Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none cytosolendoplasmic reticulum lumenphagocytic cupFCGRIA:CD3GhomodimerAntigen-antibodycomplexIgG-Ag:FCGRIA:CD3GhomodimerFCGR2AFCGRIIIA:CD3G/CD3ZdimersIgG-Ag:FCGRIIIA:CD3G/CD3Z dimersATPclusteredIgG-Ag:FCGRsclusteredIgG-Ag:p-FCGRsADPSYKclusteredIgG-Ag:p-FCGRs:SYKATPADPclusteredIgG-Ag:p-FCGRs:p-6Y-SYKVAV1,2,3clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:VAVATPADPclusteredIgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVGTPGDPRAC1:GTPCRKII:DOCK180:ELMOcomplex recruitedto phagocytic cupBAIAP2PI(3,4,5)P3WAVE RegulatoryComplexWRC:IRSp53/58:RAC1:GTP:PIP3ATPADPp-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3G-actinCDC42:GDPCDC42:GTPGDPWASP/N-WASPPI(4,5)P2CDC42:GTP:WASP/N-WASPActivated WAVE2 andWASP/N-WASP:ARP2/3complex:G-actinGTPPiMotherfilament:branchingcomplexMotherfilament:branchingcomplex:daughterfilamentCDC42:GTP, RAC1:GTPPAK1 dimerRAC1/CDC42:PAK dimerATPp-S144,T423-PAK1RAC1/CDC42:p-S144,T423-PAKPAK1ADPLIMK1ATPADPp-T508-LIMK1HSP90AA1,HSP90AB1pLIMK dimer:HSP-90Active LIMK1CFL1pCofilin: ActiveLIMK-1PI3KPI3K:p-6Y-SYKADPATPclusteredIgG-Ag:p-FCGRs:p-6Y-SYK:PLCGADPclusteredIgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGPLC gamma1,2p-PLCGDAGsI(1,4,5)P3IP3 receptorhomotetramerITPR:I(1,4,5)P3tetramerCa2+Ca2+PKC-delta/epsilonPhospho-PKC-delta/epsilonPLDPhosphatidatephosphatasePiH2OARAPLA2G6H2OPCPAH2O2-LysophosphatidylcholinePhosphatidylcholineIgG-Ag:FCGRIIASrc family kinases(SFKs)ARP2/3 complex (ATPbound)p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3ABL1PI(3,4,5)P3CRK:DOCK180:ELMO1,ELMO2PI(4,5)P2Activated WAVE2 andWASP/N-WASPWIP family proteinsSH3 domain proteinsCDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsATPADPCDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsSrc-kinasesF-actinMotherfilament:ARP2/3:actin:GDPActin:ADPG-actinMyosin-X dimerATPPI(3,4)P2Actin filament boundMyosin-XPiATPMyosinMyosin-ActinfilamentsclusteredIgG-Ag:p-FCGRsPiclusteredIgG-Ag:p-FCGRsPI(3,4,5)P3PI(4,5)P2ATPDAGscholineATPADPATPADPH2OATPADPp-4Y-PLCG1p-T,Y MAPK dimersATPAHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerRAC1:GDPADPFCGR1ACD3GAntigenIGKCIGKV4-1(21-?)IGKV1-5(23-?)IGLV(23-?)IGKVA18(21-?)Ig kappa chain V region EV15Ig kappa chain V-I region AGIg kappa chain V-I region AUIg kappa chain V-I region BANIg kappa chain V-I region BiIg kappa chain V-I region CARIg kappa chain V-I region DEEIg kappa chain V-I region DaudiIg kappa chain V-I region EUIg kappa chain V-I region GalIg kappa chain V-I region HK101Ig kappa chain V-I region HauIg kappa chain V-I region KaIg kappa chain V-I region KueIg kappa chain V-I region LayIg kappa chain V-I region MevIg kappa chain V-I region NiIg kappa chain V-I region OUIg kappa chain V-I region ReiIg kappa chain V-I region RoyIg kappa chain V-I region ScwIg kappa chain V-I region WATIg kappa chain V-I region WEAIg kappa chain V-I region WalkerIg kappa chain V-I region WesIg kappa chain V-II region CumIg kappa chain V-II region FRIg kappa chain V-II region GM607Ig kappa chain V-II region MILIg kappa chain V-II region RPMI 6410Ig kappa chain V-II region TEWIg kappa chain V-III region B6Ig kappa chain V-III region CLLIg kappa chain V-III region GOLIg kappa chain V-III region HAHIg kappa chain V-III region HICIg kappa chain V-III region IARC/BL41Ig kappa chain V-III region NG9Ig kappa chain V-III region POMIg kappa chain V-III region SIEIg kappa chain V-III region TiIg kappa chain V-III region VGIg kappa chain V-III region VHIg kappa chain V-III region WOLIg kappa chain V-IV region B17Ig kappa chain V-IV region JIIg kappa chain V-IV region LenIg kappa chain V-IV region STHIGLV8-61(1-?)IGLV4-3(1-?)IGLV1-36(1-?)IGLV2-18(1-?)IGLV2-33(1-?)IGLV3-16(1-?)IGLV5-37(1-?)IGLV1-40(1-?)IGLV1-44(1-?)IGLV3-22(1-?)IGLV7-43(1-?)IGLV5-45(1-?)IGLV4-60(1-?)IGLV10-54(1-?)IGLV2-11(1-?)IGLV2-23(1-?)IGLV3-25(1-?)IGLV3-27(1-?)IGLV3-12(1-?)IGLV7-46(1-?)IGLV11-55(1-?)IGLV4-69(1-?)Ig lambda chain V region 4AIg lambda chain V-I region BL2Ig lambda chain V-I region EPSIg lambda chain V-I region HAIg lambda chain V-I region MEMIg lambda chain V-I region NEWIg lambda chain V-I region NEWMIg lambda chain V-I region NIG-64Ig lambda chain V-I region VORIg lambda chain V-I region WAHIg lambda chain V-II region BOIg lambda chain V-II region BOHIg lambda chain V-II region BURIg lambda chain V-II region MGCIg lambda chain V-II region NEIIg lambda chain V-II region NIG-58Ig lambda chain V-II region NIG-84Ig lambda chain V-II region TOGIg lambda chain V-II region TROIg lambda chain V-II region VILIg lambda chain V-II region WINIg lambda chain V-III region LOIIg lambda chain V-III region SHIg lambda chain V-IV region BauIg lambda chain V-IV region HilIg lambda chain V-IV region KernIg lambda chain V-IV region MOLIg lambda chain V-IV region XIg lambda chain V-V region DELIg lambda chain V-VI region ARIg lambda chain V-VI region EB4Ig lambda chain V-VI region NIG-48Ig lambda chain V-VI region SUTIg lambda chain V-VI region WLTIg lambda chain V-VII region MOTIGLC1IGLC2IGLC3IGLC6IGLC7IgH heavy chain V-III region VH26 precursorIGHV7-81(1-?)IGHV(1-?)Ig heavy chain V-I region EUIg heavy chain V-I region HG3Ig heavy chain V-I region NDIg heavy chain V-I region SIEIg heavy chain V-I region WOLIg heavy chain V-II region CORIg heavy chain V-II region DAWIg heavy chain V-II region HEIg heavy chain V-II region MCEIg heavy chain V-II region NEWMIg heavy chain V-II region OUIg heavy chain V-II region WAHIg heavy chain V-III region BROIg heavy chain V-III region BURIg heavy chain V-III region BUTIg heavy chain V-III region CAMIg heavy chain V-III region DOBIg heavy chain V-III region GAIg heavy chain V-III region GALIg heavy chain V-III region HILIg heavy chain V-III region JONIg heavy chain V-III region KOLIg heavy chain V-III region LAYIg heavy chain V-III region NIEIg heavy chain V-III region POMIg heavy chain V-III region TEIIg heavy chain V-III region TILIg heavy chain V-III region TROIg heavy chain V-III region TURIg heavy chain V-III region WASIg heavy chain V-III region WEAIg heavy chain V-III region ZAPIg heavy chain V-I region MotIg heavy chain V-II region ARH-77Ig heavy chain V-II region SESSIGHG1IGHG2IGHG3IGHG4AntigenIGKCIGKV4-1(21-?)IGKV1-5(23-?)IGLV(23-?)IGKVA18(21-?)Ig kappa chain V region EV15Ig kappa chain V-I region AGIg kappa