Regulation of toll-like receptor signaling (Homo sapiens)
From WikiPathways
Description
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Quality Tags
Ontology Terms
Bibliography
- Qian C, Cao X; ''Regulation of Toll-like receptor signaling pathways in innate immune responses.''; Ann N Y Acad Sci, 2013 PubMed Europe PMC Scholia
- ''Toll-like receptor signaling pathway ''; https://www.kegg.jp/pathway/hsa04620,
- Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S; ''Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.''; Nat Immunol, 2002 PubMed Europe PMC Scholia
- Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, Wagner H, Lipford G, Bauer S; ''Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.''; Nat Immunol, 2002 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
(anti-viral compounds) | Metabolite | CHEBI:22587 (ChEBI) | |
AKT1 | GeneProduct | 207 (Entrez Gene) | Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208 |
AKT2 | GeneProduct | 208 (Entrez Gene) | Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208 |
AKT3 | GeneProduct | 10000 (Entrez Gene) | Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208 |
Apoptosis | Pathway | WP254 (WikiPathways) | |
BTK | GeneProduct | ENSG00000010671 (Ensembl) | |
CASP8 | GeneProduct | 841 (Entrez Gene) | Original kegg element: gene;87;hsa:841 |
CCL3 | GeneProduct | 6348 (Entrez Gene) | Original kegg element: gene;44;hsa:6348 |
CCL4 | GeneProduct | 6351 (Entrez Gene) | Original kegg element: gene;38;hsa:6351 |
CCL5 | GeneProduct | 6352 (Entrez Gene) | Original kegg element: gene;58;hsa:6352 |
CD14 | GeneProduct | 929 (Entrez Gene) | Original kegg element: gene;84;hsa:929 |
CD180 | GeneProduct | ENSG00000134061 (Ensembl) | |
CD40 | GeneProduct | 958 (Entrez Gene) | Original kegg element: gene;29;hsa:958 |
CD80 | GeneProduct | 941 (Entrez Gene) | Original kegg element: gene;69;hsa:941 |
CD86 | GeneProduct | 942 (Entrez Gene) | Original kegg element: gene;28;hsa:942 |
CHUK | GeneProduct | 1147 (Entrez Gene) | Original kegg element: gene;42;hsa:1147 |
CISH | GeneProduct | ENSG00000114737 (Ensembl) | |
CTNNAL1 | GeneProduct | ENSG00000119326 (Ensembl) | |
CUEDC2 | GeneProduct | ENSG00000107874 (Ensembl) | |
CXCL10 | GeneProduct | 3627 (Entrez Gene) | Original kegg element: gene;25;hsa:3627 |
CXCL11 | GeneProduct | 6373 (Entrez Gene) | Original kegg element: gene;23;hsa:6373 |
CXCL9 | GeneProduct | 4283 (Entrez Gene) | Original kegg element: gene;24;hsa:4283 |
CYLD | GeneProduct | ENSG00000083799 (Ensembl) | |
FADD | GeneProduct | 8772 (Entrez Gene) | Original kegg element: gene;56;hsa:8772 |
FBXW5 | GeneProduct | ENSG00000159069 (Ensembl) | |
FOS | GeneProduct | 2353 (Entrez Gene) | Original kegg element: gene;35;hsa:2353 hsa:3725 |
