Mammary gland development: pregnancy and lactation - stage 3 of 4 (Homo sapiens)

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11MAMMARY GLAND DEVELOPMENTPATHWAYPubertyPRLRProliferationDNAGalaninMilk proteinsEstrogen-pDifferentiation+pProgesterone+pGap junctionMitochondriaInvolutionMAPK SignalingERBB1PTPN1NFIELF5ESR2STAT5CAV1NR3C1PGRMAPKWFDCTNFRSF11ATPM3YY1TTC9STAT5ESR1ERBB4PNCKJAK2CSN2BCL2L1TNFSF11CEBPCEBPBEGFRGJB2CCND1ERBB2ORAI1MYCNFKBOxytocinIKKAUSFERBB3USF2NRGPRLEIF4GCCND1ATP2C2CEBPABCL2L1EIF4EDNAGalaninDNADNADNADNADNA+pPregnancy and lactationEmbryonic developmentInvolution


Description

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Ontology Terms

 

Bibliography

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  1. Rosen JM, Zahnow C, Kazansky A, Raught B; ''Composite response elements mediate hormonal and developmental regulation of milk protein gene expression.''; Biochem Soc Symp, 1998 PubMed Europe PMC Scholia
  2. Hennighausen L, Robinson GW; ''Information networks in the mammary gland.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  3. Blakely CM, Sintasath L, D'Cruz CM, Hahn KT, Dugan KD, Belka GK, Chodosh LA; ''Developmental stage determines the effects of MYC in the mammary epithelium.''; Development, 2005 PubMed Europe PMC Scholia
  4. Hadsell DL, Bonnette S, George J, Torres D, Klimentidis Y, Gao S, Haney PM, Summy-Long J, Soloff MS, Parlow AF, Sirito M, Sawadogo M; ''Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of eukaryotic initiation factors 4E and 4G.''; Mol Endocrinol, 2003 PubMed Europe PMC Scholia
  5. Cross BM, Hack A, Reinhardt TA, Rao R; ''SPCA2 regulates Orai1 trafficking and store independent Ca2+ entry in a model of lactation.''; PLoS One, 2013 PubMed Europe PMC Scholia
  6. Shrestha S, Cao S, Lin VC; ''The local microenvironment instigates the regulation of mammary tetratricopeptide repeat domain 9A during lactation and involution through local regulation of the activity of estrogen receptor α.''; Biochem Biophys Res Commun, 2012 PubMed Europe PMC Scholia
  7. Deb TB, Coticchia CM, Barndt R, Zuo H, Dickson RB, Johnson MD; ''Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.''; Am J Physiol Cell Physiol, 2008 PubMed Europe PMC Scholia
  8. Milani ES, Brinkhaus H, Dueggeli R, Klebba I, Mueller U, Stadler M, Kohler H, Smalley MJ, Bentires-Alj M; ''Protein tyrosine phosphatase 1B restrains mammary alveologenesis and secretory differentiation.''; Development, 2013 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135754view02:19, 9 November 2024EweitzFix PathVisio / Kaavio discrepancy with "double" line style
135753view02:17, 9 November 2024EweitzExpand MAPK gene family
135752view02:01, 9 November 2024EweitzRefine NFKB modeling as complex, not merely group
135751view01:57, 9 November 2024EweitzUse gene symbol
135750view01:52, 9 November 2024EweitzExpand NFI gene family
135715view11:37, 30 October 2024EweitzRefine interaction position
135677view03:42, 22 October 2024EweitzRefine position
135676view03:41, 22 October 2024EweitzUse gene symbols, simplification interactions
135675view03:38, 22 October 2024EweitzRefine positioning
135674view03:37, 22 October 2024EweitzRefine positioning
135673view03:36, 22 October 2024EweitzExpand NFKB gene family
135672view03:16, 22 October 2024EweitzExpand WFDC gene family
135666view02:36, 21 October 2024EweitzUse simpler, more specific interactions; use gene symbols
134256view04:59, 18 July 2024EgonwRemoved template comments
129080view14:39, 10 March 2024EweitzModified title
128957view14:48, 25 February 2024EgonwRemoved an unconnected datanode without label
128683view15:49, 19 February 2024EweitzFix slight left-truncation of "Gap junction" only seen in site rendering
128682view15:30, 19 February 2024EweitzUpgrade "Involution" to pathway
128681view15:26, 19 February 2024EweitzUntangle interaction
128680view15:23, 19 February 2024EweitzEconomize layout
128679view15:10, 19 February 2024EweitzFix mitochondria graphics discrepancy, economize layout, standardize case
128678view15:01, 19 February 2024EweitzEconomize layout
128677view14:50, 19 February 2024EweitzExperiment with clickable pathway containing other nodes; use site-visible lines for cell membrane
128670view13:25, 19 February 2024EweitzUpdate top nodes
128668view13:17, 19 February 2024EweitzUpdate top nodes
123894view10:55, 25 August 2022FinterlyReverted to version '07:17, 18 August 2022' by Finterly
123893view10:27, 25 August 2022Finterlyremoved CellularComponent "None"
123849view07:17, 18 August 2022Mkutmonfix special shape
102410view20:05, 22 December 2018EgonwReplaced another secondary ChEBI ID with primary ID.
102409view20:03, 22 December 2018EgonwReplaced a secondary ChEBI ID with primary ID.
102398view14:14, 22 December 2018DeSlUpdated layout; connected unconnected lines; changes vertical lines to graphical iso interaction.
102397view14:10, 22 December 2018DeSlAdded ID for EIF4G
102396view14:08, 22 December 2018DeSlAnnotated middle and right side.
102395view13:49, 22 December 2018DeSlANnotated left bottom part
102394view13:42, 22 December 2018DeSlAnnotated left hand side with IDs.
88703view16:18, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
77101view22:03, 17 July 2014KhanspersOntology Term : 'milk secreting cell' added !
75456view18:52, 30 May 2014BiodadosModified description
75455view18:48, 30 May 2014Biodados
75454view18:46, 30 May 2014BiodadosPeriodical save, work in progress
75453view18:43, 30 May 2014Biodados
75452view18:41, 30 May 2014Biodados
75451view18:37, 30 May 2014Biodados
75450view18:36, 30 May 2014BiodadosPeriodical save, work in progress
75449view18:33, 30 May 2014Biodados
75448view18:31, 30 May 2014Biodados
75447view18:23, 30 May 2014BiodadosPeriodical save, work in progress
75446view18:10, 30 May 2014BiodadosPeriodical save, work in progress
75445view17:47, 30 May 2014Biodados
75444view17:29, 30 May 2014Biodados