chain V-I region AUIg kappa chain V-I region BANIg kappa chain V-I region BiIg kappa chain V-I region CARIg kappa chain V-I region DEEIg kappa chain V-I region DaudiIg kappa chain V-I region EUIg kappa chain V-I region GalIg kappa chain V-I region HK101Ig kappa chain V-I region HauIg kappa chain V-I region KaIg kappa chain V-I region KueIg kappa chain V-I region LayIg kappa chain V-I region MevIg kappa chain V-I region NiIg kappa chain V-I region OUIg kappa chain V-I region ReiIg kappa chain V-I region RoyIg kappa chain V-I region ScwIg kappa chain V-I region WATIg kappa chain V-I region WEAIg kappa chain V-I region WalkerIg kappa chain V-I region WesIg kappa chain V-II region CumIg kappa chain V-II region FRIg kappa chain V-II region GM607Ig kappa chain V-II region MILIg kappa chain V-II region RPMI 6410Ig kappa chain V-II region TEWIg kappa chain V-III region B6Ig kappa chain V-III region CLLIg kappa chain V-III region GOLIg kappa chain V-III region HAHIg kappa chain V-III region HICIg kappa chain V-III region IARC/BL41Ig kappa chain V-III region NG9Ig kappa chain V-III region POMIg kappa chain V-III region SIEIg kappa chain V-III region TiIg kappa chain V-III region VGIg kappa chain V-III region VHIg kappa chain V-III region WOLIg kappa chain V-IV region B17Ig kappa chain V-IV region JIIg kappa chain V-IV region LenIg kappa chain V-IV region STHIGLV8-61(1-?)IGLV4-3(1-?)IGLV1-36(1-?)IGLV2-18(1-?)IGLV2-33(1-?)IGLV3-16(1-?)IGLV5-37(1-?)IGLV1-40(1-?)IGLV1-44(1-?)IGLV3-22(1-?)IGLV7-43(1-?)IGLV5-45(1-?)IGLV4-60(1-?)IGLV10-54(1-?)IGLV2-11(1-?)IGLV2-23(1-?)IGLV3-25(1-?)IGLV3-27(1-?)IGLV3-12(1-?)IGLV7-46(1-?)IGLV11-55(1-?)IGLV4-69(1-?)Ig lambda chain V region 4AIg lambda chain V-I region BL2Ig lambda chain V-I region EPSIg lambda chain V-I region HAIg lambda chain V-I region MEMIg lambda chain V-I region NEWIg lambda chain V-I region NEWMIg lambda chain V-I region NIG-64Ig lambda chain V-I region VORIg lambda chain V-I region WAHIg lambda chain V-II region BOIg lambda chain V-II region BOHIg lambda chain V-II region BURIg lambda chain V-II region MGCIg lambda chain V-II region NEIIg lambda chain V-II region NIG-58Ig lambda chain V-II region NIG-84Ig lambda chain V-II region TOGIg lambda chain V-II region TROIg lambda chain V-II region VILIg lambda chain V-II region WINIg lambda chain V-III region LOIIg lambda chain V-III region SHIg lambda chain V-IV region BauIg lambda chain V-IV region HilIg lambda chain V-IV region KernIg lambda chain V-IV region MOLIg lambda chain V-IV region XIg lambda chain V-V region DELIg lambda chain V-VI region ARIg lambda chain V-VI region EB4Ig lambda chain V-VI region NIG-48Ig lambda chain V-VI region SUTIg lambda chain V-VI region WLTIg lambda chain V-VII region MOTIGLC1IGLC2IGLC3IGLC6IGLC7IgH heavy chain V-III region VH26 precursorIGHV7-81(1-?)IGHV(1-?)Ig heavy chain V-I region EUIg heavy chain V-I region HG3Ig heavy chain V-I region NDIg heavy chain V-I region SIEIg heavy chain V-I region WOLIg heavy chain V-II region CORIg heavy chain V-II region DAWIg heavy chain V-II region HEIg heavy chain V-II region MCEIg heavy chain V-II region NEWMIg heavy chain V-II region OUIg heavy chain V-II region WAHIg heavy chain V-III region BROIg heavy chain V-III region BURIg heavy chain V-III region BUTIg heavy chain V-III region CAMIg heavy chain V-III region DOBIg heavy chain V-III region GAIg heavy chain V-III region GALIg heavy chain V-III region HILIg heavy chain V-III region JONIg heavy chain V-III region KOLIg heavy chain V-III region LAYIg heavy chain V-III region NIEIg heavy chain V-III region POMIg heavy chain V-III region TEIIg heavy chain V-III region TILIg heavy chain V-III region TROIg heavy chain V-III region TURIg heavy chain V-III region WASIg heavy chain V-III region WEAIg heavy chain V-III region ZAPIg heavy chain V-I region MotIg heavy chain V-II region ARH-77Ig heavy chain V-II region SESSIGHG1IGHG2IGHG3IGHG4FCGR1ACD3GCD3GCD247-1FCGR3AAntigenIGKCIGKV4-1(21-?)IGKV1-5(23-?)IGLV(23-?)IGKVA18(21-?)Ig kappa chain V region EV15Ig kappa chain V-I region AGIg kappa chain V-I region AUIg kappa chain V-I region BANIg kappa chain V-I region BiIg kappa chain V-I region CARIg kappa chain V-I region DEEIg kappa chain V-I region DaudiIg kappa chain V-I region EUIg kappa chain V-I region GalIg kappa chain V-I region HK101Ig kappa chain V-I region HauIg kappa chain V-I region KaIg kappa chain V-I region KueIg kappa chain V-I region LayIg kappa chain V-I region MevIg kappa chain V-I region NiIg kappa chain V-I region OUIg kappa chain V-I region ReiIg kappa chain V-I region RoyIg kappa chain V-I region ScwIg kappa chain V-I region WATIg kappa chain V-I region WEAIg kappa chain V-I region WalkerIg kappa chain V-I region WesIg kappa chain V-II region CumIg kappa chain V-II region FRIg kappa chain V-II region GM607Ig kappa chain V-II region MILIg kappa chain V-II region RPMI 6410Ig kappa chain V-II region TEWIg kappa chain V-III region B6Ig kappa chain V-III region CLLIg kappa chain V-III region GOLIg kappa chain V-III region HAHIg kappa chain V-III region HICIg kappa chain V-III region IARC/BL41Ig kappa chain V-III region NG9Ig kappa chain V-III region POMIg kappa chain V-III region SIEIg kappa chain V-III region TiIg kappa chain V-III region VGIg kappa chain V-III region VHIg kappa chain V-III region WOLIg kappa chain V-IV region B17Ig kappa chain V-IV region JIIg kappa chain V-IV region LenIg kappa chain V-IV region STHIGLV8-61(1-?)IGLV4-3(1-?)IGLV1-36(1-?)IGLV2-18(1-?)IGLV2-33(1-?)IGLV3-16(1-?)IGLV5-37(1-?)IGLV1-40(1-?)IGLV1-44(1-?)IGLV3-22(1-?)IGLV7-43(1-?)IGLV5-45(1-?)IGLV4-60(1-?)IGLV10-54(1-?)IGLV2-11(1-?)IGLV2-23(1-?)IGLV3-25(1-?)IGLV3-27(1-?)IGLV3-12(1-?)IGLV7-46(1-?)IGLV11-55(1-?)IGLV4-69(1-?)Ig lambda chain V region 4AIg lambda chain V-I region BL2Ig lambda chain V-I region EPSIg lambda chain V-I region HAIg lambda chain V-I region MEMIg lambda chain V-I region NEWIg lambda chain V-I region NEWMIg lambda chain V-I region NIG-64Ig lambda chain V-I region VORIg lambda chain V-I region WAHIg lambda chain V-II region BOIg lambda chain V-II region BOHIg lambda chain V-II region BURIg lambda chain V-II region MGCIg lambda chain V-II region NEIIg lambda chain V-II region NIG-58Ig lambda chain V-II region NIG-84Ig lambda chain V-II region TOGIg lambda chain V-II region TROIg lambda