Inoue A, Okudaira S; ''Two pathways for lysophosphatidic acid production.''; Biochim Biophys Acta, 2008 PubMed Europe PMC Scholia
  267. Vance DE, Walkey CJ, Cui Z; ''Phosphatidylethanolamine N-methyltransferase from liver.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  268. Baker RR; ''Enzymes of platelet activating factor synthesis in brain.''; Neurochem Res, 1995 PubMed Europe PMC Scholia
  269. Hammond LE, Neschen S, Romanelli AJ, Cline GW, Ilkayeva OR, Shulman GI, Muoio DM, Coleman RA; ''Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  270. Bobenchik AM, Augagneur Y, Hao B, Hoch JC, Ben Mamoun C; ''Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy.''; FEMS Microbiol Rev, 2011 PubMed Europe PMC Scholia
  271. Janardhan S, Srivani P, Sastry GN; ''Choline kinase: an important target for cancer.''; Curr Med Chem, 2006 PubMed Europe PMC Scholia
  272. Rüstow B, Kunze D; ''Diacylglycerol synthesized in vitro from sn-glycerol 3-phosphate and the endogenous diacylglycerol are different substrate pools for the biosynthesis of phosphatidylcholine in rat lung microsomes.''; Biochim Biophys Acta, 1985 PubMed Europe PMC Scholia
  273. Snyder F; ''Alkylglycerol phosphotransferase.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  274. Vance JE, Tasseva G; ''Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  275. Blank ML, Spector AA, Kaduce TL, Lee TC, Snyder F; ''Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and 1-alkyl-2-acetyl-sn-glycerol by human endothelial cells.''; Biochim Biophys Acta, 1986 PubMed Europe PMC Scholia
  276. Nikawa J, Yamashita S; ''Phosphatidylinositol synthase from yeast.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  277. Macfarlane MG; ''Phosphatidylglycerols and lipoamino acids.''; Adv Lipid Res, 1964 PubMed Europe PMC Scholia
  278. Nakagawa Y, Waku K; ''The metabolism of glycerophospholipid and its regulation in monocytes and macrophages.''; Prog Lipid Res, 1989 PubMed Europe PMC Scholia
  279. Snyder F, Blank M, Lee TC, Robinson M, Woodard D; ''Measurement of key enzyme activities involved in the metabolism of platelet activating factor.''; Methods Enzymol, 1987 PubMed Europe PMC Scholia
  280. Cabezas MC, Erkelens DW; ''Triglycerides and atherosclerosis: to feast or fast.''; Neth J Med, 2000 PubMed Europe PMC Scholia
  281. Pascual F, Carman GM; ''Phosphatidate phosphatase, a key regulator of lipid homeostasis.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  282. Rosonina E, Manley JL; ''From transcription to mRNA: PAF provides a new path.''; Mol Cell, 2005 PubMed Europe PMC Scholia
  283. Ofman R, Hogenhout EM, Wanders RJ; ''Identification and characterization of the mouse cDNA encoding acyl-CoA:dihydroxyacetone phosphate acyltransferase.''; Biochim Biophys Acta, 1999 PubMed Europe PMC Scholia
  284. Gibellini F, Smith TK; ''The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine.''; IUBMB Life, 2010 PubMed Europe PMC Scholia
  285. Lewis RN, McElhaney RN; ''The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  286. Paoletti L, Elena C, Domizi P, Banchio C; ''Role of phosphatidylcholine during neuronal differentiation.''; IUBMB Life, 2011 PubMed Europe PMC Scholia
  287. Francescangeli E, Goracci G; ''The de novo biosynthesis of platelet-activating factor in rat brain.''; Biochem Biophys Res Commun, 1989 PubMed Europe PMC Scholia
  288. Wu G, Vance DE; ''Choline kinase and its function.''; Biochem Cell Biol, 2010 PubMed Europe PMC Scholia
  289. Montero J, Mari M, Colell A, Morales A, Basañez G, Garcia-Ruiz C, Fernández-Checa JC; ''Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  290. Rauchová H, Drahota Z; ''Inhibition of the glycerol 3-phosphate oxidation by free fatty acids.''; Int J Biochem, 1984 PubMed Europe PMC Scholia
  291. Sugimoto H, Banchio C, Vance DE; ''Transcriptional regulation of phosphatidylcholine biosynthesis.''; Prog Lipid Res, 2008 PubMed Europe PMC Scholia
