Complement system (Homo sapiens)

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FibrinCompstatinBaIgMFXIaIgAEndougenous moleculesNeutrophil inhibitory factor (NIF)PlasminDegradationc3(H2O)BbComplement factor BaExogenous moleculesFIXaComplement proteinsIgGClusterinC4Bc2FXaThrombinC5b6-9 complexADIPOQAPOA1C1QBLeishmanial protein kinase-1Protein-SiC3bCFHR4C3bC3bBbPLTAC8GC1sCRIgKLKB1GNAI2PTX3GNAI3FDPLGPKCPor1AC1qRpFKBP13LRP2LAMB1OmpK36ITGA2BC3fC3bB3bDCNGNA1870PKACD16aFGBGpm1pRPS19C3dC3aFnBPBC5aC4a-des-ArgCR2C2C5aR1E-LDLLAMC1cC1qREfbCbpAGNA15ITGB3FCN1Gpm1pC4BPACRPFXHSV-gCC8BHIV-gp41SELPFNTXNC5a-des-ArgC1QASELEProtein-AOMCICFBMAp19C4b2b3bC3cC4aCKC3bBbSSL5ClfAPrPSAPC6LfhACHIPSA2MC9C3(H2O)OPNFXIIaVCP C4-AWASFGAELANEFXIIIFGGICAM1fMLPClfBCFPC3aR1MBL2PLAURTFECPHSCPNC4b2bCD40CD59THBSgC1qRC1INHVTNCD19SCPSFTPA1beta-GlucanSELPLGMASP1FPR1SkpSELLC8AC5L2C4BPBFnBPAC1rFGAStcEC5bSPICECFICD23ALBSSL10MCPFGBSCINIBSPC3a-des-ArgCR4MAp44SbiFXIaADMSIGN-R1SSL7CR1Protein MFCN2SICSfbgp350C4bCFHTLR2DAFARRB2ITGA2CFHR1C3HeparinRgpANS1C7C1QCEhpCR3SSL11ICAM2SFTPA2LAMA5KLKB1MASP1PTX3CRPIgMIgGDCNITGA2cC1qRPor1BVCP LAMA5LAMB1LAMC1C3PLRP2FibrinCPNCPB2c3(H2O)BbDegradationPlasminKLKB1FDCFBHeparinC3bLAMA5LAMB1LAMC1VCP SPICEHSV-gCCFPC1INHMCPCR1DAFEfbEhpSbiFNC3SbiCFHC3bSbiCFHSbiCFHCbpAPTX3CFHCRPPrPSSL5HeparinDegradationKLKB1C3dCFHCFHCFICFICFIMCPCFICFICFIVCP SPICESCINLfhACFHR1LAMA5LAMB1LAMC1CFICR1CRIgCR1HSV-gCHeparinSAPIgGFGBFGAFNTXNProtein MEfbClfAAPOA1C5b678 complexC5b67 complexC5b6 complexC5bC5aLeishmanial protein kinase-1SSL7CFHR1C3bB3bPPlasminThrombinFXaFIXaFXIaDegradationC5aC5bC5L2CPB2CPNSSL5Leishmanial protein kinase-1C9HeparinPlasmin


Description

The complement system is a central component of innate immunity and important for cellular integrity and tissue homeostasis. This pathway is a Complement Map Database (CMAP), developted by Lambris Group (University of Pennsylvania). It is a unique repository focused on documented molecular interactions described within the complement cascade and between complement and other biological systems. Information contained in CMAP (http://www.complement.us/labweb/cmap/index.php) is entirely based on published experimental data and is fully revised by experts in the field. Yang K, Dinasarapu AR, Reis ES, Deangelis RA, Ricklin D, Subramaniam S, Lambris JD. CMAP: Complement Map Database. Bioinformatics 2013 Jun 4

