Chemical compounds to monitor proteins (Homo sapiens)

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Bibliography

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1. Maloney PR, Parks DJ, Haffner CD, Fivush AM, Chandra G, Plunket KD, Creech KL, Moore LB, Wilson JG, Lewis MC, Jones SA, Willson TM; ''Identification of a chemical tool for the orphan nuclear receptor FXR.''; J Med Chem, 2000 PubMed Europe PMC Scholia
2. Picaud S, Da Costa D, Thanasopoulou A, Filippakopoulos P, Fish PV, Philpott M, Fedorov O, Brennan P, Bunnage ME, Owen DR, Bradner JE, Taniere P, O'Sullivan B, Müller S, Schwaller J, Stankovic T, Knapp S; ''PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains.''; Cancer Res, 2013 PubMed Europe PMC Scholia
3. Pellicciari R, Fiorucci S, Camaioni E, Clerici C, Costantino G, Maloney PR, Morelli A, Parks DJ, Willson TM; ''6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.''; J Med Chem, 2002 PubMed Europe PMC Scholia
4. Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ; ''The promise and peril of chemical probes.''; Nat Chem Biol, 2015 PubMed Europe PMC Scholia
5. Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE; ''Selective inhibition of BET bromodomains.''; Nature, 2010 PubMed Europe PMC Scholia
6. Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM, Huthmacher C, Gudgin E, Lugo D, Beinke S, Chapman TD, Roberts EJ, Soden PE, Auger KR, Mirguet O, Doehner K, Delwel R, Burnett AK, Jeffrey P, Drewes G, Lee K, Huntly BJ, Kouzarides T; ''Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.''; Nature, 2011 PubMed Europe PMC Scholia
7. Roth BL, Baner K, Westkaemper R, Siebert D, Rice KC, Steinberg S, Ernsberger P, Rothman RB; ''Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC Scholia
8. Ring DB, Johnson KW, Henriksen EJ, Nuss JM, Goff D, Kinnick TR, Ma ST, Reeder JW, Samuels I, Slabiak T, Wagman AS, Hammond ME, Harrison SD; ''Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo.''; Diabetes, 2003 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	135792	view	19:19, 11 November 2024	Eweitz	Modified description
	117050	view	14:16, 16 May 2021	Eweitz	Modified title
	89209	view	05:06, 23 August 2016	Egonw	Ontology Term : 'drug pathway' added !
	89208	view	05:06, 23 August 2016	Egonw	Ontology Term : 'PW:0000002' removed !
	89171	view	03:44, 23 August 2016	Ariutta	Ontology Term : 'classic metabolic pathway' added !
	81810	view	18:59, 30 August 2015	Egonw	Added the last two probes on the www.chemicalprobes.org website.
	81809	view	18:35, 30 August 2015	Egonw	Added the second FXR probe.
	81808	view	16:18, 30 August 2015	Egonw	Added another probe.
	81125	view	08:47, 25 July 2015	Egonw	Modified description
	81123	view	08:20, 25 July 2015	Egonw	Modified title
	81121	view	18:19, 24 July 2015	Egonw	Added the third BRD family compound (probe).
	81120	view	17:59, 24 July 2015	Egonw	Added the second probe.
	81119	view	17:47, 24 July 2015	Egonw	Add the other three targets.
	81118	view	16:49, 24 July 2015	Egonw	Added a link to the website for this compound.
	81117	view	16:45, 24 July 2015	Egonw	Modified description
	81116	view	16:43, 24 July 2015	Egonw	New pathway

External references

DataNodes

Name	Type	Database reference	Comment
BRD2	GeneProduct	ENSG00000204256 (Ensembl)
I-BET151	Metabolite	52912189 (PubChem-compound)

Annotated Interactions

No annotated interactions