Nuclear receptors meta-pathway (Homo sapiens)

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6, 35CAR/PXR LigandCAR target genes13IRS2CYP7A1STOMAGERCYP2A6FKBP5SLC26A2CES1CYP3A4CDC42EP3DNAJB1ABCC2CYP2C19KEAP1CYP3A7GSTA2PPP1R14CSLC2A13CES3SLC2A7SRGNGSTA4SULT2A1FGD4UGT1A3CYP4A11KTN1EPB41L4BUGT1A3PPARASQSTM1CYP2C9DegradationSERPINB2RGS2CDKN1CCYP8B1CBR3GPR153PDK4SMARCA1MYOFSLC2A14GSTT1SLC27A5SP1POU5F1UGT1A9HSPA1ANR1I3CUL1CXCR7ALOX5APCell proliferationand apoptosisJUNBCES5AMAFGCPEB4FTLNFKB2ANKRD1GPX2NR1H3GSTT2ME1RXRAHSP90AA1NAV3SERTAD2PRDX1IL12BBIRC3IP6K3CAP2Phase 2metabolismABCB11PMP2PLK2ABCC3NQO1NRG1UGT1A4GSTA2GSREP300SULT2A1ACOX1ABCB4NCOA1CES2ABCC5B3GNT5PGDFASNGGT1SLC2A4MGST1AntioxidantproteinsSLC7A11OtherDNAJC15SLC2A10UGT1A7G6PDCYP3A4GPX3SLC7A5DNERCYP3A4NR0B2NR0B2UGT1A7POLKSREBF1NCOA6ABHD2TGFB1SULT1A1NCOA2GSTP1PRRG4SDPRAKAP13ABCG8FGF19TGFB1TSC22D3ACAA1ABCG5UGT2B4ALDH3A1PCK1PPARGC1ABHLHE40TGFB2JUNSLC2A9ADH7CYP7A1PPP2R4HGFNR3C1SLC2A2CYP1B1ABCC3BAATCBR1SPINK13MGAMTranscriptionfactorsCo-activatorsSLC2A3UGT1A9Cell proliferationand differentiationSOD3SP1PTGS2SLC2A8SLC2A12PPARDCES3SLC2A6PTGR1GCC1GSTA3SMC1AMT1IPETNK2SRXN1GCLMENC1UGT1A1CYP2A6IL12ASERPINB9CYP1A1CYP2B6PPARAFTH1ABCB1IL17BUGT1A4FGFBP1THBDARL5BPPARGC1AEPHA3SPRY1Bile acid &xenobiotics transportbile acidconjugationSERPINA1GADD45BGCLCIL11ALAS1HMOX1ABCC2SRCHSP90AA1UGT1A6CYP2A6UGT1A4SLC2A1AMIGO2LRRC8ASNAI2UGT1A1CES4ATGFBR3ESR1EHHADHTXNRD3CYP2B6TNFAIP3S100PBLVRBSLCO2B1MFGE8TNS4PDE4BCYP1A2ANGPTL4NR0B2GSTA1ZIC2InflammationGPAMHBEGFTGFACYP3A5Drug and steroidmetabolismEPHA2MAFFPDGFBHSP90AB1SLC2A5TXNRD1ABCC4IL1BIFNGSLC2A11GPR115NR1H4UGT1A3SULT2A1CYP7A1MGST3BIRC2EGR1TXNTGFBR2UGT1A6Bile acidneosynthesisTranscriptionfactorsCCL20CCL2KAT2BSLC19A2MetabolismSEC14L1MGST2UGT1A9SCNN1ANFE2L2STAT3JUNUGT2B7CYP4A11GSTA5EDN2FGF13DNAJC7PRDX6SLC10A11519NR1I3364239394728475212847525293939443926253939394647519247283939444514946393344474415194725194721173424193939249193925152816, 503915474651282419LigandDNAJC7HSP90AA1CoregulatorsGenesTATA boxPBREMRXRANR1I3LigandCo-activatorsNCOA1EGFR pathwayEP300UGT1A6AHRR19, 29, 3928SRCCDKN1BAIP28CYP1B119, 24, 28, 29, 49UGT1A119, 29, 39ALDH3A124GSTA219, 29AHRJUNDNQO13219, 29IGFBP1NFE2L23729BAX28JUNCYP1A23819, 24, 28, 29, 49EGFRHSP90AA1TNFPTGES3IL245HES18ARNTCDC37CYP1A119, 24, 28, 29, 49AHRARNTAIPSRCSRCCDC37AHRARNTAHRLigandLigandLigandXREGenesTATA boxUGT1A917, 39HepatocyteproliferationNR1H317SCP2CPT1A1717APOC317FABP117CCND1PLTP17DBI1717APOA217CPT217APOA117CYP4A11ACADM17CDK41717CYP7A117MYCmitochondrialomega-oxidation17SLC27A117Cholesterolcatabolismperoxisomalbeta-oxidationKLK1517APOA517CDK1CYP8B11717PPAR alpha ligandPPARAGenesTATA boxPPREPPARARXRALigandlipoproteinmetabolismfatty acidtransportmitochondrialbeta-oxidationPXR target genes23, 