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Bibliography

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  1. Yang K, Dinasarapu AR, Reis ES, Deangelis RA, Ricklin D, Subramaniam S, Lambris JD; ''CMAP: Complement Map Database.''; Bioinformatics, 2013 PubMed Europe PMC Scholia
  2. Dinasarapu AR, Chandrasekhar A, Sahu A, Subramaniam S; ''Complement C3''; UCSD Molecule Pages, 1 (2), 34-48. (doi: 10.6072/H0.MP.A004235.01), 2012 DOI Scholia
  3. Dinasarapu AR, Saunders B, Ozerlat I, Azam K, Subramaniam S; ''Signaling gateway molecule pages--a data model perspective.''; Bioinformatics, 2011 PubMed Europe PMC Scholia
  4. Chandrasekhar A, Dinasarapu AR, Tenner AJ, Subramaniam S; ''Complement C1q subcomponent subunit A.''; UCSD Molecule Pages, 1 (2), 49-60, 2012 DOI Scholia
  5. Dinasarapu AR, Chandrasekhar A, Fujita T, Subramaniam S; ''Mannose/mannan-binding lectin.''; UCSD Molecule Pages, 2013 DOI Scholia
  6. Dinasarapu A, Chandrasekhar A, Jozsi M, Subramaniam S; ''Complement factor H.''; UCSD Molecule Pages, 1 (2), 71-86, 2012 DOI Scholia
  7. Chandrasekhar A, Dinasarapu AR, Isenman D.E, Subramaniam S; ''Complement C5.''; UCSD Molecule Pages , 1 (2), 61-70., 2012 DOI Scholia
  8. Chandrasekhar A, Dinasarapu AR, Matsushita M, Subramaniam S; ''MAp44.''; UCSD Molecule Pages., 2013 DOI Scholia
  9. Chandrasekhar A, Dinasarapu AR, Matsushita M, Subramaniam S; ''MASP-3.''; UCSD Molecule Pages., 2013 DOI Scholia
  10. Chandrasekhar A, Dinasarapu AR, Matsushita M, Subramaniam S; ''MASP-1.''; UCSD Molecule Pages., 2013 DOI Scholia
  11. Chandrasekhar A, Dinasarapu AR, Thielens N, Subramaniam S; ''MASP-2.''; UCSD Molecule Pages., 2013 DOI Scholia
  12. Chandrasekhar A, Dinasarapu AR, Thiel S, Subramaniam S; ''L-Ficolin.''; UCSD Molecule Pages, 2 (1), 37-44., 2013 DOI Scholia
  13. Chandrasekhar A, Dinasarapu AR, Cedzyaski M, Subramaniam S; ''H-Ficolin.''; UCSD Molecule Pages., 2013 DOI Scholia
  14. Dinasarapu AR, Chandrasekhar A, Hajishengallis G, Subramaniam S; ''Integrin beta-2.''; UCSD Molecule Pages., 2013 DOI Scholia
  15. Dinasarapu AR, Chandrasekhar A, Inal J, Subramaniam S; ''Complement C2.''; UCSD Molecule Pages., 2013 DOI Scholia
  16. Min J,, Chandrasekhar A, Dinasarapu AR, Kemper C, Subramaniam S; ''Properdin.''; UCSD Molecule Pages., 2014 DOI Scholia
  17. Ricklin D, Hajishengallis G, Yang K, Lambris JD; ''Complement: a key system for immune surveillance and homeostasis.''; Nat Immunol, 2010 PubMed Europe PMC Scholia
  18. Kishore U, Reid KB; ''C1q: structure, function, and receptors.''; Immunopharmacology, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134537view17:40, 22 July 2024EgonwFixed a datasource
134255view04:58, 18 July 2024EgonwRemoved template comments
127174view07:54, 9 August 2023EgonwFixed the non-numeric Entrez Gene identifiers
126884view01:33, 30 June 2023Sikedafixed Gpm1p
125340view11:43, 1 February 2023LarsgwFix typo in reference bp:DB
125288view16:57, 31 January 2023LarsgwAdd DOIs to references
124810view21:45, 11 December 2022AlexanderPicofixed citations
124781view06:34, 11 December 2022AlexanderPicofixed citations
116569view10:51, 8 May 2021EweitzModified title
107137view14:21, 17 September 2019MaintBotChEBI identifier normalization
105407view15:52, 7 August 2019DeSlModified description
105406view15:51, 7 August 2019DeSlModified description
105405view15:50, 7 August 2019DeSlModified description
105404view15:47, 7 August 2019DeSlModified description
105403view15:45, 7 August 2019DeSlModified description
105402view15:43, 7 August 2019DeSlModified description
105401view15:41, 7 August 2019DeSlModified description
105400view15:40, 7 August 2019DeSlModified description
105399view15:39, 7 August 2019DeSlModified description
105398view15:38, 7 August 2019DeSlModified description
105397view15:37, 7 August 2019DeSlModified description
105396view15:35, 7 August 2019DeSlModified description
105395view15:33, 7 August 2019DeSlModified description
105394view15:32, 7 August 2019DeSlModified description
105393view15:31, 7 August 2019DeSlAdded all lit. refs from description to main GPML
105374view15:37, 5 August 2019DeSlConnected unconnected lines
105373view15:36, 5 August 2019DeSlUpdated UTF-8 encoding in description text
105372view15:32, 5 August 2019DeSlStarted updating lit. refs from description to main PW
105315view22:44, 29 July 2019AriuttaHGNC -> HGNC Accession number.
103008view15:14, 31 January 2019Mkutmonupdated outdated Ensembl identifier
97328view19:27, 9 May 2018Khanspersconnected interactions
96979view18:20, 24 April 2018AlexanderPicoReverted to version '09:30, 7 March 2018' by AlexanderPico
96977view15:58, 24 April 2018WpblockedModified title
96299view16:30, 7 March 2018Fehrhartfixed connections
96298view16:27, 7 March 2018Fehrhartfixed connections
90154view07:48, 19 October 2016ElisaQuick edit to datanode annotation or property
89913view13:28, 6 October 2016MkutmonModified description
86150view08:26, 2 July 2016EgonwFixed a weird char in a reference.
85633view13:45, 4 June 2016EgonwReplaced a mim-conversion with Arrow.
85193view10:22, 24 April 2016EgonwRemoved redundant BioPax content, which broke RDF generation.
83005view09:25, 17 November 2015FehrhartUpdate ensembl ID for C2
78589view14:51, 7 January 2015MaintBotadded missing graphIds
78075view21:59, 29 November 2014EgonwPlaced a non-numeric Entrez Gene ID
77666view12:00, 5 October 2014EgonwReplaced 'Uniprot-SwissProt' by 'Uniprot-TrEMBL'.
77344view15:44, 23 August 2014EgonwFixed the XRef for heparan sulfate.
77343view15:43, 23 August 2014EgonwAdded DataSource annotation for Xrefs for two Ensembl IDs.
77342view14:17, 23 August 2014EgonwMarked a few DataNodes with ChEBI ids as Metabolite.
77158view20:59, 29 July 2014KhanspersOntology Term : 'complement system pathway' added !
77120view16:07, 21 July 2014AdinasarapuModified description
77119view15:59, 21 July 2014AdinasarapuModified description