IFNA10 | GeneProduct | 3446 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA13 | GeneProduct | 3447 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA1 | GeneProduct | 3439 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA14 | GeneProduct | 3448 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA16 | GeneProduct | 3449 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA17 | GeneProduct | 3451 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA21 | GeneProduct | 3452 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA2 | GeneProduct | 3440 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA4 | GeneProduct | 3441 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA5 | GeneProduct | 3442 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA6 | GeneProduct | 3443 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA7 | GeneProduct | 3444 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA8 | GeneProduct | 3445 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNAR1 | GeneProduct | 3454 (Entrez Gene) | Original kegg element: gene;49;hsa:3454 hsa:3455 |
IFNAR2 | GeneProduct | 3455 (Entrez Gene) | Original kegg element: gene;49;hsa:3454 hsa:3455 |
IFNB1 | GeneProduct | 3456 (Entrez Gene) | Original kegg element: gene;1;hsa:3456 |
IKBKB | GeneProduct | 3551 (Entrez Gene) | Original kegg element: gene;36;hsa:3551 |
IKBKE | GeneProduct | 9641 (Entrez Gene) | Original kegg element: gene;54;hsa:9641 |
IKBKG | GeneProduct | 8517 (Entrez Gene) | Original kegg element: gene;85;hsa:8517 |
IL12A | GeneProduct | 3592 (Entrez Gene) | Original kegg element: gene;45;hsa:3592 hsa:3593 |
IL12B | GeneProduct | 3593 (Entrez Gene) | Original kegg element: gene;45;hsa:3592 hsa:3593 |
IL1B | GeneProduct | 3553 (Entrez Gene) | Original kegg element: gene;51;hsa:3553 |
IL6 | GeneProduct | 3569 (Entrez Gene) | Original kegg element: gene;57;hsa:3569 |
IL8 | GeneProduct | 3576 (Entrez Gene) | Original kegg element: gene;43;hsa:3576 |
IRAK1 | GeneProduct | 3654 (Entrez Gene) | Original kegg element: gene;41;hsa:3654 |
IRAK2 | GeneProduct | ENSG00000134070 (Ensembl) | |
IRAK3 | GeneProduct | ENSG00000090376 (Ensembl) | |
IRAK4 | GeneProduct | 51135 (Entrez Gene) | Original kegg element: gene;86;hsa:51135 |
IRF3 | GeneProduct | 3661 (Entrez Gene) | Original kegg element: gene;67;hsa:3661 |
IRF5 | GeneProduct | 3663 (Entrez Gene) | Original kegg element: gene;21;hsa:3663 |
IRF7 | GeneProduct | 3665 (Entrez Gene) | Original kegg element: gene;20;hsa:3665 |
Imidazoquinolin | Metabolite | 14697812 (Chemspider) | |
JUN | GeneProduct | 3725 (Entrez Gene) | Original kegg element: gene;35;hsa:2353 hsa:3725 |
LBP | GeneProduct | 3929 (Entrez Gene) | Original kegg element: gene;77;hsa:3929 |
LY96 | GeneProduct | 23643 (Entrez Gene) | Original kegg element: gene;71;hsa:23643 |
MAP2K1 | GeneProduct | 5604 (Entrez Gene) | Original kegg element: gene;12;hsa:5604 hsa:5605 |
MAP2K2 | GeneProduct | 5605 (Entrez Gene) | Original kegg element: gene;12;hsa:5604 hsa:5605 |
MAP2K3 | GeneProduct | 5606 (Entrez Gene) | Original kegg element: gene;65;hsa:5606 hsa:5608 |
MAP2K4 | GeneProduct | 6416 (Entrez Gene) | Original kegg element: gene;63;hsa:5609 hsa:6416 |
MAP2K6 | GeneProduct | 5608 (Entrez Gene) | Original kegg element: gene;65;hsa:5606 hsa:5608 |
MAP2K7 | GeneProduct | 5609 (Entrez Gene) | Original kegg element: gene;63;hsa:5609 hsa:6416 |
MAP3K7 | GeneProduct | 6885 (Entrez Gene) | Original kegg element: gene;37;hsa:6885 |