44SLCO1B1HSP90AA123NR1I2SRPX2NCOA3FOXO1CYP4F123CYP3A423UGT1A11923DNAJC7ABCC423NRIP1UnknownCYP2B619GSTA223PSMC5PPARGC1ANCOA1NCOA2ABCB123NR1I2LigandCoregulatorsGenesTATA boxXRERXRANR1I2LigandAhR LigandCo-activatorsGenesTATA boxNR1I3NR1I24040NR3C1RXRA16, 40, 50NR1I3NR1I2NR3C1HSP90AA1GR ligandp23HSP90AA1p23NR3C110, 51HSP90AA1p23NR3C1Ligand51NR3C151LigandLigandLigandNR3C1NR3C1LigandLigandGREGenesTATA boxNR3C1NR3C1LigandLigandnGRECoregulatorsGR inhibitorytarget genesLXR ligandNR1H3LigandRXRA16, 50PTGES3RXRANR1H316, 50CYP2B647CYP2C947GenesTATA boxVDREVDR target genesVDR20, 51LigandRXRACYP3A447VDRVDR ligandRXRAVDRLigandER ligandESR1ESR1LigandLigandGenesTATA boxEREESR1LigandESR1LigandESR19ESR1ESR1LigandLigandCoregulatorsER target genes12GenesTATA boxNR1H3LigandLXRERXRALXR target genes16, 50FXR ligandNR1H426RXRALigandGenesTATA boxNR1H4RXRA26LigandFXREBile aciddetoxification46NR1H426LigandUGT1A439UGT1A6UGT1A939UGT1A339CYP2C93919CYP3A5CYP2C1919SULT2A119ABCC23347ABCC347EHHADH15FOXO13InflammationGrowth andapoptosis3030Signaltransduction30OtherInflammation3030Growth andapoptosisSignaltransduction30Metabolism30Transport3030Other30NuclearreceptorsFXR Target genesOtherGR stimulatorytarget genesMulti-drugresistanceDrug and steroidmetabolismPhase 2metabolismMulti-drugresistanceOtherOtherPhase 2metabolismDrug and steroidmetabolismPhase 2metabolismOtherDrug and steroidmetabolismMulti-drugresistanceTranscriptionfactorsOtherDrug and steroidmetabolismTranscriptionfactorsOtherDrug and steroidmetabolismPPAR alphatarget genesAhR target genesGenesTATA boxRXRALigandARENRF2 targetgenesOther5Phase 1proteinsPhase 2proteins5GSTM55GSTM1GSTM2GSTM3GSTM4TransportSLC5A25SLC5A1SLC5A4SLC5A10SLC5A9SLC5A6SLC5A11SLC5A12SLC5A3SLC5A7SLC5A8SLC5A5SLC6A2SLC6A1SLC6A4SLC6A11SLC6A9SLC6A6SLC6A13SLC6A14SLC6A3SLC6A7SLC6A8SLC6A5SLC6A16SLC6A15SLC6A18SLC6A20SLC6A17SLC6A19SLC39A2SLC39A1SLC39A4SLC39A10SLC39A9SLC39A6SLC39A11SLC39A12SLC39A3SLC39A7SLC39A8SLC39A5SLC39A13SLC39A14Growth factorsand receptorsNFE2L25NRF2 ligandKEAP1NFE2L2LigandNFE2L2NFE2L2SCD


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Bibliography

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History

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CompareRevisionActionTimeUserComment
126680view16:51, 11 June 2023EgonwFixed character encoding issues
126012view11:37, 26 March 2023EgonwWrong ligand term
125859view10:46, 13 March 2023DeSlFixed last 'ligand' classified as protein
125858view10:44, 13 March 2023DeSlResolved typo in description
125857view10:43, 13 March 2023DeSlRemoved empty comment from Description
125856view10:42, 13 March 2023DeSlConnected unconnected line
125855view10:41, 13 March 2023DeSlConverted textLabels 'ligand; to DataNode Metabolite, with ChEBI annotation; changed two protein datanodes to metaboliute for ligand.