chain V-II region VILIg lambda chain V-II region WINIg lambda chain V-III region LOIIg lambda chain V-III region SHIg lambda chain V-IV region BauIg lambda chain V-IV region HilIg lambda chain V-IV region KernIg lambda chain V-IV region MOLIg lambda chain V-IV region XIg lambda chain V-V region DELIg lambda chain V-VI region ARIg lambda chain V-VI region EB4Ig lambda chain V-VI region NIG-48Ig lambda chain V-VI region SUTIg lambda chain V-VI region WLTIg lambda chain V-VII region MOTIGLC1IGLC2IGLC3IGLC6IGLC7IgH heavy chain V-III region VH26 precursorIGHV7-81(1-?)IGHV(1-?)Ig heavy chain V-I region EUIg heavy chain V-I region HG3Ig heavy chain V-I region NDIg heavy chain V-I region SIEIg heavy chain V-I region WOLIg heavy chain V-II region CORIg heavy chain V-II region DAWIg heavy chain V-II region HEIg heavy chain V-II region MCEIg heavy chain V-II region NEWMIg heavy chain V-II region OUIg heavy chain V-II region WAHIg heavy chain V-III region BROIg heavy chain V-III region BURIg heavy chain V-III region BUTIg heavy chain V-III region CAMIg heavy chain V-III region DOBIg heavy chain V-III region GAIg heavy chain V-III region GALIg heavy chain V-III region HILIg heavy chain V-III region JONIg heavy chain V-III region KOLIg heavy chain V-III region LAYIg heavy chain V-III region NIEIg heavy chain V-III region POMIg heavy chain V-III region TEIIg heavy chain V-III region TILIg heavy chain V-III region TROIg heavy chain V-III region TURIg heavy chain V-III region WASIg heavy chain V-III region WEAIg heavy chain V-III region ZAPIg heavy chain V-I region MotIg heavy chain V-II region ARH-77Ig heavy chain V-II region SESSIGHG1IGHG2IGHG3IGHG4CD3GCD247-1FCGR3AFCGR2AFCGR1ACD3GCD247-1FCGR3AAntigenIGKCIGKV4-1(21-?)IGKV1-5(23-?)IGLV(23-?)IGKVA18(21-?)Ig kappa chain V region EV15Ig kappa chain V-I region AGIg kappa chain V-I region AUIg kappa chain V-I region BANIg kappa chain V-I region BiIg kappa chain V-I region CARIg kappa chain V-I region DEEIg kappa chain V-I region DaudiIg kappa chain V-I region EUIg kappa chain V-I region GalIg kappa chain V-I region HK101Ig kappa chain V-I region HauIg kappa chain V-I region KaIg kappa chain V-I region KueIg kappa chain V-I region LayIg kappa chain V-I region MevIg kappa chain V-I region NiIg kappa chain V-I region OUIg kappa chain V-I region ReiIg kappa chain V-I region RoyIg kappa chain V-I region ScwIg kappa chain V-I region WATIg kappa chain V-I region WEAIg kappa chain V-I region WalkerIg kappa chain V-I region WesIg kappa chain V-II region CumIg kappa chain V-II region FRIg kappa chain V-II region GM607Ig kappa chain V-II region MILIg kappa chain V-II region RPMI 6410Ig kappa chain V-II region TEWIg kappa chain V-III region B6Ig kappa chain V-III region CLLIg kappa chain V-III region GOLIg kappa chain V-III region HAHIg kappa chain V-III region HICIg kappa chain V-III region IARC/BL41Ig kappa chain V-III region NG9Ig kappa chain V-III region POMIg kappa chain V-III region SIEIg kappa chain V-III region TiIg kappa chain V-III region VGIg kappa chain V-III region VHIg kappa chain V-III region WOLIg kappa chain V-IV region B17Ig kappa chain V-IV region JIIg kappa chain V-IV region LenIg kappa chain V-IV region STHIGLV8-61(1-?)IGLV4-3(1-?)IGLV1-36(1-?)IGLV2-18(1-?)IGLV2-33(1-?)IGLV3-16(1-?)IGLV5-37(1-?)IGLV1-40(1-?)IGLV1-44(1-?)IGLV3-22(1-?)IGLV7-43(1-?)IGLV5-45(1-?)IGLV4-60(1-?)IGLV10-54(1-?)IGLV2-11(1-?)IGLV2-23(1-?)IGLV3-25(1-?)IGLV3-27(1-?)IGLV3-12(1-?)IGLV7-46(1-?)IGLV11-55(1-?)IGLV4-69(1-?)Ig lambda chain V region 4AIg lambda chain V-I region BL2Ig lambda chain V-I region EPSIg lambda chain V-I region HAIg lambda chain V-I region MEMIg lambda chain V-I region NEWIg lambda chain V-I region NEWMIg lambda chain V-I region NIG-64Ig lambda chain V-I region VORIg lambda chain V-I region WAHIg lambda chain V-II region BOIg lambda chain V-II region BOHIg lambda chain V-II region BURIg lambda chain V-II region MGCIg lambda chain V-II region NEIIg lambda chain V-II region NIG-58Ig lambda chain V-II region NIG-84Ig lambda chain V-II region TOGIg lambda chain V-II region TROIg lambda chain V-II region VILIg lambda chain V-II region WINIg lambda chain V-III region LOIIg lambda chain V-III region SHIg lambda chain V-IV region BauIg lambda chain V-IV region HilIg lambda chain V-IV region KernIg lambda chain V-IV region MOLIg lambda chain V-IV region XIg lambda chain V-V region DELIg lambda chain V-VI region ARIg lambda chain V-VI region EB4Ig lambda chain V-VI region NIG-48Ig lambda chain V-VI region SUTIg lambda chain V-VI region WLTIg lambda chain V-VII region MOTIGLC1IGLC2IGLC3IGLC6IGLC7IgH heavy chain V-III region VH26 precursorIGHV7-81(1-?)IGHV(1-?)Ig heavy chain V-I region EUIg heavy chain V-I region HG3Ig heavy chain V-I region NDIg heavy chain V-I region SIEIg heavy chain V-I region WOLIg heavy chain V-II region CORIg heavy chain V-II region DAWIg heavy chain V-II region HEIg heavy chain V-II region MCEIg heavy chain V-II region NEWMIg heavy chain V-II region OUIg heavy chain V-II region WAHIg heavy chain V-III region BROIg heavy chain V-III region BURIg heavy chain V-III region BUTIg heavy chain V-III region CAMIg heavy chain V-III region DOBIg heavy chain V-III region GAIg heavy chain V-III region GALIg heavy chain V-III region HILIg heavy chain V-III region JONIg heavy chain V-III region KOLIg heavy chain V-III region LAYIg heavy chain V-III region NIEIg heavy chain V-III region POMIg heavy chain V-III region TEIIg heavy chain V-III region TILIg heavy chain V-III region TROIg heavy chain V-III region TURIg heavy chain V-III region WASIg heavy chain V-III region WEAIg heavy chain V-III region ZAPIg heavy chain V-I region MotIg heavy chain V-II region ARH-77Ig heavy chain V-II region SESSIGHG1IGHG2IGHG3IGHG4AntigenIGKCIGKV4-1(21-?)IGKV1-5(23-?)IGLV(23-?)IGKVA18(21-?)Ig kappa chain V region EV15Ig kappa chain V-I region AGIg kappa chain V-I region AUIg kappa chain V-I region BANIg kappa chain V-I region BiIg kappa chain V-I region CARIg kappa chain V-I region DEEIg kappa chain V-I region DaudiIg kappa chain V-I region EUIg kappa chain V-I region GalIg kappa chain V-I region HK101Ig kappa chain V-I region HauIg kappa chain V-I region KaIg kappa chain V-I region KueIg kappa chain V-I region LayIg kappa chain V-I region MevIg kappa chain V-I region NiIg kappa chain V-I