Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)

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5, 7, 38, 7528, 61, 7331, 35, 665011, 16, 24, 728, 17, 274967, 8140, 4415, 461, 3, 13, 26, 57...36, 5556, 8330, 6458, 7614, 53, 844, 21, 39, 63, 7541, 5219, 782, 25, 29, 41, 54...205142, 5937, 43, 7932, 7012, 659, 3353, 8410, 22, 47, 48, 62...34, 60496, 7792, 7423, 32, 7018, 20, 45Immunoglobulin Kappa Light Chain Ig Antibody Light Chain IgG C region Ig Antibody Light Chain CDC42GTP CDC42-GTPWASP/N-WASPWIPSH3 proteins Ig Lambda C region ARP2ATP p-Y160,Y171-CD3Gp-6Y-CD3Z pCofilin Active LIMK-1 Ig Kappa Light Chain V Region actin Ig Lamda Light Chain V Region ActinADP Ig Lamda Light Chain V Region WIP family proteins p-FCGRs ARP2ATP FCGRIIIAp-2Y-CD3G/p-6Y-CD3Z dimers Ig Kappa Light Chain V Region CD3Z homodimer Ig Lambda C region actin Antigen-antibody complex Immunoglobulin Kappa Light Chain Activated WAVE2 and WASP/N-WASP clustered IgG-Agp-FCGRsp-6Y-SYKPLCG clustered IgG-Agp-FCGRsp-6Y-SYKp-VAV IgG Heavy Chain WRCIRSp53/58RAC1-GTPPIP3 p-FCGRs Immunoglobulin Kappa Light Chain Immunoglobulin Lambda Light Chain CDC42-GTPp-WASP/p-N-WASPWIPSH3 proteins CDC42-GTPWASP/N-WASP clustered IgG-Agp-FCGRsp-6Y-SYK Ig Heavy Chain V Region IgG Heavy Chain Ig Kappa Light Chain V Region Immunoglobulin Lambda Light Chain p-FCGRs p-Y291-WASP/p-Y256-N-WASP Immunoglobulin Lambda Light Chain Ig Kappa Light Chain V Region CDC42GTP ARP3ATP Ig Kappa Light Chain V Region Immunoglobulin Kappa Light Chain CDC42GTP p-FCGRs Ig Heavy Chain V Region p-Y160,Y171-CD3Gp-6Y-CD3Z Ig Heavy Chain V Region Activated WAVE2 and WASP/N-WASP Ig Antibody Light Chain clustered IgG-Agp-FCGRs actin SH3 domain proteins p-WRCIRSp53/58RAC1-GTPPIP3 Ig Lambda C region p-2Y-CD3G/p-6Y-CD3Z dimers G-actin SH3 domain proteins IgG Heavy Chain p-Y160,Y171-CD3G dimer WIP family proteins FCGRIIIAp-2Y-CD3G/p-6Y-CD3Z dimers Myosin-X dimer p-FCGRs FCGRIAp-Y160,Y171-CD3G dimer CD3G homodimer IgG Heavy Chain CDC42-GTPp-WASP/p-N-WASPWIPSH3 proteins CDC42-GTPp-WASP/p-N-WASPWIPSH3 proteins ARP2ATP p-WRCIRSp53/58RAC1-GTPPIP3 clustered IgG-Agp-FCGRs PI3K-catalytic subunit FCGRIIIAp-2Y-CD3G/p-6Y-CD3Z dimers PI3K Ig Lamda Light Chain V Region CD3G/CD3Z dimers Ig Lambda C region IgG p-Y160,Y171-CD3Gp-6Y-CD3Z p-Y291-WASP/p-Y256-N-WASP Immunoglobulin Lambda Light Chain Ig Lambda C region Antigen-antibody complex clustered IgG-Agp-FCGRsp-6Y-SYKp-3Y-PLCG WIP family proteins Ig Antibody Light Chain ARP3ATP IgG C region RAC1-GTP CD3GCD3Z heterodimer actin Ig Antibody Light Chain IgG C region IgG C region Ig Lamda Light Chain V Region RAC1-GTP Ig Antibody Light Chain p-WRCIRSp53/58RAC1-GTPPIP3 Activated WAVE2 and WASP/N-WASPARP2/3 complexG-actin p-FCGRs IgG C region ARP3ATP IgG Heavy Chain CD3Z homodimer clustered IgG-Agp-FCGRsp-6Y-SYK Ig Heavy Chain V Region Ig Lambda C region Activated WAVE2 and WASP/N-WASPARP2/3 complexG-actin IgG CDC42GTP p-WRC endoplasmic reticulum lumenphagocytic cupp-WRCIRSp53/58RAC1-GTPPIP3 clustered IgG-Agp-FCGRs IgG Heavy Chain clustered IgG-Agp-FCGRs IgG FCGRIAp-Y160,Y171-CD3G dimer p-Y291-WASP/p-Y256-N-WASP IgG Mother filamentbranching complex FCGRIIIACD3G/CD3Z dimers Immunoglobulin Kappa Light Chain Antigen-antibody complex p-Y291-WASP/p-Y256-N-WASP Ig Heavy Chain V Region Mother filamentbranching complexdaughter filament CD3 zeta dimer with phosphorylated ITAMs p-WRCIRSp53/58RAC1-GTPPIP3 IgG Heavy Chain WAVE Regulatory Complex FCGRIAp-Y160,Y171-CD3G dimer RAC1-GTP p-WRCIRSp53/58RAC1-GTPPIP3 IgG C region RAC1-GTP clustered IgG-Agp-FCGRsp-6Y-SYK IgG Heavy Chain CDC42-GTPp-WASP/p-N-WASPWIPSH3 proteins Ig Lamda Light Chain V Region Ig Antibody Light Chain Ig Lamda Light Chain V Region p-2Y-CD3G/p-6Y-CD3Z dimers PI3K-regulatory subunit clustered IgG-Agp-FCGRs p-WRC RAC1-GTP CDC42GTP FCGRIIIACD3G/CD3Z dimers Ig Kappa Light Chain V Region Ig Lamda Light Chain V Region IgG C region PAK1 dimer p-WRC Ig Heavy Chain V Region FCGRIIIAp-2Y-CD3G/p-6Y-CD3Z dimers Antigen-antibody complex p-Y160,Y171-CD3Gp-6Y-CD3Z Ig Lambda C region Activated WAVE2 and WASP/N-WASPARP2/3 complexG-actin IP3 receptorIP3 complex Antigen-antibody complex G-actin ARP2ATP G-actin IgG C region ELMO G-actin Ig Lambda C region actin IgG Heavy Chain Ig Kappa Light Chain V Region IgG clustered IgG-Agp-FCGRs IgG-AgFCGRIIIACD3G/CD3Z dimers RAC1-GTP Ig Heavy Chain V Region WASP/N-WASP ARP2/3 complex p-Y160,Y171-CD3G dimer Immunoglobulin Lambda Light Chain G-actin Ig Antibody Light Chain FCGRIIIAp-2Y-CD3G/p-6Y-CD3Z dimers Ig Kappa Light Chain V Region IgG-AgFCGRIACD3G homodimer p-2Y-CD3G/p-6Y-CD3Z dimers p-2Y-CD3G/p-6Y-CD3Z dimers Antigen-antibody complex Activated WAVE2 and WASP/N-WASPARP2/3 complexG-actin Ig Antibody Light Chain IgG C region Ig Antibody Light Chain PI3K-regulatory subunit Active RAC1/CDC42 Ig Lambda C region Ig Lamda Light Chain V Region IgG C region WIP family proteins Ig Lamda Light Chain V Region Ig Lamda Light Chain V Region FCGRIIIAp-2Y-CD3G/p-6Y-CD3Z dimers HSP-90 Antigen-antibody complex WASP/N-WASP p-Y160,Y171-CD3Gp-6Y-CD3Z Immunoglobulin Lambda Light Chain CD3 zeta dimer with phosphorylated ITAMs ARP3ATP IgG p-WRCIRSp53/58RAC1-GTPPIP3 clustered IgG-Agp-FCGRsp-6Y-SYK CDC42-GDP CDC42GTP CD3G homodimer WIP family proteins p-WRC p-2Y-CD3G/p-6Y-CD3Z dimers Antigen-antibody complex ARP3ATP Ig Antibody Light Chain CD3 zeta dimer with phosphorylated ITAMs p-Y160,Y171-CD3G dimer actin CDC42GTP CD3 zeta dimer with phosphorylated ITAMs p-WRCIRSp53/58RAC1-GTPPIP3 p-WRC IgG WIP family proteins ARP2ATP PI3K-catalytic subunit Ig Lambda C region Ig Heavy Chain V Region ARP2/3 complex Activated WAVE2 and WASP/N-WASP Active RAC1/CDC42 p-WRC actin FCGRs clustered IgG-Agp-FCGRsp-6Y-SYK RAC1-GTP p-Y160,Y171-CD3Gp-6Y-CD3Z CD3GCD3Z heterodimer Immunoglobulin Lambda Light Chain CD3 zeta dimer with phosphorylated ITAMs actin Actin filament bound Myosin-X p-2Y-CD3G/p-6Y-CD3Z dimers IgG Heavy Chain p-Y291-WASP/p-Y256-N-WASP IgG IgG C region CRKDOCK180ELMO p-Y160,Y171-CD3G dimer Immunoglobulin Kappa Light Chain Immunoglobulin Lambda Light Chain IgG Heavy Chain Ig Kappa Light Chain V Region p-WRC IgG Heavy Chain CDC42GTP Antigen-antibody complex Immunoglobulin Lambda Light Chain RAC1-GTP clustered IgG-Agp-FCGRs p-2Y-CD3G/p-6Y-CD3Z dimers p-2Y-CD3G/p-6Y-CD3Z dimers IgG p-WRCIRSp53/58RAC1-GTPPIP3 p-WRC IgG Heavy Chain p-Y160,Y171-CD3Gp-6Y-CD3Z p-WRC Immunoglobulin Kappa Light Chain p-FCGRs p-WRC p-WRCIRSp53/58RAC1-GTPPIP3 RAC1-GTP CD3G homodimer Ig Heavy Chain V Region p-Y160,Y171-CD3Gp-6Y-CD3Z FCGRIAp-Y160,Y171-CD3G dimer p-FCGRs Activated WAVE2 and WASP/N-WASP IgG p-WRC SH3 domain proteins Immunoglobulin Kappa Light Chain p-WRC p-Y160,Y171-CD3Gp-6Y-CD3Z RAC1-GTP IgG C region G-actin Antigen-antibody complex clustered IgG-Agp-FCGRsp-6Y-SYKVAV CD3 zeta dimer with phosphorylated ITAMs WIP family proteins Antigen-antibody complex FCGRIIIAp-2Y-CD3G/p-6Y-CD3Z dimers IgG CD3G/CD3Z dimers CDC42GTP ARP2/3 complex IP3 receptor homotetramer Immunoglobulin Kappa Light Chain Ig Lambda C region CD3 zeta dimer with phosphorylated ITAMs Antigen-antibody complex FCGRIIIAp-2Y-CD3G/p-6Y-CD3Z dimers IgG Immunoglobulin Lambda Light Chain cytosolIP3 receptors ARP2/3 complex ARP2/3 complex p-WRC Activated WAVE2 and WASP/N-WASP CD3 zeta dimer with phosphorylated ITAMs clustered IgG-Agp-FCGRs p-Y160,Y171-CD3G dimer Immunoglobulin Kappa Light Chain p-Y160,Y171-CD3G dimer p-Y160,Y171-CD3G dimer Ig Kappa Light Chain V Region RAC1-GDP Ig Lambda C region CDC42GTP RAC1-GTP FCGRIAp-Y160,Y171-CD3G dimer FCGRIIIAp-2Y-CD3G/p-6Y-CD3Z dimers FCGRIAp-Y160,Y171-CD3G dimer p-Y160,Y171-CD3G dimer p-WRC WIP family proteins CD3 zeta dimer with phosphorylated ITAMs Immunoglobulin Kappa Light Chain p-2Y-CD3G/p-6Y-CD3Z dimers IgG Heavy Chain ARP2ATP IP3 receptors Ig Kappa Light Chain V Region SH3 domain proteins Immunoglobulin Lambda Light Chain CD3 zeta dimer with phosphorylated ITAMs Ig Lambda C region PI3Kp-6Y-SYK Ig Lamda Light Chain V Region IgG ARP2/3 complex CD3 zeta dimer with phosphorylated ITAMs Antigen-antibody complex Ig Antibody Light Chain Ig Kappa Light Chain V Region Ig Heavy Chain V Region Ig Kappa Light Chain V Region Ig Kappa Light Chain V Region p-WRCIRSp53/58RAC1-GTPPIP3 CD3GCD3Z heterodimer Ig Antibody Light Chain Immunoglobulin Kappa Light Chain Ig Lamda Light Chain V Region CRKDOCK180ELMO p-WRCIRSp53/58RAC1-GTPPIP3 Immunoglobulin Lambda Light Chain IgG C region FCGRIAp-Y160,Y171-CD3G dimer PAK1 dimer RAC1/CDC42PAK dimer p-FCGRs CD3G homodimer FCGRIACD3G homodimer Mother filamentbranching complexdaughter filament CDC42GTP clustered IgG-Agp-FCGRsp-6Y-SYK SH3 domain proteins ARP3ATP Antigen-antibody complex CDC42-GTPp-WASP/p-N-WASPWIPSH3 proteins IgG C region p-FCGRs IP3 receptor homotetramer Ig Lambda C region Ig Antibody Light Chain IgG FCGRIACD3G homodimer CRKIIDOCK180ELMO complex recruited to phagocytic cup RAC1-GTP p-2Y-CD3G/p-6Y-CD3Z dimers CD3G homodimer Immunoglobulin Lambda Light Chain pLIMK dimerHSP-90 clustered IgG-Agp-FCGRsp-6Y-SYK clustered IgG-Agp-FCGRs Antigen-antibody complex FCGRIIIACD3G/CD3Z dimers G-actin Active LIMK1 PLC gamma1/2 p-Y160,Y171-CD3Gp-6Y-CD3Z Immunoglobulin Lambda Light Chain Immunoglobulin Kappa Light Chain ELMO Ig Lamda Light Chain V Region ARP2/3 complex p-Y160,Y171-CD3G dimer FCGRIACD3G homodimer RAC1/CDC42p-S144,T423-PAK CDC42-GTPp-WASP/p-N-WASPWIPSH3 proteins IgG C region FCGRIAp-Y160,Y171-CD3G dimer Ig Kappa Light Chain V Region Ig Antibody Light Chain p-2Y-CD3G/p-6Y-CD3Z dimers SH3 domain proteins p-FCGRs p-PLCG WAVE Regulatory Complex Ig Heavy Chain V Region IgG Heavy Chain Immunoglobulin Kappa Light Chain CDC42-GTPp-WASP/p-N-WASPWIPSH3 proteins Ig Heavy Chain V Region clustered IgG-Agp-FCGRsSYK Ig Heavy Chain V Region Myosin-X dimer Ig Kappa Light Chain V Region ARP2ATP ARP3ATP FCGRIIIAp-2Y-CD3G/p-6Y-CD3Z dimers SH3 domain proteins Active RAC1/CDC42 Mother filamentbranching complexdaughter filament p-WRCIRSp53/58RAC1-GTPPIP3 Activated WAVE2 and WASP/N-WASPARP2/3 complexG-actin FCGRIAp-Y160,Y171-CD3G dimer IgG actin clustered IgG-AgFCGRs Ig Lambda C region ActinADP IgG C region Mother filamentARP2/3actinGDP Antigen-antibody complex CD3Z homodimer FCGRIAp-Y160,Y171-CD3G dimer FCGRIIIAp-2Y-CD3G/p-6Y-CD3Z dimers IgG Heavy Chain SH3 domain proteins Ig Lambda C region RAC1-GTP Ig Heavy Chain V Region Myosin-Actin filaments p-WRCIRSp53/58RAC1-GTPPIP3 clustered IgG-Agp-FCGRs p-Y160,Y171-CD3Gp-6Y-CD3Z Immunoglobulin Kappa Light Chain CDC42GTP Ig Lamda Light Chain V Region p-VAV Ig Heavy Chain V Region PI3K Ig Heavy Chain V Region Immunoglobulin Kappa Light Chain VAV Immunoglobulin Lambda Light Chain IgG p-Y160,Y171-CD3G dimer Immunoglobulin Lambda Light Chain FCGRIAp-Y160,Y171-CD3G dimer p-Y291-WASP/p-Y256-N-WASP Ig Lamda Light Chain V Region Activated WAVE2 and WASP/N-WASP CD3G/CD3Z dimers p-Y291-WASP/p-Y256-N-WASP p-Y160,Y171-CD3G dimer clustered IgG-Agp-FCGRs Active LIMK1 CDC42GTP IgG-AgFCGRIIA Ig Antibody Light Chain Ig Lamda Light Chain V Region Ig kappa chain V-I region DEE PIIg kappa chain V-I region WEA Ig lambda chain V-VII region MOT Ig lambda chain V-IV region MOL Ig kappa chain V-I region OU CYFIP2 Ig heavy chain V-III region CAM Ig lambda chain V-IV region Kern IGHVIg heavy chain V-I region ND Ig lambda chain V-IV region Hil ARPC2 ADPIg kappa chain V-I region Ka p-6Y-CD247-1 Ig lambda chain V-I region WAH IGHG2Ig lambda chain V-IV region Hil IGHG1Ig heavy chain V-III region LAY IGLVIg kappa chain V-IV region Len Ig kappa chain V-III region HAH Ig heavy chain V-I region SIE Ig kappa chain V-IV region STH NCKIPSD IGLV8-61Ig kappa chain V-I region Hau IGLV2-33SYK GRB2-1 CDC42 Ig kappa chain V-I region Ni IGHG3 Ig heavy chain V-III region KOL Mother filamentbranching complexdaughter filamentIGHV7-81Ig lambda chain V-II region BUR Ig kappa chain V-I region AU Ig kappa chain V-II region GM607 Ig heavy chain V-II region WAH Ig kappa chain V-III region WOL Ig heavy chain V-II region MCE VAV1 Ig lambda chain V-I region WAH ACTG1IGLV3-16Ig heavy chain V-III region GAL Ig heavy chain V-III region GA Ig heavy chain V-I region SIE IGHG3 IGHV7-81Ig lambda chain V-VII region MOT FCGR3A Ig kappa chain V-I region Gal Ig kappa chain V-III region GOL Ig kappa chain V-I region Walker IGLV3-22Ig kappa chain V-I region Lay PIK3R2 Ig heavy chain V-III region GA IGLV3-12Ig kappa chain V-I region CAR Ig kappa chain V-II region RPMI 6410 BAIAP2 Ig lambda chain V-II region BO Ig heavy chain V-I region ND Ig kappa chain V-I region DEE Ig lambda chain V-II region NEI Ig kappa chain V-III region IARC/BL41 ARPC1A IGLV3-27Ig kappa chain V-III region CLL Ig heavy chain V-III region TEI Ig kappa chain V-I region WAT IGLV2-18Ig kappa chain V-II region GM607 Ig kappa chain V-I region Kue Ig lambda chain V-I region NEWM Ig lambda chain V-I region NEW Ig kappa chain V-IV region STH IGLV2-33Ig lambda chain V-II region NIG-84 Ig heavy chain V-III region WEA Ig kappa chain V-III region CLL Ig lambda chain V-VI region SUT Ig heavy chain V-III region WAS HSP90AA1 Ig heavy chain V-III region JON CDC42 Ig kappa chain V-I region WAT IGLC7Ig kappa chain V-II region TEW Ig heavy chain V-III region BRO Ig kappa chain V-I region Wes Ig heavy chain V-II region HE Ig heavy chain V-III region GAL Ig kappa chain V-I region EU Ig kappa chain V-II region MIL Ig heavy chain V-III region TRO Ig lambda chain V-IV region Hil IGLC3Ig kappa chain V-I region AU GTP PIIGHG3 Ig lambda chain V-IV region Hil Ig heavy chain V-II region DAW Ig heavy chain V-II region MCE Ig lambda chain V-I region BL2 PiIg heavy chain V-III region TUR Ig kappa chain V-I region Roy IGLV3-16Ig heavy chain V-III region BUT CDC42-GTPp-WASP/p-N-WASPWIPSH3 proteinsIg kappa chain V-III region GOL IGKVA18IGHVIg lambda chain V-IV region Hil ACTR3 Ig kappa chain V-I region Lay Ig kappa chain V-I region Lay Ig kappa chain V-I region Kue IGLC1Ig kappa chain V-III region SIE ADPIGKCBAIAP2 Ig kappa chain V-II region FR IGLV8-61WAS F-actinIg heavy chain V-I region Mot PLCG1Ig kappa chain V-III region B6 IGHV7-81Ig heavy chain V-I region SIE Ig heavy chain V-II region NEWM Ig kappa chain V-III region SIE IGLC2Ig heavy chain V-III region TRO Ig lambda chain V-II region NIG-84 Ig lambda chain V region 4A IGLV7-43IGLC1Ig kappa chain V-IV region B17 PIIGLV4-69IGHG4Ig kappa chain V-I region Wes BAIAP2 Ig heavy chain V-III region CAM Ig kappa chain V-III region SIE Ig lambda chain V-II region NIG-84 Ig lambda chain V-II region WIN IGLV1-44Ig lambda chain V-I region NIG-64 CDC42GTPIg kappa chain V-III region CLL IGHG1Ig kappa chain V-I region Mev Ig kappa chain V region EV15 Ig kappa chain V-III region POM Ig heavy chain V-III region POM Ig lambda chain V-IV region MOL Ig kappa chain V-IV region B17 Ig kappa chain V-III region NG9 p-Y160,Y171-CD3G Ig kappa chain V-I region DEE Ig lambda chain V-II region NIG-58 IGLV3-27IGHVIGLV2-11Ig heavy chain V-I region HG3 IGHVIg lambda chain V-II region NIG-58 Ig lambda chain V-III region LOI IGLV11-55FCGR1A ELMO2 GTP Ig heavy chain V-III region POM Ig heavy chain V-III region ZAP FCGR3A Ig lambda chain V-II region TOG Ig lambda chain V-I region VOR IGLV7-46Ig lambda chain V-II region VIL Ig kappa chain V-III region HAH Ig heavy chain V-II region OU IGLV8-61Ig heavy chain V-III region GAL Ig lambda chain V-I region NEWM Ig heavy chain V-III region TEI GTP p-Y256-WASL IGKV4-1FCGR3A IGLV10-54IgH heavy chain V-III region VH26 precursor IGLC2IGLV3-16Ig kappa chain V-I region Wes Ig heavy chain V-III region WAS Ig kappa chain V-I region WAT Ig heavy chain V-I region SIE Ig lambda chain V-I region MEM IGHV7-81Ig heavy chain V-II region COR IGLV3-22Ig kappa chain V-I region OU Ig heavy chain V-III region WAS IGLV3-12Ig heavy chain V-III region TRO Ig lambda chain V-II region MGC Ig kappa chain V-I region Ka Ig heavy chain V-III region HIL Ig heavy chain V-II region SESS GRB2-1 IGLV3-25Ig lambda chain V-VI region NIG-48 IGHG4IGLV5-45Ig kappa chain V-I region OU Ig heavy chain V-III region HIL Ig kappa chain V-IV region Len IGLVIg kappa chain V-III region B6 Ig kappa chain V-II region FR Ig kappa chain V-I region AG Ig heavy chain V-III region ZAP Ig kappa chain V-I region Rei Ig heavy chain V-III region DOB Ig heavy chain V-III region DOB Ig lambda chain V-IV region Bau Ig kappa chain V-I region WEA IGLV5-45Ig kappa chain V-III region HAH ARPC4 Ig heavy chain V-III region KOL Ig heavy chain V-I region ND Ig kappa chain V-III region WOL Ig kappa chain V-III region NG9 Ig kappa chain V-I region Ka Ig lambda chain V-II region NIG-84 Ig lambda chain V-IV region X Ig kappa chain V-I region BAN Ig lambda chain V-IV region Bau Ig lambda chain V-III region SH IGLV7-46IGLV10-54Ig heavy chain V-III region GAL IGKVA18Ig kappa chain V-III region VH IGLV1-36BRK1Ig heavy chain V-III region POM Ig kappa chain V-III region IARC/BL41 Ig kappa chain V-II region RPMI 6410 Ig heavy chain V-II region COR WIPF3 Ig kappa chain V-I region Lay ARPC5 Ig lambda chain V-I region MEM Ig heavy chain V-III region LAY Ig heavy chain V-III region LAY ATP IGLV10-54Ig lambda chain V-I region WAH Ig heavy chain V-I region HG3 Ig lambda chain V-II region VIL Ig lambda chain V-VI region NIG-48 GTP IGLV2-11Ig lambda chain V-IV region MOL Ig kappa chain V-III region VG Ig kappa chain V-I region Rei Ig heavy chain V-II region OU NCKAP1 Ig kappa chain V-III region IARC/BL41 Ig heavy chain V-II region WAH IGKV1-5NCKIPSD Ig heavy chain V-III region NIE Ig heavy chain V-III region GA IGLV3-22Ig kappa chain V-I region Hau ADPIGLV8-61IGLV1-44IGLV2-18Ig heavy chain V-III region POM Ig heavy chain V-III region JON Ig heavy chain V-II region HE Ig heavy chain V-III region WAS Ig heavy chain V-III region BUT IGLC2PIK3R1 ADP IGHG4Ig lambda chain V-IV region Hil Ig heavy chain V-III region BUT Ig lambda chain V-I region NIG-64 IGLV10-54IGKV4-1IGLV8-61Ig lambda chain V-II region NIG-58 WIPF2 IGHG1RAC1 Ig kappa chain V-I region AG ACTR2 IGLV1-44Ig lambda chain V region 4A IGLC6Ig heavy chain V-III region BUR IGLV11-55Ig kappa chain V-II region FR Ig kappa chain V-I region Gal Ig kappa chain V-I region Roy IGHG3 IGLV7-43Ig heavy chain V-I region HG3 Ig lambda chain V-I region NEWM Ig lambda chain V-VII region MOT Ig heavy chain V-II region HE Ig lambda chain V-VII region MOT FCGR3A Ig heavy chain V-II region OU PLC gamma1/2Ig kappa chain V-I region Bi Ig kappa chain V-I region Hau Ig lambda chain V-IV region Hil PIIg heavy chain V-III region GA IGLC7Ig lambda chain V-II region BO Ig lambda chain V-II region BOH p-6Y-CD247-1 Ig kappa chain V-II region Cum IGLV5-37Ig kappa chain V-III region GOL IGLV4-60Ig heavy chain V-III region NIE IGLV11-55IGHG1IGLV2-23Ig lambda chain V-VI region AR Ig kappa chain V-II region FR Ig heavy chain V-III region TRO IgG-AgFCGRIACD3G homodimerIg kappa chain V-I region Wes Ig heavy chain V-I region EU p-Y288,Y304-FCGR2A Ig kappa chain V-I region HK101 Ig lambda chain V-I region HA Ig heavy chain V-III region WAS Ig kappa chain V-III region VH Ig kappa chain V region EV15 IGLV8-61Ig lambda chain V-I region HA Ig heavy chain V-III region BUT IGLV1-44IGLV11-55Ig kappa chain V-III region SIE Ig lambda chain V-II region BOH Ig kappa chain V-I region Lay ARPC2 Ig lambda chain V-I region NIG-64 Ig kappa chain V-I region CAR IGKVA18Ig heavy chain V-III region TIL CDC42 Ig kappa chain V-I region WAT Activated WAVE2 and WASP/N-WASPARP2/3 complexG-actinIg kappa chain V-IV region B17 Ig kappa chain V-III region B6 Ig kappa chain V-III region GOL Ig lambda chain V-I region BL2 Ig lambda chain V-III region SH NCK1 IGLV2-11Ig kappa chain V-IV region STH H2OIg kappa chain V-I region OU Ig kappa chain V-I region AG p-Y291-WAS IGLV2-18Ig lambda chain V-VII region MOT ACTR2 Ig heavy chain V-I region EU Ig kappa chain V-II region Cum Ig heavy chain V-III region BUR Ig lambda chain V-VI region SUT Ig lambda chain V-III region SH IGLV4-3DAGsIg kappa chain V-II region