125833view07:00, 13 March 2023EgonwAdded ChEBI identifiers for ligands
120815view15:30, 11 January 2022SusanOntology Term : 'transcription factor mediated signaling pathway' added !
117808view14:40, 22 May 2021EweitzModified title
115341view14:20, 14 February 2021EgonwMade more pathways clickable
103038view11:54, 2 February 2019MaintBotReplaced an outdated Ensembl identifiers with the new one.
97489view13:23, 23 May 2018Fehrhartlayout
97488view13:17, 23 May 2018Fehrhartadded annotations
97487view13:08, 23 May 2018Fehrhartadded annotations
97484view12:58, 23 May 2018FehrhartModified description
97483view12:56, 23 May 2018Fehrhartadded annotations
97481view12:50, 23 May 2018Fehrhartadded annotations
97480view12:42, 23 May 2018Fehrhartadded annotations
97479view12:35, 23 May 2018Fehrhartadded annotations
97478view12:12, 23 May 2018FehrhartModified description
97477view12:11, 23 May 2018FehrhartModified description
97476view12:07, 23 May 2018Fehrhartall connections done (hopefully)
97475view12:04, 23 May 2018Fehrhartconnections
97474view12:02, 23 May 2018Fehrhartconnections...
97473view12:00, 23 May 2018Fehrhartfixed connections
97472view11:58, 23 May 2018Fehrhartfixed connections
97471view11:56, 23 May 2018Fehrhartfixed connections
97470view11:55, 23 May 2018Fehrhartfixed more connections
97469view11:53, 23 May 2018Fehrhartfixed more connections
97467view09:20, 23 May 2018Fehrhartfixed more connections
97463view08:48, 22 May 2018Fehrhartfixed connections
87959view13:12, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
83040view04:29, 18 November 2015Mkutmonfixed issue with references
83016view13:30, 17 November 2015FehrhartUpdate of outdated identifiers
79825view08:28, 17 April 2015EgonwFixed the Ensembl data source.
78569view14:50, 7 January 2015MaintBotadded missing graphIds
78210view14:44, 14 December 2014EgonwChanged schema.
78209view14:42, 14 December 2014MaintBotModified title
78095view11:38, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCB11GeneProductENSG00000073734 (Ensembl Human)
ABCB1GeneProductENSG00000085563 (Ensembl Human)
ABCB4GeneProductENSG00000005471 (Ensembl Human)
ABCC2GeneProductENSG00000023839 (Ensembl Human)
ABCC3GeneProductENSG00000108846 (Ensembl Human)
ABCC4GeneProductENSG00000125257 (Ensembl Human)
ABCC5GeneProductENSG00000114770 (Ensembl Human)
ABCG5GeneProductENSG00000138075 (Ensembl Human)
ABCG8GeneProductENSG00000143921 (Ensembl Human)
ABHD2GeneProductENSG00000140526 (Ensembl Human)
ACAA1GeneProductENSG00000060971 (Ensembl Human)
ACADMGeneProductENSG00000117054 (Ensembl Human)
ACOX1GeneProductENSG00000161533 (Ensembl Human)
ADH7GeneProductENSG00000196344 (Ensembl Human)
AGERGeneProductENSG00000204305 (Ensembl Human)
AHRGeneProductENSG00000106546 (Ensembl Human)
AHRRGeneProductENSG00000063438 (Ensembl Human)
AIPGeneProductENSG00000110711 (Ensembl Human)
AKAP13GeneProductENSG00000170776 (Ensembl Human)
ALAS1GeneProductENSG00000023330 (Ensembl Human)