region OUIg kappa chain V-I region ReiIg kappa chain V-I region RoyIg kappa chain V-I region ScwIg kappa chain V-I region WATIg kappa chain V-I region WEAIg kappa chain V-I region WalkerIg kappa chain V-I region WesIg kappa chain V-II region CumIg kappa chain V-II region FRIg kappa chain V-II region GM607Ig kappa chain V-II region MILIg kappa chain V-II region RPMI 6410Ig kappa chain V-II region TEWIg kappa chain V-III region B6Ig kappa chain V-III region CLLIg kappa chain V-III region GOLIg kappa chain V-III region HAHIg kappa chain V-III region HICIg kappa chain V-III region IARC/BL41Ig kappa chain V-III region NG9Ig kappa chain V-III region POMIg kappa chain V-III region SIEIg kappa chain V-III region TiIg kappa chain V-III region VGIg kappa chain V-III region VHIg kappa chain V-III region WOLIg kappa chain V-IV region B17Ig kappa chain V-IV region JIIg kappa chain V-IV region LenIg kappa chain V-IV region STHIGLV8-61(1-?)IGLV4-3(1-?)IGLV1-36(1-?)IGLV2-18(1-?)IGLV2-33(1-?)IGLV3-16(1-?)IGLV5-37(1-?)IGLV1-40(1-?)IGLV1-44(1-?)IGLV3-22(1-?)IGLV7-43(1-?)IGLV5-45(1-?)IGLV4-60(1-?)IGLV10-54(1-?)IGLV2-11(1-?)IGLV2-23(1-?)IGLV3-25(1-?)IGLV3-27(1-?)IGLV3-12(1-?)IGLV7-46(1-?)IGLV11-55(1-?)IGLV4-69(1-?)Ig lambda chain V region 4AIg lambda chain V-I region BL2Ig lambda chain V-I region EPSIg lambda chain V-I region HAIg lambda chain V-I region MEMIg lambda chain V-I region NEWIg lambda chain V-I region NEWMIg lambda chain V-I region NIG-64Ig lambda chain V-I region VORIg lambda chain V-I region WAHIg lambda chain V-II region BOIg lambda chain V-II region BOHIg lambda chain V-II region BURIg lambda chain V-II region MGCIg lambda chain V-II region NEIIg lambda chain V-II region NIG-58Ig lambda chain V-II region NIG-84Ig lambda chain V-II region TOGIg lambda chain V-II region TROIg lambda chain V-II region VILIg lambda chain V-II region WINIg lambda chain V-III region LOIIg lambda chain V-III region SHIg lambda chain V-IV region BauIg lambda chain V-IV region HilIg lambda chain V-IV region KernIg lambda chain V-IV region MOLIg lambda chain V-IV region XIg lambda chain V-V region DELIg lambda chain V-VI region ARIg lambda chain V-VI region EB4Ig lambda chain V-VI region NIG-48Ig lambda chain V-VI region SUTIg lambda chain V-VI region WLTIg lambda chain V-VII region MOTIGLC1IGLC2IGLC3IGLC6IGLC7IgH heavy chain V-III region VH26 precursorIGHV7-81(1-?)IGHV(1-?)Ig heavy chain V-I region EUIg heavy chain V-I region HG3Ig heavy chain V-I region NDIg heavy chain V-I region SIEIg heavy chain V-I region WOLIg heavy chain V-II region CORIg heavy chain V-II region DAWIg heavy chain V-II region HEIg heavy chain V-II region MCEIg heavy chain V-II region NEWMIg heavy chain V-II region OUIg heavy chain V-II region WAHIg heavy chain V-III region BROIg heavy chain V-III region BURIg heavy chain V-III region BUTIg heavy chain V-III region CAMIg heavy chain V-III region DOBIg heavy chain V-III region GAIg heavy chain V-III region GALIg heavy chain V-III region HILIg heavy chain V-III region JONIg heavy chain V-III region KOLIg heavy chain V-III region LAYIg heavy chain V-III region NIEIg heavy chain V-III region POMIg heavy chain V-III region TEIIg heavy chain V-III region TILIg heavy chain V-III region TROIg heavy chain V-III region TURIg heavy chain V-III region WASIg heavy chain V-III region WEAIg heavy chain V-III region ZAPIg heavy chain V-I region MotIg heavy chain V-II region ARH-77Ig heavy chain V-II region SESSIGHG1IGHG2IGHG3IGHG4FCGR1Ap-Y160,Y171-CD3GFCGR3Ap-6Y-CD247-1p-Y288,Y304-FCGR2ASYKAntigenIGKCIGKV4-1(21-?)IGKV1-5(23-?)IGLV(23-?)IGKVA18(21-?)Ig kappa chain V region EV15Ig kappa chain V-I region AGIg kappa chain V-I region AUIg kappa chain V-I region BANIg kappa chain V-I region BiIg kappa chain V-I region CARIg kappa chain V-I region DEEIg kappa chain V-I region DaudiIg kappa chain V-I region EUIg kappa chain V-I region GalIg kappa chain V-I region HK101Ig kappa chain V-I region HauIg kappa chain V-I region KaIg kappa chain V-I region KueIg kappa chain V-I region LayIg kappa chain V-I region MevIg kappa chain V-I region NiIg kappa chain V-I region OUIg kappa chain V-I region ReiIg kappa chain V-I region RoyIg kappa chain V-I region ScwIg kappa chain V-I region WATIg kappa chain V-I region WEAIg kappa chain V-I region WalkerIg kappa chain V-I region WesIg kappa chain V-II region CumIg kappa chain V-II region FRIg kappa chain V-II region GM607Ig kappa chain V-II region MILIg kappa chain V-II region RPMI 6410Ig kappa chain V-II region TEWIg kappa chain V-III region B6Ig kappa chain V-III region CLLIg kappa chain V-III region GOLIg kappa chain V-III region HAHIg kappa chain V-III region HICIg kappa chain V-III region IARC/BL41Ig kappa chain V-III region NG9Ig kappa chain V-III region POMIg kappa chain V-III region SIEIg kappa chain V-III region TiIg kappa chain V-III region VGIg kappa chain V-III region VHIg kappa chain V-III region WOLIg kappa chain V-IV region B17Ig kappa chain V-IV region JIIg kappa chain V-IV region LenIg kappa chain V-IV region STHIGLV8-61(1-?)IGLV4-3(1-?)IGLV1-36(1-?)IGLV2-18(1-?)IGLV2-33(1-?)IGLV3-16(1-?)IGLV5-37(1-?)IGLV1-40(1-?)IGLV1-44(1-?)IGLV3-22(1-?)IGLV7-43(1-?)IGLV5-45(1-?)IGLV4-60(1-?)IGLV10-54(1-?)IGLV2-11(1-?)IGLV2-23(1-?)IGLV3-25(1-?)IGLV3-27(1-?)IGLV3-12(1-?)IGLV7-46(1-?)IGLV11-55(1-?)IGLV4-69(1-?)Ig lambda chain V region 4AIg lambda chain V-I region BL2Ig lambda chain V-I region EPSIg lambda chain V-I region HAIg lambda chain V-I region MEMIg lambda chain V-I region NEWIg lambda chain V-I region NEWMIg lambda chain V-I region NIG-64Ig lambda chain V-I region VORIg lambda chain V-I region WAHIg lambda chain V-II region BOIg lambda chain V-II region BOHIg lambda chain V-II region BURIg lambda chain V-II region MGCIg lambda chain V-II region NEIIg lambda chain V-II region NIG-58Ig lambda chain V-II region NIG-84Ig lambda chain V-II region TOGIg lambda chain V-II region TROIg lambda chain V-II region VILIg lambda chain V-II region WINIg lambda chain V-III region LOIIg lambda chain V-III region SHIg lambda chain V-IV region BauIg lambda chain V-IV region HilIg lambda chain V-IV region KernIg lambda chain V-IV region MOLIg lambda chain V-IV region XIg lambda chain V-V region DELIg lambda chain V-VI region ARIg lambda chain V-VI region EB4Ig lambda chain V-VI region NIG-48Ig lambda chain V-VI