Evolocumab mechanism to reduce LDL cholesterol (Homo sapiens)

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LDL-C degradedWithout PCSK9 bound, LDLR is recycled to cell surface to bind and extract more LDL-C from the plasmaPCSK9LDLRLDL-CholesterolEvolocumabPCSK9LDLRLDL-CholesterolPCSK9LDLRLDL-CholesterolLDLRLDL-CholesterolLDLRLDL-CholesterolLDL-C degraded alongwith LDLR and PCSK9


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Dorey, Emma; ''PCSK9 inhibitors: the next cholesterol-lowering blockbusters?''; The Pharmaceutical Journal, 2015 DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
128627view02:10, 17 February 2024EweitzEvolocumab inhibits PCSK9
128626view02:07, 17 February 2024EweitzRefine receptor placement
128625view02:05, 17 February 2024EweitzUse standard metabolite color
128623view01:58, 17 February 2024EweitzEconomize layout
128056view12:44, 23 January 2024EweitzModified description
128055view12:42, 23 January 2024EweitzStandardize case
125296view17:22, 31 January 2023LarsgwFix references
125034view12:17, 16 January 2023Mkutmonfixed reference title
125033view12:16, 16 January 2023Mkutmonadded doi
118453view14:58, 27 May 2021Marvin M2ref removed double lines
116731view10:30, 11 May 2021EweitzModified title
105111view13:06, 8 July 2019DeSlOntology Term : 'hepatocyte' added !
105110view13:05, 8 July 2019DeSlOntology Term : 'altered cholesterol biosynthetic pathway' added !
105109view13:05, 8 July 2019DeSlOntology Term : 'altered cholesterol transport pathway' added !
105108view12:55, 8 July 2019DeSlConverted DataNode type for Evolocumab from protein to metabolite.
88049view13:44, 25 July 2016SusanOntology Term : 'drug pathway' added !
81714view18:08, 25 August 2015MaintBotfixed typo in lit ref
81680view09:59, 23 August 2015EgonwAdded an xref for Evolocumab (which links to at least a CAS registry number).
81671view22:33, 22 August 2015AlexanderPicofixing multiline label
81670view22:32, 22 August 2015AlexanderPicofixing multiline label
81669view22:24, 22 August 2015AlexanderPicoQuick edit to datanode annotation or property
81668view22:22, 22 August 2015AlexanderPicoAdded lit ref
81667view22:13, 22 August 2015AlexanderPicoModified description
81666view22:05, 22 August 2015AlexanderPicoNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
EvolocumabMetabolite
LDL-CholesterolMetaboliteCHEBI:47774 (ChEBI)
LDLRGeneProductENSG00000130164 (Ensembl)
PCSK9GeneProductENSG00000169174 (Ensembl)

Annotated Interactions

No annotated interactions

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