Isoprenoid precursor biosynthesis in Pf apicoplasts (Plasmodium falciparum)

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Description

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Bibliography

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1. Yao ZK, Krai PM, Merino EF, Simpson ME, Slebodnick C, Cassera MB, Carlier PR; ''Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies.''; Bioorg Med Chem Lett, 2015 PubMed Europe PMC Scholia
2. Yeh E, DeRisi JL; ''Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum.''; PLoS Biol, 2011 PubMed Europe PMC Scholia
3. Hunter WN; ''The non-mevalonate pathway of isoprenoid precursor biosynthesis.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
4. Hunter WN; ''Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites.''; Curr Top Med Chem, 2011 PubMed Europe PMC Scholia
5. Wiemer AJ, Hsiao CH, Wiemer DF; ''Isoprenoid metabolism as a therapeutic target in gram-negative pathogens.''; Curr Top Med Chem, 2010 PubMed Europe PMC Scholia
6. Wu W, Herrera Z, Ebert D, Baska K, Cho SH, DeRisi JL, Yeh E; ''A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis.''; Antimicrob Agents Chemother, 2015 PubMed Europe PMC Scholia
7. Borrmann S, Lundgren I, Oyakhirome S, Impouma B, Matsiegui PB, Adegnika AA, Issifou S, Kun JF, Hutchinson D, Wiesner J, Jomaa H, Kremsner PG; ''Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malaria.''; Antimicrob Agents Chemother, 2006 PubMed Europe PMC Scholia
8. Borrmann S, Adegnika AA, Matsiegui PB, Issifou S, Schindler A, Mawili-Mboumba DP, Baranek T, Wiesner J, Jomaa H, Kremsner PG; ''Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children.''; J Infect Dis, 2004 PubMed Europe PMC Scholia
9. Ruangweerayut R, Looareesuwan S, Hutchinson D, Chauemung A, Banmairuroi V, Na-Bangchang K; ''Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria.''; Malar J, 2008 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	123066	view	04:15, 23 June 2022	Egonw	Made a pathway clickable
	117380	view	10:31, 21 May 2021	Eweitz	Modified title
	106946	view	13:40, 17 September 2019	MaintBot	HMDB identifier normalization
	98907	view	14:22, 15 October 2018	DeSl	Added last missing ID.
	98906	view	14:17, 15 October 2018	DeSl	Added IDs for several proteins
	98890	view	19:47, 11 October 2018	Khanspers	fixed typo
	98889	view	19:45, 11 October 2018	Khanspers	Modified description
	98888	view	19:44, 11 October 2018	Khanspers	Modified title
	84376	view	05:52, 18 February 2016	Egonw	Ontology Term : 'PW:0000650' removed !
	84375	view	05:51, 18 February 2016	Egonw	Ontology Term : 'signaling pathway pertinent to development' added !
	81807	view	15:56, 30 August 2015	Egonw	OK, finally got around to encoding the last bit from the paper.
	81124	view	08:41, 25 July 2015	Egonw	Ontology Term : 'Plasmodium infection pathway' added !
	81096	view	08:06, 22 July 2015	Egonw	Ontology Term : 'Plasmodium falciparum malaria' added !
	81095	view	08:05, 22 July 2015	Egonw	Ontology Term : 'DOID:14067' removed !
	81094	view	08:00, 22 July 2015	Egonw	Ontology Term : 'Plasmodium falciparum malaria' added !
	81093	view	07:58, 22 July 2015	Egonw	Ontology Term : 'Plasmodium falciparum malaria' added !
	81092	view	07:53, 22 July 2015	Egonw	Ontology Term : 'Plasmodium falciparum malaria' added !
	81077	view	04:52, 21 July 2015	Egonw	Added a disease ontology tag.
	80388	view	18:55, 12 June 2015	AlexanderPico	Connected edge and tweaked label fonts
	80139	view	12:46, 14 May 2015	Egonw	Indicated the human cell embedding.
	80138	view	12:44, 14 May 2015	Egonw	Set the species to Plasmodium falciparum.
	80061	view	05:53, 4 May 2015	Egonw	Modified description
	80058	view	09:55, 3 May 2015	Egonw	Modified title
	80055	view	08:55, 3 May 2015	Egonw	Added MMV008138.
	80054	view	08:19, 3 May 2015	Egonw	Added an inhibitor which has been tested for use against malaria (see 3 new references).
	80053	view	08:11, 3 May 2015	Egonw	Added (some of) the human-parasite interaction.
	80052	view	07:45, 3 May 2015	Egonw	Modified description
	80051	view	07:44, 3 May 2015	Egonw	More content copied in. Now a proper Human cell, with an P. falciparum acipoplast embedded in it.
	80050	view	16:26, 2 May 2015	Egonw	Added ChEBI and Entrez Gene identifiers.
	80049	view	11:28, 2 May 2015	Egonw	Added a 4th paper.
	80048	view	11:11, 2 May 2015	Egonw	Modified description
	80047	view	11:10, 2 May 2015	Egonw	Added two more publications.
	80046	view	11:01, 2 May 2015	Egonw	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
D-Glyceraldehyde 3-phosphate	Metabolite	HMDB01112 (HMDB)
DOXP	Metabolite		1-deoxy-D-xylylose 5-phosphate
DXS	GeneProduct
IspC	GeneProduct
MEP	Metabolite		2C-methyl-D-erythritol 4-phosphate
pyruvate	Metabolite

Annotated Interactions

No annotated interactions