region SUTIg lambda chain V-VI region WLTIg lambda chain V-VII region MOTIGLC1IGLC2IGLC3IGLC6IGLC7IgH heavy chain V-III region VH26 precursorIGHV7-81(1-?)IGHV(1-?)Ig heavy chain V-I region EUIg heavy chain V-I region HG3Ig heavy chain V-I region NDIg heavy chain V-I region SIEIg heavy chain V-I region WOLIg heavy chain V-II region CORIg heavy chain V-II region DAWIg heavy chain V-II region HEIg heavy chain V-II region MCEIg heavy chain V-II region NEWMIg heavy chain V-II region OUIg heavy chain V-II region WAHIg heavy chain V-III region BROIg heavy chain V-III region BURIg heavy chain V-III region BUTIg heavy chain V-III region CAMIg heavy chain V-III region DOBIg heavy chain V-III region GAIg heavy chain V-III region GALIg heavy chain V-III region HILIg heavy chain V-III region JONIg heavy chain V-III region KOLIg heavy chain V-III region LAYIg heavy chain V-III region NIEIg heavy chain V-III region POMIg heavy chain V-III region TEIIg heavy chain V-III region TILIg heavy chain V-III region TROIg heavy chain V-III region TURIg heavy chain V-III region WASIg heavy chain V-III region WEAIg heavy chain V-III region ZAPIg heavy chain V-I region MotIg heavy chain V-II region ARH-77Ig heavy chain V-II region SESSIGHG1IGHG2IGHG3IGHG4FCGR1Ap-Y160,Y171-CD3GFCGR3Ap-6Y-CD247-1p-Y288,Y304-FCGR2AAntigenIGKCIGKV4-1(21-?)IGKV1-5(23-?)IGLV(23-?)IGKVA18(21-?)Ig kappa chain V region EV15Ig kappa chain V-I region AGIg kappa chain V-I region AUIg kappa chain V-I region BANIg kappa chain V-I region BiIg kappa chain V-I region CARIg kappa chain V-I region DEEIg kappa chain V-I region DaudiIg kappa chain V-I region EUIg kappa chain V-I region GalIg kappa chain V-I region HK101Ig kappa chain V-I region HauIg kappa chain V-I region KaIg kappa chain V-I region KueIg kappa chain V-I region LayIg kappa chain V-I region MevIg kappa chain V-I region NiIg kappa chain V-I region OUIg kappa chain V-I region ReiIg kappa chain V-I region RoyIg kappa chain V-I region ScwIg kappa chain V-I region WATIg kappa chain V-I region WEAIg kappa chain V-I region WalkerIg kappa chain V-I region WesIg kappa chain V-II region CumIg kappa chain V-II region FRIg kappa chain V-II region GM607Ig kappa chain V-II region MILIg kappa chain V-II region RPMI 6410Ig kappa chain V-II region TEWIg kappa chain V-III region B6Ig kappa chain V-III region CLLIg kappa chain V-III region GOLIg kappa chain V-III region HAHIg kappa chain V-III region HICIg kappa chain V-III region IARC/BL41Ig kappa chain V-III region NG9Ig kappa chain V-III region POMIg kappa chain V-III region SIEIg kappa chain V-III region TiIg kappa chain V-III region VGIg kappa chain V-III region VHIg kappa chain V-III region WOLIg kappa chain V-IV region B17Ig kappa chain V-IV region JIIg kappa chain V-IV region LenIg kappa chain V-IV region STHIGLV8-61(1-?)IGLV4-3(1-?)IGLV1-36(1-?)IGLV2-18(1-?)IGLV2-33(1-?)IGLV3-16(1-?)IGLV5-37(1-?)IGLV1-40(1-?)IGLV1-44(1-?)IGLV3-22(1-?)IGLV7-43(1-?)IGLV5-45(1-?)IGLV4-60(1-?)IGLV10-54(1-?)IGLV2-11(1-?)IGLV2-23(1-?)IGLV3-25(1-?)IGLV3-27(1-?)IGLV3-12(1-?)IGLV7-46(1-?)IGLV11-55(1-?)IGLV4-69(1-?)Ig lambda chain V region 4AIg lambda chain V-I region BL2Ig lambda chain V-I region EPSIg lambda chain V-I region HAIg lambda chain V-I region MEMIg lambda chain V-I region NEWIg lambda chain V-I region NEWMIg lambda chain V-I region NIG-64Ig lambda chain V-I region VORIg lambda chain V-I region WAHIg lambda chain V-II region BOIg lambda chain V-II region BOHIg lambda chain V-II region BURIg lambda chain V-II region MGCIg lambda chain V-II region NEIIg lambda chain V-II region NIG-58Ig lambda chain V-II region NIG-84Ig lambda chain V-II region TOGIg lambda chain V-II region TROIg lambda chain V-II region VILIg lambda chain V-II region WINIg lambda chain V-III region LOIIg lambda chain V-III region SHIg lambda chain V-IV region BauIg lambda chain V-IV region HilIg lambda chain V-IV region KernIg lambda chain V-IV region MOLIg lambda chain V-IV region XIg lambda chain V-V region DELIg lambda chain V-VI region ARIg lambda chain V-VI region EB4Ig lambda chain V-VI region NIG-48Ig lambda chain V-VI region SUTIg lambda chain V-VI region WLTIg lambda chain V-VII region MOTIGLC1IGLC2IGLC3IGLC6IGLC7IgH heavy chain V-III region VH26 precursorIGHV7-81(1-?)IGHV(1-?)Ig heavy chain V-I region EUIg heavy chain V-I region HG3Ig heavy chain V-I region NDIg heavy chain V-I region SIEIg heavy chain V-I region WOLIg heavy chain V-II region CORIg heavy chain V-II region DAWIg heavy chain V-II region HEIg heavy chain V-II region MCEIg heavy chain V-II region NEWMIg heavy chain V-II region OUIg heavy chain V-II region WAHIg heavy chain V-III region BROIg heavy chain V-III region BURIg heavy chain V-III region BUTIg heavy chain V-III region CAMIg heavy chain V-III region DOBIg heavy chain V-III region GAIg heavy chain V-III region GALIg heavy chain V-III region HILIg heavy chain V-III region JONIg heavy chain V-III region KOLIg heavy chain V-III region LAYIg heavy chain V-III region NIEIg heavy chain V-III region POMIg heavy chain V-III region TEIIg heavy chain V-III region TILIg heavy chain V-III region TROIg heavy chain V-III region TURIg heavy chain V-III region WASIg heavy chain V-III region WEAIg heavy chain V-III region ZAPIg heavy chain V-I region MotIg heavy chain V-II region ARH-77Ig heavy chain V-II region SESSIGHG1IGHG2IGHG3IGHG4FCGR1Ap-Y160,Y171-CD3GFCGR3Ap-6Y-CD247-1p-Y288,Y304-FCGR2Ap-6Y-SYKVAV1VAV2VAV3AntigenIGKCIGKV4-1(21-?)IGKV1-5(23-?)IGLV(23-?)IGKVA18(21-?)Ig kappa chain V region EV15Ig kappa chain V-I region AGIg kappa chain V-I region AUIg kappa chain V-I region BANIg kappa chain V-I region BiIg kappa chain V-I region CARIg kappa chain V-I region DEEIg kappa chain V-I region DaudiIg kappa chain V-I region EUIg kappa chain V-I region GalIg kappa chain V-I region HK101Ig kappa chain V-I region HauIg kappa chain V-I region KaIg kappa chain V-I region KueIg kappa chain V-I region LayIg kappa chain V-I region MevIg kappa chain V-I region NiIg kappa chain V-I region OUIg kappa chain V-I region ReiIg kappa chain V-I region RoyIg kappa chain V-I region ScwIg kappa chain V-I region WATIg kappa chain V-I region WEAIg kappa chain V-I region WalkerIg kappa chain V-I region WesIg kappa chain V-II region CumIg kappa chain V-II region FRIg kappa chain V-II region GM607Ig kappa chain V-II