Aryl hydrocarbon receptor pathway (Homo sapiens)

From WikiPathways

Revision as of 14:46, 14 December 2014 by MaintBot (Talk | contribs)
Jump to: navigation, search
5, 20, 45Co-activatorsHSP90AA1EGFR pathwayEP300LigandSRCAIPAHREGFRHSP90AA1TNFARNTCDC37AHRARNTAIPSRCSRCCDC37AHRARNTAHRLigandLigandLigandXREGenesTATA boxPTGES3PTGES3NCOA1UGT1A3SLC7A535Cell proliferationand differentiation9UGT1A4MYOF359IFNGSERPINB2262TGFB12CAP2UGT1A93935POLK2UGT1A7Inflammation35IL12A26CES3IL17B39IL1B92JUNBIL12B226TranscriptionfactorsMGST140UGT1A6AHRR8, 24, 352CDKN1B2CYP1B12, 8, 9, 24, 39UGT1A1ALDH3A18, 24, 359GSTA28, 24JUNDNQO1428, 24IGFBP149NFE2L224BAXJUN2CYP1A24IL22, 8, 9, 24, 39HES129CYP1A11Phase 2metabolism2, 8, 9, 24, 39Drug and steroidmetabolismOther


Description

No description

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  2. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ; ''The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  3. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  4. Jeon MS, Esser C; ''The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family.''; J Immunol, 2000 PubMed Europe PMC Scholia
  5. Smoak KA, Cidlowski JA; ''Mechanisms of glucocorticoid receptor signaling during inflammation.''; Mech Ageing Dev, 2004 PubMed Europe PMC Scholia
  6. Gao H, Fält S, Sandelin A, Gustafsson JA, Dahlman-Wright K; ''Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver.''; Mol Endocrinol, 2008 PubMed Europe PMC Scholia
  7. Nilsson S, Gustafsson JÅ; ''Estrogen receptors: therapies targeted to receptor subtypes.''; Clin Pharmacol Ther, 2011 PubMed Europe PMC Scholia
  8. Bock KW, Köhle C; ''Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions.''; Biochem Pharmacol, 2006 PubMed Europe PMC Scholia
  9. Han S, Chiang JY; ''Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.''; Drug Metab Dispos, 2009 PubMed Europe PMC Scholia
  10. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, Schneider S, Oesch-Bartlomowicz B, Zatloukalová J, Vondrácek J, Oesch F, Dietrich C; ''TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A.''; Oncogene, 2008 PubMed Europe PMC Scholia
  11. Echchgadda I, Song CS, Roy AK, Chatterjee B; ''Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  12. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed Europe PMC Scholia
  13. Fijten RR, Jennen DG, van Delft JH; ''Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants.''; Curr Drug Metab, 2013 PubMed Europe PMC Scholia
  14. Köhle C, Bock KW; ''Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.''; Biochem Pharmacol, 2007 PubMed Europe PMC Scholia
  15. ''''; , PubMed Europe PMC Scholia
  16. Pavek P, Dvorak Z; ''Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.''; Curr Drug Metab, 2008 PubMed Europe PMC Scholia
  17. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR; ''Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes.''; Proc Natl Acad Sci U S A, 2004 PubMed Europe PMC Scholia
  18. Timsit YE, Negishi M; ''CAR and PXR: the xenobiotic-sensing receptors.''; Steroids, 2007 PubMed Europe PMC Scholia
  19. Krogsdam AM, Nielsen CA, Neve S, Holst D, Helledie T, Thomsen B, Bendixen C, Mandrup S, Kristiansen K; ''Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.''; Biochem J, 2002 PubMed Europe PMC Scholia
  20. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  21. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T; ''Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms.''; Nucl Recept, 2005 PubMed Europe PMC Scholia
  22. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  23. Rodríguez-Sosa M, Elizondo G, López-Durán RM, Rivera I, Gonzalez FJ, Vega L; ''Over-production of IFN-gamma and IL-12 in AhR-null mice.''; FEBS Lett, 2005 PubMed Europe PMC Scholia
  24. Mimura J, Fujii-Kuriyama Y; ''Functional role of AhR in the expression of toxic effects by TCDD.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  25. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  26. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  27. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  28. Le Vee M, Jouan E, Fardel O; ''Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.''; Toxicol In Vitro, 2010 PubMed Europe PMC Scholia
  29. Vezina CM, Walker NJ, Olson JR; ''Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression.''; Environ Health Perspect, 2004 PubMed Europe PMC Scholia
  30. Rochette-Egly C, Germain P; ''Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).''; Nucl Recept Signal, 2009 PubMed Europe PMC Scholia
