Hair follicle development: induction - stage 1 of 3 (Homo sapiens)

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FGF20ct: codingDermal MesenchymeEpidermisTCF\\\\DegradationOR\\PlacodeFormationBMPactiveFGFR2IKBKGTP63WNT10BKRT10ct: codingSP5EDAMYCct: codingKRT10CTGFct: codingNFKBIBBMPR1AATPBMP4EGFRLEF1ct: codingFOXI3ct: codingFSTct: codingWNT10WNT10ct: codingVCANIKBKBDVLIKKinactiveWNT10AN:3?NOGGINIVLct: codingINHBACHUKEDARct: codingSP5ct: codingEDAct: codingSHHct: codingDKK4ct: codingTCFLEF1Catenin-beta1IVLTCF3TCF4TCFLEF1Catenin-beta1NFKB1EDAREDAREDANFKBIBPNFKB1IKK (Complex)IKKactiveN:3ADPNFKB1SP5WNT10CellProliferationPlacodeShapeBMPR1ABMPBMPactiveNCAM1ct: codingMSX2ct: codingPlacodeFormationLEF1LRPLRP5LRPLRP6NOGGINBMPinactiveFOLLISTATINCTGFFRIZZLEDFRIZZLEDFZD1?WNT (1st)LRPFRIZZLEDWNT (1st)WNT (1st)NOGct: codingFOLLISTATINCTGF?LRPFRIZZLEDLRPFRIZZLEDWNT10FGF20FGF20FGFR1FGF20FGFR1RASinactiveRASactive\\DVLDVL1DVL2DVL3GSK3BATPADPCatenin-beta1activeCatenin-beta1Pinactive\\Catenin-beta1UbinactivePTCFLEF1Catenin-beta1TCFLEF1Catenin-beta1CTNNB1ct: codingVCANct: codingDermalAggregativeGrowthDermalAggregativeGrowthDegradationDVLGSK3BATPADPCatenin-beta1activeCatenin-beta1inactiveP\\Catenin-beta1PUbinactiveSHHDKK4PTCH1activePTCH1inactiveSHHSMOinactiveGLIPTCH1ct: codingGLIGLI1GLI2SMOactiveINHBATP63ct: codingFGFR2ct: codingEGFRct: codingGJB6ct: codingCDH3ct: codingCDH3GJB6EGFFGF7PlacodeFormationPlacodeShapeTP63