  292. Mott GE, Brinkley AW; ''Plasmenylethanolamine: growth factor for cholesterol-reducing Eubacterium.''; J Bacteriol, 1979 PubMed Europe PMC Scholia
  293. Meyers RE, Cantley LC; ''Phosphatidylinositol 4-kinases. Assays and product analysis.''; Methods Mol Biol, 1998 PubMed Europe PMC Scholia
  294. Ishidate K, Matsuo R, Nakazawa Y; ''CDPcholine:1,2-diacylglycerol cholinephosphotransferase from rat liver microsomes. I. Solubilization and characterization of the partially purified enzyme and the possible existence of an endogenous inhibitor.''; Lipids, 1993 PubMed Europe PMC Scholia
  295. Gupta CM, Radhakrishnan R, Khorana HG; ''Glycerophospholipid synthesis: improved general method and new analogs containing photoactivable groups.''; Proc Natl Acad Sci U S A, 1977 PubMed Europe PMC Scholia
  296. Lee TC, Malone B, Blank ML, Fitzgerald V, Snyder F; ''Regulation of the synthesis of platelet-activating factor and its inactive storage precursor (1-alkyl-2-acyl-sn-glycero-3-phosphocholine) from 1-alkyl-2-acetyl-sn-glycerol by rabbit platelets.''; J Biol Chem, 1990 PubMed Europe PMC Scholia
  297. Idahl LA, Lembert N; ''Glycerol 3-phosphate-induced ATP production in intact mitochondria from pancreatic B-cells.''; Biochem J, 1995 PubMed Europe PMC Scholia
  298. Kannan L, Knudsen J, Jolly CA; ''Aging and acyl-CoA binding protein alter mitochondrial glycerol-3-phosphate acyltransferase activity.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  299. van den Bout I, Divecha N; ''PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.''; J Cell Sci, 2009 PubMed Europe PMC Scholia
  300. Hartz CS, Schalinske KL; ''Phosphatidylethanolamine N-methyltransferase and regulation of homocysteine.''; Nutr Rev, 2006 PubMed Europe PMC Scholia
  301. Ueda H, Matsunaga H, Olaposi OI, Nagai J; ''Lysophosphatidic acid: chemical signature of neuropathic pain.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  302. Hartvigsen K, Ravandi A, Harkewicz R, Kamido H, Bukhave K, Hølmera G, Kuksis A; ''1 -O-alkyl-2-(omega-oxo)acyl-sn-glycerols from shark oil and human milk fat are potential precursors of PAF mimics and GHB.''; Lipids, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126497view18:52, 10 May 2023KhanspersAdded lit ref and xref to Shark Liver Oil
124384view05:54, 24 October 2022EgonwTyped three metabolites
120261view13:40, 22 November 2021Conroy lipidsadded some DB crossrefs
117145view09:41, 18 May 2021EweitzModified title
113857view06:37, 2 December 2020EgonwReplaced a deleted PubMed identifier with the (working) duplicate
110695view13:58, 28 May 2020L DupuisUpdated Chebi identifiers
110693view13:50, 28 May 2020L DupuisCHeBi ID added for inorganic phosphate
107760view16:15, 1 November 2019DeSlOntology Term : 'phosphatidylcholine metabolic pathway' added !
107759view16:14, 1 November 2019DeSlOntology Term : 'phosphoinositide metabolic pathway' added !
107758view16:12, 1 November 2019DeSlOntology Term : 'PW:0001156' removed !
107757view16:11, 1 November 2019DeSlUpdated all curved lines for side metabolites to MIMconversion pointing to/away from anchor.
107756view15:48, 1 November 2019DeSlUpdated IDs for EC 2.7.1.153 (bottom right corner).
107755view09:55, 1 November 2019DeSlUpdated top half of PW, so side metabolites are connected to anchors.
107754view09:49, 1 November 2019DeSlAdded separate IDs for proteins under EC 2.3.1.15 .
107753view09:31, 1 November 2019DeSlChanged 2- to "1-" in 1-acyl-sn-glycero-3-phosphate (Lysophosphatidic acid; LPA) (reaction otherwise doesn't occure in humans.
107133view14:21, 17 September 2019MaintBotChEBI identifier normalization
106718view13:15, 17 September 2019MaintBotHMDB identifier normalization
106449view11:34, 29 August 2019DeSlUpdated LipidMaps ID for TAG.
105333view12:05, 31 July 2019EgonwThe class, not the reference lipid.