MAP3K7IP1 | GeneProduct | 10454 (Entrez Gene) | Original kegg element: gene;59;hsa:10454 |
MAP3K7IP2 | GeneProduct | ENSG00000055208 (Ensembl) | Original kegg element: gene;59;hsa:10454 |
MAP3K7IP3 | GeneProduct | ENSG00000157625 (Ensembl) | Original kegg element: gene;61;hsa:23118 |
MAP3K8 | GeneProduct | 1326 (Entrez Gene) | Original kegg element: gene;13;hsa:1326 |
MAPK10 | GeneProduct | 5602 (Entrez Gene) | Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602 |
MAPK11 | GeneProduct | 5600 (Entrez Gene) | Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300 |
MAPK12 | GeneProduct | 6300 (Entrez Gene) | Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300 |
MAPK13 | GeneProduct | 5603 (Entrez Gene) | Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300 |
MAPK14 | GeneProduct | 1432 (Entrez Gene) | Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300 |
MAPK1 | GeneProduct | 5594 (Entrez Gene) | Original kegg element: gene;11;hsa:5594 hsa:5595 |
MAPK3 | GeneProduct | 5595 (Entrez Gene) | Original kegg element: gene;11;hsa:5594 hsa:5595 |
MAPK8 | GeneProduct | 5599 (Entrez Gene) | Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602 |
MAPK9 | GeneProduct | 5601 (Entrez Gene) | Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602 |
MBL2 | GeneProduct | ENSG00000165471 (Ensembl) | |
MLST8 | GeneProduct | 64223 (Entrez Gene) | |
MYD88 | GeneProduct | 4615 (Entrez Gene) | Original kegg element: gene;47;hsa:4615 |
MYD88s | GeneProduct | ENSG00000172936 (Ensembl) | |
NEU1 | GeneProduct | ENSG00000184494 (Ensembl) | |
NFKB1 | GeneProduct | 4790 (Entrez Gene) | Original kegg element: gene;14;hsa:4790 |
NFKB2 | GeneProduct | 4791 (Entrez Gene) | Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970 |
NFKBIA | GeneProduct | 4792 (Entrez Gene) | Original kegg element: gene;64;hsa:4792 |
OTUD5 | GeneProduct | ENSG00000068308 (Ensembl) | |
PELI1 | GeneProduct | ENSG00000197329 (Ensembl) | |
PELI2 | GeneProduct | ENSG00000139946 (Ensembl) | |
PELI3 | GeneProduct | ENSG00000174516 (Ensembl) | |
PIK3CA | GeneProduct | 5290 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3CB | GeneProduct | 5291 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3CD | GeneProduct | 5293 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3CG | GeneProduct | 5294 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3R1 | GeneProduct | 5295 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3R2 | GeneProduct | 5296 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3R3 | GeneProduct | 8503 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3R5 | GeneProduct | 23533 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PLK1 | GeneProduct | ENSG00000166851 (Ensembl) | |
PTPN6 | GeneProduct | ENSG00000111679 (Ensembl) | |
RAC1 | GeneProduct | 5879 (Entrez Gene) | Original kegg element: gene;48;hsa:5879 |
RBCK1 | GeneProduct | ENSG00000125826 (Ensembl) | |
RELA | GeneProduct | 5970 (Entrez Gene) | Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970 |
RIPK1 | GeneProduct | 8737 (Entrez Gene) | Original kegg element: gene;17;hsa:8737 |
RNF216 | GeneProduct | ENSG00000011275 (Ensembl) | |