ALDH3A1GeneProductENSG00000108602 (Ensembl Human)
ALOX5APGeneProductENSG00000132965 (Ensembl Human)
AMIGO2GeneProductENSG00000139211 (Ensembl Human)
ANGPTL4GeneProductENSG00000167772 (Ensembl Human)
ANKRD1GeneProductENSG00000148677 (Ensembl Human)
APOA1GeneProductENSG00000118137 (Ensembl Human)
APOA2GeneProductENSG00000158874 (Ensembl Human)
APOA5GeneProductENSG00000110243 (Ensembl Human)
APOC3GeneProductENSG00000110245 (Ensembl Human)
ARL5BGeneProductENSG00000165997 (Ensembl Human)
ARNTGeneProduct405 (Entrez Gene)
Antioxidant proteinsPathway
B3GNT5GeneProductENSG00000176597 (Ensembl Human)
BAATGeneProductENSG00000136881 (Ensembl Human)
BAX GeneProductENSG00000087088 (Ensembl Human)
BHLHE40GeneProductENSG00000134107 (Ensembl Human)
BIRC2GeneProductENSG00000110330 (Ensembl Human)
BIRC3GeneProductENSG00000023445 (Ensembl Human)
BLVRBGeneProductENSG00000090013 (Ensembl Human)
Bile acid detoxificationPathway
Bile acid neosynthesisPathway
Bile acid & xenobiotics transportPathway
CAP2GeneProductENSG00000112186 (Ensembl Human)
CBR1GeneProductENSG00000159228 (Ensembl Human)
CBR3GeneProductENSG00000159231 (Ensembl Human)
CCL20GeneProductENSG00000115009 (Ensembl Human)
CCL2GeneProductENSG00000108691 (Ensembl Human)
CCND1GeneProductENSG00000110092 (Ensembl Human)
CDC37GeneProductENSG00000105401 (Ensembl Human)
CDC42EP3GeneProductENSG00000163171 (Ensembl Human)
CDK1GeneProductENSG00000170312 (Ensembl Human)
CDK4GeneProductENSG00000135446 (Ensembl Human)
CDKN1BGeneProductENSG00000111276 (Ensembl Human)
CDKN1CGeneProductENSG00000129757 (Ensembl Human)
CES1GeneProductENSG00000198848 (Ensembl Human)
CES2GeneProductENSG00000172831 (Ensembl Human)
CES3GeneProductENSG00000172828 (Ensembl Human)
CES4AGeneProductENSG00000172824 (Ensembl Human)
CES5AGeneProductENSG00000159398 (Ensembl Human)
CPEB4GeneProductENSG00000113742 (Ensembl Human)
CPT1AGeneProductENSG00000110090 (Ensembl Human)
CPT2GeneProductENSG00000157184 (Ensembl Human)
CUL1GeneProductENSG00000055130 (Ensembl Human)
CXCR7GeneProductENSG00000144476 (Ensembl Human)
CYP1A1GeneProductENSG00000140465 (Ensembl Human)
CYP1A2GeneProductENSG00000140505 (Ensembl Human)
CYP1B1GeneProductENSG00000138061 (Ensembl Human)
CYP2A6GeneProductENSG00000255974 (Ensembl Human)
CYP2B6GeneProductENSG00000197408 (Ensembl Human)
CYP2C19GeneProductENSG00000165841 (Ensembl Human)
CYP2C9GeneProductENSG00000138109 (Ensembl Human)
CYP3A4GeneProductENSG00000160868 (Ensembl Human)
CYP3A5GeneProductENSG00000106258 (Ensembl Human)
CYP3A7GeneProductENSG00000160870 (Ensembl Human)
CYP4A11GeneProductENSG00000187048 (Ensembl Human)
CYP4F12GeneProductENSG00000186204 (Ensembl Human)
CYP7A1GeneProductENSG00000167910 (Ensembl Human)
CYP8B1GeneProductENSG00000180432 (Ensembl Human)
Cell proliferation and apoptosisPathway
Cell proliferation

and differentiation

Pathway
Cholesterol catabolismPathway
Co-activators
DBIGeneProductENSG00000155368 (Ensembl Human)
DNAJB1GeneProductENSG00000132002 (Ensembl Human)