98235view12:32, 14 August 2018EgonwReplace a PubChem SID with a ChEBI ID.
98103view11:11, 20 July 2018DeSlOntology Term : 'glycerophospholipid metabolic pathway' added !
95594view14:18, 5 January 2018DeSlChanged part of the layout for readability of this pathway.
93096view15:17, 28 July 2017DeSlChanged all the PubChem Substance ID's (around 13) to more stereospecific IDs.
93077view08:52, 28 July 2017ElisaFixed unconnected lines and changed arrows in the legend from interactions to graphical elements
93029view16:02, 26 July 2017DeSlChanged hydrate ID from PubChem compounds to correct HMDB ID for D-glucose-6-P
92861view15:19, 10 July 2017EgonwFixed PubChem compound ID (was salt, now pure compound).
85647view17:10, 4 June 2016EgonwFixed the PubChem SID.
84117view10:00, 16 January 2016EgonwFixed a typo in the label.
83825view11:17, 14 December 2015EgonwRemoved data source info from identifiers.
76320view07:17, 2 July 2014Mkutmonadded chebi identifiers to metabolites annotated with GO terms
71989view11:13, 24 October 2013MkutmonChanged Unknown -> Metabolite for 3 (S-adenosyl-methionine) and 3 (S-adenosylhomocysteine)
71699view19:49, 17 October 2013MaintBotUpdated data sources
70448view22:31, 1 August 2013AmanzoPeriodical save, work in progress
70447view22:21, 1 August 2013AmanzoPeriodical save, work in progress
70404view16:13, 29 July 2013AmanzoWork in progress
70403view16:07, 29 July 2013AmanzoPeriodical save, work in progress
70390view16:04, 26 July 2013AmanzoPeriodical save, work in progress
70389view23:52, 25 July 2013AmanzoWork in progress
70388view23:42, 25 July 2013AmanzoPeriodical save, work in progress
70387view23:32, 25 July 2013AmanzoPeriodical save, work in progress
70384view17:34, 23 July 2013AmanzoWork in progress
70381view23:33, 21 July 2013AmanzoPeriodical save, work in progress
70380view23:22, 21 July 2013AmanzoPeriodical save, work in progress
70379view23:12, 21 July 2013AmanzoPeriodical save, work in progress
70378view23:02, 21 July 2013AmanzoPeriodical save, work in progress
70377view22:52, 21 July 2013AmanzoPeriodical save, work in progress
70376view22:42, 21 July 2013AmanzoPeriodical save, work in progress
70375view22:32, 21 July 2013AmanzoPeriodical save, work in progress
70374view22:21, 21 July 2013AmanzoPeriodical save, work in progress
70373view22:11, 21 July 2013AmanzoPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate (CDP-DAG, CMP-PA)MetaboliteLMGP13010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphate (Phosphatidic acid; PA)MetaboliteLMGP10010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol) (PI)MetaboliteLMGP06010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-phosphate) (PGP)
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) (PG)MetaboliteLMGP04010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphocholine (PC, Lecithin)MetaboliteLMGP01010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (PE)MetaboliteLMGP02010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphoserine (PS)MetaboliteLMGP03010000 (LIPID MAPS)
1,2-diacyl-sn-glycerol (1,2-diacylglycerol; 1,2-DAG)MetaboliteLMGL02010000 (LIPID MAPS)
1-Acyl dihydroxyacetone phosphate (Acyl-DHAP)MetaboliteHMDB11750 (HMDB)
1-Alkenyl-2-acylglycerophosphocholine (Plasmenylcholine)MetaboliteSID 4209 (PubChem-substance)
1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (Platelet Activating Factor, PAF)MetaboliteCHEBI:36707 (ChEBI)
1-Alkyl-2-acetyl-sn-glycerol 3-phosphateMetaboliteCHEBI:17555 (ChEBI)
1-Alkyl-2-acetyl-sn-glycerolMetaboliteSID 6564 (PubChem-substance)
1-Alkyl-sn-glycerol 3-phosphateMetaboliteSID 92741300 (PubChem-substance)
1-Alkyldihydroxyacetone phosphate (Octanoyl DHAP)MetaboliteCID 53481029 (PubChem-compound)
1-alkenyl-2-acylglycerophosphoethanolamine (Plasmenylethanolamine)MetaboliteSID 7325 (PubChem-substance)
1-alkyl-2-acyl-sn-glycero-3-phosphate phosphatase

