Liver X receptor pathway (Homo sapiens)

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NR1H325LXR ligandNR1H3LigandGenesTATA boxNR1H3LigandLXRERXRA28, 42RXRA28, 42ABCG825CYP3A445ABCG5CYP2B625CYP7A14545SREBF143FASNLXR target genes45Drug and steroidmetabolismMulti-drugresistanceTranscriptionfactorsOtherSCD


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Bibliography

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  7. Krogsdam AM, Nielsen CA, Neve S, Holst D, Helledie T, Thomsen B, Bendixen C, Mandrup S, Kristiansen K; ''Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.''; Biochem J, 2002 PubMed Europe PMC Scholia
  8. Mimura J, Fujii-Kuriyama Y; ''Functional role of AhR in the expression of toxic effects by TCDD.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  9. Pavek P, Dvorak Z; ''Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.''; Curr Drug Metab, 2008 PubMed Europe PMC Scholia
  10. Hashimoto K, Mori M; ''Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review].''; Endocr J, 2011 PubMed Europe PMC Scholia
  11. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T; ''The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.''; Hepatology, 2001 PubMed Europe PMC Scholia
  12. Echchgadda I, Song CS, Roy AK, Chatterjee B; ''Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  13. Jeon MS, Esser C; ''The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family.''; J Immunol, 2000 PubMed Europe PMC Scholia
  14. Le Vee M, Jouan E, Fardel O; ''Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.''; Toxicol In Vitro, 2010 PubMed Europe PMC Scholia
  15. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M; ''2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
  16. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  17. Han S, Chiang JY; ''Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.''; Drug Metab Dispos, 2009 PubMed Europe PMC Scholia
  18. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  19. Timsit YE, Negishi M; ''CAR and PXR: the xenobiotic-sensing receptors.''; Steroids, 2007 PubMed Europe PMC Scholia
  20. Haarmann-Stemmann T, Bothe H, Abel J; ''Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
  21. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed Europe PMC Scholia
  22. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, Schneider S, Oesch-Bartlomowicz B, Zatloukalová J, Vondrácek J, Oesch F, Dietrich C; ''TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A.''; Oncogene, 2008 PubMed Europe PMC Scholia
  23. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  24. Gao H, Fält S, Sandelin A, Gustafsson JA, Dahlman-Wright K; ''Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver.''; Mol Endocrinol, 2008 PubMed Europe PMC Scholia
  25. Rodríguez-Sosa M, Elizondo G, López-Durán RM, Rivera I, Gonzalez FJ, Vega L; ''Over-production of IFN-gamma and IL-12 in AhR-null mice.''; FEBS Lett, 2005 PubMed Europe PMC Scholia
  26. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT; ''A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  27. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  28. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  29. Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT; ''The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  30. Weiss C, Faust D, Dürk H, Kolluri SK, Pelzer A, Schneider S, Dietrich C, Oesch F, Göttlicher M; ''TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.''; Oncogene, 2005 PubMed Europe PMC Scholia
  31. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  32. Li AC, Glass CK; ''PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis.''; J Lipid Res, 2004 PubMed Europe PMC Scholia
  33. Vezina CM, Walker NJ, Olson JR; ''Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression.''; Environ Health Perspect, 2004 PubMed Europe PMC Scholia
  34. Rowlands JC, Gustafsson JA; ''Aryl hydrocarbon receptor-mediated signal transduction.''; Crit Rev Toxicol, 1997 PubMed Europe PMC Scholia
  35. Bock KW; ''From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans.''; Biochem Pharmacol, 2011 PubMed Europe PMC Scholia
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  37. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  38. Rochette-Egly C, Germain P; ''Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).''; Nucl Recept Signal, 2009 PubMed Europe PMC Scholia
  39. ''''; , PubMed Europe PMC Scholia
  40. Nilsson S, Gustafsson JÅ; ''Estrogen receptors: therapies targeted to receptor subtypes.''; Clin Pharmacol Ther, 2011 PubMed Europe PMC Scholia
  41. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  42. Willson TM, Kliewer SA; ''PXR, CAR and drug metabolism.''; Nat Rev Drug Discov, 2002 PubMed Europe PMC Scholia
  43. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, Phillips DH; ''AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.''; Chem Res Toxicol, 2007 PubMed Europe PMC Scholia
  44. Smoak KA, Cidlowski JA; ''Mechanisms of glucocorticoid receptor signaling during inflammation.''; Mech Ageing Dev, 2004 PubMed Europe PMC Scholia
  45. Köhle C, Bock KW; ''Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.''; Biochem Pharmacol, 2007 PubMed Europe PMC Scholia
  46. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  47. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T; ''''; , PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116465view10:06, 7 May 2021EweitzModified title
106631view20:55, 12 September 2019KhanspersModified description
105637view05:06, 10 August 2019KhanspersModified description
94790view23:00, 5 October 2017AlexanderPicoConverted lines
94780view22:20, 5 October 2017AlexanderPicoConverted lines and reconnected interactions
88692view15:56, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
82709view09:24, 23 October 2015EgonwMore specific ChEBI identifier.
79886view13:20, 23 April 2015Mkutmonremoved redundant publication xref (pubmed: 15581595)
79885view12:40, 23 April 2015Mkutmonremoved redundant publication xref (pubmed: 15581595)
79599view05:44, 27 March 2015EgonwFixed a bunch of PubMed references (character encodings, messed up Biopax/XML).
79598view05:36, 27 March 2015EgonwProper ChEBI identifier ("ligand" is the chemical term in ChEBI).
79553view12:22, 25 March 2015FehrhartUpdate of GenIDs and comments
79542view15:07, 24 March 2015RiannefijtenModified description
79541view15:06, 24 March 2015Riannefijtenfixed unconnected lines, added reference, changed pathway nodes to labels
79484view13:05, 23 March 2015EgonwAnnotated "ligand" with its ChEBI identifier.
78513view10:29, 7 January 2015MaintBotadded missing graphIds
78254view22:06, 17 December 2014KhanspersModified title
78214view15:03, 14 December 2014MaintBotModified title
78213view14:58, 14 December 2014EgonwChanged GPML schema.
78087view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCG5GeneProductENSG00000138075 (Ensembl Human)
ABCG8GeneProductENSG00000143921 (Ensembl Human)
CYP2B6GeneProductENSG00000197408 (Ensembl Human)
CYP3A4GeneProductENSG00000160868 (Ensembl Human)
CYP7A1GeneProductENSG00000167910 (Ensembl Human) is not affected in human
Drug and steroid metabolismPathway
FASNGeneProductENSG00000169710 (Ensembl Human)
Multi-drug resistancePathway
NR1H3GeneProductENSG00000025434 (Ensembl Human)
OtherPathway
RXRAGeneProductENSG00000186350 (Ensembl Human)
SCDGeneProductENSG00000099194 (Ensembl Human)
SREBF1GeneProductENSG00000072310 (Ensembl Human)
Transcription factorsPathway

Annotated Interactions

No annotated interactions

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