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Comments

 
Laboratório de Biodados - UFMG / Brazil

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Bibliography

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  2. Richardson GD, Bazzi H, Fantauzzo KA, Waters JM, Crawford H, Hynd P, Christiano AM, Jahoda CA; ''KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin.''; Development, 2009 PubMed Europe PMC Scholia
  3. Zhang Y, Andl T, Yang SH, Teta M, Liu F, Seykora JT, Tobias JW, Piccolo S, Schmidt-Ullrich R, Nagy A, Taketo MM, Dlugosz AA, Millar SE; ''Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.''; Development, 2008 PubMed Europe PMC Scholia
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  5. Fliniaux I, Mikkola ML, Lefebvre S, Thesleff I; ''Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes.''; Dev Biol, 2008 PubMed Europe PMC Scholia
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  11. Nowak JA, Polak L, Pasolli HA, Fuchs E; ''Hair follicle stem cells are specified and function in early skin morphogenesis.''; Cell Stem Cell, 2008 PubMed Europe PMC Scholia
  12. Reddy S, Andl T, Bagasra A, Lu MM, Epstein DJ, Morrisey EE, Millar SE; ''Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis.''; Mech Dev, 2001 PubMed Europe PMC Scholia
  13. Cui CY, Kunisada M, Childress V, Michel M, Schlessinger D; ''Shh is required for Tabby hair follicle development.''; Cell Cycle, 2011 PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
129134view14:13, 12 March 2024Mkutmonfix references
129074view14:31, 10 March 2024EweitzModified title
129071view14:10, 10 March 2024EweitzOntology Term : 'hair follicle cell' added !
118091view10:53, 24 May 2021EweitzModified title
115431view10:46, 19 February 2021DeSlAdded other 2 PWs in description with linkout
115430view10:35, 19 February 2021DeSlRemoved email address + last modified item
115429view10:34, 19 February 2021DeSlSmall title change
106725view13:19, 17 September 2019MkutmonHMDB identifier normalization
88629view14:39, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
79882view12:11, 23 April 2015Mkutmonadded xrefs for ATP and ADP
79881view12:07, 23 April 2015Mkutmonchanged datanodes without text label to labels
78710view13:44, 18 January 2015EgonwManually added some missing graph IDs.
77319view00:35, 15 August 2014DanieltrinunesModified description
77318view00:34, 15 August 2014DanieltrinunesModified description
77317view22:37, 14 August 2014Danieltrinunes
77316view22:36, 14 August 2014Danieltrinunes
77314view22:27, 14 August 2014DanieltrinunesModified description
75844view21:26, 10 June 2014DanieltrinunesModified title
75843view21:14, 10 June 2014DanieltrinunesChanges in accordance to SBGN pattern.
75842view21:08, 10 June 2014Danieltrinunesok
75524view20:06, 6 June 2014Daniel.trinunesModified title
75437view15:52, 30 May 2014Daniel.trinunesModified description
75373view20:46, 20 May 2014Daniel.trinunesModified description
75372view20:43, 20 May 2014Daniel.trinunesModified description
75371view20:22, 20 May 2014Daniel.trinunesModified description
75370view20:19, 20 May 2014Daniel.trinunesModified description
75369view20:18, 20 May 2014Daniel.trinunesModified description
75228view19:27, 12 May 2014Daniel.trinunesNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
?
ADP
ATP
BMPProtein
BMP4GeneProductENSG00000125378 (Ensembl)
BMPR1AGeneProductENSG00000107779 (Ensembl)
CDH3GeneProductENSG00000062038 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
CTGFGeneProductENSG00000118523 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
Catenin-beta1GeneProductENSG00000168036 (Ensembl)
DKK4GeneProductENSG00000104371 (Ensembl)
DVLProtein
DVL1GeneProductENSG00000107404 (Ensembl)
DVL2GeneProductENSG00000107404 (Ensembl)
DVL3GeneProductENSG00000107404 (Ensembl)
EDAGeneProductENSG00000158813 (Ensembl)
EDARGeneProductENSG00000135960 (Ensembl)
EGFGeneProductENSG00000138798 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
FGF20GeneProductENSG00000078579 (Ensembl)
FGF7GeneProductENSG00000140285 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FOLLISTATINGeneProductENSG00000134363 (Ensembl)
FOXI3GeneProductENSG00000214336 (Ensembl)
FRIZZLEDProtein
FSTGeneProductENSG00000134363 (Ensembl)
FZD1GeneProductENSG00000157240 (Ensembl)
GJB6GeneProductENSG00000121742 (Ensembl)
GLIProtein
GLI1GeneProductENSG00000107404 (Ensembl)
GLI2GeneProductENSG00000107404 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKGGeneProductENSG00000073009 (Ensembl)
IKKComplex
INHBAGeneProductENSG00000122641 (Ensembl)
IVLGeneProductENSG00000163207 (Ensembl)
KRT10GeneProductENSG00000186395 (Ensembl)
LEF1GeneProductENSG00000138795 (Ensembl)
LRPProtein
LRP5GeneProductENSG00000162337 (Ensembl)
LRP6GeneProductENSG00000070018 (Ensembl)
MSX2GeneProductENSG00000120149 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
NCAM1GeneProductENSG00000262279 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKBIBGeneProductENSG00000104825 (Ensembl)
NOGGeneProductENSG00000183691 (Ensembl)
NOGGINGeneProductENSG00000183691 (Ensembl)
PTCH1GeneProductENSG00000185920 (Ensembl)
RASProtein
SHHGeneProductENSG00000164690 (Ensembl)
SMOGeneProductENSG00000128602 (Ensembl)
SP5GeneProductENSG00000204335 (Ensembl)
TCFProtein
TCF3GeneProductENSG00000071564 (Ensembl)
TCF4GeneProductENSG00000071564 (Ensembl)
TP63GeneProductENSG00000073282 (Ensembl)
VCANGeneProductENSG00000038427 (Ensembl)
WNT (1st)Protein
WNT10Protein
WNT10AGeneProductENSG00000135925 (Ensembl)
WNT10BGeneProductENSG00000169884 (Ensembl)
WNT10GeneProductENSG00000135925 (Ensembl)

Annotated Interactions

No annotated interactions
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