  31. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  32. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  33. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, Phillips DH; ''AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.''; Chem Res Toxicol, 2007 PubMed Europe PMC Scholia
  34. Rowlands JC, Gustafsson JA; ''Aryl hydrocarbon receptor-mediated signal transduction.''; Crit Rev Toxicol, 1997 PubMed Europe PMC Scholia
  35. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT; ''A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  36. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T; ''The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.''; Hepatology, 2001 PubMed Europe PMC Scholia
  37. Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT; ''The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  38. Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R; ''Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.''; Nucleic Acids Res, 2009 PubMed Europe PMC Scholia
  39. ''''; , PubMed Europe PMC Scholia
  40. Weiss C, Faust D, Dürk H, Kolluri SK, Pelzer A, Schneider S, Dietrich C, Oesch F, Göttlicher M; ''TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.''; Oncogene, 2005 PubMed Europe PMC Scholia
  41. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  42. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  43. Haarmann-Stemmann T, Bothe H, Abel J; ''Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
  44. Li AC, Glass CK; ''PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis.''; J Lipid Res, 2004 PubMed Europe PMC Scholia
  45. Hashimoto K, Mori M; ''''; , PubMed Europe PMC Scholia
  46. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  47. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M; ''2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
  48. Willson TM, Kliewer SA; ''PXR, CAR and drug metabolism.''; Nat Rev Drug Discov, 2002 PubMed Europe PMC Scholia
  49. Lindsey S, Papoutsakis ET; ''The aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidization.''; Br J Haematol, 2011 PubMed Europe PMC Scholia
  50. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  51. Bock KW; ''From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans.''; Biochem Pharmacol, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
123110view05:44, 4 July 2022EgonwMade a pathway clickable
120645view15:08, 22 December 2021EweitzNudge group up
120644view15:07, 22 December 2021EweitzStraighten arrow
120643view15:06, 22 December 2021EweitzTighten graphics, align
120640view01:25, 22 December 2021EweitzModified description
117655view11:46, 22 May 2021EweitzModified title
106304view17:45, 20 August 2019KhanspersModified description
105535view06:04, 9 August 2019KhanspersModified description
95229view18:54, 26 November 2017DeSlModified description
95226view18:52, 26 November 2017DeSlOntology Term : 'aryl hydrocarbon receptor signaling pathway' added !
95142view02:47, 17 November 2017AlexanderPicoadded graphical lines
95141view02:45, 17 November 2017AlexanderPicoremoved bad interactions
95140view02:41, 17 November 2017AlexanderPicoupdated node label
95139view02:38, 17 November 2017MaintBotremoved odd charactes from node lable
88902view08:20, 17 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
79696view11:00, 5 April 2015EgonwFixed the references section.
79690view20:11, 4 April 2015AlexanderPicoModified title
79597view05:34, 27 March 2015EgonwUpdated the Ensembl data source.
79544view15:12, 24 March 2015RiannefijtenModified description
79543view15:10, 24 March 2015Riannefijtenfixed unconnected line
79516view07:53, 24 March 2015Riannefijtenadded reference
79486view13:14, 23 March 2015EgonwAnnotated "ligand" with the ChEBI identifier for 'aryl hydrocarbon receptor agonist'.
79481view13:00, 23 March 2015RiannefijtenUpdated connections and the annotations
78579view14:50, 7 January 2015MaintBotadded missing graphIds
78253view22:04, 17 December 2014KhanspersModified title
78212view14:51, 14 December 2014EgonwChanged GPML schema.
78211view14:46, 14 December 2014MaintBotModified title
78086view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AHRGeneProductENSG00000106546 (Ensembl Human)
AHRRGeneProductENSG00000063438 (Ensembl Human)
AIPGeneProductENSG00000110711 (Ensembl Human)
ALDH3A1GeneProductENSG00000108602 (Ensembl Human)
ARNTGeneProduct405 (Entrez Gene)
BAX GeneProductENSG00000087088 (Ensembl Human)
CAP2GeneProductENSG00000112186 (Ensembl Human)
CDC37GeneProductENSG00000105401 (Ensembl Human)
CDKN1BGeneProductENSG00000111276 (Ensembl Human)
CES3GeneProductENSG00000172828 (Ensembl Human)
CYP1A1GeneProductENSG00000140465 (Ensembl Human)
CYP1A2GeneProductENSG00000140505 (Ensembl Human)
CYP1B1GeneProductENSG00000138061 (Ensembl Human)
Cell proliferation