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Leishmanial protein kinase-1GeneProduct
A2MGeneProductENSG00000175899 (Ensembl)
ADIPOQGeneProductENSG00000181092 (Ensembl)
ADMGeneProductENSG00000148926 (Ensembl)
ALBGeneProductENSG00000163631 (Ensembl)
APOA1GeneProductENSG00000118137 (Ensembl)
ARRB2GeneProductENSG00000141480 (Ensembl)
C1INHGeneProductENSG00000149131 (Ensembl)
C1QAGeneProductP02745 (Uniprot-TrEMBL)
C1QBGeneProductENSG00000173369 (Ensembl)
C1QCGeneProductENSG00000159189 (Ensembl)
C1qRpGeneProductENSG00000125810 (Ensembl)
C1rGeneProductP00736 (Uniprot-SwissProt)
C1sGeneProductENSG00000182326 (Ensembl)
C2GeneProductENSG00000204364 (Ensembl)
C3(H2O)GeneProduct629 (Entrez Gene)
C3GeneProductENSG00000125730 (Ensembl)
C3a-des-ArgGeneProduct718 (Entrez Gene)
C3aGeneProduct718 (Entrez Gene)
C3aR1GeneProductENSG00000171860
C3bB3bGeneProductAlternative C5 convertase

Complex Components C3b

Bb
C3bB3bPGeneProductAlternative C5 convertase and CFP complex

Complex Components C3b Bb

CFP
C3bBbGeneProductComplex Components

C3b

Bb
C3bBbPGeneProductComplex Components

C3b Bb

CFP
C3bGeneProductP01024 (Uniprot-TrEMBL)
C3cGeneProduct718 (Entrez Gene)
C3dGeneProduct718 (Entrez Gene)
C3fGeneProduct718 (Entrez Gene)
C4-AGeneProduct720 (Entrez Gene)
C4BPAGeneProductENSG00000123838 (Ensembl)
C4BPBGeneProductENSG00000123843 (Ensembl)
C4a-des-ArgGeneProduct720 (Entrez Gene)
C4aGeneProduct720 (Entrez Gene)
C4b2bGeneProductComplex Components

