DNA replication (Danio rerio)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none OriginOrc3Orc2Orc5Orc2Orc3Orc5Orc4Orc1Orc3Orc5Orc4Orc2Cdc6Cdc6Cdt1Cdt1GemininCdc6Cdt1Mcm10Cdt1Phosphorylation of Mcm 2-7 complexDNA polymerase alpha: primase: origin complexDNA polymerase alpha: primase: origin complexCTPGTPUTPATPRNA PrimerdCTPdGTPdUTPdATPPhosphorylated Orc1UbiquitinATPADPPhosphorylated Cdc6Ubiquitinated Orc1Ubiquitinated Cdc6Degraded by proteasome in cytosolDegraded by proteasome in cytosolRNA primer-DNA primerRNA primer-DNA primerATPADPp49p58p70p180RFC36RFC37RFC38RFC40RFC140Mcm 4,6,7 trimer forms and associatesUbiquitinwith the replication forkOrc2Orc3RFC Heteropentamer:RNA primer-DNA primerATPPCNA homotrimerRFC Heteropentamer:RNA primer-DNA primer:RNA primer-DNA primer:origin duplex:PCNAPrimaseDNA PolymeraseaPre-replicative complex2. Activation of the pre-replicative complex3. DNA replication initiationPre-replicative complex1. Assembly of the pre-replicative complexMcm2Mcm3Mcm4Mcm6Mcm7Orc ComplexCdc6Cdt1Mcm2Mcm3Mcm4Mcm6Mcm74. Switching of origins to post-replicative state5. Leading/lagging strand synthesisOrc complexProcessive complexOrc complexOrc complexOrc complexMcm5Mcm5HOMOLOGY MAPPrpa2zgc:56310RPA4POLAprim1zgc:110727POLE2POLEorc3lORC2Lzgc:77827zgc:85772orc1lorc6lgmnnCDT1UBA52MCM6mcm5mcm4mcm3mcm2MCM7MCM10zgc:56598zgc:77841rfc5rfc4rfc3zgc:110810RFC1pcnaASKzgc:101602rpa1zgc:56264pold2POLD3POLD4POLD1CDC6UBCName: DNA ReplicationLast Modified: 10/17/2013Organism: Danio rerio


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Image:Unconnected.pngFix interactions
Image:Curated.pngReview changes for Approved
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : sphingolipid metabolic pathway
 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116856
Approved
view10:52, 14 May 2021EweitzModified title
91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ASKGeneProduct
CDC6GeneProduct
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
ORC2LGeneProduct
POLAGeneProduct
POLD1GeneProduct556456 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
RFC1GeneProduct
RPA4GeneProduct
UBA52GeneProduct641289 (Entrez Gene)
UBCGeneProduct
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1lGeneProduct335020 (Entrez Gene)
orc3lGeneProduct334315 (Entrez Gene)
orc6lGeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProduct368733 (Entrez Gene)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

Annotated Interactions

No annotated interactions
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