DNAJC15GeneProductENSG00000120675 (Ensembl Human)
DNAJC7GeneProductENSG00000168259 (Ensembl Human)
DNERGeneProductENSG00000187957 (Ensembl Human)
DegradationPathway
Drug and steroid metabolismPathway
EDN2GeneProductENSG00000127129 (Ensembl Human)
EGFR pathwayPathway
EGFRGeneProductENSG00000146648 (Ensembl Human)
EGR1GeneProductENSG00000120738 (Ensembl Human)
EHHADHGeneProductENSG00000113790 (Ensembl Human)
ENC1GeneProductENSG00000171617 (Ensembl Human)
EP300GeneProductENSG00000100393 (Ensembl Human)
EPB41L4BGeneProductENSG00000095203 (Ensembl Human)
EPHA2GeneProductENSG00000142627 (Ensembl Human)
EPHA3GeneProductENSG00000044524 (Ensembl Human)
ESR1GeneProductENSG00000091831 (Ensembl Human)
ETNK2GeneProductENSG00000143845 (Ensembl Human)
FABP1GeneProductENSG00000163586 (Ensembl Human)
FASNGeneProductENSG00000169710 (Ensembl Human)
FGD4GeneProductENSG00000139132 (Ensembl Human)
FGF13GeneProductENSG00000129682 (Ensembl Human)
FGF19GeneProductENSG00000162344 (Ensembl Human)
FGFBP1GeneProductENSG00000137440 (Ensembl Human)
FKBP5GeneProductENSG00000096060 (Ensembl Human)
FOXO1GeneProductENSG00000150907 (Ensembl Human)
FTH1GeneProductENSG00000167996 (Ensembl Human)
FTLGeneProductENSG00000087086 (Ensembl Human)
G6PDGeneProductENSG00000160211 (Ensembl Human)
GADD45BGeneProductENSG00000099860 (Ensembl Human)
GCC1GeneProductENSG00000179562 (Ensembl Human)
GCLCGeneProductENSG00000001084 (Ensembl Human)
GCLMGeneProductENSG00000023909 (Ensembl Human)
GGT1GeneProductENSG00000100031 (Ensembl Human)
GPAMGeneProductENSG00000119927 (Ensembl Human)
GPR115GeneProductENSG00000153294 (Ensembl Human)
GPR153GeneProductENSG00000158292 (Ensembl Human)
GPX2GeneProductENSG00000176153 (Ensembl Human)
GPX3GeneProductENSG00000211445 (Ensembl Human)
GSRGeneProductENSG00000104687 (Ensembl Human)
GSTA1GeneProductENSG00000243955 (Ensembl Human)
GSTA2GeneProductENSG00000244067 (Ensembl Human)
GSTA3GeneProductENSG00000174156 (Ensembl Human)
GSTA4GeneProductENSG00000170899 (Ensembl Human)
GSTA5GeneProductENSG00000182793 (Ensembl Human)
GSTM1GeneProductENSG00000134184 (Ensembl Human)
GSTM2GeneProductENSG00000213366 (Ensembl Human)
GSTM3GeneProductENSG00000134202 (Ensembl Human)
GSTM4GeneProductENSG00000168765 (Ensembl Human)
GSTM5GeneProductENSG00000134201 (Ensembl Human)
GSTP1GeneProductENSG00000084207 (Ensembl Human)
GSTT1GeneProductENSG00000184674 (Ensembl Human)
GSTT2GeneProductENSG00000099984 (Ensembl Human)
Growth and apoptosisPathway
Growth factors and receptorsPathway
HBEGFGeneProductENSG00000113070 (Ensembl Human)
HES1GeneProductENSG00000114315 (Ensembl Human)
HGFGeneProductENSG00000019991 (Ensembl Human)
HMOX1GeneProductENSG00000100292 (Ensembl Human)
HSP90AA1 GeneProductENSG00000080824 (Ensembl Human)
HSP90AA1GeneProductENSG00000080824 (Ensembl Human)
HSP90AB1GeneProductENSG00000096384 (Ensembl Human)
HSPA1AGeneProductENSG00000204389 (Ensembl Human)
Hepatocyte proliferationPathwayin mice (possibly also in humans?)