External references

DataNodes

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NameTypeDatabase referenceComment
ATP2C2GeneProduct
BCL2L1GeneProduct
CAV1GeneProduct
CCND1GeneProduct
CEBPGeneProduct
CEBPAGeneProduct
CEBPBGeneProduct
CSN2GeneProduct
EGFRGeneProduct
EIF4EGeneProduct
EIF4GGeneProduct
ELF5GeneProduct
ERBB1GeneProduct
ERBB2GeneProduct
ERBB3GeneProduct
ERBB4GeneProduct
ESR1GeneProduct
ESR2GeneProduct
GJB2GeneProduct
IKKAGeneProduct
JAK2GeneProduct
MAPKGeneProduct
MYCGeneProduct
NFIGeneProduct
NFKBGeneProduct
NR3C1GeneProduct
NRGGeneProduct
ORAI1GeneProduct
OxytocinGeneProduct
PGRGeneProduct
PNCKGeneProduct
PRLGeneProduct
PTPN1GeneProduct
STAT5GeneProduct
TNFRSF11AGeneProduct
TNFSF11GeneProduct
TPM3GeneProduct
TTC9GeneProduct
USFGeneProduct
USF2GeneProduct
WFDCGeneProduct
YY1GeneProduct

Annotated Interactions

No annotated interactions

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