eIF5A regulation in response to inhibition of the nuclear export system (Homo sapiens)

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1NucleusSINE: Selective inhibitors of nuclear exportSINEApoptosisEIF5AEXP4IGF2BP1EIF5AEIF5AEXP4EIF5ACytoplasmIGF2BP1CRM1EIF5AIGF2BP1CRM1


Description

Model of eIF5A regulation in response to inhibition of the nuclear export system. Under normal conditions, IGF2BP1 is exported by XPO1 and binds to eIF5A in cytoplasm. The binding with IGF2BP1 prevents eIF5A from accumulating in mitochondria. SINE (Selective Inhibitors of Nuclear Export) inhibits the nuclear export of IGF2BP1, resulting in decreased cytoplasmic IGF2BP1. Unbound eIF5A accumulates in mitochondria and induces apoptosis.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Miyake T, Pradeep S, Wu SY, Rupaimoole R, Zand B, Wen Y, Gharpure KM, Nagaraja AS, Hu W, Cho MS, Dalton HJ, Previs RA, Taylor ML, Hisamatsu T, Kang Y, Liu T, Shacham S, McCauley D, Hawke DH, Wiktorowicz JE, Coleman RL, Sood AK; ''XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A.''; Clin Cancer Res, 2015 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
123388view06:20, 23 July 2022EgonwMade a pathway clickable
87966view13:14, 25 July 2016SusanOntology Term : 'nuclear protein transport pathway' added !
87384view11:05, 22 July 2016MaintBotadded missing graphids
81679view23:42, 22 August 2015AlexanderPicoAdded pathway node for Apoptosis
81297view00:10, 15 August 2015MaintBotModified description
81296view00:04, 15 August 2015KhanspersNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
CRM1GeneProductENSG00000082898 (Ensembl)
EIF5AGeneProductENSG00000132507 (Ensembl)
EXP4GeneProductENSG00000132953 (Ensembl)
IGF2BP1GeneProductENSG00000159217 (Ensembl)

Annotated Interactions

No annotated interactions

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