Colchicine metabolic pathway (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ; ''Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation.''; Biochem Pharmacol, 1997 PubMed Europe PMC Scholia
2. Dvorak Z, Modriansky M, Pichard-Garcia L, Balaguer P, Vilarem MJ, Ulrichová J, Maurel P, Pascussi JM; ''Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation.''; Mol Pharmacol, 2003 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	117685 Approved	view	12:08, 22 May 2021	Eweitz	Modified title
	92288	view	12:39, 19 May 2017	Egonw	Ontology Term : 'xenobiotic metabolic pathway' added !
	74479	view	07:42, 25 April 2014	Egonw	Fixed the Uniprot ID.
	71707	view	19:59, 17 October 2013	MaintBot	Updated data sources
	70549	view	22:27, 10 August 2013	Egonw	Modified description
	70548	view	22:26, 10 August 2013	Egonw	Cholchicine decreases the expression of the CYP that metabolises it.
	70542	view	12:31, 10 August 2013	Egonw	Indicated the source of the two current conversions.
	70518	view	13:08, 9 August 2013	Egonw	Added a related paper, explaining a loop.
	70517	view	13:07, 9 August 2013	Egonw	Simplified the diagram.
	70513	view	12:41, 9 August 2013	Egonw	Modified description
	70512	view	12:40, 9 August 2013	Egonw	Ontology Term : 'phase I biotransformation pathway via cytochrome P450' added !
	70511	view	12:38, 9 August 2013	Egonw	Added the ChemSpider IDs for 2DMC and 3DMC.
	70510	view	12:35, 9 August 2013	Egonw	New pathway

External references

DataNodes

Name	Type	Database reference	Comment
2DMC	Metabolite	22210 (Chemspider)
3DMC	Metabolite	264748 (Chemspider)
CYP3A4	Protein	CYP3A4 (Uniprot/TrEMBL)
Colchicine	Metabolite	5933 (Chemspider)

Annotated Interactions

No annotated interactions