(Phosphatidate phosphatase)

EC 3.1.3.4		ProteinQ92539 (Uniprot/TrEMBL)
1-alkyl-2-acyl-sn-glycero-3-phosphocholine (Plasmanylcholine, Platelet Activating Factor, PAF)MetaboliteCHEBI:36702 (ChEBI)
1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine (Plasmanylethanolamine)MetaboliteCHEBI:36712 (ChEBI)
1-alkyl-2-acyl-sn-glycerol 3-phosphateMetaboliteCHEBI:37296 (ChEBI)
1-alkyl-2-acyl-sn-glycerolMetaboliteCID 17756737 (PubChem-compound)
1-alkyl-2-acyl-sn-glycerophoethanolamine desaturase

(Plasmanylethanolamine desaturase)

EC 1.14.99.19		ProteinEC 1.14.99.19 (Enzyme Nomenclature)
1-phosphatidylinositol 4-kinase EC 2.7.1.67ProteinQ9BTU6 (Uniprot/TrEMBL)
1-phosphatidylinositol 4-phosphate 5-kinase EC 2.7.1.68ProteinQ99755 (Uniprot/TrEMBL)
1D-myo-Inositol-1-PMetaboliteCID 5288642 (PubChem-compound)
2-acyl-sn-glycero-3-phosphate (Lysophosphatidic acid; LPA)MetaboliteLMGP10050000 (LIPID MAPS)
2-acylglycerol-3-phosphate O-acyltransferase EC 2.3.1.52ProteinEC 2.3.1.52 (Enzyme Nomenclature)
2H2OMetabolite
3 (S-adenosyl-methionine)CID 34756 (PubChem-compound)
3 (S-adenosylhomocysteine)CID 439155 (PubChem-compound)
ADPMetaboliteCID 6022 (PubChem-compound)
ATPMetaboliteCID 5957 (PubChem-compound)
Acetyl-CoAMetaboliteCID 444493 (PubChem-compound)
Acyl coenzyme A (Acyl-CoA)MetaboliteSID 3342 (PubChem-substance)
Acyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acyltransferase EC 2.3.1.-ProteinEC 2.3.1.- (Enzyme Nomenclature)
Acyl-CoAMetaboliteSID 3342 (PubChem-substance)
Acylglycerone-phosphate reductase

(1-alkyl-sn-glycerol-3-phosphate dehydrogenase)

EC 1.1.1.101		ProteinP40471 (Uniprot/TrEMBL)
Adenosine diphosphate (ADP)MetaboliteCID 6022 (PubChem-compound)
Adenosine triphosphate (ATP)MetaboliteCID 5957 (PubChem-compound)
Alkylacetylglycerophosphatase EC 3.1.3.59ProteinEC 3.1.3.59 (Enzyme Nomenclature)
Alkyldihydroxyacetonephosphate synthase

(Alkyl-DHAP synthase)

EC 2.5.1.26		ProteinO00116 (Uniprot/TrEMBL)
Alkylglycerophosphate 2-O-acetyltransferase EC 2.3.1.105ProteinEC 2.3.1.105 (Enzyme Nomenclature)
CDP-DAGMetaboliteLMGP13010000 (LIPID MAPS)
CDP-choline:1-alkyl-2-acyl-sn-glycerophosphocholine transferase

(Diacylglycerol cholinephosphotransferase)

EC 2.7.8.2		ProteinQ9Y6K0 (Uniprot/TrEMBL)
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EC 2.7.8.5ProteinQ32NB8 (Uniprot/TrEMBL)
CDP-diacylglyreol-inositol 3-phosphatidyltransferase EC 2.7.8.11ProteinO14735 (Uniprot/TrEMBL)
CDP-ethanolamine:1-alkyl-2-acyl-sn-glycerophosphoethanolamine transferase

(Ethanolaminephosphotransferase)

