DNA replication (Drosophila melanogaster)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none OriginOrc3Orc2Orc5Orc2Orc3Orc5Orc4Orc1Orc3Orc5Orc4Orc2Cdc6Cdc6Cdt1Cdt1GemininCdc6Cdt1Mcm10Cdt1Phosphorylation of Mcm 2-7 complexDNA polymerase alpha: primase: origin complexDNA polymerase alpha: primase: origin complexRNA PrimerPhosphorylated Orc1Phosphorylated Cdc6Ubiquitinated Orc1Ubiquitinated Cdc6Degraded by proteasome in cytosolDegraded by proteasome in cytosolRNA primer-DNA primerRNA primer-DNA primerp49p58p70p180RFC36RFC37RFC38RFC40CTPRFC140GTPMcm 4,6,7 trimer forms and associatesUTPwith the replication forkATPOrc2dCTPOrc3dGTPRFC Heteropentamer:RNA primer-DNA primerdUTPPCNA homotrimerdATPRFC Heteropentamer:RNA primer-DNA primer:UbiquitinRNA primer-DNA primer:origin duplex:PCNAATPPrimaseADPDNA PolymeraseATPaADPPre-replicative complexUbiquitin2. Activation of the pre-replicative complexATP3. DNA replication initiationPre-replicative complex1. Assembly of the pre-replicative complexMcm2Mcm3Mcm4Mcm6Mcm7Orc ComplexCdc6Cdt1Mcm2Mcm3Mcm4Mcm6Mcm74. Switching of origins to post-replicative state5. Leading/lagging strand synthesisOrc complexProcessive complexOrc complexOrc complexOrc complexMcm5Mcm5HOMOLOGY MAPPCG9273RPA3RPA4DNApol-alpha180DNApol-alpha50DNAprimPole2DNApol-epsilonlatOrc2Orc5Orc4Orc1Orc6GMNNdupRpL40Mcm6Mcm5dpaMcm3Mcm2Mcm7Mcm10CDK2DNApol-alpha73RfC3CG8142RfC38RfC40Gnf1mus209ASKl(1)G0148RpA-70CDC45LCG12018POLD3POLD4DNApol-deltaCG5971Ubi-p63EName: DNA ReplicationLast Modified: 10/17/2013Organism: Drosophila melanogaster


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Image:Unconnected.pngFix interactions
Image:MissingXref.pngAnnotate nodes
Image:Curated.pngReview changes for Approved

Ontology Terms

Pathway Ontology : tRNA maturation pathway
 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139036
Approved
view19:26, 12 May 2025KhanspersModified description
116917view11:58, 15 May 2021EweitzModified title
77446view20:30, 8 September 2014MaintBot
71551view19:25, 17 October 2013MaintBotAutomated update of data sources
67164view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62530view13:38, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62523view12:47, 29 April 2013EgonwConnected dots.
40888view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35216view15:48, 11 February 2010Thomasadded literature
35212view15:45, 11 February 2010ThomasModified description
35202view15:40, 11 February 2010ThomasModified description
21870view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:DNA replication Reactome]] moved to [[Pathway:WP565]]: Moved to stable identifier
8513view14:01, 7 January 2008MaintBotAdded to category $category
19416view14:01, 7 January 2008D.KorenUploaded new pathway
8511view14:01, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ADPMetabolite
ASKGeneProduct
ATPMetabolite
CDC45LGeneProduct31052 (Entrez Gene)
CDK2GeneProduct
CG12018GeneProduct38228 (Entrez Gene)
CG5971GeneProduct38989 (Entrez Gene)
CG8142GeneProduct32763 (Entrez Gene)
CG9273GeneProduct35364 (Entrez Gene)
CTPMetabolite
DNApol-alpha180GeneProduct42553 (Entrez Gene)
DNApol-alpha50GeneProduct38942 (Entrez Gene)
DNApol-alpha73GeneProduct43278 (Entrez Gene)
DNApol-deltaGeneProduct39746 (Entrez Gene)
DNApol-epsilonGeneProduct42758 (Entrez Gene)
DNAprimGeneProduct44915 (Entrez Gene)
GMNNGeneProduct
GTPMetabolite
Gnf1GeneProduct40607 (Entrez Gene)
Mcm10GeneProduct35390 (Entrez Gene)
Mcm2GeneProduct40973 (Entrez Gene)
Mcm3GeneProduct31449 (Entrez Gene)
Mcm5GeneProduct41296 (Entrez Gene)
Mcm6GeneProduct31603 (Entrez Gene)
Mcm7GeneProduct39014 (Entrez Gene)
Orc1GeneProduct35686 (Entrez Gene)
Orc2GeneProduct41703 (Entrez Gene)
Orc4GeneProduct37970 (Entrez Gene)
Orc5GeneProduct34794 (Entrez Gene)
Orc6GeneProduct36017 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
Pole2GeneProduct38661 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RfC3GeneProduct34423 (Entrez Gene)
RfC38GeneProduct34550 (Entrez Gene)
RfC40GeneProduct38492 (Entrez Gene)
RpA-70GeneProduct40972 (Entrez Gene)
RpL40GeneProduct33629 (Entrez Gene)
UTPMetabolite
Ubi-p63EGeneProduct38456 (Entrez Gene)
UbiquitinMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite
dpaGeneProduct35679 (Entrez Gene)
dupGeneProduct47121 (Entrez Gene)
l(1)G0148GeneProduct31598 (Entrez Gene)
latGeneProduct36454 (Entrez Gene)
mus209GeneProduct37290 (Entrez Gene)

Annotated Interactions

No annotated interactions
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