region MILIg kappa chain V-II region RPMI 6410Ig kappa chain V-II region TEWIg kappa chain V-III region B6Ig kappa chain V-III region CLLIg kappa chain V-III region GOLIg kappa chain V-III region HAHIg kappa chain V-III region HICIg kappa chain V-III region IARC/BL41Ig kappa chain V-III region NG9Ig kappa chain V-III region POMIg kappa chain V-III region SIEIg kappa chain V-III region TiIg kappa chain V-III region VGIg kappa chain V-III region VHIg kappa chain V-III region WOLIg kappa chain V-IV region B17Ig kappa chain V-IV region JIIg kappa chain V-IV region LenIg kappa chain V-IV region STHIGLV8-61(1-?)IGLV4-3(1-?)IGLV1-36(1-?)IGLV2-18(1-?)IGLV2-33(1-?)IGLV3-16(1-?)IGLV5-37(1-?)IGLV1-40(1-?)IGLV1-44(1-?)IGLV3-22(1-?)IGLV7-43(1-?)IGLV5-45(1-?)IGLV4-60(1-?)IGLV10-54(1-?)IGLV2-11(1-?)IGLV2-23(1-?)IGLV3-25(1-?)IGLV3-27(1-?)IGLV3-12(1-?)IGLV7-46(1-?)IGLV11-55(1-?)IGLV4-69(1-?)Ig lambda chain V region 4AIg lambda chain V-I region BL2Ig lambda chain V-I region EPSIg lambda chain V-I region HAIg lambda chain V-I region MEMIg lambda chain V-I region NEWIg lambda chain V-I region NEWMIg lambda chain V-I region NIG-64Ig lambda chain V-I region VORIg lambda chain V-I region WAHIg lambda chain V-II region BOIg lambda chain V-II region BOHIg lambda chain V-II region BURIg lambda chain V-II region MGCIg lambda chain V-II region NEIIg lambda chain V-II region NIG-58Ig lambda chain V-II region NIG-84Ig lambda chain V-II region TOGIg lambda chain V-II region TROIg lambda chain V-II region VILIg lambda chain V-II region WINIg lambda chain V-III region LOIIg lambda chain V-III region SHIg lambda chain V-IV region BauIg lambda chain V-IV region HilIg lambda chain V-IV region KernIg lambda chain V-IV region MOLIg lambda chain V-IV region XIg lambda chain V-V region DELIg lambda chain V-VI region ARIg lambda chain V-VI region EB4Ig lambda chain V-VI region NIG-48Ig lambda chain V-VI region SUTIg lambda chain V-VI region WLTIg lambda chain V-VII region MOTIGLC1IGLC2IGLC3IGLC6IGLC7IgH heavy chain V-III region VH26 precursorIGHV7-81(1-?)IGHV(1-?)Ig heavy chain V-I region EUIg heavy chain V-I region HG3Ig heavy chain V-I region NDIg heavy chain V-I region SIEIg heavy chain V-I region WOLIg heavy chain V-II region CORIg heavy chain V-II region DAWIg heavy chain V-II region HEIg heavy chain V-II region MCEIg heavy chain V-II region NEWMIg heavy chain V-II region OUIg heavy chain V-II region WAHIg heavy chain V-III region BROIg heavy chain V-III region BURIg heavy chain V-III region BUTIg heavy chain V-III region CAMIg heavy chain V-III region DOBIg heavy chain V-III region GAIg heavy chain V-III region GALIg heavy chain V-III region HILIg heavy chain V-III region JONIg heavy chain V-III region KOLIg heavy chain V-III region LAYIg heavy chain V-III region NIEIg heavy chain V-III region POMIg heavy chain V-III region TEIIg heavy chain V-III region TILIg heavy chain V-III region TROIg heavy chain V-III region TURIg heavy chain V-III region WASIg heavy chain V-III region WEAIg heavy chain V-III region ZAPIg heavy chain V-I region MotIg heavy chain V-II region ARH-77Ig heavy chain V-II region SESSIGHG1IGHG2IGHG3IGHG4FCGR1Ap-Y160,Y171-CD3GFCGR3Ap-6Y-CD247-1p-Y288,Y304-FCGR2Ap-6Y-SYKVAV1VAV2VAV3PI(3,4,5)P3AntigenIGKCIGKV4-1(21-?)IGKV1-5(23-?)IGLV(23-?)IGKVA18(21-?)Ig kappa chain V region EV15Ig kappa chain V-I region AGIg kappa chain V-I region AUIg kappa chain V-I region BANIg kappa chain V-I region BiIg kappa chain V-I region CARIg kappa chain V-I region DEEIg kappa chain V-I region DaudiIg kappa chain V-I region EUIg kappa chain V-I region GalIg kappa chain V-I region HK101Ig kappa chain V-I region HauIg kappa chain V-I region KaIg kappa chain V-I region KueIg kappa chain V-I region LayIg kappa chain V-I region MevIg kappa chain V-I region NiIg kappa chain V-I region OUIg kappa chain V-I region ReiIg kappa chain V-I region RoyIg kappa chain V-I region ScwIg kappa chain V-I region WATIg kappa chain V-I region WEAIg kappa chain V-I region WalkerIg kappa chain V-I region WesIg kappa chain V-II region CumIg kappa chain V-II region FRIg kappa chain V-II region GM607Ig kappa chain V-II region MILIg kappa chain V-II region RPMI 6410Ig kappa chain V-II region TEWIg kappa chain V-III region B6Ig kappa chain V-III region CLLIg kappa chain V-III region GOLIg kappa chain V-III region HAHIg kappa chain V-III region HICIg kappa chain V-III region IARC/BL41Ig kappa chain V-III region NG9Ig kappa chain V-III region POMIg kappa chain V-III region SIEIg kappa chain V-III region TiIg kappa chain V-III region VGIg kappa chain V-III region VHIg kappa chain V-III region WOLIg kappa chain V-IV region B17Ig kappa chain V-IV region JIIg kappa chain V-IV region LenIg kappa chain V-IV region STHIGLV8-61(1-?)IGLV4-3(1-?)IGLV1-36(1-?)IGLV2-18(1-?)IGLV2-33(1-?)IGLV3-16(1-?)IGLV5-37(1-?)IGLV1-40(1-?)IGLV1-44(1-?)IGLV3-22(1-?)IGLV7-43(1-?)IGLV5-45(1-?)IGLV4-60(1-?)IGLV10-54(1-?)IGLV2-11(1-?)IGLV2-23(1-?)IGLV3-25(1-?)IGLV3-27(1-?)IGLV3-12(1-?)IGLV7-46(1-?)IGLV11-55(1-?)IGLV4-69(1-?)Ig lambda chain V region 4AIg lambda chain V-I region BL2Ig lambda chain V-I region EPSIg lambda chain V-I region HAIg lambda chain V-I region MEMIg lambda chain V-I region NEWIg lambda chain V-I region NEWMIg lambda chain V-I region NIG-64Ig lambda chain V-I region VORIg lambda chain V-I region WAHIg lambda chain V-II region BOIg lambda chain V-II region BOHIg lambda chain V-II region BURIg lambda chain V-II region MGCIg lambda chain V-II region NEIIg lambda chain V-II region NIG-58Ig lambda chain V-II region NIG-84Ig lambda chain V-II region TOGIg lambda chain V-II region TROIg lambda chain V-II region VILIg lambda chain V-II region WINIg lambda chain V-III region LOIIg lambda chain V-III region SHIg lambda chain V-IV region BauIg lambda chain V-IV region HilIg lambda chain V-IV region KernIg lambda chain V-IV region MOLIg lambda chain V-IV region XIg lambda chain V-V region DELIg lambda chain V-VI region ARIg lambda chain V-VI region EB4Ig lambda chain V-VI region NIG-48Ig lambda chain V-VI region SUTIg lambda chain V-VI region WLTIg lambda chain V-VII region MOTIGLC1IGLC2IGLC3IGLC6IGLC7IgH heavy chain V-III region VH26 precursorIGHV7-81(1-?)IGHV(1-?)Ig heavy chain V-I region EUIg heavy chain V-I region HG3Ig heavy chain V-I region NDIg heavy chain V-I region SIEIg heavy chain