Cum IGLV3-22ADP ADPp-Y291-WAS Ig heavy chain V-II region OU Ig heavy chain V-II region HE GTP Ig lambda chain V-II region VIL Ig lambda chain V-IV region Kern GTPIg kappa chain V-II region GM607 Ig kappa chain V-I region Gal Ig kappa chain V-III region NG9 Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-VI region SUT Ig lambda chain V-VII region MOT IGLV7-43CDC42 Ig kappa chain V-II region TEW Ig kappa chain V-I region DEE IGHVIg lambda chain V-II region NIG-58 WAS IGLV4-60Ig heavy chain V-II region DAW Ig kappa chain V-IV region Len ActinADPIGLV1-40Ig kappa chain V-III region VG IGLC3IGLC1Ig lambda chain V-I region MEM IGLV1-44Ig kappa chain V-I region CAR Ig lambda chain V-III region SH IGLV3-27IIg kappa chain V-II region TEW PLA2G6p-Y160,Y171-CD3G IGHV7-81IGLV3-25IGLV3-25Ig lambda chain V-II region BO Ig kappa chain V-I region Kue Ig kappa chain V-III region NG9 CD3G Ig kappa chain V region EV15 IGLV7-43Ig lambda chain V-II region VIL IGKVA18Ig lambda chain V-II region TRO Ig kappa chain V-I region Gal Ig kappa chain V-III region HIC CDC42 Ig lambda chain V-VI region WLT Ig lambda chain V-VII region MOT Ig lambda chain V-I region HA Ig lambda chain V-VI region NIG-48 FCGR3A Ig kappa chain V-I region Rei Ig heavy chain V-III region WAS IGLV7-46PiIg lambda chain V-I region WAH Ig lambda chain V-I region BL2 IGLV3-27IGLV1-40Ig kappa chain V-IV region JI Ig kappa chain V-I region Mev Ig heavy chain V-II region NEWM Ig heavy chain V-II region ARH-77 Ig kappa chain V-I region HK101 CFL1IGLV3-22Ig heavy chain V-I region Mot Ig heavy chain V-III region TEI IGLC6PIK3R1 Ig kappa chain V-III region CLL Ig kappa chain V-II region RPMI 6410 WIPF2 Ig lambda chain V-V region DEL MYO10 Ig heavy chain V-III region KOL Ig lambda chain V-V region DEL Ig lambda chain V-II region MGC IGLV7-46Ig kappa chain V-I region Hau CD3G Ig kappa chain V-I region Rei PIIg kappa chain V-I region Hau Ig lambda chain V-II region TRO Ig lambda chain V-I region NEW Ig lambda chain V region 4A IGLC1Ig heavy chain V-III region ZAP ARPC5 IGKV1-5Ig kappa chain V-I region Bi Ig lambda chain V-II region VIL Ig kappa chain V-I region Hau FCGRIACD3G homodimerIg heavy chain V-II region DAW Ig heavy chain V-II region DAW Ig lambda chain V-VI region NIG-48 Ig heavy chain V-III region BUT Ig lambda chain V-VI region NIG-48 Ig kappa chain V-II region TEW IGLV5-45Ig lambda chain V-II region BO Ig kappa chain V-I region Gal IGLV4-3Ig kappa chain V-II region GM607 Ig lambda chain V-I region NIG-64 Ig kappa chain V-I region Bi Ig kappa chain V-III region HAH Ig lambda chain V-II region TRO Ig heavy chain V-III region KOL Ig kappa chain V-III region CLL Ig lambda chain V-IV region X IGLV2-33Ig kappa chain V-I region Walker IGLV4-60Ig lambda chain V-I region BL2 IGLV3-25p-S144,T423-PAK1 Ig kappa chain V-I region DEE Ig kappa chain V-I region OU IgH heavy chain V-III region VH26 precursor Ig heavy chain V-III region TUR Ig lambda chain V-IV region MOL Ig kappa chain V-I region Walker IGLC3Ig heavy chain V-III region WEA Ig heavy chain V-III region DOB Ig lambda chain V-I region NEWM Ig kappa chain V-I region AG IGLV3-27Ig kappa chain V-III region NG9 IGLV11-55Ig lambda chain V-I region MEM IGLV2-11Ig kappa chain V-III region NG9 IGLC2WAVE Regulatory ComplexIg lambda chain V-VI region WLT Ig kappa chain V-II region TEW IGHG4IGLV3-22Ig kappa chain V-I region Hau BAIAP2 GTP Ig lambda chain V-II region BO Ig kappa chain V-I region WEA Ig lambda chain V region 4A Ig heavy chain V-I region WOL Ig kappa chain V-II region GM607 IGLV4-3Ig lambda chain V-II region VIL Ig heavy chain V-III region BUR Ig kappa chain V-III region VH Ig lambda chain V-I region HA WIPF1 p-Y288,Y304-FCGR2A ELMO2 Ig lambda chain V-II region WIN Ig heavy chain V-II region MCE p-Y160,Y171-CD3G Ig kappa chain V-I region Lay Ig kappa chain V-II region RPMI 6410 IGLV1-44Ig heavy chain V-III region BRO p-6Y-SYK Ig heavy chain V-III region KOL Ig kappa chain V-II region GM607 Ig heavy chain V-II region MCE Ig lambda chain V-IV region MOL IGLV3-12Ig kappa chain V-III region B6 Ig lambda chain V-I region MEM Ig lambda chain V-I region BL2 Ig lambda chain V-II region BOH Ig kappa chain V-I region Wes Ig lambda chain V-I region MEM WIPF2 IGLV7-43Ig kappa chain V-I region Bi Ig lambda chain V-I region EPS Ig heavy chain V-III region TEI Ig lambda chain V-I region BL2 Ig kappa chain V-I region Scw Ig kappa chain V-I region EU Ig lambda chain V-IV region X Ig kappa chain V-I region OU IGLV4-69Ig heavy chain V-III region WEA Ig lambda chain V-II region WIN Ig heavy chain V-III region BRO ATP FCGR1A p-Y288,Y304-FCGR2A Ig kappa chain V-III region VG IGHG2Ig heavy chain V-III region TRO Ig lambda chain V-II region BOH PIIGLV2-18Ig lambda chain V-IV region Kern Ig kappa chain V-I region Bi Ig heavy chain V-III region TUR Ig heavy chain V-III region BUR Ig heavy chain V-III region BRO Ig heavy chain V-I region EU Ig lambda chain V-I region MEM Src-kinasesIGLV2-33Ig kappa chain V-I region Lay IGLC1Ig heavy chain V-II region COR Ig kappa chain V-II region TEW Ig kappa chain V-I region Ni IGLV7-43IGLV5-37ARPC3 Ig heavy chain V-I region EU Ig heavy chain V-III region HIL CYFIP2 Ig lambda chain V-VII region MOT Ig lambda chain V-III region SH Ig kappa chain V-I region HK101 Ig lambda chain V-II region VIL Ig heavy chain V-I region ND Ig lambda chain V-VI region SUT Ig heavy chain V-III region TIL BAIAP2 Ig lambda chain V-II region BUR Ig lambda chain V-I region HA Ig kappa chain V-III region VH Ig kappa chain V-IV region B17 IGLV2-18PIIGHG2Ig kappa chain V-I region Scw IGLV4-69IGHVIGLV4-60IGLV7-46Ig heavy chain V-II region OU Ig heavy chain V-II region MCE Ig heavy chain V-III region TEI Ig heavy chain V-III region GA GRB2-1 IGLV7-43Ig lambda chain V-II region NIG-84 FCGR3A Ig lambda chain V-I region NIG-64 Ig lambda chain V-I region VOR Ig lambda chain V-III region SH BRK1Ig lambda chain V-IV region MOL DOCK1 Ig kappa chain V-I region WEA Ig lambda chain V-IV region X IGLC3Ig kappa chain V-I region Scw Ig kappa chain V-I region OU Ig lambda chain V-IV region X Ig kappa chain V-III region VH Ig heavy chain V-III region TUR CDC42-GTPWASP/N-WASPIg lambda chain V-III region SH Ig kappa chain V-III region Ti Ig heavy chain V-I region ND Ig kappa chain V-I region Scw Ig kappa chain V-I region BAN Ig heavy chain V-II region ARH-77 IgH heavy chain V-III region VH26 precursor Ig heavy chain V-I region HG3 Ig lambda chain V-I region NEW Ig heavy chain V-III region WEA IGKVA18Ig kappa chain V-III region CLL FCGR1A Ig lambda chain V-II region TOG IGLV4-3IGLV5-45Ig lambda chain V-VII region MOT IGLV3-12IGLV4-69Ig kappa chain V-IV region JI Ig kappa chain V-IV region B17 ACTG1Ig heavy chain V-III region GAL ITPR3 Ig heavy chain V-I region ND Ig kappa chain V-I region HK101 Ig lambda chain V-I region VOR ITPR1 Ig lambda chain V-II region BOH Ig heavy chain V-III region JON IGLVIg heavy chain V-III region BRO Ig kappa chain V-IV region JI WIPF1 Ig kappa chain V-I region Daudi Ig kappa chain V-I region Gal Ig heavy chain V-II region COR Ig kappa chain V-III region VG Ig kappa chain V-I region Mev Ig kappa chain V-III region VG Ig kappa chain V-I region AG Ig lambda chain V-VI region SUT Ig heavy chain V-III region TEI Ig kappa chain V-I region Rei ACTG1Ig lambda chain V-IV region Bau Ig kappa chain V-I region Gal Ig lambda chain V-II region BUR IGLV3-22Ig lambda chain V-VI region EB4 Ig kappa chain V-I region WEA IGLV2-18PIIGLV3-27IGLV10-54Ig heavy chain V-III region BUR ATPIg kappa chain V-I region Mev IGLC6IGLV3-12Ig heavy chain V-III region BRO Ig lambda chain V-II region BUR p-Y160,Y171-CD3G Ig kappa chain V-I region Hau IGLV3-22IGHV7-81Ig heavy chain V-II region SESS Ig kappa chain V-III region NG9 Ig kappa chain V-III region NG9 Ig heavy chain V-II region COR Ig kappa chain V-I region Walker FCGR3A Ig lambda chain V-VII region MOT Ig heavy chain V-II region SESS Ig lambda chain V-III region SH ARPC4 Ig kappa chain V-I region HK101 clustered IgG-Agp-FCGRsSYKIg lambda chain V-VI region SUT Ig kappa chain V-III region HIC MyosinIGHVIg heavy chain V-III region TIL Ig lambda chain V-VI region WLT Ig heavy chain V-III region JON Ig heavy chain V-II region COR IGHG2IGLV7-43Ig lambda chain V-I region VOR IGLVIg kappa chain V-I region HK101 Ig kappa chain V-I region CAR Ig lambda chain V-VI region EB4 Ig lambda chain V-VI region AR Ig heavy chain V-II region COR IGLV8-61IGKVA18IGLV3-12Ig kappa chain V-II region RPMI 6410 Myosin-Actin filamentsIg kappa chain V-I region Daudi IGKV4-1Ig lambda chain V-I region NEWM WIPF3 IGLV3-25Ig kappa chain V-III region SIE IGLV3-25FCGR3A Ig heavy chain V-III region WEA Ig heavy chain V-III region TRO IGLV4-69Ig kappa chain V-III region CLL Ig kappa chain V-III region VG IGLC2Ig lambda chain V-VI region AR Ig heavy chain V-III region JON Ig kappa chain V-I region DEE ATPIGLV10-54Ig kappa chain V-I region Ka Ig kappa chain V-I region Kue Ig kappa chain V-III region SIE Ig lambda chain V-I region BL2 IGKV4-1Ig kappa chain V-IV region Len Ig lambda chain V-VI region AR Ig kappa chain V-I region HK101 Ig heavy chain V-III region TRO Ig kappa chain V-IV region Len Ig heavy chain V-III region TRO Ig lambda chain V-II region TRO Ig heavy chain V-III region HIL Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-I region AG Ig lambda chain V-IV region Kern IGLV5-37Ig kappa chain V-I region Rei Ig lambda chain V-II region NEI IGKV1-5Ig kappa chain V-I region Roy Ig heavy chain V-I region ND Ig lambda chain V-I region WAH HSP-90NCK1 DAGsIg lambda chain V-I region VOR Ig heavy chain V-I region Mot Ig heavy chain V-III region DOB Ig heavy chain V-III region HIL Ig kappa chain V-I region EU IGKV4-1IGLV3-25Ig lambda chain V-I region EPS Ig kappa chain V-IV region JI IGLV8-61Ig lambda chain V-I region NEW IGLV7-43IGLV3-25Ig heavy chain V-II region DAW Ig kappa chain V-IV region B17 IGLV5-37Ig kappa chain V-II region FR Ig heavy chain V-II region MCE Ig kappa chain V-II region RPMI 6410 Ig heavy chain V-II region MCE IGLV3-22IGHG4IGKV4-1IGLV4-3RAC1 PIIGLV1-44Ig kappa chain V-III region CLL Ig lambda chain V-I region HA Ig heavy chain V-II region OU Ig heavy chain V-III region ZAP Ig heavy chain V-I region SIE IGLVIg kappa chain V-II region TEW Ig kappa chain V-III region HIC IGLV2-33Ig heavy chain V-III region WAS Ig heavy chain V-II region OU IGLV2-33Ig kappa chain V-I region Scw Ig kappa chain V-III region GOL Ig lambda chain V-VI region NIG-48 SH3 domain proteinsBRK1ERKIg heavy chain V-III region TRO Ig lambda chain V-I region NEWM Ig lambda chain V-II region NEI BAIAP2 Ig kappa chain V-I region Roy Ig lambda chain V-VI region EB4 Ig kappa chain V-I region Ni Ig lambda chain V-V region DEL IGHVIg kappa chain V-I region CAR Ig heavy chain V-III region NIE Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-III region IARC/BL41 Ig heavy chain V-II region DAW IGLVIg lambda chain V-VI region WLT Ig kappa chain V-I region WEA Ig kappa chain V-IV region STH NCKIPSD IGLV2-11Ig lambda chain V-I region HA Ig heavy chain V-II region HE Ig kappa chain V-I region AG WIPF2 Phospho-PKC-delta/epsilonIg heavy chain V-III region GA Ig kappa chain V-I region Rei FCGR1A Ig kappa chain V-III region POM Ig lambda chain V-II region MGC Ig kappa chain V-III region B6 IGLV4-60H2OIg heavy chain V-III region ZAP Ig lambda chain V-V region DEL ACTR2 Ig lambda chain V-II region MGC Ig heavy chain V-III region DOB IGHG3 IGLV1-40IGLC1PIK3CA IGLC7Ig kappa chain V-I region EU IGLV5-45Ig kappa chain V-I region Mev Ig kappa chain V-I region Lay Ig kappa chain V-I region Daudi Ig kappa chain V-III region GOL Ig heavy chain V-III region GAL IGLVFCGR3A IGLV1-36IGLV4-3Ig heavy chain V-III region GA Ig kappa chain V-I region WEA IGLC3IGLV4-3IGHV7-81Ig lambda chain V-VII region MOT Ig kappa chain V-I region Daudi Ig heavy chain V-II region ARH-77 Ig heavy chain V-II region WAH Ig kappa chain V-IV region Len Ig heavy chain V-I region SIE p-Y288,Y304-FCGR2A IGLC7Ig heavy chain V-III region TRO Ig heavy chain V-II region ARH-77 Ig lambda chain V-III region LOI Ig lambda chain V-II region VIL IGHG1Ig kappa chain V-I region DEE Ig lambda chain V region 4A Ig heavy chain V-I region HG3 IGKV1-5ARPC2 Mother filamentbranching complexIg heavy chain V-III region TRO Ig lambda chain V-II region BO Ig kappa chain V-I region Hau Ig heavy chain V-II region ARH-77 Ig heavy chain V-III region ZAP IGLV2-11Ig lambda chain V-I region EPS IGLV7-46IGLV2-11Activated WAVE2 and WASP/N-WASPIg lambda chain V-II region WIN Ig heavy chain V-III region BUT Ig kappa chain V-I region Ka IGHG1Ig kappa chain V-IV region Len Ig lambda chain V-II region MGC Ig kappa chain V-I region BAN Ig kappa chain V region EV15 IGHG2Ig heavy chain V-III region BUT Ig lambda chain V-I region VOR IGHVIGLVp-Y174-VAV1 Ig kappa chain V-III region NG9 Ig lambda chain V-VI region NIG-48 Ig kappa chain V-I region Ni IGLC2Ig kappa chain V-II region MIL Ig lambda chain V-VI region SUT Ig kappa chain V-III region Ti Ig heavy chain V-III region NIE Ig lambda chain V-VI region EB4 Ig kappa chain V-IV region JI Ig heavy chain V-III region NIE Ig kappa chain V-I region Rei IGLV10-54IGLV7-46Ig kappa chain V-III region GOL Ig kappa chain V-I region BAN Ig heavy chain V-III region KOL Ig kappa chain V-IV region JI Ig lambda chain V-III region LOI clustered IgG-Agp-FCGRsp-6Y-SYKp-VAVFCGR1A Ig heavy chain V-III region BRO IGLV2-33Ig kappa chain V-I region WAT Ig lambda chain V-II region BO Ig kappa chain V-III region HAH Ig kappa chain V-III region POM IGLV5-45IGLV4-69WIPF1 PIIGLV2-18Ig kappa chain V-I region WEA IGHG1Ig lambda chain V-VI region EB4 ACTBIg heavy chain V-III region TRO Ig lambda chain V-VI region SUT Ig lambda chain V-IV region Kern Ig lambda chain V-I region MEM Ig kappa chain V-I region AU Ig lambda chain V-II region BOH VAVIg lambda chain V-VI region WLT Ig heavy chain V-III region JON Ig lambda chain V-VI region NIG-48 IGLV2-11Ig heavy chain V-III region WAS Ig lambda chain V-IV region X RAC1 ARPC5 Ig kappa chain V-I region CAR Ig kappa chain V-II region MIL Ig kappa chain V-IV region STH Ig kappa chain V-III region SIE p-Y753,Y759,Y1217-PLCG2 Ig lambda chain V-I region EPS Ig kappa chain V-I region AU Ig heavy chain V-III region ZAP IGKCIg kappa chain V-IV region Len Ig lambda chain V-VI region AR FCGR2AIg lambda chain V region 4A Ig kappa chain V-I region Ni IGLV1-40IGKV1-5H2OIGLV5-37Ig lambda chain V-II region NIG-58 p-Y160,Y171-CD3G Ig lambda chain V region 4A Ig kappa chain V-III region HAH Ig heavy chain V-III region TIL Ig lambda chain V-II region TOG Ig lambda chain V-I region NEW p-Y288,Y304-FCGR2A Ig heavy chain V-II region HE Ig heavy chain V-III region GAL Ig lambda chain V-II region BUR Ig lambda chain V-IV region MOL ARPC4 Ig kappa chain V-III region HIC IGLV1-36IGLC7IGLV4-69Ig kappa chain V-III region GOL Ig kappa chain V-I region AU ADPADP Active LIMK1Ig kappa chain V-I region Scw PIK3R2 Ig lambda chain V-VI region SUT Ig lambda chain V-V region DEL Ig lambda chain V-VII region MOT Ig lambda chain V-II region BO CDC42-GDPIg lambda chain V-IV region Hil Ig heavy chain V-I region WOL Ig heavy chain V-III region WEA IGKV4-1Ig kappa chain V-III region HIC Ig heavy chain V-I region HG3 Ig lambda chain V-VI region AR Ig heavy chain V-II region DAW Ig kappa chain V-I region HK101 IGLV2-11Ig kappa chain V-III region POM p-Y291-WAS NCKAP1 Ig kappa chain V-I region Kue Ig lambda chain V-I region NEW Ig lambda chain V-II region NIG-58 Ig lambda chain V-I region EPS Ig kappa chain V-I region Ka Ig kappa chain V-III region GOL Ig heavy chain V-III region JON IGLV1-44Ig lambda chain V-IV region MOL Ig kappa chain V-III region Ti Ig heavy chain V-III region WEA Ig heavy chain V-III region BUT IGLV3-27Ig lambda chain V-I region HA Ig heavy chain V-III region CAM ACTG1Ig kappa chain V-I region EU IGLV11-55Ig kappa chain V-I region Mev Ig lambda chain V-IV region X Ig kappa chain V-I region EU Ig heavy chain V-I region EU Ig kappa chain V region EV15 Ig kappa chain V-I region Ni IGLV11-55Ig heavy chain V-III region KOL Ig lambda chain V-II region BO WIPF1 IGLVIGLV3-22PIp-4Y-PLCG1 Ig kappa chain V-II region FR Ig lambda chain V-VI region WLT Ig lambda chain V-I region VOR Ig heavy chain V-I region EU IGHVIGLV8-61Ig heavy chain V-II region COR Ig lambda chain V-II region BOH p-S144,T423-PAK1Ig lambda chain V-IV region MOL Ig kappa chain V-II region TEW IGLV4-60Ig lambda chain V-I region VOR Ig kappa chain V-I region OU Ig lambda chain V-II region NIG-84 Ig kappa chain V-III region HIC ACTBIg kappa chain V-III region VH IGLVIGLV11-55IGLVPhosphatidate phosphataseIg kappa chain V-III region GOL Ig kappa chain V-I region Lay IGKV1-5Ig kappa chain V-III region IARC/BL41 Ig lambda chain V-II region WIN Ig lambda chain V-IV region Bau Ig heavy chain V-III region POM IGHVIGLV5-37Ig lambda chain V-VI region AR Ig kappa chain V-IV region STH Ig kappa chain V-II region MIL Ig lambda chain V-I region NIG-64 IGLV2-23Ig kappa chain V-I region Kue NCKAP1 Ig kappa chain V-I region WEA Ig lambda chain V-II region TRO Ig heavy chain V-II region COR Ig kappa chain V-II region Cum Ig lambda chain V-VI region EB4 Ig lambda chain V-VI region AR CDC42 CRKIGLC6FCGR1A Ig heavy chain V-II region DAW Ig heavy chain V-II region NEWM MYO10 Ig heavy chain V-III region BUT ARPC3 IGHG1Ig lambda chain V-II region VIL IGLV2-23IGLV11-55G-actinIg kappa chain V-II region FR IGLV3-22Ig lambda chain V-I region WAH Ig heavy chain V-I region ND PIIg kappa chain V-I region AG Ig kappa chain V-I region Scw Ig kappa chain V-III region POM CYFIP2 Ig heavy chain V-III region ZAP Ig kappa chain V-I region Mev Ig heavy chain V-I region ND Ig kappa chain V-I region DEE IGLV2-11IGKCADPIg kappa chain V-I region Wes Ig kappa chain V-III region B6 Ig heavy chain V-II region NEWM BAIAP2 Ig lambda chain V-I region VOR Ig heavy chain V-III region TRO Ig heavy chain V-III region GA IGLC7IGLV11-55Ig kappa chain V-II region GM607 BRK1IGLV7-46Ig lambda chain V-I region NEWM IGHG2Ig lambda chain V-IV region MOL Ig kappa chain V-I region Mev Ig kappa chain V-III region VH WIPF1 Ig heavy chain V-III region TIL Ig heavy chain V-III region LAY IGLV2-18Ig lambda chain V region 4A Ig kappa chain V-I region Bi Ig lambda chain V-VI region AR Ig kappa chain V-III region POM Ig lambda chain V-I region HA IGKV4-1Ig lambda chain V-II region NIG-58 Ig heavy chain V-III region LAY BRK1Ig heavy chain V-III region TIL Ig lambda chain V-III region LOI Ig heavy chain V-II region ARH-77 Ig kappa chain V-II region TEW Ig heavy chain V-I region HG3 Myosin-X dimerIg heavy chain V-I region Mot IGLV5-45Ig lambda chain V-I region NEW Ig heavy chain V-III region POM Ig heavy chain V-III region CAM Ig heavy chain V-II region HE Ig heavy chain V-III region POM Ig kappa chain V-I region HK101 IGLV2-18PIIGLV2-11Ig kappa chain V-I region Bi Ig kappa chain V-I region DEE Ig kappa chain V-I region Daudi BRK1Ig kappa chain V-III region HIC Ig kappa chain V region EV15 IgH heavy chain V-III region VH26 precursor Ig heavy chain V-III region TRO IGLV1-36Ig kappa chain V-III region CLL IGLV3-25CDC42 Ig kappa chain V-IV region JI Ig kappa chain V region EV15 Ig lambda chain V-II region NIG-84 Ig kappa chain V-I region Scw Ig lambda chain V-IV region X Ig kappa chain V-II region Cum Ig kappa chain V-II region Cum Ig heavy chain V-II region MCE IGLV8-61Ig kappa chain V-I region BAN IGLV3-16Ig heavy chain V-III region HIL Ig kappa chain V-III region B6 Ig lambda chain V-II region MGC IGLVITPR3 IGLC6Ig lambda chain V-VI region AR IGLC3IGLV8-61Ig kappa chain V-I region Ka Ig heavy chain V-I region HG3 PIK3CA p-6Y-SYK Ig kappa chain V-I region AU Ig heavy chain V-I region WOL IGLV5-37IGHG4IGLC2ATP IGLV10-54CYFIP2 Ig lambda chain V-VI region EB4 Ig kappa chain V-I region Ka Ig heavy chain V-I region WOL Ig kappa chain V-III region CLL Ig heavy chain V-III region NIE Ig