and differentiation

Pathway
Drug and steroid metabolismPathway
EGFR pathwayPathway
EGFRGeneProductENSG00000146648 (Ensembl Human)
EP300GeneProductENSG00000100393 (Ensembl Human)
GSTA2GeneProductENSG00000244067 (Ensembl Human)
HES1GeneProductENSG00000114315 (Ensembl Human)
HSP90AA1 GeneProductENSG00000080824 (Ensembl Human)
HSP90AA1GeneProductENSG00000080824 (Ensembl Human)
IFNGGeneProductENSG00000111537 (Ensembl Human)
IGFBP1 GeneProductENSG00000146678 (Ensembl Human)
IL12AGeneProductENSG00000168811 (Ensembl Human)
IL12BGeneProductENSG00000113302 (Ensembl Human)
IL17BGeneProductENSG00000127743 (Ensembl Human)
IL1BGeneProductENSG00000125538 (Ensembl Human)
IL2 GeneProductENSG00000109471 (Ensembl Human)
InflammationPathway
JUNBGeneProductENSG00000171223 (Ensembl Human)
JUNDGeneProductENSG00000130522 (Ensembl Human)
JUNGeneProductENSG00000177606 (Ensembl Human)
Ligand ProteinOmeprazole, TCDD, PCB
MGST1GeneProductENSG00000008394 (Ensembl Human)
MYOFGeneProductENSG00000138119 (Ensembl Human)
NCOA1GeneProductENSG00000084676 (Ensembl Human)
NFE2L2GeneProductENSG00000116044 (Ensembl Human)
NQO1GeneProductENSG00000181019 (Ensembl Human)
OtherPathway
POLKGeneProductENSG00000122008 (Ensembl Human)
PTGES3GeneProductENSG00000110958 (Ensembl Human)
Phase 2 metabolismPathway
SERPINB2GeneProductENSG00000197632 (Ensembl Human)
SLC7A5GeneProductENSG00000103257 (Ensembl Human)
SRC GeneProductENSG00000197122 (Ensembl Human)
SRC GeneProductENSG00000197122 (Ensembl Human)
SRCGeneProductENSG00000197122 (Ensembl Human)
TGFB1GeneProductENSG00000105329 (Ensembl Human)
TNF GeneProductENSG00000232810 (Ensembl Human)
Transcription factorsPathway
UGT1A1GeneProductENSG00000241635 (Ensembl Human)
UGT1A3GeneProductENSG00000243135 (Ensembl Human)
UGT1A4GeneProductENSG00000244474 (Ensembl Human)
UGT1A6GeneProductENSG00000167165 (Ensembl Human)
UGT1A7GeneProductENSG00000244122 (Ensembl Human)
UGT1A9GeneProductENSG00000241119 (Ensembl Human)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2873"
Personal tools