C4b

C2b
C4b2b3bGeneProductClassical C5 convertase

Complex Components C4b C2b

C3b
C4bGeneProduct720 (Entrez Gene)
C5L2GeneProductENSG00000134830 (Ensembl)
C5a-des-ArgGeneProduct727 (Entrez Gene)
C5aGeneProduct727 (Entrez Gene)
C5aR1GeneProductENSG00000197405 (Ensembl)
C5bGeneProduct727 (Entrez Gene)
C6GeneProductENSG00000039537 (Ensembl)
C7GeneProductENSG00000112936 (Ensembl)
C8AGeneProductENSG00000157131 (Ensembl)
C8BGeneProductENSG00000021852 (Ensembl)
C8GGeneProductENSG00000176919 (Ensembl)
C9GeneProductENSG00000113600 (Ensembl)
CD16aGeneProductENSG00000203747 (Ensembl)
CD19GeneProductENSG00000177455 (Ensembl)
CD23GeneProductENSG00000104921 (Ensembl)
CD40GeneProductENSG00000101017 (Ensembl)
CD59GeneProductENSG00000085063 (Ensembl)
CFBGeneProduct1037 (HGNC)
CFHGeneProductENSG00000000971 (Ensembl)
CFHR1GeneProductENSG00000080910 (Ensembl)
CFHR4GeneProductENSG00000134365 (Ensembl)
CFIGeneProductENSG00000205403 (Ensembl)
CFPGeneProductENSG00000126759 (Ensembl)
CHIPSGeneProduct5332454 (Entrez Gene)
CKGeneProductENSG00000113712 (Ensembl)
CPB2 GeneProductENSG00000120054 (Ensembl)
CPNGeneProductENSG00000120054 (Ensembl)
CR1GeneProductENSG00000203710 (Ensembl)
CR2GeneProductENSG00000117322 (Ensembl)
CR3GeneProductENSG00000160255 (Ensembl) gene ITGB2
CR4GeneProductENSG00000140678 (Ensembl) GENE ITGAX
CRIgGeneProductENSG00000155659 (Ensembl)
CRPGeneProductENSG00000132693 (Ensembl)
CbpAGeneProduct933487 (Entrez Gene)
ClfAGeneProduct2859231 (Entrez Gene)
ClfBGeneProduct5331889 (Entrez Gene)
DAFGeneProductENSG00000196352 (Ensembl)
DCNGeneProductENSG00000011465 (Ensembl)
E-LDLGeneProductENSG00000173486 (Ensembl)
ELANEGeneProductENSG00000197561 (Ensembl)
EfbGeneProduct3238454 (Entrez Gene)
EhpGeneProductYP_043213 (Entrez Gene)
FCN1GeneProductENSG00000085265 (Ensembl)
FCN2GeneProductENSG00000160339 (Ensembl)
FDGeneProductENSG00000197766 (Ensembl)
FGAGeneProduct2243 (Entrez Gene)
FGAGeneProductENSG00000171560 (Ensembl)
FGBGeneProduct2244 (Entrez Gene)
FGBGeneProductENSG00000171564 (Ensembl)
FGGGeneProductENSG00000171557 (Ensembl)
FKBP13GeneProductENSG00000173486 (Ensembl)
FNGeneProductENSG0000011541 (Ensembl)
FPR1GeneProductENSG00000171051 (Ensembl)
FXGeneProductENSG00000126218 (Ensembl)
FXIIIGeneProductENSG00000124491 (Ensembl)
FXIIaGeneProductP00748 (Uniprot-TrEMBL)
FXIaGeneProductP03951 (Uniprot-TrEMBL)
FnBPAGeneProduct3913735 (Entrez Gene)
FnBPBGeneProduct3913823 (Entrez Gene)
GNA15GeneProductENSG00000060558 (Ensembl)
GNA1870GeneProduct12393750 (Entrez Gene)
GNAI2GeneProductENSG00000114353 (Ensembl)
GNAI3GeneProductENSG00000065135 (Ensembl)
Gpm1pGeneProduct A factor H-, FHL-1-, and plasminogen-binding surface protein of Candida albicans
Gpm1pGeneProductXP_721143 (Entrez Gene)
HIV-gp41GeneProduct155971 (Entrez Gene)
HSGeneProduct28815 Ce
HSV-gCGeneProduct2703410 (Entrez Gene)
