Methapyrilene metabolic pathway (Rattus norvegicus)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Graham EE, Walsh RJ, Hirst CM, Maggs JL, Martin S, Wild MJ, Wilson ID, Harding JR, Kenna JG, Peter RM, Williams DP, Park BK; ''Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.''; J Pharmacol Exp Ther, 2008 PubMed Europe PMC Scholia
2. Ratra GS, Cottrell S, Powell CJ; ''Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene.''; Toxicol Sci, 1998 PubMed Europe PMC Scholia
3. Craig A, Sidaway J, Holmes E, Orton T, Jackson D, Rowlinson R, Nickson J, Tonge R, Wilson I, Nicholson J; ''Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat.''; J Proteome Res, 2006 PubMed Europe PMC Scholia
4. Uehara T, Kiyosawa N, Hirode M, Omura K, Shimizu T, Ono A, Mizukawa Y, Miyagishima T, Nagao T, Urushidani T; ''Gene expression profiling of methapyrilene-induced hepatotoxicity in rat.''; J Toxicol Sci, 2008 PubMed Europe PMC Scholia
5. Mercer AE, Regan SL, Hirst CM, Graham EE, Antoine DJ, Benson CA, Williams DP, Foster J, Kenna JG, Park BK; ''Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.''; Toxicol Appl Pharmacol, 2009 PubMed Europe PMC Scholia

History

View all...

Compare	Revision	Action	Time	User	Comment
	116990	view	10:48, 16 May 2021	Eweitz	Modified title
	92292	view	12:42, 19 May 2017	Egonw	Ontology Term : 'xenobiotic metabolic pathway' added !
	77786	view	08:49, 18 October 2014	Egonw	A few more pointers.
	77785	view	08:25, 18 October 2014	Egonw	Extended the pathway. Haven't found specific CYP reactions yet.
	70608	view	11:11, 16 August 2013	Egonw	Widened the box.
	70606	view	09:53, 16 August 2013	Egonw
	70605	view	09:47, 16 August 2013	Egonw
	70600	view	09:26, 16 August 2013	Egonw	Added two more metabolite structures.
	70595	view	20:08, 15 August 2013	Egonw
	70587	view	15:19, 15 August 2013	Egonw	Ontology Term : 'cellular detoxification pathway' added !
	70586	view	15:17, 15 August 2013	Egonw	Added a first conversion and a paper discussing the metabolism.
	70585	view	15:08, 15 August 2013	Egonw	New pathway

External references

DataNodes

View all...

Name	Type	Database reference	Comment
CYPs	Protein
GSH	Protein
Hepatotoxicity	Pathway
MP-Noxide	Metabolite	138399 (Chemspider)
Methapyrilene	Metabolite	3956 (Chemspider)
Periportal Liver Necrosis	Pathway
demethylated methapyrilene	Metabolite	157251 (PubChem-compound)
methapyrilene-S-oxide glutathion conjugate	Metabolite
methapyrilene-S-oxide	Metabolite	29303354 (Chemspider)	Structure has been submitted to PubChem.

Annotated Interactions

No annotated interactions