This pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Breast Cancer. These proteins were then used to determine the most important pathways involved in Breast Cancer by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCarta, KEGG, and NCI-Nature. The pathways were then annotated. Protein-protein relations for the most important proteins for Breast Cancer were determined by annotating the pathways and by literature review. The protein-protein interactions are mapped onto this pathway.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway WP1984(80445) with a 91.0% conversion rate.
Fritz G, Kaina B; ''Activation of c-Jun N-terminal kinase 1 by UV irradiation is inhibited by wortmannin without affecting c-iun expression.''; Mol Cell Biol, 1999 PubMedEurope PMCScholia
Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH; ''Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.''; J Biol Chem, 2008 PubMedEurope PMCScholia
Hall LL, Th'ng JP, Guo XW, Teplitz RL, Bradbury EM; ''A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation.''; Cancer Res, 1996 PubMedEurope PMCScholia
Muأ±oz E, Courtois G, Veschambre P, Jalinot P, Israأ«l A; ''Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3.''; J Virol, 1994 PubMedEurope PMCScholia
Li YJ, Azuma A, Usuki J, Abe S, Matsuda K, Sunazuka T, Shimizu T, Hirata Y, Inagaki H, Kawada T, Takahashi S, Kudoh S, Omura S; ''EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-beta signaling in lung fibroblasts.''; Respir Res, 2006 PubMedEurope PMCScholia
Wang W, Seki M, Narita Y, Sonoda E, Takeda S, Yamada K, Masuko T, Katada T, Enomoto T; ''Possible association of BLM in decreasing DNA double strand breaks during DNA replication.''; EMBO J, 2000 PubMedEurope PMCScholia
Franklin RA, Tordai A, Patel H, Gardner AM, Johnson GL, Gelfand EW; ''Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes.''; J Clin Invest, 1994 PubMedEurope PMCScholia
Yu Y, Wang Y, Ren X, Tsuyada A, Li A, Liu LJ, Wang SE; ''Context-dependent bidirectional regulation of the MutS homolog 2 by transforming growth factor β contributes to chemoresistance in breast cancer cells.''; Mol Cancer Res, 2010 PubMedEurope PMCScholia
Zhang M, Lee CH, Luo DD, Krupa A, Fraser D, Phillips A; ''Polarity of response to transforming growth factor-beta1 in proximal tubular epithelial cells is regulated by beta-catenin.''; J Biol Chem, 2007 PubMedEurope PMCScholia
Sweezey NB, Ghibu F, Gagnon S, Schotman E, Hamid Q; ''Glucocorticoid receptor mRNA and protein in fetal rat lung in vivo: modulation by glucocorticoid and androgen.''; Am J Physiol, 1998 PubMedEurope PMCScholia
Gu RG, Zhou CW, Ma QZ; ''[Effect of dihydrotestosterone on the transcriptions and expressions of Smad3 and Smad4 in LNCaP cell line].''; Zhonghua Nan Ke Xue, 2006 PubMedEurope PMCScholia
Wang C, Bian Z, Wei D, Zhang JG; ''miR-29b regulates migration of human breast cancer cells.''; Mol Cell Biochem, 2011 PubMedEurope PMCScholia
Paci C, Gobbato R, Carboni T, Sanguigni S, Santone A, Curatola L; ''P300 auditory event-related potentials and neuropsychological study during donepezil treatment in vascular dementia.''; Neurol Sci, 2006 PubMedEurope PMCScholia
Taplin ME, Bubley GJ, Ko YJ, Small EJ, Upton M, Rajeshkumar B, Balk SP; ''Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.''; Cancer Res, 1999 PubMedEurope PMCScholia
Bhat-Nakshatri P, Wang G, Collins NR, Thomson MJ, Geistlinger TR, Carroll JS, Brown M, Hammond S, Srour EF, Liu Y, Nakshatri H; ''Estradiol-regulated microRNAs control estradiol response in breast cancer cells.''; Nucleic Acids Res, 2009 PubMedEurope PMCScholia
Terasaki M, Reese TS; ''Interactions among endoplasmic reticulum, microtubules, and retrograde movements of the cell surface.''; Cell Motil Cytoskeleton, 1994 PubMedEurope PMCScholia
Zhang H, Shi X, Zhang QJ, Hampong M, Paddon H, Wahyuningsih D, Pelech S; ''Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells.''; J Biol Chem, 2002 PubMedEurope PMCScholia
Si ML, Zhu S, Wu H, Lu Z, Wu F, Mo YY; ''miR-21-mediated tumor growth.''; Oncogene, 2007 PubMedEurope PMCScholia
Paul R, Dalibart R, Lemoine S, Lestienne P; ''Expression of E. coli RecA targeted to mitochondria of human cells.''; Mutat Res, 2001 PubMedEurope PMCScholia
Wang ZX, Lu BB, Wang H, Cheng ZX, Yin YM; ''MicroRNA-21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN.''; Arch Med Res, 2011 PubMedEurope PMCScholia
Su M, Bansal AK, Mantovani R, Sodek J; ''Recruitment of nuclear factor Y to the inverted CCAAT element (ICE) by c-Jun and E1A stimulates basal transcription of the bone sialoprotein gene in osteosarcoma cells.''; J Biol Chem, 2005 PubMedEurope PMCScholia
Ray R, Thomas S, Miller DM; ''Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene.''; Am J Med Sci, 1990 PubMedEurope PMCScholia
Horton JK, Stefanick DF, Naron JM, Kedar PS, Wilson SH; ''Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure.''; J Biol Chem, 2005 PubMedEurope PMCScholia
Persianinov LS; ''The use of electro-analgesia in obstetrics and gynecology. A survey by invitation.''; Acta Obstet Gynecol Scand, 1975 PubMedEurope PMCScholia
Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
Ontology Terms
Bibliography
History
External references
DataNodes
Annotated Interactions
No annotated interactions