IFNGGeneProductENSG00000111537 (Ensembl Human)
IGFBP1 GeneProductENSG00000146678 (Ensembl Human)
IL11GeneProductENSG00000095752 (Ensembl Human)
IL12AGeneProductENSG00000168811 (Ensembl Human)
IL12BGeneProductENSG00000113302 (Ensembl Human)
IL17BGeneProductENSG00000127743 (Ensembl Human)
IL1BGeneProductENSG00000125538 (Ensembl Human)
IL2 GeneProductENSG00000109471 (Ensembl Human)
IP6K3GeneProductENSG00000161896 (Ensembl Human)
IRS2GeneProductENSG00000185950 (Ensembl Human)
InflammationPathway
JUNBGeneProductENSG00000171223 (Ensembl Human)
JUNDGeneProductENSG00000130522 (Ensembl Human)
JUNGeneProductENSG00000177606 (Ensembl Human)
KAT2BGeneProductENSG00000114166 (Ensembl Human)
KEAP1GeneProductENSG00000079999 (Ensembl Human)
KLK15GeneProductENSG00000174562 (Ensembl Human)
KTN1GeneProductENSG00000126777 (Ensembl Human)
LRRC8AGeneProductENSG00000136802 (Ensembl Human)
Ligand
Ligand ProteinOmeprazole, TCDD, PCB
MAFFGeneProductENSG00000185022 (Ensembl Human)
MAFGGeneProductENSG00000197063 (Ensembl Human)
ME1GeneProductENSG00000065833 (Ensembl Human)
MFGE8GeneProductENSG00000140545 (Ensembl Human)
MGAMGeneProductENSG00000179087 (Ensembl Human)
MGST1GeneProductENSG00000008394 (Ensembl Human)
MGST2GeneProductENSG00000085871 (Ensembl Human)
MGST3GeneProductENSG00000143198 (Ensembl Human)
MT1IPGeneProduct644314 (Entrez Gene)
MYCGeneProductENSG00000136997 (Ensembl Human)
MYOFGeneProductENSG00000138119 (Ensembl Human)
MetabolismPathway
Multi-drug resistancePathway
NAV3GeneProductENSG00000067798 (Ensembl Human)
NCOA1GeneProductENSG00000084676 (Ensembl Human)
NCOA2GeneProductENSG00000140396 (Ensembl Human)
NCOA3GeneProductENSG00000124151 (Ensembl Human)
NCOA6GeneProductENSG00000198646 (Ensembl Human)
NFE2L2GeneProductENSG00000116044 (Ensembl Human)
NFKB2GeneProductENSG00000077150 (Ensembl Human)
NQO1GeneProductENSG00000181019 (Ensembl Human)
NR0B2GeneProductENSG00000131910 (Ensembl Human)
NR1H3GeneProductENSG00000025434 (Ensembl Human)
NR1H4GeneProductENSG00000012504 (Ensembl Human)
NR1I2GeneProductENSG00000144852 (Ensembl Human)
NR1I3GeneProductENSG00000143257 (Ensembl Human)
NR3C1GeneProductENSG00000113580 (Ensembl Human)
NRG1GeneProductENSG00000157168 (Ensembl Human)
NRIP1GeneProductENSG00000180530 (Ensembl Human)
Nuclear receptorsPathway
OtherPathway
PCK1GeneProductENSG00000124253 (Ensembl Human)
PDE4BGeneProductENSG00000184588 (Ensembl Human)
PDGFBGeneProductENSG00000100311 (Ensembl Human)
PDK4GeneProductENSG00000004799 (Ensembl Human)
PGDGeneProductENSG00000142657 (Ensembl Human)
PLK2GeneProductENSG00000145632 (Ensembl Human)
PLTPGeneProductENSG00000100979 (Ensembl Human)
PMP2GeneProductENSG00000147588 (Ensembl Human)
POLKGeneProductENSG00000122008 (Ensembl Human)
POU5F1GeneProductENSG00000204531 (Ensembl Human)
PPAR alpha ligand
PPARAGeneProductENSG00000186951 (Ensembl Human)
PPARDGeneProductENSG00000112033 (Ensembl Human)
PPARGC1AGeneProductENSG00000109819 (Ensembl Human)
PPP1R14CGeneProductENSG00000198729 (Ensembl Human)
PPP2R4GeneProductENSG00000119383 (Ensembl Human) plays a role in translocation of CAR
PRDX1GeneProductENSG00000117450 (Ensembl Human)
PRDX6GeneProductENSG00000117592 (Ensembl Human)
PRRG4GeneProductENSG00000135378 (Ensembl Human)
PSMC5GeneProductENSG00000087191 (Ensembl Human)
PTGES3GeneProductENSG00000110958 (Ensembl Human)