kappa chain V-IV region B17 RAC1 IGLC2Ig heavy chain V-III region BUR Ig kappa chain V-I region Wes Ig kappa chain V-III region VH ACTR2 Ig lambda chain V-II region VIL IGLV3-12Ig heavy chain V-I region WOL Ig heavy chain V-III region GAL GRB2-1 IGLV2-33Ig kappa chain V-II region FR Ig heavy chain V-III region TIL Ig kappa chain V-I region Wes CYFIP2 Ig kappa chain V-I region Walker ACTR2 Ig heavy chain V-I region SIE IGLV5-45Ig kappa chain V-III region NG9 Ig kappa chain V-I region OU GRB2-1 Ig lambda chain V-VI region SUT p-Y291-WAS Ig lambda chain V-I region MEM Ig lambda chain V-IV region Kern IGKVA18Ig heavy chain V-I region Mot IGLV3-22ACTR3 Ig heavy chain V-III region CAM Ig kappa chain V-I region Mev Ig lambda chain V-IV region Bau Ig heavy chain V-III region WAS ACTBIg kappa chain V-III region IARC/BL41 Ig heavy chain V-II region NEWM Ig lambda chain V-III region LOI IgH heavy chain V-III region VH26 precursor Ig heavy chain V-III region GAL IGLC7IGLV4-60Ig lambda chain V-I region NEW IGHG4Ig lambda chain V-II region TRO Ig lambda chain V-II region WIN Ig heavy chain V-II region WAH Ig kappa chain V-I region CAR Ig heavy chain V-III region CAM Ig heavy chain V-I region WOL CDC42 IGLC7Ig kappa chain V-I region Ka Ig lambda chain V-VII region MOT IGLV7-46Ig kappa chain V region EV15 Ig kappa chain V-I region AG IP3 receptor homotetramerCD247-1 IGHG1Ig heavy chain V-III region BUR IGLV1-44Ig lambda chain V-II region TOG Ig kappa chain V-I region OU p-Y288,Y304-FCGR2A Ig heavy chain V-III region GAL IGLC3Ig kappa chain V-II region MIL IGLV2-11IGLV11-55G-actinIg lambda chain V-II region TRO Ig heavy chain V-II region NEWM IGLC6p-6Y-CD247-1 Ig kappa chain V-III region HAH IGLC1IGKVA18ADPIg heavy chain V-III region GAL Ig heavy chain V-III region POM Ig kappa chain V-III region POM VAV2 IGLV8-61IGLC3Ig heavy chain V-I region HG3 Ig heavy chain V-II region NEWM IGLV2-33Ig heavy chain V-II region SESS PIIg lambda chain V-II region NEI ADPGRB2-1 Ig kappa chain V region EV15 Ig lambda chain V-IV region Kern Ig kappa chain V-III region WOL Ig kappa chain V-I region DEE Ig kappa chain V-I region WAT Ig kappa chain V-IV region STH Ig kappa chain V-I region Ni Ig heavy chain V-I region SIE Ig kappa chain V-III region B6 Ig kappa chain V-III region IARC/BL41 Ig kappa chain V-I region Roy Ig lambda chain V-III region SH Ig lambda chain V-II region BUR IGHV7-81Ig lambda chain V-I region NEW p-Y160,Y171-CD3G Ig heavy chain V-III region BRO Ig kappa chain V region EV15 Ig kappa chain V-II region GM607 Ig heavy chain V-III region HIL Ig lambda chain V-IV region Bau Ig kappa chain V-IV region JI CD247-1 VAV3 Ig kappa chain V-III region WOL Ig kappa chain V-III region WOL Ig lambda chain V-II region NEI Ig heavy chain V-III region ZAP Ig lambda chain V-II region TRO CRKIIDOCK180ELMO complex recruited to phagocytic cupIg heavy chain V-II region HE ARPC1A Ig heavy chain V-II region WAH Ig heavy chain V-III region TEI p-Y173-VAV3 Ig lambda chain V-II region NEI Ig lambda chain V-VI region WLT Ig heavy chain V-II region SESS IGLV1-40Ig lambda chain V-II region NIG-84 FCGR3A Ig heavy chain V-II region DAW Ig kappa chain V-I region Kue clustered IgG-Agp-FCGRsp-6Y-SYKp-3Y-PLCGIGHG4pCofilin Active LIMK-1Ig kappa chain V-IV region Len Ig lambda chain V-II region NEI Ig heavy chain V-I region Mot Ig lambda chain V-VI region WLT Ig lambda chain V-I region MEM Ig kappa chain V-I region Ni NCKIPSD IGLV4-60Ig heavy chain V-I region EU Ig kappa chain V-III region VG Ig lambda chain V-I region NIG-64 IGKVA18IGLV3-16IGLV5-37Ig lambda chain V-II region WIN Ig heavy chain V-I region SIE IGLV4-3Ig heavy chain V-III region HIL Ig kappa chain V-I region AG Ig kappa chain V region EV15 Ig lambda chain V-II region BO PiIg lambda chain V-IV region X Ig kappa chain V-I region Walker NCKAP1 Ig kappa chain V-I region WAT IGLV3-12Ig heavy chain V-III region BUR Ig lambda chain V-I region MEM Ig kappa chain V-III region POM Ig kappa chain V-IV region Len Ig heavy chain V-II region OU IGHG1p-T508-LIMK1Ig kappa chain V-III region CLL Ig heavy chain V-III region LAY Ig kappa chain V-III region VH IGLV3-27Ig heavy chain V-I region Mot Ig kappa chain V-III region IARC/BL41 IGHG4IGLV8-61GTP IGLV4-3PIIg heavy chain V-III region LAY Ig kappa chain V-III region WOL Ig lambda chain V-II region BUR IGKVA18Ig kappa chain V-I region Gal CRKIg heavy chain V-III region POM Ig kappa chain V-IV region JI Ig heavy chain V-II region NEWM WIPF1 Ig heavy chain V-III region BUR Ig heavy chain V-III region TUR Ig kappa chain V-III region VH Ig lambda chain V-IV region Kern clustered IgG-Agp-FCGRsp-6Y-SYKIGLV5-37Ig kappa chain V-I region Mev Ig kappa chain V-I region Roy CDC42 Ig lambda chain V-IV region Bau GTP Ig kappa chain V-I region Daudi Ig heavy chain V-III region TUR Ig kappa chain V-I region AG Ig kappa chain V-II region GM607 IGLV1-40RAC1 Ig kappa chain V-I region Rei Ig kappa chain V-III region HAH Ig heavy chain V-I region Mot Ig lambda chain V-IV region X IGLV3-12p-6Y-CD247-1 Ig kappa chain V-IV region STH IGHG2IGLV7-46Ig kappa chain V-III region SIE IGLVIGHG1IGHG3 IGLV3-22Ig heavy chain V-III region NIE IGLC6Ig heavy chain V-I region SIE Ig heavy chain V-III region BUR Ig heavy chain V-II region HE IGHG1Ig heavy chain V-III region JON WIPF2 FCGR2A Ig kappa chain V-I region Ka Ig kappa chain V-III region IARC/BL41 IGKV1-5IGLV3-12IGLC6Ig kappa chain V-I region Daudi Ig kappa chain V-III region VH Ig heavy chain V-III region TIL Ig lambda chain V-II region TRO ARPC5 WRCIRSp53/58RAC1-GTPPIP3Ig lambda chain V-II region WIN Ig lambda chain V-II region VIL Ig heavy chain V-I region Mot Ig kappa chain V-III region SIE Ig lambda chain V-VI region NIG-48 Ig kappa chain V-III region HAH Ig kappa chain V-III region Ti Ig kappa chain V-III region CLL Ig heavy chain V-III region KOL Ig lambda chain V-II region TOG NCK1 Ig lambda chain V-I region EPS Ig heavy chain V-III region DOB Ig heavy chain V-III region TEI Ig kappa chain V-I region CAR IGKVA18IgH heavy chain V-III region VH26 precursor BRK1PIIg kappa chain V-I region Ka GDPIGLC7Ig kappa chain V-I region Lay Ig kappa chain V-III region B6 IGLV2-23GTP Ig kappa chain V-I region Ni Ig heavy chain V-III region WEA Ig lambda chain V-I region BL2 Ig kappa chain V-I region Scw ARPC3 Ig heavy chain V-III region WAS Ig lambda chain V-IV region Bau Ig heavy chain V-III region JON Ig lambda chain V-II region NEI Ig heavy chain V-III region BUT Ig lambda chain V-II region TRO ARPC4 Ig kappa chain V-I region Hau Ig heavy chain V-III region BUR Ig kappa chain V-I region CAR PLDIg kappa chain V-I region Kue Ig kappa chain V-III region VH Ig lambda chain V-II region WIN Ig heavy chain V-I region HG3 IGLV2-18IGLV3-16Ig lambda chain V-II region NEI Ig kappa chain V-III region WOL ARPC4 p-Y160,Y171-CD3G Ig heavy chain V-III region KOL Ig kappa chain V-II region GM607 Ig heavy chain V-III region HIL Ig heavy chain V-II region COR Ig kappa chain V-II region FR IGLV10-54IGLV2-11PAK1Ig lambda chain V-II region BUR Ig lambda chain V-IV region Bau IGLV4-3Ig heavy chain V-III region LAY PIIg heavy chain V-III region JON IGLV2-23Ig kappa chain V-III region POM p-Y256-WASL Ig kappa chain V-III region VG Ig heavy chain V-III region WEA Ig kappa chain V-III region VH Ig kappa chain V-I region Gal ARPC3 Ig lambda chain V-III region LOI Ig lambda chain V region 4A Ig lambda chain V-I region BL2 Ig kappa chain V-I region WAT Ig lambda chain V-VII region MOT Ig heavy chain V-I region WOL Ig lambda chain V-II region TOG Ig heavy chain V-I region WOL Ig lambda chain V-I region VOR IGHG3 Ig kappa chain V-IV region STH PI3KIg kappa chain V-I region BAN Ig heavy chain V-III region BUT IGKV4-1Ig kappa chain V-II region TEW GRB2-1 NCKAP1 Ig kappa chain V-I region AG Ig lambda chain V-II region NIG-58 Ig kappa chain V-II region MIL Ig heavy chain V-III region KOL Ig heavy chain V-III region TIL Ig heavy chain V-III region BUT Ig kappa chain V-IV region JI IGHV7-81Ig heavy chain V-I region Mot Ig kappa chain V-I region EU Ig heavy chain V-III region TEI Ig heavy chain V-II region OU FCGRIIIACD3G/CD3Z dimersIg lambda chain V-VII region MOT p-Y256-WASL Ig kappa chain V-III region GOL Ig lambda chain V-III region SH Ig kappa chain V-III region POM Ig kappa chain V-I region Rei Ig kappa chain V-I region CAR IGLC2Ig heavy chain V-I region EU Ig kappa chain V-III region CLL Ig heavy chain V-III region KOL Ig lambda chain V-VI region EB4 IGLC1Ig heavy chain V-III region GA IGLV4-69IGLV7-43Ig heavy chain V-II region ARH-77 Ig lambda chain V-VI region WLT IGLC1Ig heavy chain V-II region SESS p-WRCIRSp53/58RAC1-GTPPIP3Ig kappa chain V-I region AU IGKV4-1Ig lambda chain V-III region LOI Ig kappa chain V-I region AG Ig lambda chain V-IV region Kern Ig lambda chain V-V region DEL Ig lambda chain V-I region EPS RAC1 Ig kappa chain V-I region Mev Ig lambda chain V-I region WAH Ig kappa chain V-I region Ni Ig kappa chain V-I region Mev Ig heavy chain V-I region HG3 IGLV3-27clustered IgG-AgFCGRsIg heavy chain V-III region WEA Ig kappa chain V-IV region STH Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-I region VOR IGLV3-27Ig heavy chain V-III region NIE Ig kappa chain V-I region WEA RAC1 IGLC6Ig heavy chain V-III region BRO Ig lambda chain V-II region TOG IGLV4-60Ig kappa chain V-I region HK101 IGHG4Ig lambda chain V-II region NIG-84 Ig kappa chain V-I region Ni Ig kappa chain V-I region Bi Ig heavy chain V-III region TRO Ig heavy chain V-III region HIL IGHVIg lambda chain V-VI region EB4 p-6Y-SYK IGLV2-33Ig kappa chain V-I region Mev Ig lambda chain V-III region LOI IGLV10-54IGKV1-5Ig lambda chain V-I region NEW Ig kappa chain V-I region Hau RAC1 Ig kappa chain V-III region HIC IGLV3-16Ig kappa chain V-III region B6 Ig kappa chain V-III region VG ACTR3 Ig heavy chain V-II region SESS Ig heavy chain V-II region SESS ATPIg heavy chain V-III region BUR WIPF3 Ig kappa chain V-I region WAT Ig lambda chain V-VI region NIG-48 Ig kappa chain V-I region EU Ig heavy chain V-III region TUR ARPC2 ARPC3 GTP Ig kappa chain V-I region Scw Ig heavy chain V-III region LAY Ig kappa chain V-I region EU Ig heavy chain V-I region WOL Ig heavy chain V-III region LAY Ig heavy chain V-I region EU Ig kappa chain V-III region Ti Ig kappa chain V-III region IARC/BL41 IGLV1-36p-Y291-WAS IGLV1-36Ig lambda chain V-II region VIL IGHVIg kappa chain V-II region TEW Ig heavy chain V-III region WEA IGLC2Ig kappa chain V-I region CAR IGLC6IGLV2-18IGLV7-46Ig kappa chain V-III region HIC IGLC2Ig kappa chain V-I region Lay IGHG3 Ig lambda chain V-II region MGC Ig kappa chain V-III region HAH IGLC7ACTG1Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-I region BL2 IGKV1-5Ig heavy chain V-III region TIL Ig heavy chain V-III region BRO Ig kappa chain V-IV region STH Ig kappa chain V-I region Walker Ig heavy chain V-II region ARH-77 Ig kappa chain V-III region VG Ig heavy chain V-II region NEWM PIIGLV8-61Ig kappa chain V-IV region Len Ig kappa chain V-II region MIL Ig kappa chain V-I region BAN Ig heavy chain V-II region SESS IGLC2Ig heavy chain V-III region GA Ig heavy chain V-I region WOL p-Y172-VAV2 Ig kappa chain V-I region Walker IGLV5-37Ig lambda chain V-II region BUR Ig lambda chain V-I region NIG-64 ACTBIg kappa chain V-III region B6 IGLV2-18Ig heavy chain V-III region ZAP ARPC2 IGLV4-3Ig lambda chain V-I region NEWM Ig lambda chain V-II region BOH ELMO1 Ig heavy chain V-II region NEWM Ig heavy chain V-III region TIL CYFIP2 Ig lambda chain V-I region NIG-64 IP3 receptorIP3 complexIg lambda chain V-IV region Bau Ig lambda chain V-VI region NIG-48 Ig heavy chain V-II region OU Ig lambda chain V-II region TRO p-PLCGp-WRCIRSp53/58RAC1-GTPPIP3Ig heavy chain V-I region Mot FCGR3A Ig heavy chain V-III region KOL Ig kappa chain V-IV region STH IGLV2-23Ig heavy chain V-II region ARH-77 Ig heavy chain V-III region BUR Ig kappa chain V-III region GOL Ig heavy chain V-II region WAH IGLV4-3Ig heavy chain V-III region BUT Ig kappa chain V-I region Lay Ig kappa chain V-I region Bi IGLV3-16Ig heavy chain V-I region WOL p-6Y-CD247-1 Ig heavy chain V-III region TEI Ig heavy chain V-III region WEA WIPF1 Ig lambda chain V-I region HA IGLV4-69Ig lambda chain V-III region SH Ig lambda chain V-IV region Bau Ig kappa chain V-I region Kue Ig heavy chain V-III region DOB Ig heavy chain V-III region TIL IGLVIg heavy chain V-I region WOL Ig lambda chain V-IV region Bau Ig heavy chain V-III region DOB Ig heavy chain V-III region TUR Ig kappa chain V-IV region B17 BAIAP2Ig lambda chain V-II region BOH Ig heavy chain V-II region COR ACTR3 Ig kappa chain V-III region IARC/BL41 Ig lambda chain V-III region LOI Ig heavy chain V-II region SESS Ig lambda chain V-I region VOR Ig heavy chain V-III region GA Ig lambda chain V-IV region Hil Ig kappa chain V-II region MIL Ig lambda chain V-II region TRO IGLV3-12Ig kappa chain V-I region BAN Ig lambda chain V-VI region EB4 Ig kappa chain V-I region CAR Ig kappa chain V region EV15 IGKV1-5Ig heavy chain V-II region SESS Ig lambda chain V-II region WIN Ig lambda chain V-IV region Kern RAC1 IgH heavy chain V-III region VH26 precursor ACTR3 IGLC7Ig lambda chain V-II region TOG Ig kappa chain V-II region Cum Ig kappa chain V-I region OU IGLV4-69IGHG1Ig kappa chain V-I region Roy Ig lambda chain V-II region TOG GTP Ig kappa chain V-III region CLL Ig kappa chain V-I region OU Ig kappa chain V-III region WOL Ig kappa chain V-III region GOL PAIGLV11-55PiIGKCIGLV3-22Ig kappa chain V-IV region Len Ig kappa chain V-I region Ni IGLV3-16IGLC7IgH heavy chain V-III region VH26 precursor Ig lambda chain V-I region NEW Ig lambda chain V region 4A Ig heavy chain V-II region WAH Ig kappa chain V-III region Ti Ig kappa chain V-III region POM IGLV2-23IGKCIg kappa chain V-I region CAR IGLV5-45Ig lambda chain V-II region MGC IGLV4-60Ig kappa chain V-I region OU Ig heavy chain V-III region TUR Ig lambda chain V-II region BOH Ig heavy chain V-III region HIL CDC42 ACTBIg heavy chain V-I region Mot IGKCIg kappa chain V-III region POM Ig heavy chain V-II region SESS IGKCNCK1 ATPAntigen-antibody complexIg heavy chain V-II region MCE IGLC2ATPIg kappa chain V-I region Roy IGLV11-55PIIg lambda chain V-IV region Kern Ig heavy chain V-I region HG3 Ig lambda chain V-I region NIG-64 IGLV3-16ATPIGLV3-27IGKV1-5Src family kinases Ig kappa chain V-III region Ti IGLC3Ig kappa chain V-II region FR Ig kappa chain V-I region Daudi NCKAP1 Ig kappa chain V-I region Gal Ig heavy chain V-III region POM Ig kappa chain V-IV region JI IGLV1-40Ig heavy chain V-III region TEI Ig kappa chain V-I region AU IGLV3-25Ig heavy chain V-III region ZAP ACTR3 IGLV5-37Ig lambda chain V-III region LOI IGLC3Ig heavy chain V-I region HG3 Ig heavy chain V-I region ND p-Y291-WAS IGLV4-60Ig kappa chain V-I region Mev Ig kappa chain V-III region SIE Ig heavy chain V-III region WAS Ig kappa chain V-III region Ti Ig heavy chain V-II region WAH PIK3CB Ig kappa chain V-I region HK101 IGLV7-43Ig heavy chain V-I region EU Ig heavy chain V-II region NEWM Ig kappa chain V-I region Ka FCGR2A Ig kappa chain V-I region Wes Ig kappa chain V-II region Cum Ig lambda chain V-II region BUR Ig heavy chain V-I region HG3 Ig lambda chain V-II region BOH CDC42 IGHV7-81Ig kappa chain V-II region RPMI 6410 LIMK1Ig kappa chain V-I region Rei Ig kappa chain V-I region Ka IGHG1Ig heavy chain V-II region ARH-77 Ig heavy chain V-III region NIE p-Y160,Y171-CD3G IGLV3-16Ig heavy chain V-III region POM Ig kappa chain V-IV region JI Ig lambda chain V-II region MGC Ig kappa chain V-IV region JI Ig lambda chain V-II region TOG Ig lambda chain V-IV region Hil Ig lambda chain V-VI region EB4 IGLC1ARPC2 IGLV1-44ATPARPC4 IGLV3-25IGKV4-1Ig heavy chain V-II region OU ACTR2 p-Y160,Y171-CD3G Ig lambda chain V-VI region EB4 Ig kappa chain V-IV region Len Ig lambda chain V-II region NEI Ig heavy chain V-III region DOB Ig kappa chain V-II region FR H2OIGLV1-36Ig kappa chain V-I region Hau ADPNCK1 Ig kappa chain V-I region Gal Ig heavy chain V-II region NEWM Ig kappa chain V-III region IARC/BL41 IGKV4-1Ig lambda chain V-IV region X Ig heavy chain V-III region TEI Ig kappa chain V-II region Cum Ig kappa chain V-I region Wes IGLV1-36Ig lambda chain V-I region NIG-64 IGKV4-1Ig kappa chain V-III region NG9 IGLC3Ig kappa chain V-II region TEW Ig kappa chain V-III region IARC/BL41 Ig kappa chain V-II region Cum PIIg kappa chain V-I region AG IGLC6p-6Y-SYK Ig heavy chain V-II region SESS IGHVIg lambda chain V region 4A IGKCIg kappa chain V-I region AU IGLV4-69Ig heavy chain V-III region TUR Ig heavy chain V-II region DAW NCKIPSD Ig lambda chain V-VI region SUT CD3G Ig kappa chain V-I region HK101 IGLV1-44Ig lambda chain V-I region NEWM NCK1 Ig lambda chain V-II region BOH Ig kappa chain V-III region SIE Ig heavy chain V-II region SESS Ig heavy chain V-II region OU Ig lambda chain V-I region NEWM Ig kappa chain V-III region POM p-6Y-SYK Ig kappa chain V-I region BAN Ig lambda chain V-I region NEW Ig kappa chain V-II region Cum Ig heavy chain V-III region GAL Ig heavy chain V-III region NIE Ig kappa chain V-I region Hau Ig heavy chain V-III region NIE Ig kappa chain V-I region WAT Ig heavy chain V-III region NIE Ig heavy chain V-II region SESS Ig kappa chain V-III region HAH Ig lambda chain V-V region DEL Ig heavy chain V-I region ND Ig lambda chain V-II region TOG IGLV10-54Ig lambda chain V-III region LOI Ig kappa chain V-I region Ka Ig kappa chain V-I region EU Ig kappa chain V-II region GM607 FCGR1A PIIg lambda chain V-II region NIG-58 Ig lambda chain V-II region NIG-84 IGLC2p-Y160,Y171-CD3G Ig heavy chain V-III region JON ATP Ig kappa chain V-I region Rei Ig lambda chain V-VI region SUT Ig kappa chain V-III region HIC IGLV2-33Ig lambda chain V-II region BOH Ig kappa chain V-III region B6 Ig heavy chain V-II region WAH IGLV3-27Ig lambda chain V-II region VIL Ig kappa chain V-III region VG p-6Y-CD247-1 Ig lambda chain V-III region LOI GTP clustered IgG-Agp-FCGRsp-6Y-SYKVAVATPIg lambda chain V-IV region X IGKCIGHV7-81PIIGLV4-69FCGR3A ACTBIg heavy chain V-II region WAH CYFIP2 Ig heavy chain V-I region EU Ig kappa chain V-III region POM IGLV5-45IGKCIg heavy chain V-III region KOL Ig lambda chain V-I region EPS Ig kappa chain V-I region CAR IGLC7Ig lambda chain V-I region WAH Ig heavy chain V-III region GAL Ig heavy chain V-III region CAM IGLC6Ca2+IGLV4-3Ig kappa chain V-IV region STH IGKCIg kappa chain V-I region Hau Ig lambda chain V-IV region Kern ARPC2 Ig kappa chain V-I region Ni ARPC1A IGLV10-54Ig kappa chain V-III region IARC/BL41 Ig lambda chain V-IV region Hil ATP Ig kappa chain V-III region Ti IGKCIg heavy chain V-III region POM IGLV3-16Ig lambda chain V-II region TOG IGLC3Ig lambda chain V-IV region Bau IGLV4-69Ig lambda chain V-I region EPS Ig lambda chain V-III region LOI Ig lambda chain V-III region SH IGLV2-23IGLV4-3IGLV2-18Ig kappa chain V-III region B6 Ig kappa chain V-I region Wes ACTBIg lambda chain V-II region MGC Ig heavy chain V-III region GA ADPIg kappa chain V-I region Wes IGHG4Ig kappa chain V-I region BAN Ig heavy chain V-III region POM IGLV7-43CYFIP2 RAC1/CDC42p-S144,T423-PAKIg lambda chain V-II region BO IGHG3 Ig kappa chain V-I region Bi Ig kappa chain V-III region WOL Ig lambda chain V-I region BL2 Ig lambda chain V-V region DEL IGLV10-54PAK1 RAC1-GTPIg kappa chain V-III region Ti IgH heavy chain V-III region VH26 precursor Ig heavy chain V-III region BUR IGHG2p-Y291-WAS NCKAP1 Ig lambda chain V-II region BUR NCKIPSD Ig kappa chain V-I region Walker Ig kappa chain V-III region HAH Ig heavy chain V-III region GAL IGLVIg lambda chain V-II region BOH IGLV1-40Ig kappa chain V-II region MIL Ig lambda chain V-II region WIN Ig heavy chain V-III region NIE IGLVIg kappa chain V-I region Daudi ITPR1 Ig kappa chain V-I region Daudi Ig lambda chain V-VI region AR Ig heavy chain V-II region HE GTP Ig kappa chain V-III region WOL Ig kappa chain V-III region WOL