Sulindac metabolic pathway (Rattus norvegicus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Sulindac-SSulfindac sulfideMsrAFMOMsrB-likeenzymeSulindac-RSulindac sulfoneName: Sulindac Metabolic PathwayOrganism: Rattus norvegicus


Description

No description

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Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

 

Bibliography

  1. Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H; ''Studies on the metabolism and biological activity of the epimers of sulindac.''; Drug Metab Dispos, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117021
Approved
view11:36, 16 May 2021EweitzModified title
105114view13:42, 8 July 2019DeSlupdate typo (InterPro)
105113view13:41, 8 July 2019DeSlConverted FMO ID from Wikidata to Interpro
102139view09:51, 2 December 2018EgonwFixed a typo.
102138view09:50, 2 December 2018EgonwReplaced a Wikipedia with a Wikidata identifier.
102137view09:36, 2 December 2018EgonwFixed an interaction that was not properly connected.
102136view09:35, 2 December 2018EgonwModified description
92291view12:41, 19 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
87596view08:13, 25 July 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
70622view15:52, 16 August 2013EgonwThe significant oxidation of Sulindac-S is actually not reported for rat CYPs.
70620view15:06, 16 August 2013EgonwHow did I manage to switch the R and S epimer??
70616view14:30, 16 August 2013EgonwRemoved another human gene.
70615view13:39, 16 August 2013EgonwRemoved a human CYP protein.
70614view12:13, 16 August 2013EgonwAdded the CYP enzymes.
70613view12:07, 16 August 2013EgonwAdded the literature reference.
70612view12:06, 16 August 2013EgonwThe text specifies more specific genes.
70610view11:51, 16 August 2013EgonwA -like enzyme is not a GeneProduct (don't complain about a missing identifier), and set the data source for the WP identifier.
70609view11:50, 16 August 2013EgonwNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
FMOGeneProductFlavin-containing monooxygenase
MsrAGeneProductENSRNOG00000012440 (Ensembl)
MsrB-like enzymeGeneProduct
Sulfindac sulfideMetabolite4509492 (Chemspider)
Sulindac sulfoneMetabolite4582441 (Chemspider) The structure for the sulfone in the paper is inconsistent with the entries in ChemSpider and PubChem; I assume the paper made typographic errors.
Sulindac-RMetabolite16046677 (PubChem-compound)
Sulindac-SMetabolite11245227 (PubChem-compound)

Annotated Interactions

No annotated interactions

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