EC 2.7.8.1		ProteinQ92539 (Uniprot/TrEMBL)
CMPMetaboliteCID 6131 (PubChem-compound)
CTPMetaboliteCID 6176 (PubChem-compound)
Cardiolipin (DPG, CL)MetaboliteLMPG12010000 (LIPID MAPS)
Cardiolipin synthase EC 2.7.8.-ProteinQ9UJA2 (Uniprot/TrEMBL)
Choline kinase EC 2.7.1.32ProteinQ9Y259 (Uniprot/TrEMBL)
Choline-phosphate cytidylyltransferase EC 2.7.7.15ProteinQ9Y259 (Uniprot/TrEMBL)
CholineMetaboliteCID 305 (PubChem-compound)
CholineMetaboliteCID 305 (PubChem-substance)
CoA-SHMetaboliteCID 6816 (PubChem-compound)
Coenzyme A (CoA-SH)MetaboliteCID 6816 (PubChem-compound)
Cytidine 5'-diphosphocholine (CDP-choline)MetaboliteSID 3601 (PubChem-substance)
Cytidine diphosphate choline (CDP-choline)MetaboliteCID 25202509 (PubChem-compound)
Cytidine diphosphate ethanolamine (CDP-ethanolamine)MetaboliteCID 123727 (PubChem-compound)
Cytidine monophosphate (CMP)MetaboliteCID 6131 (PubChem-compound)
Cytidine triphosphate (CTP)MetaboliteCID 6176 (PubChem-compound)
Cytochrome bMetaboliteCHEBI:38551 (ChEBI)
D-Glucose-6-PMetaboliteCID 44134741 (PubChem-compound)
Diacylglycerol O-acyltransferase EC 2.3.1.20ProteinQ86VF5 (Uniprot/TrEMBL)
Diacylglycerol cholinephosphotransferase EC 2.7.8.2ProteinQ8WUD6 (Uniprot/TrEMBL)
Dihydroxyacetone phosphateMetaboliteCID 668 (PubChem-compound)
Ethanolamine kinase EC 2.7.1.82ProteinQ9Y259 (Uniprot/TrEMBL)
Ethanolamine-phosphate cytidylyltransferase EC 2.7.7.14ProteinQ99447 (Uniprot/TrEMBL)
EthanolamineMetaboliteCID 700 (PubChem-compound)
Ethanolaminephosphotransferase EC 2.7.8.1ProteinQ9Y6K0 (Uniprot/TrEMBL)
Fatty acid MetabolismPathway00071 (KEGG Pathway)
Fatty acyl-CoAMetaboliteSID 24701368 (PubChem-substance)
Glycerol kinase EC 2.7.1.30ProteinP32189 (Uniprot/TrEMBL)
Glycerol-3-PMetaboliteCID 7048686 (PubChem-compound)
Glycerol-3-phosphate 2-O-acyltransferase EC 2.3.1.198ProteinO80437 (Uniprot/TrEMBL)
Glycerol-3-phosphate dehydrogenase (NAD+) EC 1.1.1.8ProteinP21695 (Uniprot/TrEMBL)
GlycerolMetaboliteCID 753 (PubChem-compound)
GlycolysisPathway00010 (KEGG Pathway)
H2O
H2OMetabolite
InositolMetaboliteCID 892 (PubChem-compound)
L-serine-phosphatidylethanolamine phosphatidyltransferase EC 2.7.8.29ProteinP48651 (Uniprot/TrEMBL)
NAD+ (Coenzyme I)MetaboliteCID 5892 (PubChem-compound)
NADH + H+MetaboliteCID 439153 (PubChem-compound)
NADP (Coenzyme II)MetaboliteCID 5886 (PubChem-compound)
NADPH + H+MetaboliteCID 5884 (PubChem-compound)
Nitrogen group transferasa EC 2.6.-.-ProteinEC 2.6.-.- (Enzyme Nomenclature)
O2 + NADH + H+Metabolite
PIP2[4',5']MetaboliteLMGP08010003 (LIPID MAPS)
PIP3[3',4',5']MetaboliteLMGP09010001 (LIPID MAPS)
PPiMetabolite
Phosphatidate cytidylyltransferase EC 2.7.7.41ProteinO95674 (Uniprot/TrEMBL)
Phosphatidate phosphatase EC 3.1.3.4ProteinQ14693 (Uniprot/TrEMBL)
Phosphatidylethanolamine N-methyltransferase EC 2.1.1.17ProteinQ9UBM1 (Uniprot/TrEMBL)
Phosphatidylglycerophosphatase EC 3.1.3.27ProteinQ8WUK0 (Uniprot/TrEMBL)
Phosphatidylinositol-4,5-bisphosphate 3-kinase EC 2.7.1.153ProteinQ42338 (Uniprot/TrEMBL)
Phosphatidylinositol-4-phosphate (PIP)MetaboliteLMGP07010003 (LIPID MAPS)
Phosphocholine (Choline-P)MetaboliteCID 1014 (PubChem-compound)
PhosphorylethanolamineMetaboliteCID 1015 (PubChem-compound)
PiMetabolite
Pyrimidine MetabolismPathway00240 (KEGG Pathway)
SerineMetaboliteCID 5951 (PubChem-compound)
sn-glycerol-3-phosphate (glycerol-3-P)MetaboliteCID 7048686 (PubChem-compound)
triacyl-sn-glycerol (Triacylglycerol; TAG)MetaboliteLMGL03010000 (LIPID MAPS)

Annotated Interactions

No annotated interactions

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