Aryl hydrocarbon receptor pathway (Homo sapiens)

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25, 33, 35, 51OtherInflammationDrug and steroid metabolismTranscriptionfactorsCo-activatorsCell proliferation and differentiationPhase 2 metabolismEP300EGFR pathwayHSP90AA1LigandSRCAIPAHREGFRHSP90AA1TNFARNTCDC37AHRARNTAIPSRCSRCCDC37AHRARNTAHRLigandLigandLigandXREGenesTATA boxPTGES3PTGES3NCOA1UGT1A321SLC7A532UGT1A4MYOF2132IFNG30SERPINB2TGFB115CAP215UGT1A931POLK2115UGT1A721IL12A30CES3IL17B3132IL1B15JUNBIL12B1530MGST143UGT1A6AHRR8, 21, 42CDKN1B15CYP1B1158, 15, 31, 32, 42UGT1A1ALDH3A18, 21, 4232GSTA2JUND8, 426NQO18, 42IGFBP1NFE2L278BAX15JUN27CYP1A2IL28, 15, 31, 32, 42HES123CYP1A1448, 15, 31, 32, 42


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Bibliography

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  32. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
123110view05:44, 4 July 2022EgonwMade a pathway clickable
120645view15:08, 22 December 2021EweitzNudge group up
120644view15:07, 22 December 2021EweitzStraighten arrow
120643view15:06, 22 December 2021EweitzTighten graphics, align
120640view01:25, 22 December 2021EweitzModified description
117655view11:46, 22 May 2021EweitzModified title
106304view17:45, 20 August 2019KhanspersModified description
105535view06:04, 9 August 2019KhanspersModified description
95229view18:54, 26 November 2017DeSlModified description
95226view18:52, 26 November 2017DeSlOntology Term : 'aryl hydrocarbon receptor signaling pathway' added !
95142view02:47, 17 November 2017AlexanderPicoadded graphical lines
95141view02:45, 17 November 2017AlexanderPicoremoved bad interactions
95140view02:41, 17 November 2017AlexanderPicoupdated node label
95139view02:38, 17 November 2017MaintBotremoved odd charactes from node lable
88902view08:20, 17 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
79696view11:00, 5 April 2015EgonwFixed the references section.
79690view20:11, 4 April 2015AlexanderPicoModified title
79597view05:34, 27 March 2015EgonwUpdated the Ensembl data source.
79544view15:12, 24 March 2015RiannefijtenModified description
79543view15:10, 24 March 2015Riannefijtenfixed unconnected line
79516view07:53, 24 March 2015Riannefijtenadded reference
79486view13:14, 23 March 2015EgonwAnnotated "ligand" with the ChEBI identifier for 'aryl hydrocarbon receptor agonist'.
79481view13:00, 23 March 2015RiannefijtenUpdated connections and the annotations
78579view14:50, 7 January 2015MaintBotadded missing graphIds
78253view22:04, 17 December 2014KhanspersModified title
78212view14:51, 14 December 2014EgonwChanged GPML schema.
78211view14:46, 14 December 2014MaintBotModified title
78086view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AHRGeneProductENSG00000106546 (Ensembl Human)
AHRRGeneProductENSG00000063438 (Ensembl Human)
AIPGeneProductENSG00000110711 (Ensembl Human)
ALDH3A1GeneProductENSG00000108602 (Ensembl Human)
ARNTGeneProduct405 (Entrez Gene)
BAX GeneProductENSG00000087088 (Ensembl Human)
CAP2GeneProductENSG00000112186 (Ensembl Human)
CDC37GeneProductENSG00000105401 (Ensembl Human)
CDKN1BGeneProductENSG00000111276 (Ensembl Human)
CES3GeneProductENSG00000172828 (Ensembl Human)
CYP1A1GeneProductENSG00000140465 (Ensembl Human)
CYP1A2GeneProductENSG00000140505 (Ensembl Human)
CYP1B1GeneProductENSG00000138061 (Ensembl Human)
EGFR pathwayPathwayWP1910 (WikiPathways)
EGFRGeneProductENSG00000146648 (Ensembl Human)
EP300GeneProductENSG00000100393 (Ensembl Human)
GSTA2GeneProductENSG00000244067 (Ensembl Human)
HES1GeneProductENSG00000114315 (Ensembl Human)
HSP90AA1 GeneProductENSG00000080824 (Ensembl Human)
HSP90AA1GeneProductENSG00000080824 (Ensembl Human)
IFNGGeneProductENSG00000111537 (Ensembl Human)
IGFBP1 GeneProductENSG00000146678 (Ensembl Human)
IL12AGeneProductENSG00000168811 (Ensembl Human)
IL12BGeneProductENSG00000113302 (Ensembl Human)
IL17BGeneProductENSG00000127743 (Ensembl Human)
IL1BGeneProductENSG00000125538 (Ensembl Human)
IL2 GeneProductENSG00000109471 (Ensembl Human)
JUNBGeneProductENSG00000171223 (Ensembl Human)
JUNDGeneProductENSG00000130522 (Ensembl Human)
JUNGeneProductENSG00000177606 (Ensembl Human)
LigandMetaboliteCHEBI:72768 (ChEBI) Omeprazole, TCDD, PCB
MGST1GeneProductENSG00000008394 (Ensembl Human)
MYOFGeneProductENSG00000138119 (Ensembl Human)
NCOA1GeneProductENSG00000084676 (Ensembl Human)
NFE2L2GeneProductENSG00000116044 (Ensembl Human)
NQO1GeneProductENSG00000181019 (Ensembl Human)
POLKGeneProductENSG00000122008 (Ensembl Human)
PTGES3GeneProductENSG00000110958 (Ensembl Human)
SERPINB2GeneProductENSG00000197632 (Ensembl Human)
SLC7A5GeneProductENSG00000103257 (Ensembl Human)
SRC GeneProductENSG00000197122 (Ensembl Human)
SRC GeneProductENSG00000197122 (Ensembl Human)
SRCGeneProductENSG00000197122 (Ensembl Human)
TGFB1GeneProductENSG00000105329 (Ensembl Human)
TNF GeneProductENSG00000232810 (Ensembl Human)
UGT1A1GeneProductENSG00000241635 (Ensembl Human)
UGT1A3GeneProductENSG00000243135 (Ensembl Human)
UGT1A4GeneProductENSG00000244474 (Ensembl Human)
UGT1A6GeneProductENSG00000167165 (Ensembl Human)
UGT1A7GeneProductENSG00000244122 (Ensembl Human)
UGT1A9GeneProductENSG00000241119 (Ensembl Human)

Annotated Interactions

No annotated interactions

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