HeparinGeneProduct28304 (ChEBI)
IBSPGeneProductENSG00000029559 (Ensembl)
ICAM1GeneProductENSG00000090339 (Ensembl)
ICAM2GeneProductENSG00000108622 (Ensembl)
ITGA2BGeneProductENSG00000005961 (Ensembl)
ITGA2GeneProductENSG00000164171 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
KLKB1GeneProductENSG00000164344 (Ensembl)
LAMA5GeneProductENSG00000130702 (Ensembl)
LAMB1GeneProductENSG00000091136 (Ensembl)
LAMC1GeneProductENSG00000135862 (Ensembl)
LRP2GeneProductENSG00000081479 (Ensembl)
LTAGeneProduct28640 (ChEBI)
LfhAGeneProductAAN47894 (Entrez Gene)
MASP1GeneProductENSG00000127241 (Ensembl)
MAp19GeneProduct10747 (Entrez Gene)
MAp44GeneProduct5648 (Entrez Gene)
MBL2GeneProductENSG00000165471 (Ensembl)
MCPGeneProductENSG00000117335 (Ensembl)
NS1GeneProductAAM51537|780 (Entrez Gene)
OMCIGeneProductAAT65682 (Entrez Gene)
OPNGeneProductENSG00000118785
OmpK36GeneProductAEW62399 (Entrez Gene)
PKAGeneProductENSG00000072062 (Ensembl)
PKCGeneProductENSG00000154229 (Ensembl)
PLAURGeneProductENSG00000011422 (Ensembl)
PLGGeneProductENSG00000122194 (Ensembl)
PTX3GeneProductENSG00000163661 (Ensembl)
Por1AGeneProduct
Por1BGeneProduct
PrPGeneProductENSG00000171867 (Ensembl)
Protein MGeneProduct2940887 (NCBI Protein)
Protein-AGeneProduct5332074 (Entrez Gene)
Protein-SGeneProductENSG00000184500 (Ensembl)
RPS19GeneProductENSG00000105372 (Ensembl)
RgpAGeneProduct6330747 (NCBI Protein) Gngipain-1
SAPGeneProductENSG00000132703 (Ensembl)
SCINGeneProductENSG00000106804 (Ensembl)
SCPGeneProduct1030336 (NCBI Protein) Streptococcal C5a peptidase
SELEGeneProductENSG00000007908 (Ensembl)
SELLGeneProductENSG00000188404 (Ensembl)
SELPGeneProductENSG00000174175 (Ensembl)
SELPLGGeneProductENSG00000110876 (Ensembl)
SFTPA1GeneProductENSG00000122852 (Ensembl)
SFTPA2GeneProductENSG00000185303 (Ensembl)
SICGeneProduct269972 (Entrez Gene)
SIGN-R1 GeneProductENSMUSG00000031494 (Ensembl)
SPICEGeneProductSmall inhbitor of complement enzymes
SSL10GeneProduct2859141 (Entrez Gene)
SSL11GeneProduct1123177 (Entrez Gene)
SSL5GeneProduct2859140 (Entrez Gene)
SSL7GeneProduct2859139 (Entrez Gene)
SbiGeneProduct5331420 (Entrez Gene)
SfbGeneProduct3573107 (Entrez Gene)
SkpGeneProductADD54834 (Entrez Gene)
StcEGeneProductAAU25886 (Entrez Gene)
TFECP GeneProductT. foetus extracellular cysteine proteinase
THBSGeneProductENSG00000137801 (Ensembl)
TLR2GeneProduct7097 (Entrez Gene)
TXNGeneProductENSG00000136810 (Ensembl)
VCP GeneProduct3707640 (Entrez Gene)
VTNGeneProductENSG00000255604 (Ensembl)
WASGeneProductENSG00000015285 (Ensembl)
beta-GlucanGeneProduct28793 (ChEBI)
cC1qRGeneProductENSG00000179218 (Ensembl)
fMLPGeneProduct53490 (ChEBI)
gC1qRGeneProductENSG00000108561 (Ensembl)
gp350GeneProductYP_001129462 (Entrez Gene)
iC3bGeneProductP01024 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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