PTGR1GeneProductENSG00000106853 (Ensembl Human)
PTGS2GeneProductENSG00000073756 (Ensembl Human)
Phase 1

proteins

Pathway
Phase 2 metabolismPathway
Phase 2

proteins

Pathway
RGS2GeneProductENSG00000116741 (Ensembl Human)
RXRAGeneProductENSG00000186350 (Ensembl Human)
S100PGeneProductENSG00000163993 (Ensembl Human)
SCDGeneProductENSG00000099194 (Ensembl Human)
SCNN1AGeneProductENSG00000111319 (Ensembl Human)
SCP2GeneProductENSG00000116171 (Ensembl Human)
SDPRGeneProductENSG00000168497 (Ensembl Human)
SEC14L1GeneProductENSG00000129657 (Ensembl Human)
SERPINA1GeneProductENSG00000197249 (Ensembl Human)
SERPINB2GeneProductENSG00000197632 (Ensembl Human)
SERPINB9GeneProductENSG00000170542 (Ensembl Human)
SERTAD2GeneProductENSG00000179833 (Ensembl Human)
SLC10A1GeneProductENSG00000100652 (Ensembl Human) inhibition
SLC19A2GeneProductENSG00000117479 (Ensembl Human)
SLC26A2GeneProductENSG00000155850 (Ensembl Human)
SLC27A1GeneProductENSG00000130304 (Ensembl Human)
SLC27A5GeneProductENSG00000083807 (Ensembl Human)
SLC2A10GeneProductENSG00000197496 (Ensembl Human)
SLC2A11GeneProductENSG00000133460 (Ensembl Human)
SLC2A12GeneProductENSG00000146411 (Ensembl Human)
SLC2A13GeneProductENSG00000151229 (Ensembl Human)
SLC2A14GeneProductENSG00000173262 (Ensembl Human)
SLC2A1GeneProductENSG00000117394 (Ensembl Human)
SLC2A2GeneProductENSG00000163581 (Ensembl Human)
SLC2A3GeneProductENSG00000059804 (Ensembl Human)
SLC2A4GeneProductENSG00000181856 (Ensembl Human)
SLC2A5GeneProductENSG00000142583 (Ensembl Human)
SLC2A6GeneProductENSG00000160326 (Ensembl Human)
SLC2A7GeneProductENSG00000197241 (Ensembl Human)
SLC2A8GeneProductENSG00000136856 (Ensembl Human)
SLC2A9GeneProductENSG00000109667 (Ensembl Human)
SLC39A10GeneProductENSG00000196950 (Ensembl Human)
SLC39A11GeneProductENSG00000133195 (Ensembl Human)
SLC39A12GeneProductENSG00000148482 (Ensembl Human)
SLC39A13GeneProductENSG00000165915 (Ensembl Human)
SLC39A14GeneProductENSG00000104635 (Ensembl Human)
SLC39A1GeneProductENSG00000143570 (Ensembl Human)
SLC39A2GeneProductENSG00000165794 (Ensembl Human)
SLC39A3GeneProductENSG00000141873 (Ensembl Human)
SLC39A4GeneProductENSG00000147804 (Ensembl Human)
SLC39A5GeneProductENSG00000139540 (Ensembl Human)
SLC39A6GeneProductENSG00000141424 (Ensembl Human)
SLC39A7GeneProductENSG00000112473 (Ensembl Human)
SLC39A8GeneProductENSG00000138821 (Ensembl Human)
SLC39A9GeneProductENSG00000029364 (Ensembl Human)
SLC5A10GeneProductENSG00000154025 (Ensembl Human)
SLC5A11GeneProductENSG00000158865 (Ensembl Human)
SLC5A12GeneProductENSG00000148942 (Ensembl Human)
SLC5A1GeneProductENSG00000100170 (Ensembl Human)
SLC5A2GeneProductENSG00000140675 (Ensembl Human)
SLC5A3GeneProductENSG00000198743 (Ensembl Human)
SLC5A4GeneProductENSG00000100191 (Ensembl Human)
SLC5A5GeneProductENSG00000105641 (Ensembl Human)
SLC5A6GeneProductENSG00000138074 (Ensembl Human)
SLC5A7GeneProductENSG00000115665 (Ensembl Human)
SLC5A8GeneProductENSG00000256870 (Ensembl Human)
SLC5A9GeneProductENSG00000117834 (Ensembl Human)
SLC6A11GeneProductENSG00000132164 (Ensembl Human)
SLC6A13GeneProductENSG00000010379 (Ensembl Human)
SLC6A14GeneProductENSG00000087916 (Ensembl Human)
SLC6A15GeneProductENSG00000072041 (Ensembl Human)
SLC6A16GeneProductENSG00000063127 (Ensembl Human)
SLC6A17GeneProductENSG00000197106 (Ensembl Human)