Ig lambda chain V-II region BO Ig kappa chain V-I region HK101 Ig lambda chain V region 4A Ig kappa chain V region EV15 Ig lambda chain V-V region DEL Ig kappa chain V-I region EU Ig kappa chain V-I region EU Ig kappa chain V-III region NG9 Ig kappa chain V-I region Ka Ig lambda chain V-II region BO Ig kappa chain V-II region MIL Ig heavy chain V-I region SIE ABL1Ig lambda chain V-I region BL2 p-Y256-WASL Ig heavy chain V-III region GAL IGHG4Ig lambda chain V-I region NEW IGLV2-33clustered IgG-Agp-FCGRsIg kappa chain V-I region BAN Ig kappa chain V-III region Ti Ig kappa chain V-II region TEW Ig heavy chain V-II region OU IGLV10-54Ig lambda chain V-I region BL2 Ig kappa chain V-I region DEE Ig kappa chain V-IV region STH IGLV1-36IIg heavy chain V-I region WOL CDC42 p-Y256-WASL Ig heavy chain V-II region COR IGKV4-1IGKV1-5Ig kappa chain V-IV region JI IGLV5-45PI3Kp-6Y-SYKIg kappa chain V-I region OU Ig heavy chain V-III region JON Ig heavy chain V-I region EU Ig kappa chain V-I region DEE Ig heavy chain V-III region GA Ig heavy chain V-III region TUR Ig kappa chain V-III region GOL IGLV7-46Ig kappa chain V-IV region JI Ig heavy chain V-III region GA Ig lambda chain V-I region MEM CD247-1 Ig kappa chain V-II region FR Ig kappa chain V-II region GM607 Ig heavy chain V-III region CAM Ig kappa chain V-III region HAH GTP Ig heavy chain V-III region TUR IGKV1-5Ig kappa chain V-III region NG9 Ig kappa chain V-III region VG Ig heavy chain V-III region TEI IGLC1NCK1 IGLV3-16ITPR2 Ig heavy chain V-III region CAM Ig kappa chain V-I region Walker ARPC1A p-S,T508-LIMK1 IGLV5-37CYFIP2 ACTBIg kappa chain V-I region Ni Ig heavy chain V-III region BRO Ig kappa chain V-III region Ti Ig kappa chain V-I region Daudi Ig kappa chain V-I region Kue Ig kappa chain V-III region WOL Ig lambda chain V-II region NIG-58 RAC1-GDPIg heavy chain V-III region WAS NCKAP1 IGLC1Ig heavy chain V-III region CAM Ig heavy chain V-III region DOB Ig lambda chain V-VI region EB4 IGLV1-40Ig lambda chain V-I region HA Ig kappa chain V-III region VH CYFIP2 Ig lambda chain V-IV region Kern Ig kappa chain V-III region B6 RAC1 Ig kappa chain V-IV region STH IGHG4IGLC3Ig kappa chain V-III region NG9 Arachidonic acidIGLV3-12Ig heavy chain V-III region DOB IGHG2IGHV7-81IGLV8-61Ig kappa chain V-III region CLL p-Y288,Y304-FCGR2A IGKVA18Ig heavy chain V-II region WAH IGLV3-22Ig heavy chain V-I region ND GTPIGHG2Ig heavy chain V-II region OU IGLV2-33HSP90AB1 Ig lambda chain V-II region NIG-58 IgH heavy chain V-III region VH26 precursor Ig heavy chain V-I region SIE Ig kappa chain V-I region Bi Ig lambda chain V-I region WAH IGKVA18Ig kappa chain V-II region FR Ig kappa chain V-I region Mev Ig kappa chain V-I region Gal Ig heavy chain V-I region HG3 p-T508-LIMK1 Ig kappa chain V-I region Rei Ig kappa chain V-I region Roy Ig kappa chain V-I region AU Ig heavy chain V-III region NIE Ig heavy chain V-III region ZAP IGHG4Ig lambda chain V-I region VOR Ig lambda chain V-I region NIG-64 p-6Y-SYK Ig lambda chain V-II region NEI Ig heavy chain V-II region HE Ig kappa chain V-II region GM607 IGLV2-11Ig heavy chain V-II region MCE Ig kappa chain V-III region HAH Ig heavy chain V-I region WOL Ig kappa chain V-I region Kue p-Y160,Y171-CD3G Ig kappa chain V-III region HAH ATPIg lambda chain V-II region BO IGLV2-23RAC1/CDC42PAK dimerIg kappa chain V-III region NG9 IGHG3 PIIGLV3-12Ig lambda chain V region 4A Ig heavy chain V-III region LAY p-S,T508-LIMK1 Ig lambda chain V-II region WIN BRK1IGHV7-81Ig lambda chain V-II region NIG-84 Ig kappa chain V-I region Gal Ig heavy chain V-II region SESS Ig heavy chain V-III region POM PIIg kappa chain V-III region SIE Ig heavy chain V-III region TEI Ig heavy chain V-I region SIE Ig heavy chain V-III region WEA Ig lambda chain V-VI region WLT Ig lambda chain V-VI region NIG-48 FCGR1A Ig lambda chain V-II region NIG-58 Ig kappa chain V-I region WEA Ig heavy chain V-II region ARH-77 Ig kappa chain V-I region HK101 IGLV1-36Ig kappa chain V-I region Scw Ig heavy chain V-III region BUT IGLV7-43Ig heavy chain V-I region Mot ACTR3 Ig kappa chain V-III region GOL Ig heavy chain V-I region SIE Ig kappa chain V-III region Ti Ig lambda chain V-I region NIG-64 Ig kappa chain V-III region HIC Ig kappa chain V-I region AU Ig heavy chain V-III region NIE Ig lambda chain V-II region BUR Ig kappa chain V-I region Mev Ig kappa chain V-I region OU IGHG3 pLIMK dimerHSP-90Ig lambda chain V-I region HA Ig lambda chain V-II region BO Ig kappa chain V-I region DEE IGKCIg kappa chain V-I region DEE Ig kappa chain V-I region Ni IGLC3Ig heavy chain V-III region TUR Ig heavy chain V-III region ZAP IGLC6IGLV2-33ARPC1A Ig lambda chain V-V region DEL ACTBIg lambda chain V-II region TOG Ig kappa chain V-II region FR PIFCGR1A clustered IgG-Agp-FCGRsIg kappa chain V-I region WEA PAK1 IGLV1-40Ig lambda chain V-IV region Hil Ig heavy chain V-III region TRO Ig lambda chain V-II region MGC Ig kappa chain V-I region Daudi Ig lambda chain V-I region EPS NCKIPSD ATP ELMO1 Ig lambda chain V-II region NIG-58 Ig heavy chain V-III region ZAP Ig kappa chain V-I region Daudi Ig kappa chain V region EV15 Ig kappa chain V-III region VG Ig kappa chain V-III region WOL Ig kappa chain V-III region IARC/BL41 Ig lambda chain V-IV region X Ig lambda chain V-VI region WLT Ig kappa chain V-I region WEA Ig lambda chain V region 4A Ig kappa chain V-I region Walker GDP Ig heavy chain V-I region ND Ig heavy chain V-III region WEA IGHG2IgH heavy chain V-III region VH26 precursor IGLV1-40Ig kappa chain V-III region HAH Ig kappa chain V-I region Wes Ig kappa chain V-I region Roy PIACTG1Ig kappa chain V-II region GM607 Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-I region EPS WIPF3 IGLC3ATP Active RAC1/CDC42Ig lambda chain V-V region DEL Ig lambda chain V-VI region WLT Ig kappa chain V-II region TEW IGLC2Ig heavy chain V-III region JON Ig heavy chain V-III region BUT Ig kappa chain V-I region Rei IGLC1IGLV4-60Ig lambda chain V-II region WIN IGLV3-25Ig kappa chain V-IV region Len IGLV5-45Ig kappa chain V-I region Roy Ig kappa chain V-I region BAN Ig lambda chain V-III region SH IGLV3-27Ig kappa chain V-I region DEE DOCK1 Ig heavy chain V-II region WAH Ig heavy chain V-I region HG3 Ig heavy chain V-III region DOB ITPR2 IGLV1-40Ig kappa chain V-I region WEA Ig kappa chain V-I region WAT Ig lambda chain V-VII region MOT Ig heavy chain V-I region Mot IGLV3-16Ig heavy chain V-II region ARH-77 ACTG1ARPC5 Ig lambda chain V-IV region Bau p-Y288,Y304-FCGR2A IgH heavy chain V-III region VH26 precursor ADP IGLV2-23Ig kappa chain V-I region Gal Ig heavy chain V-II region NEWM Ig lambda chain V-I region NEWM 2-LysophosphatidylcholineIg kappa chain V-II region MIL IGLV4-60Ig heavy chain V-III region KOL Ig heavy chain V-III region TUR Ig lambda chain V-II region TOG Ig lambda chain V-I region BL2 Ig kappa chain V-II region Cum Ig heavy chain V-II region ARH-77 IGHG2IGLV1-44Ig heavy chain V-II region COR Ig lambda chain V-IV region MOL Ig lambda chain V-VI region WLT IGLV1-44Ig heavy chain V-III region CAM Ig heavy chain V-III region LAY Ig heavy chain V-III region WAS Ig lambda chain V-VI region WLT IGKV1-5IGLC1Ig kappa chain V-I region Scw Ig kappa chain V-I region WEA Ig kappa chain V-I region Hau Ig kappa chain V-II region FR FCGR1A Ig kappa chain V-I region Kue Ig kappa chain V-III region HIC Ig heavy chain V-II region MCE IGLV8-61IGLV3-12IGHG1Ig lambda chain V-VI region SUT Ig heavy chain V-III region TUR IGLV5-37IGLC6Ig heavy chain V-III region GA Ig kappa chain V-III region HIC Ig heavy chain V-III region POM IGLV5-45Ig kappa chain V-I region OU Ig heavy chain V-I region EU Ig kappa chain V-III region B6 Ig heavy chain V-I region SIE IGLV2-23Ig lambda chain V-IV region Hil Ig heavy chain V-III region GA Ig heavy chain V-I region SIE Ig lambda chain V-II region BOH BRK1Ig kappa chain V-I region Daudi BAIAP2 IGLV11-55Ig kappa chain V-I region Daudi Ig heavy chain V-I region ND Ig kappa chain V-I region Lay Ig heavy chain V-III region TEI IGLV5-45Ig kappa chain V-I region Ni SYKIg kappa chain V-I region Bi Ig lambda chain V-V region DEL Ig lambda chain V-II region TRO IGLV10-54Ig kappa chain V region EV15 IGLV4-60Ig lambda chain V-VI region EB4 Ig lambda chain V-II region MGC ATP IGLV2-23Ig heavy chain V-III region HIL IGLV3-16IGLV1-36Ig heavy chain V-I region EU Ig lambda chain V-I region EPS Ig lambda chain V region 4A Ig heavy chain V-II region HE Ig lambda chain V-IV region Kern Ig heavy chain V-II region OU IGLV1-40Ig heavy chain V-III region BRO Ig lambda chain V-IV region MOL Ig kappa chain V-IV region B17 IGLV1-40Ig kappa chain V-I region Scw p-Y288,Y304-FCGR2A Ig kappa chain V-I region AU GRB2-1 RAC1 Ig lambda chain V-IV region Bau IGLV2-11Ig lambda chain V-I region NIG-64 Ig kappa chain V-I region WAT Ig kappa chain V-III region WOL Ig kappa chain V-I region Bi IGKVA18Ig lambda chain V-I region WAH IGLC3WIPF2 IGLV7-46p-6Y-CD247-1 Ig kappa chain V-I region Walker IGKV4-1IGLV11-55IGLV2-18IGLV1-44Ig kappa chain V-IV region B17 Ig lambda chain V-II region TOG ADPIg lambda chain V-I region MEM Ig kappa chain V-I region Kue Ig heavy chain V-III region JON Ig lambda chain V-II region NEI Ig kappa chain V-I region Hau Ig lambda chain V-I region MEM Ig kappa chain V-II region Cum IGLV1-40Ig heavy chain V-II region MCE IGLV5-37Ig lambda chain V-I region WAH WIP family proteinsIgG-AgFCGRIIAIg lambda chain V-II region NIG-58 RAC1 Ig lambda chain V-II region BUR Ig lambda chain V-II region WIN Ig heavy chain V-III region TIL Ig lambda chain V-I region VOR Ig lambda chain V-IV region Hil IGLV4-3Ig lambda chain V-I region HA Ig kappa chain V-I region Scw ADPIg lambda chain V-I region WAH Ig kappa chain V-I region Lay IGLV7-46IGKV1-5IGLV2-18Ig lambda chain V-IV region Hil Ig heavy chain V-II region HE PIFCGR1A Ig lambda chain V-V region DEL IGLC1Ig kappa chain V-IV region B17 Ig lambda chain V-VI region NIG-48 Ig lambda chain V-I region WAH IGLV7-43Ig lambda chain V-II region NEI IGLV3-12Ig lambda chain V-I region HA IgH heavy chain V-III region VH26 precursor Ig kappa chain V-I region AG Ig heavy chain V-II region WAH IGLV3-12Ig heavy chain V-III region HIL Ig heavy chain V-III region HIL p-6Y-CD247-1 Ig kappa chain V-IV region B17 Ig lambda chain V-VI region AR WIPF3 IGHG3 Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-I region AG IGKVA18Ig heavy chain V-III region HIL Ig heavy chain V-III region JON p-Y256-WASL IGLV4-69IGLC7Ig kappa chain V-IV region B17 Ig lambda chain V-VI region AR Ig lambda chain V-I region WAH p-6Y-SYK IGHG3 Ig heavy chain V-II region WAH Ig heavy chain V-III region BRO Ig heavy chain V-I region ND Ig kappa chain V-II region Cum IGLV7-43Ig kappa chain V-I region HK101 IGHV7-81Ig kappa chain V-III region SIE IGLV4-69Ig lambda chain V-VI region SUT Ig kappa chain V-I region Bi NCKAP1 Ig lambda chain V-I region VOR Ig kappa chain V-I region Kue IGLV3-27Mother filamentARP2/3actinGDPIg heavy chain V-III region TIL Ca2+Ig lambda chain V-VI region WLT Ig kappa chain V-I region AU p-S3-CFL1 IGHG4Ig lambda chain V-II region NIG-58 Ig lambda chain V-II region NEI IGLC6Ig kappa chain V-I region Kue PIIg lambda chain V-I region HA Ig heavy chain V-III region DOB clustered IgG-Agp-FCGRsIg heavy chain V-III region CAM ARPC4 Ig kappa chain V-IV region B17 IGLV1-36Ig lambda chain V-VI region SUT Ig lambda chain V-VI region NIG-48 Ig lambda chain V-IV region Bau IGKCIg kappa chain V-III region POM Ig kappa chain V-I region EU NCK1 Ig kappa chain V-III region VG ACTG1IGLV10-54Ig kappa chain V-II region RPMI 6410 IGHG2Ig lambda chain V-I region NEWM clustered IgG-Agp-FCGRsp-6Y-SYKPLCGIg lambda chain V-I region NEWM Ig lambda chain V-II region TRO Ig heavy chain V-II region DAW Ig kappa chain V-I region Walker Ig heavy chain V-II region DAW IGLV3-27Ig heavy chain V-II region MCE Ig kappa chain V-I region Wes FCGR3A CDC42 ACTG1Ig kappa chain V-I region Roy IGLV1-44Ig heavy chain V-III region WEA Ig heavy chain V-II region MCE ACTR2 CD3G IGLV2-23IGHG3 IGLV4-69Ig heavy chain V-II region HE Ig lambda chain V-IV region X Ig kappa chain V region EV15 IGLV2-18Ig kappa chain V-I region Rei Ig heavy chain V-III region HIL Ig heavy chain V-III region BUT Ig lambda chain V-II region NIG-84 ARPC5 Ig kappa chain V-I region WAT ATPIg lambda chain V-I region EPS Ig kappa chain V-I region Bi Ig heavy chain V-II region MCE Ig lambda chain V-II region MGC Ig lambda chain V-II region BO IGKCIg heavy chain V-III region WAS PLCG2 IGLV11-55Ig kappa chain V-I region Ka WASL Ig heavy chain V-II region DAW Ig kappa chain V-I region Wes Ig kappa chain V-I region HK101 IGLV2-23NCKIPSD Ig kappa chain V-III region GOL Ig lambda chain V-III region SH Ig kappa chain V-I region BAN Ig kappa chain V-III region SIE Ig lambda chain V-I region BL2 Ig lambda chain V-II region VIL IGLV4-3BAIAP2 Ig lambda chain V-VI region SUT Ig kappa chain V-I region AU IGLV2-33Ig heavy chain V-II region MCE IGLC7Ig lambda chain V-I region NEWM Ig kappa chain V-IV region JI Ig heavy chain V-II region NEWM Ig lambda chain V region 4A IGHG2Ig lambda chain V-II region NIG-84 Ig lambda chain V-I region EPS Ig heavy chain V-III region CAM Ig kappa chain V-III region IARC/BL41 IGLV3-25Ig kappa chain V-II region MIL Ig kappa chain V-III region WOL p-6Y-CD247-1 Ig kappa chain V-I region Walker Ig kappa chain V-I region Kue CDC42 Ig kappa chain V-I region DEE IgH heavy chain V-III region VH26 precursor Ig heavy chain V-III region BUR Ig heavy chain V-III region DOB Ig heavy chain V-III region CAM Ig kappa chain V-III region SIE Ig kappa chain V-III region VG WIPF3 IgG-AgFCGRIIIACD3G/CD3Z dimersIGLV2-11Ig kappa chain V-I region Roy PhosphatidylcholineIg lambda chain V-II region BOH Ig heavy chain V-II region DAW Ig kappa chain V-I region Daudi Ig kappa chain V-II region RPMI 6410 NCKAP1 Ig heavy chain V-II region NEWM Ig heavy chain V-I region EU IgH heavy chain V-III region VH26 precursor Ig kappa chain V-III region HIC Ig lambda chain V-III region LOI Ig kappa chain V-I region EU Ig lambda chain V-II region BUR IGLV3-25Ig kappa chain V-I region Scw WIPF2 Ig kappa chain V-I region WAT GTP Ig kappa chain V-III region WOL IGKV1-5Ig lambda chain V-V region DEL Ig lambda chain V-II region TRO IGLV4-60Ig kappa chain V-III region VG Ig kappa chain V-II region FR RAC1 Ig heavy chain V-II region ARH-77 Ig lambda chain V-II region NIG-84 IGHG3 IGLV1-36ATP Ig heavy chain V-III region CAM Ig kappa chain V-II region Cum IGKCIg kappa chain V-I region EU Ig heavy chain V-I region ND Ig kappa chain V-III region VH Ig lambda chain V-II region MGC Ig kappa chain V-I region AU Ig heavy chain V-III region POM Ig lambda chain V-I region WAH Ig heavy chain V-III region WEA WASL Ig lambda chain V-VI region NIG-48 ATPIg lambda chain V-I region MEM IGLC1Ig lambda chain V-II region NEI Ig kappa chain V-II region GM607 Ig kappa chain V-III region HIC ARP2/3 complex Ig heavy chain V-II region COR Ig heavy chain V-III region TIL Ig lambda chain V-IV region Kern Ig kappa chain V-I region CAR Ig kappa chain V-IV region B17 Ig lambda chain V-II region NIG-84 IGHG2IGKVA18PAK1 dimerIg kappa chain V-III region VH Ig lambda chain V-I region EPS Ig heavy chain V-III region GAL Ig lambda chain V-VI region NIG-48 Ig lambda chain V-I region NEWM Ig kappa chain V-III region NG9 FCGR1A ARPC3 Ig lambda chain V-V region DEL IGLV3-25Ig lambda chain V-I region NIG-64 Ig kappa chain V-III region HIC PCIg heavy chain V-II region ARH-77 Ig lambda chain V-IV region Kern PKC-delta/epsilonIg lambda chain V-VI region AR IGHG3 Ig kappa chain V-I region Wes Ig lambda chain V-IV region MOL Ig heavy chain V-III region WAS Ig kappa chain V-III region Ti FCGR1A Ig lambda chain V-II region VIL p-4Y-PLCG1BRK1Ig lambda chain V-II region WIN Ig heavy chain V-II region OU Ig heavy chain V-III region BUR Ig kappa chain V-I region Roy Ig lambda chain V-III region SH Ig lambda chain V-IV region MOL PIIg heavy chain V-I region Mot IGLV3-22Ig kappa chain V-III region Ti Actin filament bound Myosin-XIg heavy chain V-I region EU IGLV1-44cholineIGLC7Ig lambda chain V-VI region AR Ig kappa chain V-I region WAT Ig heavy chain V-II region HE Ig heavy chain V-III region KOL Ig lambda chain V-I region NEW IGLV5-45Ig lambda chain V-I region BL2 Ig heavy chain V-II region COR IGHG4Ig kappa chain V-I region Rei Ig kappa chain V-III region CLL Ig lambda chain V-IV region MOL Ig heavy chain V-III region DOB Ig kappa chain V-I region WEA IGLV1-36IGLV3-16Ig lambda chain V-I region NEW Ig lambda chain V-IV region Hil CDC42-GTPWASP/N-WASPWIPSH3 proteinsIg lambda chain V-I region NEW GDPIGLV5-45Ig heavy chain V-III region LAY Ig kappa chain V-IV region Len IGLV7-43Ig lambda chain V-I region MEM RAC1 WIPF3 Ig lambda chain V-I region WAH IGLV5-37Ig lambda chain V-VI region WLT Ig lambda chain V-II region NIG-84 IGLC6Ig heavy chain V-III region LAY Ig kappa chain V-I region Roy ARPC1A WASP/N-WASPIg heavy chain V-I region WOL FCGR1A Ig kappa chain V-IV region Len Ig kappa chain V-I region Gal Ig lambda chain V-II region NIG-58 Ig lambda chain V-V region DEL IGLV5-37IGLV4-60IGLV7-46Ig kappa chain V-II region MIL ARPC3 Ig heavy chain V-III region KOL IgH heavy chain V-III region VH26 precursor Ig lambda chain V-II region MGC IGHVIg kappa chain V-II region GM607 p-Y256-WASL Ig lambda chain V-II region VIL Ig kappa chain V-IV region STH Ig heavy chain V-III region TIL ATPIg kappa chain V-I region Gal Ig lambda chain V-II region MGC Ig lambda chain V-II region TOG Ig kappa chain V-I region Roy Ig kappa chain V-I region BAN Ig lambda chain V-I region EPS Ig lambda chain V-VI region EB4 ATPIg heavy chain V-II region ARH-77 Ig heavy chain V-III region TEI Ig kappa chain V-III region SIE Ig kappa chain V-I region EU IGLV1-36Ig kappa chain V-I region BAN Ig heavy chain V-III region DOB Ig kappa chain V-III region B6 Ig kappa chain V-II region TEW IGLV7-46Ig lambda chain V-IV region X p-Y288,Y304-FCGR2A ARPC1A IGLV1-36IGLC2p-6Y-CD247-1 Ig heavy chain V-III region LAY CD3G Ig heavy chain V-III region BRO Ig kappa chain V-II region MIL Ig lambda chain V-II region BUR Ig kappa chain V-I region Walker Ig heavy chain V-II region COR IGLV2-23CRKDOCK180ELMOIg kappa chain V-II region MIL IGHV7-81Ig kappa chain V-I region Bi Ig kappa chain V-I region BAN Ig lambda chain V-IV region X Ig lambda chain V-I region VOR Ig kappa chain V-IV region B17 p-Y288,Y304-FCGR2A FCGR3A IGHG1p-6Y-CD247-1 Ig kappa chain V-III region Ti GTP Ig lambda chain V-III region LOI Ig lambda chain V-VI region AR Ig heavy chain V-II region WAH PIK3CB Ig lambda chain V-I region HA Ig kappa chain V-II region MIL GTP Ig heavy chain V-III region LAY Ig heavy chain V-III region CAM GDP Ig heavy chain V-III region TUR Ig heavy chain V-III region WAS WIPF2 Ig lambda chain V-III region LOI Ig heavy chain V-II region HE Ig heavy chain V-III region BRO Ig heavy chain V-III region ZAP Ig heavy chain V-III region BRO Ig lambda chain V-III region SH IGLV1-40IGLV3-27Ig heavy chain V-I region Mot Ig lambda chain V-II region BUR IGHV7-81WIPF3 Ig kappa chain V-II region Cum Ig lambda chain V-I region NEWM Ig heavy chain V-II region DAW Ig kappa chain V-II region TEW WIPF1 Ig lambda chain V-II region TRO Ig heavy chain V-I region WOL IGLV2-23ARPC5 Ig lambda chain V-I region NIG-64 Ig heavy chain V-III region NIE Ig lambda chain V-II region NEI Ig lambda chain V-VI region EB4 Ig kappa chain V-I region WAT Ig kappa chain V-I region CAR ATPIGHG2Ig lambda chain V-II region WIN Ig heavy chain V-II region NEWM Ig heavy chain V-III region JON Ig heavy chain V-II region WAH Ig heavy chain V-III region ZAP IGLV2-33Ig kappa chain V-III region POM IGLV3-25Ig lambda chain V-IV region MOL IGHVIg kappa chain V-I region Lay Ig kappa chain V-I region Lay Ig heavy chain V-II region DAW Ig kappa chain V-I region AU IGKV4-1Ig kappa chain V-I region Walker Ig kappa chain V-I region Scw 696814, 68