V-I region WOLIg heavy chain V-II region CORIg heavy chain V-II region DAWIg heavy chain V-II region HEIg heavy chain V-II region MCEIg heavy chain V-II region NEWMIg heavy chain V-II region OUIg heavy chain V-II region WAHIg heavy chain V-III region BROIg heavy chain V-III region BURIg heavy chain V-III region BUTIg heavy chain V-III region CAMIg heavy chain V-III region DOBIg heavy chain V-III region GAIg heavy chain V-III region GALIg heavy chain V-III region HILIg heavy chain V-III region JONIg heavy chain V-III region KOLIg heavy chain V-III region LAYIg heavy chain V-III region NIEIg heavy chain V-III region POMIg heavy chain V-III region TEIIg heavy chain V-III region TILIg heavy chain V-III region TROIg heavy chain V-III region TURIg heavy chain V-III region WASIg heavy chain V-III region WEAIg heavy chain V-III region ZAPIg heavy chain V-I region MotIg heavy chain V-II region ARH-77Ig heavy chain V-II region SESSIGHG1IGHG2IGHG3IGHG4FCGR1Ap-Y160,Y171-CD3GFCGR3Ap-6Y-CD247-1p-Y288,Y304-FCGR2Ap-6Y-SYKp-Y174-VAV1p-Y172-VAV2p-Y173-VAV3AntigenIGKCIGKV4-1(21-?)IGKV1-5(23-?)IGLV(23-?)IGKVA18(21-?)Ig kappa chain V region EV15Ig kappa chain V-I region AGIg kappa chain V-I region AUIg kappa chain V-I region BANIg kappa chain V-I region BiIg kappa chain V-I region CARIg kappa chain V-I region DEEIg kappa chain V-I region DaudiIg kappa chain V-I region EUIg kappa chain V-I region GalIg kappa chain V-I region HK101Ig kappa chain V-I region HauIg kappa chain V-I region KaIg kappa chain V-I region KueIg kappa chain V-I region LayIg kappa chain V-I region MevIg kappa chain V-I region NiIg kappa chain V-I region OUIg kappa chain V-I region ReiIg kappa chain V-I region RoyIg kappa chain V-I region ScwIg kappa chain V-I region WATIg kappa chain V-I region WEAIg kappa chain V-I region WalkerIg kappa chain V-I region WesIg kappa chain V-II region CumIg kappa chain V-II region FRIg kappa chain V-II region GM607Ig kappa chain V-II region MILIg kappa chain V-II region RPMI 6410Ig kappa chain V-II region TEWIg kappa chain V-III region B6Ig kappa chain V-III region CLLIg kappa chain V-III region GOLIg kappa chain V-III region HAHIg kappa chain V-III region HICIg kappa chain V-III region IARC/BL41Ig kappa chain V-III region NG9Ig kappa chain V-III region POMIg kappa chain V-III region SIEIg kappa chain V-III region TiIg kappa chain V-III region VGIg kappa chain V-III region VHIg kappa chain V-III region WOLIg kappa chain V-IV region B17Ig kappa chain V-IV region JIIg kappa chain V-IV region LenIg kappa chain V-IV region STHIGLV8-61(1-?)IGLV4-3(1-?)IGLV1-36(1-?)IGLV2-18(1-?)IGLV2-33(1-?)IGLV3-16(1-?)IGLV5-37(1-?)IGLV1-40(1-?)IGLV1-44(1-?)IGLV3-22(1-?)IGLV7-43(1-?)IGLV5-45(1-?)IGLV4-60(1-?)IGLV10-54(1-?)IGLV2-11(1-?)IGLV2-23(1-?)IGLV3-25(1-?)IGLV3-27(1-?)IGLV3-12(1-?)IGLV7-46(1-?)IGLV11-55(1-?)IGLV4-69(1-?)Ig lambda chain V region 4AIg lambda chain V-I region BL2Ig lambda chain V-I region EPSIg lambda chain V-I region HAIg lambda chain V-I region MEMIg lambda chain V-I region NEWIg lambda chain V-I region NEWMIg lambda chain V-I region NIG-64Ig lambda chain V-I region VORIg lambda chain V-I region WAHIg lambda chain V-II region BOIg lambda chain V-II region BOHIg lambda chain V-II region BURIg lambda chain V-II region MGCIg lambda chain V-II region NEIIg lambda chain V-II region NIG-58Ig lambda chain V-II region NIG-84Ig lambda chain V-II region TOGIg lambda chain V-II region TROIg lambda chain V-II region VILIg lambda chain V-II region WINIg lambda chain V-III region LOIIg lambda chain V-III region SHIg lambda chain V-IV region BauIg lambda chain V-IV region HilIg lambda chain V-IV region KernIg lambda chain V-IV region MOLIg lambda chain V-IV region XIg lambda chain V-V region DELIg lambda chain V-VI region ARIg lambda chain V-VI region EB4Ig lambda chain V-VI region NIG-48Ig lambda chain V-VI region SUTIg lambda chain V-VI region WLTIg lambda chain V-VII region MOTIGLC1IGLC2IGLC3IGLC6IGLC7IgH heavy chain V-III region VH26 precursorIGHV7-81(1-?)IGHV(1-?)Ig heavy chain V-I region EUIg heavy chain V-I region HG3Ig heavy chain V-I region NDIg heavy chain V-I region SIEIg heavy chain V-I region WOLIg heavy chain V-II region CORIg heavy chain V-II region DAWIg heavy chain V-II region HEIg heavy chain V-II region MCEIg heavy chain V-II region NEWMIg heavy chain V-II region OUIg heavy chain V-II region WAHIg heavy chain V-III region BROIg heavy chain V-III region BURIg heavy chain V-III region BUTIg heavy chain V-III region CAMIg heavy chain V-III region DOBIg heavy chain V-III region GAIg heavy chain V-III region GALIg heavy chain V-III region HILIg heavy chain V-III region JONIg heavy chain V-III region KOLIg heavy chain V-III region LAYIg heavy chain V-III region NIEIg heavy chain V-III region POMIg heavy chain V-III region TEIIg heavy chain V-III region TILIg heavy chain V-III region TROIg heavy chain V-III region TURIg heavy chain V-III region WASIg heavy chain V-III region WEAIg heavy chain V-III region ZAPIg heavy chain V-I region MotIg heavy chain V-II region ARH-77Ig heavy chain V-II region SESSIGHG1IGHG2IGHG3IGHG4FCGR1Ap-Y160,Y171-CD3GFCGR3Ap-6Y-CD247-1p-Y288,Y304-FCGR2AName: Fcgamma receptor (FCGR) dependent phagocytosisOrganism: Homo sapiens


Description

Phagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phagocytosis is a complex process involving the recognition of invading foreign particles by specific types of phagocytic receptors and the subsequent internalization of the particles. Fc gamma receptors (FCGRs) are among the best studied phagocytic receptors that bind to Fc portion of immunoglobulin G (IgG). Through their antigen binding F(ab) end, antibodies bind to specific antigen while their constant (Fc) region binds to FCGRs on phagocytes. The clustering of FCGRs by IgG antibodies on the phagocyte initiates a variety of signals, which lead, through the reorganisation of actin cytoskeleton and membrane remodelling, to the formation of pseudopod and phagosome. Fc gamma receptors are classified into three classes: FCGRI, FCGRII and FCGRIII. Each class of these FCGRs consists of several individual isoforms. Among all these isoforms FCGRI, FCGRIIA and FCGRIIIA, are able to mediate phagocytosis (Joshi et al. 2006, Garcia Garcia & Rosales 2002, Nimmerjahn & Ravetch 2006). View original pathway at:Reactome.

