TCA cycle nutrient use and invasiveness of ovarian cancer (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
2. Yang L, Moss T, Mangala LS, Marini J, Zhao H, Wahlig S, Armaiz-Pena G, Jiang D, Achreja A, Win J, Roopaimoole R, Rodriguez-Aguayo C, Mercado-Uribe I, Lopez-Berestein G, Liu J, Tsukamoto T, Sood AK, Ram PT, Nagrath D; ''Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer.''; Mol Syst Biol, 2014 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	128641	view	19:44, 17 February 2024	Eweitz	Refine legend, economize layout, standardize case
	127248	view	17:31, 28 August 2023	Khanspers	Added literature reference and updated description
	127227	view	20:03, 25 August 2023	Khanspers	added reference
	123109	view	15:01, 3 July 2022	Egonw	Made a pathway clickable
	117183	view	10:19, 18 May 2021	Eweitz	Modified title
	112051	view	17:09, 17 September 2020	Khanspers	Ontology Term : 'ovarian cancer' added !
	112050	view	17:06, 17 September 2020	Khanspers	updated phospho sites and added references
	108102	view	10:15, 29 November 2019	Fehrhart	Ontology Term : 'cancer pathway' added !
	106479	view	19:43, 3 September 2019	Khanspers	Modified description
	106190	view	12:08, 16 August 2019	MaintBot	HMDB identifier normalization
	105431	view	04:31, 8 August 2019	Khanspers	Modified description
	105408	view	15:55, 7 August 2019	DeSl	Small layout changes to make textLabels more readable.
	105391	view	17:51, 6 August 2019	Khanspers	Modified description
	105390	view	17:51, 6 August 2019	Khanspers	Modified description
	105389	view	17:50, 6 August 2019	Khanspers	Modified description
	105388	view	17:50, 6 August 2019	Khanspers	Modified description
	105387	view	17:49, 6 August 2019	Khanspers	Modified description
	90260	view	23:06, 27 October 2016	AlexanderPico	Changed Stat3 to default node color
	89885	view	13:01, 6 October 2016	Mkutmon	Modified description
	78079	view	23:52, 30 November 2014	Khanspers	fixed unconnected interactions
	77985	view	18:05, 4 November 2014	Khanspers	Added lit ref and fixed arrow
	77984	view	18:04, 4 November 2014	Khanspers	Ontology Term : 'reproductive system disease' added !
	77983	view	18:03, 4 November 2014	Khanspers	Modified description
	77956	view	19:38, 30 October 2014	Khanspers	Ontology Term : 'altered citric acid cycle pathway' added !
	77955	view	19:34, 30 October 2014	Khanspers	Ontology Term : 'cancer' added !
	77954	view	19:34, 30 October 2014	Khanspers	Modified description
	77917	view	20:00, 29 October 2014	Khanspers	Modified title
	77916	view	19:59, 29 October 2014	Khanspers	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
D-Glutamine	Metabolite	HMDB03423 (HMDB)
EGFR	GeneProduct	1956 (Entrez Gene)
ERK1	GeneProduct	5595 (Entrez Gene)
ERK2	GeneProduct	5594 (Entrez Gene)
Glucose	Metabolite	HMDB00122 (HMDB)
JAK1	GeneProduct	3716 (Entrez Gene)
Lactate	Metabolite	HMDB00190 (HMDB)
Pyruvate	Metabolite	HMDB00243 (HMDB)
STAT3	GeneProduct	6774 (Entrez Gene)
TCA Cycle	Pathway	WP78 (WikiPathways)

Annotated Interactions

No annotated interactions