Description

Phagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phagocytosis is a complex process involving the recognition of invading foreign particles by specific types of phagocytic receptors and the subsequent internalization of the particles. Fc gamma receptors (FCGRs) are among the best studied phagocytic receptors that bind to Fc portion of immunoglobulin G (IgG). Through their antigen binding F(ab) end, antibodies bind to specific antigen while their constant (Fc) region binds to FCGRs on phagocytes. The clustering of FCGRs by IgG antibodies on the phagocyte initiates a variety of signals, which lead, through the reorganisation of actin cytoskeleton and membrane remodelling, to the formation of pseudopod and phagosome. Fc gamma receptors are classified into three classes: FCGRI, FCGRII and FCGRIII. Each class of these FCGRs consists of several individual isoforms. Among all these isoforms FCGRI, FCGRIIA and FCGRIIIA, are able to mediate phagocytosis (Joshi et al. 2006, Garcia Garcia & Rosales 2002, Nimmerjahn & Ravetch 2006). Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=2029480

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  48. Knaus UG, Wang Y, Reilly AM, Warnock D, Jackson JH.; ''Structural requirements for PAK activation by Rac GTPases.''; PubMed Europe PMC Scholia
  49. Bernard O.; ''Lim kinases, regulators of actin dynamics.''; PubMed Europe PMC Scholia
  50. Marshall JG, Booth JW, Stambolic V, Mak T, Balla T, Schreiber AD, Meyer T, Grinstein S.; ''Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis.''; PubMed Europe PMC Scholia
  51. Indik ZK, Park JG, Hunter S, Schreiber AD.; ''The molecular dissection of Fc gamma receptor mediated phagocytosis.''; PubMed Europe PMC Scholia
  52. Huang MM, Indik Z, Brass LF, Hoxie JA, Schreiber AD, Brugge JS.; ''Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII.''; PubMed Europe PMC Scholia
  53. Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW.; ''The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.''; PubMed Europe PMC Scholia
  54. Bompard G, Caron E.; ''Regulation of WASP/WAVE proteins: making a long story short.''; PubMed Europe PMC Scholia
  55. Iyer SS, Barton JA, Bourgoin S, Kusner DJ.; ''Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis.''; PubMed Europe PMC Scholia
  56. Lee WL, Cosio G, Ireton K, Grinstein S.; ''Role of CrkII in Fcgamma receptor-mediated phagocytosis.''; PubMed Europe PMC Scholia
  57. Tay HK, Melendez AJ.; ''Fcgamma RI-triggered generation of arachidonic acid and eicosanoids requires iPLA2 but not cPLA2 in human monocytic cells.''; PubMed Europe PMC Scholia
  58. Rohatgi R, Nollau P, Ho HY, Kirschner MW, Mayer BJ.; ''Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway.''; PubMed Europe PMC Scholia
  59. Li R, Soosairajah J, Harari D, Citri A, Price J, Ng HL, Morton CJ, Parker MW, Yarden Y, Bernard O.; ''Hsp90 increases LIM kinase activity by promoting its homo-dimerization.''; PubMed Europe PMC Scholia
  60. Miki H, Suetsugu S, Takenawa T.; ''WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac.''; PubMed Europe PMC Scholia
  61. Chong C, Tan L, Lim L, Manser E.; ''The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.''; PubMed Europe PMC Scholia
  62. Nakanishi O, Suetsugu S, Yamazaki D, Takenawa T.; ''Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex.''; PubMed Europe PMC Scholia
  63. Corrotte M, Chasserot-Golaz S, Huang P, Du G, Ktistakis NT, Frohman MA, Vitale N, Bader MF, Grant NJ.; ''Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis.''; PubMed Europe PMC Scholia
  64. Mitchell MA, Huang MM, Chien P, Indik ZK, Pan XQ, Schreiber AD.; ''Substitutions and deletions in the cytoplasmic domain of the phagocytic receptor Fc gamma RIIA: effect on receptor tyrosine phosphorylation and phagocytosis.''; PubMed Europe PMC Scholia
  65. Le Clainche C, Pantaloni D, Carlier MF.; ''ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays.''; PubMed Europe PMC Scholia
  66. Deckert M, Tartare-Deckert S, Couture C, Mustelin T, Altman A.; ''Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product.''; PubMed Europe PMC Scholia
  67. Massol P, Montcourrier P, Guillemot JC, Chavrier P.; ''Fc receptor-mediated phagocytosis requires CDC42 and Rac1.''; PubMed Europe PMC Scholia
  68. Xu X, Chong AS.; ''Vav in natural killer cells is tyrosine phosphorylated upon cross-linking of Fc gamma RIIIA and is constitutively associated with a serine/threonine kinase.''; PubMed Europe PMC Scholia
  69. Scott CC, Dobson W, Botelho RJ, Coady-Osberg N, Chavrier P, Knecht DA, Heath C, Stahl P, Grinstein S.; ''Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis.''; PubMed Europe PMC Scholia
  70. Park H, Cox D.; ''Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP.''; PubMed Europe PMC Scholia
  71. Mullins RD, Heuser JA, Pollard TD.; ''The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments.''; PubMed Europe PMC Scholia
  72. Kiener PA, Rankin BM, Burkhardt AL, Schieven GL, Gilliland LK, Rowley RB, Bolen JB, Ledbetter JA.; ''Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.''; PubMed Europe PMC Scholia
  73. Chavrier P.; ''May the force be with you: Myosin-X in phagocytosis.''; PubMed Europe PMC Scholia
  74. Hall AB, Gakidis MA, Glogauer M, Wilsbacher JL, Gao S, Swat W, Brugge JS.; ''Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.''; PubMed Europe PMC Scholia
  75. Moon KD, Post CB, Durden DL, Zhou Q, De P, Harrison ML, Geahlen RL.; ''Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase.''; PubMed Europe PMC Scholia
  76. Wang QJ.; ''PKD at the crossroads of DAG and PKC signaling.''; PubMed Europe PMC Scholia
  77. Amann KJ, Pollard TD.; ''The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments.''; PubMed Europe PMC Scholia
  78. Nimmerjahn F, Ravetch JV.; ''Fcgamma receptors: old friends and new family members.''; PubMed Europe PMC Scholia
  79. Agarwal A, Salem P, Robbins KC.; ''Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling.''; PubMed Europe PMC Scholia
  80. Kim YJ, Sekiya F, Poulin B, Bae YS, Rhee SG.; ''Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.''; PubMed Europe PMC Scholia
  81. Millard TH, Sharp SJ, Machesky LM.; ''Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex.''; PubMed Europe PMC Scholia
  82. Le Clainche C, Carlier MF.; ''Regulation of actin assembly associated with protrusion and adhesion in cell migration.''; PubMed Europe PMC Scholia
  83. Ernst LK, Duchemin AM, Anderson CL.; ''Association of the high-affinity receptor for IgG (Fc gamma RI) with the gamma subunit of the IgE receptor.''; PubMed Europe PMC Scholia
  84. Tsang E, Giannetti AM, Shaw D, Dinh M, Tse JK, Gandhi S, Ho H, Wang S, Papp E, Bradshaw JM.; ''Molecular mechanism of the Syk activation switch.''; PubMed Europe PMC Scholia
  85. Swanson JA, Johnson MT, Beningo K, Post P, Mooseker M, Araki N.; ''A contractile activity that closes phagosomes in macrophages.''; PubMed Europe PMC Scholia
  86. Takeuchi M, Harigai M, Momohara S, Ball E, Abe J, Furuichi K, Kamatani N.; ''Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase.''; PubMed Europe PMC Scholia
  87. Sekiya F, Poulin B, Kim YJ, Rhee SG.; ''Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation.''; PubMed Europe PMC Scholia
  88. Zalevsky J, Lempert L, Kranitz H, Mullins RD.; ''Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities.''; PubMed Europe PMC Scholia
  89. Brooks DG, Qiu WQ, Luster AD, Ravetch JV.; ''Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.''; PubMed Europe PMC Scholia
  90. Strzelecka A, Kwiatkowska K, Sobota A.; ''Tyrosine phosphorylation and Fcgamma receptor-mediated phagocytosis.''; PubMed Europe PMC Scholia
  91. Ghazizadeh S, Bolen JB, Fleit HB.; ''Tyrosine phosphorylation and association of Syk with Fc gamma RII in monocytic THP-1 cells.''; PubMed Europe PMC Scholia
  92. Cory GO, Garg R, Cramer R, Ridley AJ.; ''Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.''; PubMed Europe PMC Scholia
  93. van Vugt MJ, Heijnen IA, Capel PJ, Park SY, Ra C, Saito T, Verbeek JS, van de Winkel JG.; ''FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118475view20:32, 27 May 2021FinterlyRemoved incorrect and duplicated openControlledVocabulary PW:0000234
114947view16:47, 25 January 2021ReactomeTeamReactome version 75
113391view11:46, 2 November 2020ReactomeTeamReactome version 74
112853view13:31, 12 October 2020DeSlFixing ontology tag error
112849view13:02, 12 October 2020DeSlOntology Term : 'innate immune response pathway' added !
112596view15:57, 9 October 2020ReactomeTeamReactome version 73
101512view11:37, 1 November 2018ReactomeTeamreactome version 66
101048view21:19, 31 October 2018ReactomeTeamreactome version 65
100579view19:52, 31 October 2018ReactomeTeamreactome version 64
100128view16:38, 31 October 2018ReactomeTeamreactome version 63
99678view15:07, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99271view12:45, 31 October 2018ReactomeTeamreactome version 62
94053view13:54, 16 August 2017ReactomeTeamreactome version 61
93681view11:30, 9 August 2017ReactomeTeamreactome version 61
89466view13:21, 15 September 2016Mkutmonfix ontology tag annotation
87448view13:50, 22 July 2016MkutmonOntology Term : 'PW:0000234' added !
86805view09:26, 11 July 2016ReactomeTeamreactome version 56
83122view10:02, 18 November 2015ReactomeTeamVersion54
81461view12:59, 21 August 2015ReactomeTeamVersion53
76936view08:20, 17 July 2014ReactomeTeamFixed remaining interactions
76641view12:01, 16 July 2014ReactomeTeamFixed remaining interactions
75971view10:02, 11 June 2014ReactomeTeamRe-fixing comment source
75674view10:59, 10 June 2014ReactomeTeamReactome 48 Update
75029view13:54, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74673view08:44, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-LysophosphatidylcholineMetaboliteCHEBI:17504 (ChEBI)
ABL1ProteinP00519 (Uniprot-TrEMBL)
ACTBProteinP60709 (Uniprot-TrEMBL)
ACTG1ProteinP63261 (Uniprot-TrEMBL)
ACTR2 ProteinP61160 (Uniprot-TrEMBL)
ACTR3 ProteinP61158 (Uniprot-TrEMBL)
ADP MetaboliteCHEBI:16761 (ChEBI)
ADPMetaboliteCHEBI:16761 (ChEBI)
ARP2/3 complex ComplexREACT_160979 (Reactome)
ARPC1A ProteinQ92747 (Uniprot-TrEMBL)
ARPC2 ProteinO15144 (Uniprot-TrEMBL)
ARPC3 ProteinO15145 (Uniprot-TrEMBL)
ARPC4 ProteinP59998 (Uniprot-TrEMBL)
ARPC5 ProteinO15511 (Uniprot-TrEMBL)
ATP MetaboliteCHEBI:15422 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Actin ADPComplexREACT_148188 (Reactome)
Actin filament bound Myosin-XComplexREACT_161386 (Reactome)
Activated WAVE2 and WASP/N-WASP