RNF31 | GeneProduct | ENSG00000092098 (Ensembl) | |
RNF41 | GeneProduct | ENSG00000181852 (Ensembl) | |
SARM1 | GeneProduct | ENSG00000004139 (Ensembl) | |
SFTPA1 | GeneProduct | ENSG00000185303 (Ensembl) | |
SFTPD | GeneProduct | ENSG00000133661 (Ensembl) | |
SIGIRR | GeneProduct | ENSG00000185187 (Ensembl) | |
SMAD6 | GeneProduct | ENSG00000137834 (Ensembl) | |
SOCS1 | GeneProduct | ENSG00000185338 (Ensembl) | |
SPP1 | GeneProduct | 6696 (Entrez Gene) | Original kegg element: gene;15;hsa:6696 |
SQSTM1 | GeneProduct | ENSG00000161011 (Ensembl) | |
STAT1 | GeneProduct | 6772 (Entrez Gene) | Original kegg element: gene;62;hsa:6772 |
SYK | GeneProduct | ENSG00000165025 (Ensembl) | |
TBK1 | GeneProduct | 29110 (Entrez Gene) | Original kegg element: gene;52;hsa:29110 |
TICAM1 | GeneProduct | 148022 (Entrez Gene) | Original kegg element: gene;82;hsa:148022 |
TICAM2 (TAG) | GeneProduct | ENSG00000134970 (Ensembl) | |
TICAM2 | GeneProduct | 353376 (Entrez Gene) | Original kegg element: gene;80;hsa:353376 |
TIRAP | GeneProduct | 114609 (Entrez Gene) | Original kegg element: gene;83;hsa:114609 |
TLR1 | GeneProduct | 7096 (Entrez Gene) | Original kegg element: gene;75;hsa:7096 |
TLR2 | GeneProduct | 7097 (Entrez Gene) | Original kegg element: gene;74;hsa:7097 |
TLR2s | GeneProduct | ENSG00000137462 (Ensembl) | |
TLR3 | GeneProduct | 7098 (Entrez Gene) | Original kegg element: gene;73;hsa:7098 |
TLR4 | GeneProduct | 7099 (Entrez Gene) | Original kegg element: gene;79;hsa:7099 |
TLR4s | GeneProduct | ENSG00000136869 (Ensembl) | |
TLR5 | GeneProduct | 7100 (Entrez Gene) | Original kegg element: gene;72;hsa:7100 |
TLR6 | GeneProduct | 10333 (Entrez Gene) | Original kegg element: gene;76;hsa:10333 |
TLR7 | GeneProduct | 51284 (Entrez Gene) | Original kegg element: gene;39;hsa:51284 hsa:51311 |
TLR8 | GeneProduct | 51311 (Entrez Gene) | Original kegg element: gene;39;hsa:51284 hsa:51311 |
TLR9 | GeneProduct | 54106 (Entrez Gene) | Original kegg element: gene;78;hsa:54106 |
TNF | GeneProduct | 7124 (Entrez Gene) | Original kegg element: gene;66;hsa:7124 |
TNFAIP3 | GeneProduct | ENSG00000118503 (Ensembl) | |
TOLLIP | GeneProduct | 54472 (Entrez Gene) | Original kegg element: gene;81;hsa:54472 |
TRAF3 | GeneProduct | 7187 (Entrez Gene) | Original kegg element: gene;16;hsa:7187 |
TRAF6 | GeneProduct | 7189 (Entrez Gene) | Original kegg element: gene;53;hsa:7189 |
TRAFD1 | GeneProduct | ENSG00000135148 (Ensembl) | |
TREM1 | GeneProduct | ENSG00000124731 (Ensembl) | |
Tifa | GeneProduct | ENSG00000145365 (Ensembl) | |
Trim30 | GeneProduct | ENSMUSG00000030921 (Ensembl) | |
USP7 | GeneProduct | ENSG00000187555 (Ensembl) | |
ZMYND11 | GeneProduct | ENSG00000015171 (Ensembl) | |
hsa-let-7e | GeneProduct | ||
hsa-let-7e | GeneProduct | ENSG00000198972 (Ensembl) | |
hsa-let-7i (gene) | GeneProduct | ENSG00000199179 (Ensembl) | |
hsa-mir-105-1 | GeneProduct | ENSG00000207957 (Ensembl) | |
hsa-mir-146a | GeneProduct | ENSG00000207936 (Ensembl) | |
hsa-mir-155 | GeneProduct | ENSG00000207795 (Ensembl) | |
hsa-mir-98 | GeneProduct | 407054 (Entrez Gene) |
Annotated Interactions
No annotated interactions