Sulindac metabolic pathway (Rattus norvegicus)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H; ''Studies on the metabolism and biological activity of the epimers of sulindac.''; Drug Metab Dispos, 2011 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	117021	view	11:36, 16 May 2021	Eweitz	Modified title
	105114	view	13:42, 8 July 2019	DeSl	update typo (InterPro)
	105113	view	13:41, 8 July 2019	DeSl	Converted FMO ID from Wikidata to Interpro
	102139	view	09:51, 2 December 2018	Egonw	Fixed a typo.
	102138	view	09:50, 2 December 2018	Egonw	Replaced a Wikipedia with a Wikidata identifier.
	102137	view	09:36, 2 December 2018	Egonw	Fixed an interaction that was not properly connected.
	102136	view	09:35, 2 December 2018	Egonw	Modified description
	92291	view	12:41, 19 May 2017	Egonw	Ontology Term : 'xenobiotic metabolic pathway' added !
	87596	view	08:13, 25 July 2016	MirellaKalafati	Ontology Term : 'classic metabolic pathway' added !
	70622	view	15:52, 16 August 2013	Egonw	The significant oxidation of Sulindac-S is actually not reported for rat CYPs.
	70620	view	15:06, 16 August 2013	Egonw	How did I manage to switch the R and S epimer??
	70616	view	14:30, 16 August 2013	Egonw	Removed another human gene.
	70615	view	13:39, 16 August 2013	Egonw	Removed a human CYP protein.
	70614	view	12:13, 16 August 2013	Egonw	Added the CYP enzymes.
	70613	view	12:07, 16 August 2013	Egonw	Added the literature reference.
	70612	view	12:06, 16 August 2013	Egonw	The text specifies more specific genes.
	70610	view	11:51, 16 August 2013	Egonw	A -like enzyme is not a GeneProduct (don't complain about a missing identifier), and set the data source for the WP identifier.
	70609	view	11:50, 16 August 2013	Egonw	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
FMO	GeneProduct	Flavin-containing monooxygenase (Wikipedia)
MsrA	GeneProduct	ENSRNOG00000012440 (Ensembl)
MsrB2	GeneProduct	ENSRNOG00000016873 (Ensembl)
MsrB3	GeneProduct	ENSRNOG00000042668 (Ensembl)
Sulfindac sulfide	Metabolite	4509492 (Chemspider)
Sulindac sulfone	Metabolite	4582441 (Chemspider)	The structure for the sulfone in the paper is inconsistent with the entries in ChemSpider and PubChem; I assume the paper made typographic errors.
Sulindac-R	Metabolite	16046677 (PubChem-compound)
Sulindac-S	Metabolite	11245227 (PubChem-compound)

Annotated Interactions

No annotated interactions