ARP2/3 complex

G-actin		ComplexREACT_160776 (Reactome)
Activated WAVE2 and WASP/N-WASPComplexREACT_160331 (Reactome)
Active LIMK1ComplexREACT_19790 (Reactome)
Active RAC1/CDC42ComplexREACT_20094 (Reactome)
Antigen-antibody complexComplexREACT_8124 (Reactome)
Arachidonic acidMetaboliteCHEBI:15843 (ChEBI)
BAIAP2 ProteinQ9UQB8 (Uniprot-TrEMBL)
BAIAP2ProteinQ9UQB8 (Uniprot-TrEMBL)
BRK1ProteinQ8WUW1 (Uniprot-TrEMBL)
CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
CD3G ProteinP09693 (Uniprot-TrEMBL)
CDC42 GTPComplexREACT_12889 (Reactome)
CDC42 ProteinP60953 (Uniprot-TrEMBL)
CDC42-GDPComplexREACT_20401 (Reactome)
CDC42-GTP

WASP/N-WASP WIP

SH3 proteins		ComplexREACT_160812 (Reactome)
CDC42-GTP WASP/N-WASPComplexREACT_160830 (Reactome)
CDC42-GTP

p-WASP/p-N-WASP WIP

SH3 proteins		ComplexREACT_161223 (Reactome)
CFL1ProteinP23528 (Uniprot-TrEMBL)
CRK

DOCK180

ELMO		ComplexREACT_160373 (Reactome)
CRKII

DOCK180

ELMO complex recruited to phagocytic cup		ComplexREACT_161310 (Reactome)
CRKProteinP46108 (Uniprot-TrEMBL)
CYFIP2 ProteinQ96F07 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
DAGsMetaboliteCHEBI:18035 (ChEBI)
DOCK1 ProteinQ14185 (Uniprot-TrEMBL)
ELMO1 ProteinQ92556 (Uniprot-TrEMBL)
ELMO2 ProteinQ96JJ3 (Uniprot-TrEMBL)
ERKProteinREACT_24485 (Reactome)
F-actinREACT_20433 (Reactome)
FCGR1A ProteinP12314 (Uniprot-TrEMBL)
FCGR2A ProteinP12318 (Uniprot-TrEMBL)
FCGR2AProteinP12318 (Uniprot-TrEMBL)
FCGR3A ProteinP08637 (Uniprot-TrEMBL)
FCGRIA CD3G homodimerComplexREACT_161114 (Reactome)
FCGRIIIA CD3G/CD3Z dimersComplexREACT_161118 (Reactome)
G-actinComplexREACT_19528 (Reactome)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2-1 ProteinP62993-1 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HSP-90REACT_19960 (Reactome)
HSP90AA1 ProteinP07900 (Uniprot-TrEMBL)
HSP90AB1 ProteinP08238 (Uniprot-TrEMBL)
IMetaboliteCHEBI:16595 (ChEBI)
IGHG1ProteinP01857 (Uniprot-TrEMBL)
IGHG2ProteinP01859 (Uniprot-TrEMBL)
IGHG3 ProteinP01860 (Uniprot-TrEMBL)
IGHG4ProteinP01861 (Uniprot-TrEMBL)
IGHV7-81ProteinQ6PIL0 (Uniprot-TrEMBL)
IGHVProteinA2KUC3 (Uniprot-TrEMBL)
IGKCProteinP01834 (Uniprot-TrEMBL)
IGKV1-5ProteinP01602 (Uniprot-TrEMBL)
IGKV4-1ProteinP06312 (Uniprot-TrEMBL)
IGKVA18ProteinA2NJV5 (Uniprot-TrEMBL)
IGLC1ProteinP0CG04 (Uniprot-TrEMBL)
IGLC2ProteinP0CG05 (Uniprot-TrEMBL)
IGLC3ProteinP0CG06 (Uniprot-TrEMBL)
IGLC6ProteinP0CF74 (Uniprot-TrEMBL)
IGLC7ProteinA0M8Q6 (Uniprot-TrEMBL)
IGLV1-36ProteinQ5NV67 (Uniprot-TrEMBL)
IGLV1-40ProteinQ5NV69 (Uniprot-TrEMBL)
IGLV1-44ProteinQ5NV81 (Uniprot-TrEMBL)
IGLV10-54ProteinQ5NV86 (Uniprot-TrEMBL)
IGLV11-55ProteinQ5NV87 (Uniprot-TrEMBL)
IGLV2-11ProteinQ5NV84 (Uniprot-TrEMBL)
IGLV2-18ProteinQ5NV65 (Uniprot-TrEMBL)
IGLV2-23ProteinQ5NV89 (Uniprot-TrEMBL)
IGLV2-33ProteinQ5NV66 (Uniprot-TrEMBL)
IGLV3-12ProteinQ5NV85 (Uniprot-TrEMBL)
IGLV3-16ProteinQ5NV64 (Uniprot-TrEMBL)
IGLV3-22ProteinQ5NV75 (Uniprot-TrEMBL)
IGLV3-25ProteinQ5NV90 (Uniprot-TrEMBL)
IGLV3-27ProteinQ5NV91 (Uniprot-TrEMBL)
IGLV4-3ProteinQ5NV61 (Uniprot-TrEMBL)
IGLV4-60ProteinQ5NV79 (Uniprot-TrEMBL)
IGLV4-69ProteinQ5NV92 (Uniprot-TrEMBL)
IGLV5-37ProteinQ5NV68 (Uniprot-TrEMBL)
IGLV5-45ProteinQ5NV82 (Uniprot-TrEMBL)
IGLV7-43ProteinQ5NV80 (Uniprot-TrEMBL)
IGLV7-46ProteinQ5NV83 (Uniprot-TrEMBL)
IGLV8-61ProteinQ5NV62 (Uniprot-TrEMBL)
IGLVProteinA2NXD2 (Uniprot-TrEMBL)
IP3 receptor IP3 complexComplexREACT_12249 (Reactome)
IP3 receptor homotetramerComplexREACT_12247 (Reactome)
ITPR1 ProteinQ14643 (Uniprot-TrEMBL)
ITPR2 ProteinQ14571 (Uniprot-TrEMBL)
ITPR3 ProteinQ14573 (Uniprot-TrEMBL)
Ig heavy chain V-I region EU ProteinP01742 (Uniprot-TrEMBL)
Ig heavy chain V-I region HG3 ProteinP01743 (Uniprot-TrEMBL)
Ig heavy chain V-I region Mot ProteinP06326 (Uniprot-TrEMBL)
Ig heavy chain V-I region ND ProteinP01744 (Uniprot-TrEMBL)
Ig heavy chain V-I region SIE ProteinP01761 (Uniprot-TrEMBL)
Ig heavy chain V-I region WOL ProteinP01760 (Uniprot-TrEMBL)
Ig heavy chain V-II region ARH-77 ProteinP06331 (Uniprot-TrEMBL)
Ig heavy chain V-II region COR ProteinP01815 (Uniprot-TrEMBL)
Ig heavy chain V-II region DAW ProteinP01816 (Uniprot-TrEMBL)
Ig heavy chain V-II region HE ProteinP01818 (Uniprot-TrEMBL)
Ig heavy chain V-II region MCE ProteinP01817 (Uniprot-TrEMBL)
Ig heavy chain V-II region NEWM ProteinP01825 (Uniprot-TrEMBL)
Ig heavy chain V-II region OU ProteinP01814 (Uniprot-TrEMBL)
Ig heavy chain V-II region SESS ProteinP04438 (Uniprot-TrEMBL)
Ig heavy chain V-II region WAH ProteinP01824 (Uniprot-TrEMBL)
Ig heavy chain V-III region BRO ProteinP01766 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUR ProteinP01773 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUT ProteinP01767 (Uniprot-TrEMBL)
Ig heavy chain V-III region CAM ProteinP01768 (Uniprot-TrEMBL)
Ig heavy chain V-III region DOB ProteinP01782 (Uniprot-TrEMBL)
Ig heavy chain V-III region GA ProteinP01769 (Uniprot-TrEMBL)
Ig heavy chain V-III region GAL ProteinP01781 (Uniprot-TrEMBL)
Ig heavy chain V-III region HIL ProteinP01771 (Uniprot-TrEMBL)
Ig heavy chain V-III region JON ProteinP01780 (Uniprot-TrEMBL)
Ig heavy chain V-III region KOL ProteinP01772 (Uniprot-TrEMBL)
Ig heavy chain V-III region LAY ProteinP01775 (Uniprot-TrEMBL)
Ig heavy chain V-III region NIE ProteinP01770 (Uniprot-TrEMBL)
Ig heavy chain V-III region POM ProteinP01774 (Uniprot-TrEMBL)
Ig heavy chain V-III region TEI ProteinP01777 (Uniprot-TrEMBL)
Ig heavy chain V-III region TIL ProteinP01765 (Uniprot-TrEMBL)
Ig heavy chain V-III region TRO ProteinP01762 (Uniprot-TrEMBL)
Ig heavy chain V-III region TUR ProteinP01779 (Uniprot-TrEMBL)
Ig heavy chain V-III region WAS ProteinP01776 (Uniprot-TrEMBL)
Ig heavy chain V-III region WEA ProteinP01763 (Uniprot-TrEMBL)
Ig heavy chain V-III region ZAP ProteinP01778 (Uniprot-TrEMBL)
Ig kappa chain V region EV15 ProteinP06315 (Uniprot-TrEMBL)
Ig kappa chain V-I region AG ProteinP01593 (Uniprot-TrEMBL)
Ig kappa chain V-I region AU ProteinP01594 (Uniprot-TrEMBL)
Ig kappa chain V-I region BAN ProteinP04430 (Uniprot-TrEMBL)
Ig kappa chain V-I region Bi ProteinP01595 (Uniprot-TrEMBL)
Ig kappa chain V-I region CAR ProteinP01596 (Uniprot-TrEMBL)
Ig kappa chain V-I region DEE ProteinP01597 (Uniprot-TrEMBL)
Ig kappa chain V-I region Daudi ProteinP04432 (Uniprot-TrEMBL)
Ig kappa chain V-I region EU ProteinP01598 (Uniprot-TrEMBL)
Ig kappa chain V-I region Gal ProteinP01599 (Uniprot-TrEMBL)
Ig kappa chain V-I region HK101 ProteinP01601 (Uniprot-TrEMBL)
Ig kappa chain V-I region Hau ProteinP01600 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ka ProteinP01603 (Uniprot-TrEMBL)
Ig kappa chain V-I region Kue ProteinP01604 (Uniprot-TrEMBL)
Ig kappa chain V-I region Lay ProteinP01605 (Uniprot-TrEMBL)
Ig kappa chain V-I region Mev ProteinP01612 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ni ProteinP01613 (Uniprot-TrEMBL)
Ig kappa chain V-I region OU ProteinP01606 (Uniprot-TrEMBL)
Ig kappa chain V-I region Rei ProteinP01607 (Uniprot-TrEMBL)
Ig kappa chain V-I region Roy ProteinP01608 (Uniprot-TrEMBL)
Ig kappa chain V-I region Scw ProteinP01609 (Uniprot-TrEMBL)
Ig kappa chain V-I region WAT ProteinP80362 (Uniprot-TrEMBL)
Ig kappa chain V-I region WEA ProteinP01610 (Uniprot-TrEMBL)
Ig kappa chain V-I region Walker ProteinP04431 (Uniprot-TrEMBL)
Ig kappa chain V-I region Wes ProteinP01611 (Uniprot-TrEMBL)
Ig kappa chain V-II region Cum ProteinP01614 (Uniprot-TrEMBL)
Ig kappa chain V-II region FR ProteinP01615 (Uniprot-TrEMBL)
Ig kappa chain V-II region GM607 ProteinP06309 (Uniprot-TrEMBL)
Ig kappa chain V-II region MIL ProteinP01616 (Uniprot-TrEMBL)
Ig kappa chain V-II region RPMI 6410 ProteinP06310 (Uniprot-TrEMBL)
Ig kappa chain V-II region TEW ProteinP01617 (Uniprot-TrEMBL)
Ig kappa chain V-III region B6 ProteinP01619 (Uniprot-TrEMBL)
Ig kappa chain V-III region CLL ProteinP04207 (Uniprot-TrEMBL)
Ig kappa chain V-III region GOL ProteinP04206 (Uniprot-TrEMBL)
Ig kappa chain V-III region HAH ProteinP18135 (Uniprot-TrEMBL)
Ig kappa chain V-III region HIC ProteinP18136 (Uniprot-TrEMBL)
Ig kappa chain V-III region IARC/BL41 ProteinP06311 (Uniprot-TrEMBL)
Ig kappa chain V-III region NG9 ProteinP01621 (Uniprot-TrEMBL)
Ig kappa chain V-III region POM ProteinP01624 (Uniprot-TrEMBL)
Ig kappa chain V-III region SIE ProteinP01620 (Uniprot-TrEMBL)
Ig kappa chain V-III region Ti ProteinP01622 (Uniprot-TrEMBL)
Ig kappa chain V-III region VG ProteinP04433 (Uniprot-TrEMBL)
Ig kappa chain V-III region VH ProteinP04434 (Uniprot-TrEMBL)
Ig kappa chain V-III region WOL ProteinP01623 (Uniprot-TrEMBL)
Ig kappa chain V-IV region B17 ProteinP06314 (Uniprot-TrEMBL)
Ig kappa chain V-IV region JI ProteinP06313 (Uniprot-TrEMBL)
Ig kappa chain V-IV region Len ProteinP01625 (Uniprot-TrEMBL)
Ig kappa chain V-IV region STH ProteinP83593 (Uniprot-TrEMBL)
Ig lambda chain V region 4A ProteinP04211 (Uniprot-TrEMBL)
Ig lambda chain V-I region BL2 ProteinP06316 (Uniprot-TrEMBL)
Ig lambda chain V-I region EPS ProteinP06888 (Uniprot-TrEMBL)
Ig lambda chain V-I region HA ProteinP01700 (Uniprot-TrEMBL)
Ig lambda chain V-I region MEM ProteinP06887 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEW ProteinP01701 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEWM ProteinP01703 (Uniprot-TrEMBL)
Ig lambda chain V-I region NIG-64 ProteinP01702 (Uniprot-TrEMBL)
Ig lambda chain V-I region VOR ProteinP01699 (Uniprot-TrEMBL)
Ig lambda chain V-I region WAH ProteinP04208 (Uniprot-TrEMBL)
Ig lambda chain V-II region BO ProteinP01710 (Uniprot-TrEMBL)
Ig lambda chain V-II region BOH ProteinP01706 (Uniprot-TrEMBL)
Ig lambda chain V-II region BUR ProteinP01708 (Uniprot-TrEMBL)
Ig lambda chain V-II region MGC ProteinP01709 (Uniprot-TrEMBL)
Ig lambda chain V-II region NEI ProteinP01705 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-58 ProteinP01713 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-84 ProteinP04209 (Uniprot-TrEMBL)
Ig lambda chain V-II region TOG ProteinP01704 (Uniprot-TrEMBL)
Ig lambda chain V-II region TRO ProteinP01707 (Uniprot-TrEMBL)
Ig lambda chain V-II region VIL ProteinP01711 (Uniprot-TrEMBL)
Ig lambda chain V-II region WIN ProteinP01712 (Uniprot-TrEMBL)
Ig lambda chain V-III region LOI ProteinP80748 (Uniprot-TrEMBL)
Ig lambda chain V-III region SH ProteinP01714 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Bau ProteinP01715 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Hil ProteinP01717 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Kern ProteinP01718 (Uniprot-TrEMBL)
Ig lambda chain V-IV region MOL ProteinP06889 (Uniprot-TrEMBL)
Ig lambda chain V-IV region X ProteinP01716 (Uniprot-TrEMBL)
Ig lambda chain V-V region DEL ProteinP01719 (Uniprot-TrEMBL)
Ig lambda chain V-VI region AR ProteinP01721 (Uniprot-TrEMBL)
Ig lambda chain V-VI region EB4 ProteinP06319 (Uniprot-TrEMBL)
Ig lambda chain V-VI region NIG-48 ProteinP01722 (Uniprot-TrEMBL)
Ig lambda chain V-VI region SUT ProteinP06317 (Uniprot-TrEMBL)
Ig lambda chain V-VI region WLT ProteinP06318 (Uniprot-TrEMBL)
Ig lambda chain V-VII region MOT ProteinP01720 (Uniprot-TrEMBL)
IgG-Ag

FCGRIA

CD3G homodimer		ComplexREACT_161410 (Reactome)
IgG-Ag FCGRIIAComplexREACT_161266 (Reactome)
IgG-Ag

FCGRIIIA

CD3G/CD3Z dimers		ComplexREACT_161242 (Reactome)
IgH heavy chain V-III region VH26 precursor ProteinP01764 (Uniprot-TrEMBL)
LIMK1ProteinP53667 (Uniprot-TrEMBL)
MYO10 ProteinQ9HD67 (Uniprot-TrEMBL)
Mother filament

ARP2/3 actin

GDP		ComplexREACT_161497 (Reactome)
Mother filament

branching complex

daughter filament		ComplexREACT_161289 (Reactome)
Mother filament branching complexComplexREACT_161230 (Reactome)
Myosin-Actin filamentsComplexREACT_160496 (Reactome)
Myosin-X dimerComplexREACT_160739 (Reactome)
MyosinProteinREACT_160342 (Reactome)
NCK1 ProteinP16333 (Uniprot-TrEMBL)
NCKAP1 ProteinQ9Y2A7 (Uniprot-TrEMBL)
NCKIPSD ProteinQ9NZQ3 (Uniprot-TrEMBL)
PAMetaboliteCHEBI:16337 (ChEBI)
PAK1 ProteinQ13153 (Uniprot-TrEMBL)
PAK1 dimerComplexREACT_23136 (Reactome)
PAK1ProteinQ13153 (Uniprot-TrEMBL)
PCMetaboliteCHEBI:16110 (ChEBI)
PI3K p-6Y-SYKComplexREACT_160388 (Reactome)
PI3KComplexREACT_4240 (Reactome)
PIMetaboliteCHEBI:16152 (ChEBI)
PIMetaboliteCHEBI:16618 (ChEBI)
PIMetaboliteCHEBI:18348 (ChEBI)
PIK3CA ProteinP42336 (Uniprot-TrEMBL)
PIK3CB ProteinP42338 (Uniprot-TrEMBL)
PIK3R1 ProteinP27986 (Uniprot-TrEMBL)
PIK3R2 ProteinO00459 (Uniprot-TrEMBL)
PKC-delta/epsilonREACT_12301 (Reactome)
PLA2G6ProteinO60733 (Uniprot-TrEMBL)
PLC gamma1/2ProteinREACT_120292 (Reactome)
PLCG1ProteinP19174 (Uniprot-TrEMBL)
PLCG2 ProteinP16885 (Uniprot-TrEMBL)
PLDProteinREACT_161489 (Reactome)
Phosphatidate phosphataseProteinREACT_160956 (Reactome)
PhosphatidylcholineMetaboliteCHEBI:16110 (ChEBI)
Phospho-PKC-delta/epsilonProteinREACT_12203 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RAC1 ProteinP63000 (Uniprot-TrEMBL)
RAC1-GDPComplexREACT_22018 (Reactome)
RAC1-GTPComplexREACT_21594 (Reactome)
RAC1/CDC42 PAK dimerComplexREACT_160723 (Reactome)
RAC1/CDC42 p-S144,T423-PAKComplexREACT_160965 (Reactome)
SH3 domain proteinsProteinREACT_160607 (Reactome)
SYK ProteinP43405 (Uniprot-TrEMBL)
SYKProteinP43405 (Uniprot-TrEMBL)
Src family kinases ProteinREACT_161384 (Reactome)
Src-kinasesProteinREACT_161502 (Reactome)
VAV1 ProteinP15498 (Uniprot-TrEMBL)
VAV2 ProteinP52735 (Uniprot-TrEMBL)
VAV3 ProteinQ9UKW4 (Uniprot-TrEMBL)
VAVProteinREACT_21165 (Reactome)
WAS ProteinP42768 (Uniprot-TrEMBL)
WASL ProteinO00401 (Uniprot-TrEMBL)
WASP/N-WASPProteinREACT_161400 (Reactome)
WAVE Regulatory ComplexComplexREACT_161217 (Reactome)
WIP family proteinsProteinREACT_161452 (Reactome)
WIPF1 ProteinO43516 (Uniprot-TrEMBL)
WIPF2 ProteinQ8TF74 (Uniprot-TrEMBL)
WIPF3 ProteinA6NGB9 (Uniprot-TrEMBL)
WRC