SLC6A18GeneProductENSG00000164363 (Ensembl Human)
SLC6A19GeneProductENSG00000174358 (Ensembl Human)
SLC6A1GeneProductENSG00000157103 (Ensembl Human)
SLC6A20GeneProductENSG00000163817 (Ensembl Human)
SLC6A2GeneProductENSG00000103546 (Ensembl Human)
SLC6A3GeneProductENSG00000142319 (Ensembl Human)
SLC6A4GeneProductENSG00000108576 (Ensembl Human)
SLC6A5GeneProductENSG00000165970 (Ensembl Human)
SLC6A6GeneProductENSG00000131389 (Ensembl Human)
SLC6A7GeneProductENSG00000011083 (Ensembl Human)
SLC6A8GeneProductENSG00000130821 (Ensembl Human)
SLC6A9GeneProductENSG00000196517 (Ensembl Human)
SLC7A11GeneProductENSG00000151012 (Ensembl Human)
SLC7A5GeneProductENSG00000103257 (Ensembl Human)
SLCO1B1GeneProductENSG00000134538 (Ensembl Human)
SLCO2B1GeneProductENSG00000137491 (Ensembl Human) inhibition
SMARCA1GeneProductENSG00000102038 (Ensembl Human)
SMC1AGeneProductENSG00000072501 (Ensembl Human)
SNAI2GeneProductENSG00000019549 (Ensembl Human)
SOD3GeneProductENSG00000109610 (Ensembl Human)
SP1GeneProductENSG00000185591 (Ensembl Human)
SPINK13GeneProductENSG00000214510 (Ensembl Human)
SPRY1GeneProductENSG00000164056 (Ensembl Human)
SQSTM1GeneProductENSG00000161011 (Ensembl Human)
SRC GeneProductENSG00000197122 (Ensembl Human)
SRC GeneProductENSG00000197122 (Ensembl Human)
SRCGeneProductENSG00000197122 (Ensembl Human)
SREBF1GeneProductENSG00000072310 (Ensembl Human)
SRGNGeneProductENSG00000122862 (Ensembl Human)
SRPX2GeneProductENSG00000102359 (Ensembl Human)
SRXN1GeneProductENSG00000172070 (Ensembl Human)
STAT3GeneProductENSG00000168610 (Ensembl Human)
STOMGeneProductENSG00000148175 (Ensembl Human)
SULT1A1GeneProductENSG00000196502 (Ensembl Human) during fasting
SULT2A1GeneProductENSG00000105398 (Ensembl Human)
Signal transductionPathway
TGFAGeneProductENSG00000163235 (Ensembl Human)
TGFB1GeneProductENSG00000105329 (Ensembl Human)
TGFB2GeneProductENSG00000092969 (Ensembl Human)
TGFBR2GeneProductENSG00000163513 (Ensembl Human)
TGFBR3GeneProductENSG00000069702 (Ensembl Human)
THBDGeneProductENSG00000178726 (Ensembl Human)
TNF GeneProductENSG00000232810 (Ensembl Human)
TNFAIP3GeneProductENSG00000118503 (Ensembl Human)
TNS4GeneProductENSG00000131746 (Ensembl Human)
TSC22D3GeneProductENSG00000157514 (Ensembl Human)
TXNGeneProductENSG00000136810 (Ensembl Human)
TXNRD1GeneProductENSG00000198431 (Ensembl Human)
TXNRD3GeneProductENSG00000197763 (Ensembl Human)
Transcription factorsPathway
TransportPathway
UGT1A1GeneProductENSG00000241635 (Ensembl Human)
UGT1A3GeneProductENSG00000243135 (Ensembl Human)
UGT1A4GeneProductENSG00000244474 (Ensembl Human)
UGT1A6GeneProductENSG00000167165 (Ensembl Human)
UGT1A7GeneProductENSG00000244122 (Ensembl Human)
UGT1A9GeneProductENSG00000241119 (Ensembl Human)
UGT2B4GeneProductENSG00000156096 (Ensembl Human)
UGT2B7GeneProductENSG00000171234 (Ensembl Human)
Unknown
VDRGeneProductENSG00000111424 (Ensembl Human)
ZIC2GeneProductENSG00000043355 (Ensembl Human)
bile acid conjugationPathway
fatty acid transportPathway
lipoprotein metabolismPathway
mitochondrial beta-oxidationPathway
mitochondrial omega-oxidationPathway
p23GeneProductENSG00000110958 (Ensembl Human)
peroxisomal beta-oxidationPathway

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2882"
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