IRSp53/58 RAC1-GTP

PIP3		ComplexREACT_160732 (Reactome)
cholineMetaboliteCHEBI:15354 (ChEBI)
clustered IgG-Ag FCGRsComplexREACT_160485 (Reactome)
clustered IgG-Ag

p-FCGRs

SYK		ComplexREACT_161298 (Reactome)
clustered IgG-Ag

p-FCGRs p-6Y-SYK

PLCG		ComplexREACT_161309 (Reactome)
clustered IgG-Ag

p-FCGRs p-6Y-SYK

VAV		ComplexREACT_160419 (Reactome)
clustered IgG-Ag

p-FCGRs p-6Y-SYK

p-3Y-PLCG		ComplexREACT_160360 (Reactome)
clustered IgG-Ag

p-FCGRs p-6Y-SYK

p-VAV		ComplexREACT_161035 (Reactome)
clustered IgG-Ag

p-FCGRs

p-6Y-SYK		ComplexREACT_161038 (Reactome)
clustered IgG-Ag p-FCGRsComplexREACT_160515 (Reactome)
clustered IgG-Ag p-FCGRsComplexREACT_160696 (Reactome)
p-4Y-PLCG1 ProteinP19174 (Uniprot-TrEMBL)
p-4Y-PLCG1ProteinP19174 (Uniprot-TrEMBL)
p-6Y-CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
p-6Y-SYK ProteinP43405 (Uniprot-TrEMBL)
p-PLCGProteinREACT_160862 (Reactome)
p-S,T508-LIMK1 ProteinP53667 (Uniprot-TrEMBL)
p-S144,T423-PAK1 ProteinQ13153 (Uniprot-TrEMBL)
p-S144,T423-PAK1ProteinQ13153 (Uniprot-TrEMBL)
p-S3-CFL1 ProteinP23528 (Uniprot-TrEMBL)
p-T508-LIMK1 ProteinP53667 (Uniprot-TrEMBL)
p-T508-LIMK1ProteinP53667 (Uniprot-TrEMBL)
p-WRC

IRSp53/58 RAC1-GTP

PIP3		ComplexREACT_160497 (Reactome)
p-WRC

IRSp53/58 RAC1-GTP

PIP3		ComplexREACT_161191 (Reactome)
p-Y160,Y171-CD3G ProteinP09693 (Uniprot-TrEMBL)
p-Y172-VAV2 ProteinP52735 (Uniprot-TrEMBL)
p-Y173-VAV3 ProteinQ9UKW4 (Uniprot-TrEMBL)
p-Y174-VAV1 ProteinP15498 (Uniprot-TrEMBL)
p-Y256-WASL ProteinO00401 (Uniprot-TrEMBL)
p-Y288,Y304-FCGR2A ProteinP12318 (Uniprot-TrEMBL)
p-Y291-WAS ProteinP42768 (Uniprot-TrEMBL)
p-Y753,Y759,Y1217-PLCG2 ProteinP16885 (Uniprot-TrEMBL)
pCofilin Active LIMK-1ComplexREACT_20103 (Reactome)
pLIMK dimer HSP-90ComplexREACT_19543 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
2-LysophosphatidylcholineArrowREACT_160241 (Reactome)
ABL1REACT_160185 (Reactome)
ADPArrowREACT_12062 (Reactome)
ADPArrowREACT_160105 (Reactome)
ADPArrowREACT_160161 (Reactome)
ADPArrowREACT_160185 (Reactome)
ADPArrowREACT_160224 (Reactome)
ADPArrowREACT_160233 (Reactome)
ADPArrowREACT_160238 (Reactome)
ADPArrowREACT_160260 (Reactome)
ADPArrowREACT_160265 (Reactome)
ADPArrowREACT_160287 (Reactome)
ADPArrowREACT_160304 (Reactome)
ADPArrowREACT_19168 (Reactome)
ADPArrowREACT_19276 (Reactome)
ARP2/3 complex REACT_160118 (Reactome)
ATPREACT_12062 (Reactome)
ATPREACT_160090 (Reactome)
ATPREACT_160105 (Reactome)
ATPREACT_160161 (Reactome)
ATPREACT_160185 (Reactome)
ATPREACT_160224 (Reactome)
ATPREACT_160233 (Reactome)
ATPREACT_160238 (Reactome)
ATPREACT_160257 (Reactome)
ATPREACT_160260 (Reactome)
ATPREACT_160265 (Reactome)
ATPREACT_160287 (Reactome)
ATPREACT_160304 (Reactome)
ATPREACT_19168 (Reactome)
ATPREACT_19276 (Reactome)
Actin ADPArrowREACT_160291 (Reactome)
Actin filament bound Myosin-XArrowREACT_160257 (Reactome)
Activated WAVE2 and WASP/N-WASP

ARP2/3 complex

G-actin		REACT_160206 (Reactome)
Activated WAVE2 and WASP/N-WASPArrowREACT_160164 (Reactome)
Activated WAVE2 and WASP/N-WASPREACT_160118 (Reactome)
Active LIMK1ArrowREACT_19168 (Reactome)
Active LIMK1REACT_19276 (Reactome)
Active RAC1/CDC42REACT_160204 (Reactome)
Antigen-antibody complexREACT_160141 (Reactome)
Antigen-antibody complexREACT_160169 (Reactome)
Antigen-antibody complexREACT_160317 (Reactome)
Arachidonic acidArrowREACT_160241 (Reactome)
BAIAP2REACT_160150 (Reactome)
CDC42 GTPArrowREACT_160236 (Reactome)
CDC42 GTPREACT_160173 (Reactome)
CDC42-GDPREACT_160236 (Reactome)
CDC42-GTP

WASP/N-WASP WIP

SH3 proteins		REACT_160238 (Reactome)
CDC42-GTP WASP/N-WASPREACT_160166 (Reactome)
CDC42-GTP

p-WASP/p-N-WASP WIP

SH3 proteins		ArrowREACT_160238 (Reactome)
CFL1REACT_19276 (Reactome)
CRK

DOCK180

ELMO		REACT_160134 (Reactome)
CRKII

DOCK180

ELMO complex recruited to phagocytic cup		REACT_160127 (Reactome)
DAGsArrowREACT_12078 (Reactome)
DAGsArrowREACT_160284 (Reactome)
ERKREACT_160224 (Reactome)
F-actinREACT_160206 (Reactome)
FCGR2AREACT_160141 (Reactome)
FCGRIA CD3G homodimerREACT_160317 (Reactome)
FCGRIIIA CD3G/CD3Z dimersREACT_160169 (Reactome)
G-actinREACT_160118 (Reactome)
G-actinREACT_160291 (Reactome)
GDPArrowREACT_160127 (Reactome)
GDPArrowREACT_160236 (Reactome)
GDPArrowREACT_160258 (Reactome)
GTPREACT_160127 (Reactome)
GTPREACT_160236 (Reactome)
GTPREACT_160258 (Reactome)
H2OREACT_12078 (Reactome)
H2OREACT_160135 (Reactome)
H2OREACT_160241 (Reactome)
H2OREACT_160284 (Reactome)
HSP-90ArrowREACT_19168 (Reactome)
HSP-90REACT_19307 (Reactome)
IArrowREACT_12078 (Reactome)
IP3 receptor IP3 complexREACT_12074 (Reactome)
IP3 receptor homotetramerREACT_12008 (Reactome)
IREACT_12008 (Reactome)
LIMK1REACT_160233 (Reactome)
Mother filament

ARP2/3 actin

GDP		ArrowREACT_160164 (Reactome)
Mother filament

ARP2/3 actin

GDP		REACT_160291 (Reactome)
Mother filament

branching complex

daughter filament		ArrowREACT_160291 (Reactome)
Mother filament

branching complex

daughter filament		REACT_160090 (Reactome)
Mother filament

branching complex

daughter filament		REACT_160257 (Reactome)
Myosin-Actin filamentsArrowREACT_160090 (Reactome)
Myosin-X dimerREACT_160257 (Reactome)
MyosinREACT_160090 (Reactome)
PAArrowREACT_160135 (Reactome)
PAK1 dimerREACT_160204 (Reactome)
PAK1REACT_160161 (Reactome)
PAREACT_160284 (Reactome)
PCREACT_160135 (Reactome)
PI3K p-6Y-SYKREACT_160265 (Reactome)
PI3KREACT_160316 (Reactome)
PIArrowREACT_160203 (Reactome)
PIArrowREACT_160265 (Reactome)
PIREACT_12078 (Reactome)
PIREACT_160105 (Reactome)
PIREACT_160150 (Reactome)
PIREACT_160173 (Reactome)
PIREACT_160201 (Reactome)
PIREACT_160257 (Reactome)
PIREACT_160265 (Reactome)
PKC-delta/epsilonREACT_12062 (Reactome)
PLA2G6REACT_160241 (Reactome)
PLC gamma1/2REACT_160294 (Reactome)
PLDREACT_160135 (Reactome)
Phosphatidate phosphataseREACT_160284 (Reactome)
PhosphatidylcholineREACT_160241 (Reactome)
Phospho-PKC-delta/epsilonArrowREACT_12062 (Reactome)
PiArrowREACT_160090 (Reactome)
PiArrowREACT_160257 (Reactome)
PiArrowREACT_160284 (Reactome)
PiArrowREACT_160291 (Reactome)
RAC1-GDPREACT_160127 (Reactome)
RAC1-GDPREACT_160258 (Reactome)
RAC1-GTPArrowREACT_160127 (Reactome)
RAC1-GTPArrowREACT_160258 (Reactome)
RAC1-GTPREACT_160150 (Reactome)
RAC1/CDC42 PAK dimerREACT_160161 (Reactome)
RAC1/CDC42 p-S144,T423-PAKArrowREACT_160161 (Reactome)
REACT_12008 (Reactome) The IP3 receptor (IP3R) is an IP3-gated calcium channel. It is a large, homotetrameric protein, similar to other calcium channel proteins such as ryanodine. The four subunits form a 'four-leafed clover' structure arranged around the central calcium channel. Binding of ligands such as IP3 results in conformational changes in the receptor's structure that leads to channel opening.
REACT_12062 (Reactome) Diacylglycerol (DAG) positively regulates the autophosphorylation of protein kinase C-delta (PKC-delta), which stimulates ERK1/2 and triggers neurite outgrowth. DAG also stimulates the translocation of PKC from the cytosol to the plasma membrane. PKC-delta contributes to growth factor specificity and response to neuronal cells by promoting cell-type-specific differences in growth factor signalling. DAG can also activate PKC-epsilon in the same manner.
REACT_12074 (Reactome) IP3 promotes the release of intracellular calcium.
REACT_12078 (Reactome) Inositol 1,4,5-triphosphate (IP3) is a second messenger produced by phospholipase C (PLC) metabolism of phosphoinositol 4,5-bisphosphate (PIP2) (Canossa et al. 2001).
REACT_160090 (Reactome) In addition to the membrane remodeling for pseudopod extension, particle internalization requires a contractility force pulling the forming phagosome into the cytoplasm. Myosin motor proteins are the actin-binding proteins, with ATPase activity move along actin fibers, and produce the driving force for phagosome formation and transport. Several myosin motors including myosins IC, II, V, IXb are involved in FCGR-mediated phagocytosis as force generators and actin-based transport motors (Swanson et al. 1999). Nonmuscle myosin II, is a motor protein known to generate intracellular contractile forces and tension by associating with F-actin. It has been observed to localize around forming phagosomes and suggested a role in phagocytic-cup squeezing during FCGR-mediated phagocytosis. Each myosin II motor protein exists as a complex consisting of two copies each of myosin II heavy chain (MHC), essential light chains (ELC), and myosin regulatory light chain (MRLC). Selective inhibition of myosin II by ML-7, a myosin light-chain kinase (MLCK) inhibitor, prevents phagocytic cup closure, but not pseudopod extension for the formation of phagocytic cups in FCGR-mediated phagocytosis (Grooves et al. 2008, Araki 2006). Tight ring of actin filaments within the elongating pseudopodia squeezes the deformable particles. In the classical zipper model for phagocytosis, the pseudopod extends over the IgG-coated particles, in which FCGRs in the phagocyte plasma membrane interact sequentially with Fc portions of IgG molecules zippering the membrane along the particle. This sequential IgG-FCGR binding might not occur by itself, but requires forced zipper closure, where myosin-II contractile activity may promote the binding between the FCGR and its ligands, to facilitate the efficient extension and subsequent closure of phagocytic cups (Araki 2006, ). Myosin IC mediates the purse-string-like contraction that closes phagosomes. Myosin-V has been implicated in membrane trafficking events (Swanson et al. 1999).
REACT_160094 (Reactome) SYK is a tyrosine kinase related to ZAP70 that is expressed in all hematopoietic cells and coimmunoprecipitates with the gamma chain associated with FCGRIIIA in macrophages and with FCERI in mast cells. SYK is very important for FCGR phagocytosis and is recruited to these phosphorylated ITAM residues through its two SRC homology 2 (SH2) domains (Agarwal et al. 1993). When SYK kinase expression is inhibited with antisense oligonucleotides both in vitro and in vivo, phagocytosis and inflammation are abolished (Matsuda et al. 1997). The domain structure of SYK comprises a regulatory region at the N-terminus consisting of a pair of SH2 domains separated by an inter-SH2 linker called interdomain A, an SH2-domain-kinase linker termed interdomain B, and a C-terminal kinase domain (Arias-Palomo et al. 2009). In resting state SYK exists in an auto-inhibited conformation by the interactions between the SH2-SH2 regulatory region and the inter-SH2 linker and the catalytic domain. This interdomain interaction reduces the conformational flexibility required by the kinase domain for catalysis (Arias-Palomo et al. 2007). Changes in the orientation of the SH2 domains could control the disruption of the auto inhibitory interactions and the activation of SYK. These movements could be totally or partially induced by the binding to phosphorylated ITAMs and/or phosphorylation of tyrosine residues in interdomain A or B (Arias-Palomo et al. 2009). Tsang et al. suggested that SYK functions as an OR-gate switch with respect to phosphorylation and ITAM binding, as either one stimulus OR the other is sufficient to cause full activation (Tsang et al. 2008).
REACT_160105 (Reactome) PLCG is tyrosine phosphorylated by either SYK or Src kinases on three tyrosine residues and this phosphorylation enhances the activity of PLCG. Although maximal activation requires binding of PLCG to PIP3 with its plecstrin homology (PH) domain.
REACT_160118 (Reactome) Once activated the VCA region in WAVE2 or WASP/N-WASP becomes available for binding to ARP2/3 and actin monomer. The actin monomer binds to the V domain and ARP2/3 complex binds to the CA domain. The simultaneous binding of G-actin and the ARP2/3 complex to the VCA region contributes to the activation of ARP2/3-complex-mediated actin polymerization. The VCA module acts as a platform on which an actin monomer binds to the ARP2/3 complex to trigger actin polymerization (Takenawa & Suetsugu 2007).
REACT_160127 (Reactome) RAC1 is activated from inactive GDP-bound state to active GTP-bound form by the GEF activity of DOCK180:ELMO complex.
REACT_160134 (Reactome) Macrophages lacking all the three isoforms of VAV did not affect FCGR-mediated phagocytosis suggesting that RAC1 is regulated by GEFs other than VAV downstream of the FCGR (Hall et al 2006). DOCK180, a member of GEFs, is found to be involved in the activation of RAC1. DOCK180 associates with the adaptor protein CRKII and the complex is found to accumulate at the phagocytic cup. DOCK180 is recruited to the sites of phagocytosis by binding to SH3 domain of CRKII through its proline-rich motif (Hasegawa et al 1996). CRKII is likely recruited to the activated FCGR complex by binding phosphorylated ITAM tyrosines on the receptor or through other phosphotyrosines on ancillary proteins that are recruited to the receptor complex (Lee et al 2007). Unlike the usual GEFs, DOCK180 does not contain the conserved Dbl homology (DH) domain. Instead, it has a DHR-2 or DOCKER domain capable of loading RAC with GTP (Brugnera et al 2002). Binding of DOCK180 to RAC alone is insufficient for GTP loading, and a DOCK180-ELMO interaction is required. ELMO1, as well as ELMO2, form a complex with DOCK180 and they function together as a bipartite GEF to optimally activate RAC (Gumienny et al 2001, Brugnera et al 2002).
REACT_160135 (Reactome) Phospholipase D (PLD) catalyses the hydrolysis of the membrane phospholipid, phosphatidylcholine (PC) to generate choline and metabolically active phosphatidic acid (PA) (Lennartz 1999). Pharmacological inhibition studies show that PLD participates in FCGR-mediated phagocytosis (Kusner et al. 1996). There is an increase in the activity of PLD following the activation of phagocytosis via FCGR (Kusner et al. 1999). Following activation of FCGR, PLD translocates to the plasma membrane at the phagocytic cup and generate PA. This PA can be converted to DAG through the action of phosphatidic acid phosphatase-1 (PAP-1). Thus activation of PLD may be an additional pathway leading to PKC activation.
The two isoforms PLD1 and PLD2 are both shown to be essential for the formation of phagosome at different stages. PLD1 is localized on the endosomal/lysosomal compartment and PLD2 is localized at the plasma membrane. PLD2 may be linked to phagosome formation whereas PLD1 may be involved in the focal exocytosis at the plasma membrane and also in the maturation process (Carrotte et al. 2006).
REACT_160141 (Reactome) FCGRII (CD32) is a low-affinity receptor encoded by three different genes (A, B and C) (Brooks et al. 1989). FCGRIIA functions as a single-chain transmembrane receptor containing both the ligand-binding extracellular domain and a signal transducing cytoplasmic domain that contains distinct immunoreceptor tyrosine-based activation motif (ITAM). This ITAM-like domain in FCGRIIA contains two YXXL motifs with a spacer sequence of 12 amino acids instead of the usual 7. Isoform FCGRIIB is expressed in various leukocytes, including human monocytes and, as opposed to the activating Fc receptors it has an immunoreceptor tyrosine-based inhibitory motif (ITIM) and negatively regulates phagocytosis (Van den Herik-Oudijk IE et al. 1995, Mitchell et al. 1994, Tridandapani et al. 2002).
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal. This cross-linking results in the localization of FCGRs into lipid rafts and this may aid in recruiting and complexing with additional signalling proteins associated with lipid rafts (Bournazos et al. 2009, Kwiatkowska & Sobota 2001, Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues within the ITAM located on the cytoplasmic portion of FCGRIIA by membrane-associated tyrosine kinases of the Src family (Mitchell et al. 1994).
REACT_160150 (Reactome) WASP family verprolin-homologous (WAVE) proteins function downstream of RAC1 and are involved in activation of the ARP2/3 complex. This resulting actin polymerization mediates the projection of the plasma membrane in lamellipodia and membrane ruffles. The WAVE proteins exist as pentameric hetero-complex called WAVE Regulatory Complex (WRC). This WRC consists of WAVE family proteins, ABI (Abelson-interacting protein), NAP1 (also known as p125NAP1), SRA1 (or the closely related PIR121; SRA1 is also known as CYFIP1) and HSPC300 (also known as BRICK). There are three structurally conserved WAVE family proteins (WAVE1, 2, and 3) present in mammals. Among these, WAVE2 is important for the activation of ARP2/3complex in the formation of branched actin filaments. WAVEs are intrinsically inactive and are stimulated by Rac GTPase and phosphatidylinositols. The C-terminal VCA domain in WAVE2 can bind both ARP2/3 complex and actin monomers and is masked in the inactive state. The WAVE2 complex, is activated upon binding PIP3 to the polybasic region of WAVE2 and RAC1-GTP to the SRA1 subunit. This most likely occurs through allosteric changes leading to ARP2/3 interaction. The interactions between WAVEs and RAC are indirect. BAIAP2/IRSp53, an insulin receptor substrate, acts as a linker, binding both activated RAC1, and the proline-rich region of WAVE2 forming a trimolecular complex. SRA1/PIR121 in the WAVE regulatory complex binds directly to RAC1-GTP and link it to WAVE2. (Derivery et al. 2009, Yamazaki et al. 2006, Takenawa & Suetsugu 2007, Chen et al. 2010, Pollard 2007, Lebensohn & Kirschner 2009)
REACT_160161 (Reactome) PAK1 needs autophosphorylation for complete activation. PAK1 is autophosphorylated at several sites, but S144 flanking the kinase inhibitor region and T423 within the catalytic domain are the two conserved sites that regulate the catalytic activity (Chong et al. 2001, Parrini et al. 2001).
REACT_160164 (Reactome) After incorporation at the branch the actin bound to VCA domain in WASP/WAVE undergoes ATP hydrolysis and this destabilizes its interaction with WASP/WAVE. This dissociates the branched junction from the membrane-bound WASP/WAVE (Kovar 2006).
REACT_160166 (Reactome) WASP interacting proteins (WIP) family of proteins which includes WIP, corticosteroids and regional expression-16 (CR16) and WIP related (WIRE/WICH) with their specific proline rich sequence interact with the WH1 domain of WASP/N-WASP. These proteins form heterocomplexes with WASP/N-WASP and may help in the WASP proteins stability (Aspenstrom 2002, Kato et al. 2002, Ho et al. 2001, Moreau et al. 2000).
SH3 domain containing adaptor proteins like GRB2 (Carlier et al. 2000), NCK (Rohatgi et al. 2001) and WISH (DIP/SPIN90) (Fukuoka et al. 2001) bind to the proline rich domain in N-WASP/WASP and activate ARP2/3 complex. By binding simultaneously with N-WASP, GRB2 works synergistically with CDC42 in the activation of ARP2/3 complex (Carlier et al. 2000).
REACT_160169 (Reactome) FCGRIII (CD16) is a low affinity Fc gamma receptor and is encoded by two genes (A and B), the transmembrane form FCGRIIIA and the GPI anchored FCGRIIIB (Edberg et al. 1989). Between the two isoforms FCGRIIIA is involved in phagocytosis whereas FCGRIIIB is capable of inducing calcium signalling and actin polymerisation, but its role in phagocytosis is still not clear (Garcia Garcia & Rosales 2002). FCGRIIIA is expressed in macrophages and natural killer cells as a multi chain complex consisting of a single alpha chain containing IgG binding domains and a signal transducing gamma and/or zeta dimer (Wirthmuller et al. 1992, Lanier et al. 1989). Both gamma and zeta chains contain a conserved immunoreceptor tyrosine based activation motif (ITAM), which has 2 copies of the YXXL sequence (Isakov 1997). However, the gamma chain of FCGRIIIA is approximately sixfold more efficient in mediating phagocytosis than the zeta subunit (Park & Schreiber 1995). Phosphorylation of the conserved tyrosine residues of the ITAM in these accessory proteins is required for the phagocytic signal mediated by FCRGIIIA.
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal.
This cross linking results in the localisation of FCGRs into lipid rafts and this may aid in their recruiting and complexing with additional signalling proteins associated with lipid rafts (Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues within the ITAM located on the cytoplasmic portion of accessory gamma/zeta chains by membrane associated tyrosine kinases of the Src family (Park et al. 1993).
REACT_160173 (Reactome) Wiskott-Aldrich syndrome protein (WASP) and Neural-WASP (N-WASP) proteins are scaffolds that transduce signals from cell surface receptors to the activation of the ARP2/3 complex and actin polymerization. WASP and N-WASP possess a central GTPase binding domain (GBD) and an NH2-terminal WASP homology domain 1 (WH1), adjacent to this is a basic region (B) and a C-terminal containing VCA region that contains: a V domain (verprolin homology/WASP homology 2), a C domain (connecting), and an A motif (acidic). The VCA region is responsible for binding to and activating the ARP2/3 complex (Bompard & Caron 2004, Callebaut et al 1998). Under resting conditions, WASP and N-WASP are maintained in an autoinhibition state via interaction of the N-terminal GBD and the C-terminal VCA domains. This prevents access of the ARP2/3 complex to the VCA region. Activated CDC42 binds to the GBD region in N-WASP and this interaction releases the VCA region from autoinhibition enabling binding of the ARP2/3 complex stimulating actin polymerization (Kim et al 2000, Park & Cox 2009). Phosphoinositides (PtdIns(4,5)P2) interact with the basic (B) region in WASP and this interaction is important for activation of the WASP and ARP2/3 complex.(Higgs & Pollard 2000).
REACT_160185 (Reactome) Abelson interactor-1 (ABL) tyrosine kinase phosphorylates the strictly conserved tyrosine 150 in WAVE2 (Y151 in WAVE1 and 3) (Leng et al. 2003, Chen et al. 2010).
REACT_160201 (Reactome) VAV family members are cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho-family GTPases (RAC, RHO and CDC42). VAV1 is found predominantly in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. VAV proteins link the cell surface receptors like FCGR to the intracellular Rho GTPases and the actin cytoskeleton during phagocytosis (Hall et al 2006). Experiments using two-hybrid system suggest that VAV1 with its SH2 domain directly binds to the phosphorylated Y342 of SYK (Deckert et al. 1996). VAV proteins are also recruited to membrane through their PH domain by binding PI(3,4,5)P3 produced by PI3K.
REACT_160203 (Reactome) Activated PLCG translocates to the plasmamembrane and interacts with the inositol ring of the membrane bound phosphatidylinositol 4,5-bisphosphate (PIP2) with its PH domain. The active enzyme promotes intracelllular signaling by catalysing the hydrolysis of PIP2 to generate the second messengers IP3 and DAG.
REACT_160204 (Reactome) PAK1, a downstream effector of CDC42 and RAC1, is found localized in phagosomes. Upon activation, PAK1 phosphorylates LIMK, which directly phosphorylates and inactivates cofilin, a protein that mediates depolymerization of actin filaments. Thus, RAC and CDC42 coordinate actin dynamics by inducing actin polymerization via ARP2/3 on one hand, and inhibiting actin depolyerization via LIMK and cofilin on the other (Garcia-Garcia & Rosales 2002).
PAK1 exists as homodimer in a trans-inhibited conformation. The kinase inhibitory (KI) domain of one PAK1 molecule binds to the C-terminal catalytic domain of the other and inhibits catalytic activity. GTPases RAC1/CDC42 bind the GBD domain of PAK1 thereby altering the conformation of the KI domain, relieving inhibition of its catalytic domain, and allowing PAK1 autophosphorylation that is required for full kinase activity (Parrini et al. 2002, Zhao & Manser 2005).
REACT_160206 (Reactome) Once activated, the ARP2/3 complex nucleates new actin filaments that extend from the sides of pre-existing mother actin filaments at a 70-degree angle to form Y-branched networks (Firat-Karalar & Welch 2010). These branched actin filaments push the cell membrane forward to form a pseudopod. The ARP2/3 complex is composed of two Arps (actin-related proteins), ARP2 and ARP3, and five unique proteins ARPC1, ARPC2, ARPC3, ARPC4 and ARPC5 (Gournier et al. 2001). Both ARP2 and ARP3 subunit binds ATP. There are two proposed models to explain the process of actin nucleation by ARP2/3 complex: the barbed-end branching model and the dendritic nucleation/side branching model (Le Clainche & Carlier 2008).
In barbed-end branching model the branching/ternary complex (G-actin-WASP/WAVE-Arp2/3 complex) binds to the barbed end of the mother filament. G-actin bound to VCA domain or one of the Arp subunit would incorporate into the mother filament at the barbed end, thus positioning ARP2/3 complex to initiate the daughter branch on the side of the the mother filament. ARP2/3 nucleates the formation of a new actin filament branches, which elongate at the barbed ends (Le Clainche & Carlier 2008, Pantaloni et al 2000, Le Clainche et al. 2003, Egile et al. 2005). In side branching model the branching complex binds to the side of the mother actin filament and mimics an actin nucleus and initiates lateral branch (Le Clainche & Carlier 2008, Amann & Pollard 2001).
REACT_160224 (Reactome) The ARP2/3 complex shows higher affinity for the phosphorylated VCA domain of WAVE2 than for the unphosphorylated VCA domain. WAVE proteins are phosphorylated by various stimulations. Active ERK (Mitogen activated protein kinase 3) phosphorylates the WAVE regulatory complex (WRC) on multiple serine/threonine sites within the proline-rich domains (PRDs) of WAVE2 and ABI1. Phosphorylation of the PRDs would disrupt their interaction with SH3 and PLP binding domains, potentially altering WRC activation. ERK phosphorylates both S343 and T346 in WAVE2 and S183, S216, S225, S392, and S410 in ABI1. Cumulatively, the phosphorylation of both WAVE2 and ABI in the WAVE regulatory complex (WRC) contribute to the RAC-induced WRC conformational change that exposes the VCA domain, leading to binding and activation of ARP2/3 (Mendoza et al. 2011, Nakanishi et al. 2007).
REACT_160233 (Reactome) LIM-kinase is responsible for the tight regulation of the activity of cofilin (a protein that depolymerizes actin filaments) and thus maintains the balance between actin assembly and disassembly. LIMK is one of the downstream targets of PAK1 and is activated through phosphorylation by PAK1 on T508 within its activation loop.
REACT_160236 (Reactome) FCGR mediated phagocytosis requires CDC42 to stimulate actin polymerization, generating the force for phagocytic cup protrusion or pseudopod extension. CDC42 activation is restricted at the advancing edge of the phagocytic cup, where actin is concentrated, and is deactivated at the base of the phagocytic cup (Beemiller et al 2010). The mechanism behind the recruitment and activation of CDC42 during FCGR phagocytosis is unknown. VAV regulates the activation of RAC1 but not CDC42 and the GEF responsible for CDC42 activation during FCGR-mediated phagocytosis remains unidentified (Adam et al 2004, Patel et al 2002).
REACT_160238 (Reactome) WASP is phosphorylated on Tyr291 (Cory et al. 2002) and N-WASP on Tyr256 (Wu et al. 2004) by Src family of tyrosine kinases and this phosphorylation may release the autoinhibitory intramolecular interactions. The phosphorylation seems to be enhanced by the activation of CDC42. WASP phosphorylation and binding of CDC42 have a synergistic effect on the activation of the ARP2/3 complex (Takenawa & Suetsugu 2007). In N-WASP, the phosphorylation may reduce its nuclear translocation and may sustain it in its functional site in the cytoplasm (Wu et al. 2004).
REACT_160241 (Reactome) Several members of phospholipase A (PLA) are involved in phagocytosis. Macrophages express three classes of PLA2: secreted Ca-dependent (sPLA2), cytosolic Ca-dependent (cPLA2) and cytosolic Ca-independent (iPLA2) of which iPLA2 is involved in FCGR mediated arachidonic acid (AA) production. Aggregation of FCGR triggers phosphorylation and membrane translocation of iPLA2. Protein kinase C (PKC), ERK and p38MAPK seems to regulate iPLA2 in monocytes, neutrophils and macrophages. Phosphorylated iPLA2 then mediates production of AA and lysoophospholipids from phosphatidylcholine. iPLA2 inhibitors (bromoenol lactone) block AA release and phagocytosis which can be restored upon addition of exogenous AA, suggesting a critical role for iPLA2 in FCGR phagocytosis (Lennartz et al. 1993, Tay & Melendez). Release of AA by activated iPLA2 changes the physical characteristic of the membrane which may facilitate pseudopod extension.
REACT_160257 (Reactome) Myosin-X (Myosin 10) is one of the downstream effectors of PI3K in FCGR-phagocytosis and is involved in pseudopod extension and closure of phagocytic cups. It is recruited to the forming phagosome by binding, through its second PH domain to membrane PIP3, a major product of PI3-kinase (Cox et al. 2002). Myosin-X may act as a motor to transport membrane cargo molecules to the forming pseudopods, influencing actin dynamics. It is not understood with certainty how myosin X contributes to the mechanism of pseudopod extension. It selectively binds to actin bundle such that each head may bind, in an ATP-sensitive manner, to two adjacent actin filaments within the actin bundle. Myosin X hydrolyze ATP and converts this chemical energy to mechanical energy moving toward the plus end/barbed end of the actin filament facing towards the tip of the growing pseudopods (Araki 2006, Chavrier 2003, Watanabe et al 2010).
REACT_160258 (Reactome) The organized movements of membranes and the actin cytoskeleton are coordinated in phagocytosis by small GTPases of the Rho family. Specifically, RAC1 and CDC42 are known to be stimulated upon engagement of FCGR and are essential for the extension of the pseudopods that surround and engulf the phagocytic particle (Scott et al 2005). RAC1 is known to regulate actin dynamics. It is active throughout the phagocytic cup and activated RAC1 is necessary to assemble F actin. However, closing the phagocytic cup requires RAC1 to be deactivated (Naakaya et al 2007). Deletion of RAC1 prevents FCGR mediated phagocytosis (Hall et al 2006). RAC1 activation involves transition from an inactive GDP bound to an active GTP bound state catalysed by guanine exchanges factors (GEFs). VAV has been implicated in the activation of RAC1 (Patel et al 2002).
REACT_160260 (Reactome) VAV proteins exist in an auto-inhibitory state folded in such a way as to inhibit the GEF activity of its DH domain. This folding is mediated through binding of tyrosines in the acidic domain to the DH domain and through binding of the CH domain to the C1 region. Activation of VAV may involve at least three different events to relieve this auto-inhibition. Phosphorylation of the tyrosines in the acidic domain causes them to be displaced from the DH domain, binding of a ligand to the CH domain may cause it to release the C1 domain and binding of PIP3 to PH domain may alter its conformation. VAV1 is phosphorylated on Y174 in the acidic domain, and this is mediated by Syk and Src-family tyrosine kinases. Once activated, VAV1 is then involved in the activation of RAC and CDC42 downstream of FCGR.
REACT_160265 (Reactome) Activated PI3K phosphorylates phosphatidylinositol (PI) 4-phosphate and PI 4,5-bisphosphate (PIP2) to generate PI 3,4-bisphosphate and PI 3,4,5-triphosphate (PIP3) and these second messengers recruit other signaling proteins containing plecstrin homology (PH) domain. PIP3 rapidly accumulates at sites of phagocytosis and disappears after the phagosome has been sealed off from the plasma membrane.
REACT_160284 (Reactome) Phosphatidic acid phosphatase (PAP) bound to the plasma membrane catalyzes the dephosphorylation of phosphatidic acid (PA), yielding diacylglycerol (DAG) and inorganic phosphate. In humans, Diacylglycerol pyrophosphate (DPPL1 and DPPL2) perform this reaction.
REACT_160287 (Reactome) Multiple sites of phosphorylation are known to exist in SYK, which both regulate its activity and also serve as docking sites for other proteins. Some of these sites include Y131 of interdomain A, Y323, Y348, and Y352 of interdomain B, and Y525 and Y526 within the activation loop of the kinase domain and Y630 in the C-terminus (Zhang et al. 2002, Lupher et al. 1998, Furlong et al. 1997). Phosphorylation of these tyrosine residues disrupts autoinhibitory interactions and results in kinase activation even in the absence of phosphorylated ITAM tyrosines (Tsang et al. 2008). SYK is primarily phosphorylated by Src family kinases and this acts as an initiating trigger by generating few molecules of activated SYK which are then involved in major SYK autophosphorylation (Hillal et al. 1997).
REACT_160291 (Reactome) ATP bound G-actin monomers are added to the fast growing barbed ends of both the mother and the daughter filaments and the polymerization of these filaments drives membrane protrusion. Pseudopodia extend around the antibody bound particle to form the phagocytic cup. This elongation continues until the filament reaches a steady state equilibrium with free G-actin monomers.
REACT_160294 (Reactome) PLCgamma (PLCG) is recruited to FCGR and the phosphorylated Y342 and Y346 in SYK have been reported to be involved in the interaction of PLCG (Law et al. 1996). PLCG accumulates at the phagocytic cup during FCGR, but the exact role of PLCG in the regulation of phagocytosis is not clear. It may be involved in FCGR signaling by activating PKC through DAG production (Garcia-Garcia & Rosales 2002 )
REACT_160304 (Reactome) After cross linking, Fc gamma receptors are sequestered to lipid rafts where they are complexed with some of the tyrosine kinases of Src family and undergo phosphorylation on the tyrosine residues contained in conserved ITAM sequences. At least six out of nine members of the Src family kinases (SRC, FYN, FGR, HCK, YES and LYN ) have been identified in the phagocytic cells and are implicated in the initiation of Fc gamma mediated signaling. (Suzuki et al. 2000, Majeed et al. 2001, Kwiatkowska et al. 2003). Some of these kinases have been found associated with specific receptors. In monocytes HCK and LYN have been found associated with FCGRI (Durden et al. 1995), whereas only HCK with FCGRIIA (Ghazizadeh et al. 1994) while FGR in neutrophils (Hamada et al. 1993) and LCK in NK cells with FCGRIIIA (Pignata et al. 1993)
The implication of Src kinases in phosphorylation was first supported by pharmacological findings that herbimycin A, a tyrosine kinase inhibitor relatively specific for Src-family kinases, potently suppressed Fc receptor mediated functions (Greenberg et al. 1993, Suzuki et al. 2000). However, their particular involvement in phagocytosis remains unclear, as targeted disruption of single or multiple Src family genes did not result in significant alterations in phagocytosis (Hunter et al. 1993, Fitzer Attas et al. 2000, Suzuki et al. 2000). HCK, FGR and LYN triple-deficient (-/-) macrophages have shown significant delays in FCGR mediated phagocytosis, but these deficiencies do not completly disrupt the process (Fitzer Attas et al. 2000).
Tyrosine residues Y288 and Y304 (Y282 and Y298 according to the literature reference, it is 6 residues shorter compared to uniprot entry due to an alternate initiation codon usage), within ITAM sequence in the cytoplasmic domain of FCGRIIA are the key target sites that are phosphorylated by Src family kinases (Mitchell et al, 1994). In case of FCGRIA and FCGRIIIA the specific tyrosine residues within ITAMs of the associated gamma/zeta chains are phosphorylated by activated Src family kinases (SFKs) (Park et al. 1993).
REACT_160316 (Reactome) PI3K is one of the downstream effector of activated SYK. The p85 alpha regulatory subunit of PI3K have been shown to interact with SYK and FCGRs, and transient and restricted accumulation of lipid products of the kinase have been observed at sites of the phagosomal cup (Yanagi et al. 1994, Marshall et al. 2001). Leverrier at al. has demonstrated that p110beta is the major class I catalytic isoform required for FCGR-mediated phagocytosis by primary macrophages (Leverrier at al. 2003). p85 alpha subunit interacts with phosphorylated SYK at tyrosine 317 with its C-terminal SH2 domain, whereas other tyrosine residues like 342 and 346 in the linker region may contribute to the interaction with N-terminal SH2 domain (Moon et al, 2005). The main role of PI3K in phagocytosis appears to be the regulation of pseudopod extension necessary for particle internalization and may also regulate phagocytosis through activation of ERK (Garcia-Garcia & Rosales. 2002).
REACT_160317 (Reactome) FCGRI is coded by three different genes (A, B, and C) and is expressed on most myeloid cells including monocytes, macrophages and dendritic cells (Allen & Seed 1988). FCGRI is a high affinity IgG receptor capable of binding monomeric IgG. FCGRI exists as a complex containing ligand (IgG) binding extracellular alpha-chain and homodimer of signal transducing FcR gamma (CD3G) chains, or a heterodimer of signal transducing FcR gamma and zeta chains (Ernst et al. 1993, Scholl & Geha 1993, van Vugt et al. 1996). The cytoplasmic domain of FCGRI does not have signaling motifs, however it is suggested that the gamma-subunit might be required for generating the phagocytic signal (Duchemin et al. 1994, Indik et al. 1995).
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal. This cross-linking results in the localization of FCGRs into lipid rafts and this may aid in recruiting and complexing with additional signalling proteins associated with lipid rafts (Bournazos et al. 2009, Kwiatkowska & Sobota 2001, Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues with in the immuno tyrosine activation motif (ITAM) located on the cytoplasmic portion of accessory gamma/zeta chains by membrane-associated tyrosine kinases of the Src family (Duchemin et al. 1994, van Vugt et al. 1996).
REACT_19168 (Reactome) Binding of Hsp90 to the LIMK proteins protects them from degradation and promotes their dimer formation and transphosphorylation. It is estimated that LIMK1 contains at least 5 phospho-amino acids primarily phospho-serines, in its kinase domain. The positions of these serine residues are not known. Transphosphorylation of these serine residues in LIMK1 increases its stability.
REACT_19276 (Reactome) Cofilin is a member of the ADF (actin-depolymerizing factor) protein family, that is involved in regulating actin dynamics in the growth cone. It binds to actin in a one-to-one molar ratio, and stimulates both the severing of actin filaments and depolymerization of actin subunits from the actin filament end.
Activated LIMK phosphorylates cofilin on conserved serine 3 (Ser3/S3), located near the actin binding site. After phosphorylation cofilin is inactive and looses its affinity for actin and releases from G-actin monomers. Now the ADP-actin monomers are free and can exchange ADP with cytoplasmic ATP and they are ready for reincorporation at the barbed end of the a growing filament.
REACT_19307 (Reactome) After phosphorylation on Thr 508, LIMK undergoes homodimerization. Homodimer formation is promoted by the binding of heat shock protein 90 (Hsp90) to a short sequence in the kinase domain of LIMKs. LIMKs are further phosphorylated after homodimer formation and transphosphorylation of the kinase domain.
SH3 domain proteinsREACT_160166 (Reactome)
SYKREACT_160094 (Reactome)
Src family kinases REACT_160304 (Reactome)
Src-kinasesREACT_160238 (Reactome)
VAVREACT_160201 (Reactome)
WASP/N-WASPREACT_160173 (Reactome)
WAVE Regulatory ComplexREACT_160150 (Reactome)
WIP family proteinsREACT_160166 (Reactome)
WRC

IRSp53/58 RAC1-GTP

PIP3		REACT_160185 (Reactome)
WRC

IRSp53/58 RAC1-GTP

PIP3		REACT_160224 (Reactome)
cholineArrowREACT_160135 (Reactome)
clustered IgG-Ag FCGRsREACT_160304 (Reactome)
clustered IgG-Ag

p-FCGRs

SYK		REACT_160287 (Reactome)
clustered IgG-Ag

p-FCGRs p-6Y-SYK

PLCG		REACT_160105 (Reactome)
clustered IgG-Ag

p-FCGRs p-6Y-SYK

VAV		REACT_160260 (Reactome)
clustered IgG-Ag

p-FCGRs p-6Y-SYK

p-3Y-PLCG		ArrowREACT_160105 (Reactome)
clustered IgG-Ag

p-FCGRs p-6Y-SYK

p-VAV		ArrowREACT_160260 (Reactome)
clustered IgG-Ag

p-FCGRs p-6Y-SYK

p-VAV		REACT_160258 (Reactome)
clustered IgG-Ag

p-FCGRs

p-6Y-SYK		ArrowREACT_160203 (Reactome)
clustered IgG-Ag

p-FCGRs

p-6Y-SYK		ArrowREACT_160287 (Reactome)
clustered IgG-Ag

p-FCGRs

p-6Y-SYK		REACT_160134 (Reactome)
clustered IgG-Ag

p-FCGRs

p-6Y-SYK		REACT_160201 (Reactome)
clustered IgG-Ag

p-FCGRs

p-6Y-SYK		REACT_160260 (Reactome)
clustered IgG-Ag

p-FCGRs

p-6Y-SYK		REACT_160294 (Reactome)
clustered IgG-Ag

p-FCGRs

p-6Y-SYK		REACT_160316 (Reactome)
clustered IgG-Ag p-FCGRsArrowREACT_160090 (Reactome)
clustered IgG-Ag p-FCGRsArrowREACT_160304 (Reactome)
clustered IgG-Ag p-FCGRsREACT_160090 (Reactome)
clustered IgG-Ag p-FCGRsREACT_160094 (Reactome)
p-4Y-PLCG1REACT_12078 (Reactome)
p-PLCGArrowREACT_160203 (Reactome)
p-S144,T423-PAK1ArrowREACT_160161 (Reactome)
p-S144,T423-PAK1REACT_160233 (Reactome)
p-T508-LIMK1ArrowREACT_160233 (Reactome)
p-T508-LIMK1REACT_19307 (Reactome)
p-WRC

IRSp53/58 RAC1-GTP

PIP3		ArrowREACT_160185 (Reactome)
p-WRC

IRSp53/58 RAC1-GTP

PIP3		ArrowREACT_160224 (Reactome)
pCofilin Active LIMK-1ArrowREACT_19276 (Reactome)
pLIMK dimer HSP-90REACT_19168 (Reactome)
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