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Quality Tags

Image:Reactome.pngCommunity: Reactome
Image:Unconnected.pngFix interactions

Ontology Terms

 

Bibliography

View all...
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History

View all...
CompareRevisionActionTimeUserComment
118475view20:32, 27 May 2021FinterlyRemoved incorrect and duplicated openControlledVocabulary PW:0000234
114947
Reactome
view16:47, 25 January 2021ReactomeTeamReactome version 75
113391view11:46, 2 November 2020ReactomeTeamReactome version 74
112853view13:31, 12 October 2020DeSlFixing ontology tag error
112849view13:02, 12 October 2020DeSlOntology Term : 'innate immune response pathway' added !
112596view15:57, 9 October 2020ReactomeTeamReactome version 73
101512view11:37, 1 November 2018ReactomeTeamreactome version 66
101048view21:19, 31 October 2018ReactomeTeamreactome version 65
100579view19:52, 31 October 2018ReactomeTeamreactome version 64
100128view16:38, 31 October 2018ReactomeTeamreactome version 63
99678view15:07, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99271view12:45, 31 October 2018ReactomeTeamreactome version 62
94053view13:54, 16 August 2017ReactomeTeamreactome version 61
93681view11:30, 9 August 2017ReactomeTeamreactome version 61
89466view13:21, 15 September 2016Mkutmonfix ontology tag annotation
87448view13:50, 22 July 2016MkutmonOntology Term : 'PW:0000234' added !
86805view09:26, 11 July 2016ReactomeTeamreactome version 56
83122view10:02, 18 November 2015ReactomeTeamVersion54
81461view12:59, 21 August 2015ReactomeTeamVersion53
76936view08:20, 17 July 2014ReactomeTeamFixed remaining interactions
76641view12:01, 16 July 2014ReactomeTeamFixed remaining interactions
75971view10:02, 11 June 2014ReactomeTeamRe-fixing comment source
75674view10:59, 10 June 2014ReactomeTeamReactome 48 Update
75029view13:54, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74673view08:44, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
2-LysophosphatidylcholineMetabolite428981 (Reactome)
ABL1Protein375987 (Reactome)
ADPMetaboliteCHEBI:16761 (ChEBI)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerComplexR-HSA-5226920 (Reactome)
ARAMetabolite140356 (Reactome)
ARP2/3 complex (ATP bound)ComplexR-HSA-1861670 (Reactome)
ATPMetaboliteCHEBI:15422 (ChEBI)
Actin filament bound Myosin-XComplexR-HSA-1861625 (Reactome)
Actin:ADPComplexR-HSA-202994 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		ComplexR-HSA-442565 (Reactome)
Activated WAVE2 and WASP/N-WASPComplexR-HSA-2197675 (Reactome)
Active LIMK1ComplexR-HSA-419630 (Reactome)
Antigen R-NUL-173548 (Reactome)
Antigen-antibody complexComplexR-HSA-173552 (Reactome)
BAIAP2Protein442574 (Reactome)
CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
CD3G ProteinP09693 (Uniprot-TrEMBL)
CDC42:GDPComplexR-HSA-418830 (Reactome)
CDC42:GTP, RAC1:GTPComplexR-HSA-389778 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsComplexR-HSA-2197683 (Reactome)
CDC42:GTP:WASP/N-WASPComplexR-HSA-442584 (Reactome)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsComplexR-HSA-2197680 (Reactome)
CDC42:GTPComplexR-HSA-182921 (Reactome)
CFL1Protein350751 (Reactome)
CRK:DOCK180:ELMO1,ELMO2ComplexR-HSA-2029141 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		ComplexR-HSA-2029130 (Reactome)
Ca2+Metabolite111875 (Reactome)
Ca2+Metabolite74016 (Reactome)
DAGsMetabolite112275 (Reactome)
F-actin201877 (Reactome)
FCGR1A ProteinP12314 (Uniprot-TrEMBL)
FCGR2A ProteinP12318 (Uniprot-TrEMBL)
FCGR2AProteinP12318 (Uniprot-TrEMBL)
FCGR3A ProteinP08637 (Uniprot-TrEMBL)
FCGRIA:CD3G homodimerComplexR-HSA-2029093 (Reactome)
FCGRIIIA:CD3G/CD3Z dimersComplexR-HSA-2029097 (Reactome)
G-actinComplexR-HSA-201857 (Reactome)
GDPMetabolite29420 (Reactome)
GTPMetabolite29438 (Reactome)
H2OMetabolite29356 (Reactome)
HSP90AA1,HSP90AB1ComplexR-HSA-419619 (Reactome)
I(1,4,5)P3Metabolite114520 (Reactome)
IGHG1 ProteinP01857 (Uniprot-TrEMBL)
IGHG2 ProteinP01859 (Uniprot-TrEMBL)
IGHG3 ProteinP01860 (Uniprot-TrEMBL)
IGHG4 ProteinP01861 (Uniprot-TrEMBL)
IGHV(1-?) ProteinA2KUC3 (Uniprot-TrEMBL)
IGHV7-81(1-?) ProteinQ6PIL0 (Uniprot-TrEMBL)
IGKC ProteinP01834 (Uniprot-TrEMBL)
IGKV1-5(23-?) ProteinP01602 (Uniprot-TrEMBL)
IGKV4-1(21-?) ProteinP06312 (Uniprot-TrEMBL)
IGKVA18(21-?) ProteinA2NJV5 (Uniprot-TrEMBL)
IGLC1 ProteinP0CG04 (Uniprot-TrEMBL)
IGLC2 ProteinP0CG05 (Uniprot-TrEMBL)
IGLC3 ProteinP0CG06 (Uniprot-TrEMBL)
IGLC6 ProteinP0CF74 (Uniprot-TrEMBL)
IGLC7 ProteinA0M8Q6 (Uniprot-TrEMBL)
IGLV(23-?) ProteinA2NXD2 (Uniprot-TrEMBL)
IGLV1-36(1-?) ProteinQ5NV67 (Uniprot-TrEMBL)
IGLV1-40(1-?) ProteinQ5NV69 (Uniprot-TrEMBL)
IGLV1-44(1-?) ProteinQ5NV81 (Uniprot-TrEMBL)
IGLV10-54(1-?) ProteinQ5NV86 (Uniprot-TrEMBL)
IGLV11-55(1-?) ProteinQ5NV87 (Uniprot-TrEMBL)
IGLV2-11(1-?) ProteinQ5NV84 (Uniprot-TrEMBL)
IGLV2-18(1-?) ProteinQ5NV65 (Uniprot-TrEMBL)
IGLV2-23(1-?) ProteinQ5NV89 (Uniprot-TrEMBL)
IGLV2-33(1-?) ProteinQ5NV66 (Uniprot-TrEMBL)
IGLV3-12(1-?) ProteinQ5NV85 (Uniprot-TrEMBL)
IGLV3-16(1-?) ProteinQ5NV64 (Uniprot-TrEMBL)
IGLV3-22(1-?) ProteinQ5NV75 (Uniprot-TrEMBL)
IGLV3-25(1-?) ProteinQ5NV90 (Uniprot-TrEMBL)
IGLV3-27(1-?) ProteinQ5NV91 (Uniprot-TrEMBL)
IGLV4-3(1-?) ProteinQ5NV61 (Uniprot-TrEMBL)
IGLV4-60(1-?) ProteinQ5NV79 (Uniprot-TrEMBL)
IGLV4-69(1-?) ProteinQ5NV92 (Uniprot-TrEMBL)
IGLV5-37(1-?) ProteinQ5NV68 (Uniprot-TrEMBL)
IGLV5-45(1-?) ProteinQ5NV82 (Uniprot-TrEMBL)
IGLV7-43(1-?) ProteinQ5NV80 (Uniprot-TrEMBL)
IGLV7-46(1-?) ProteinQ5NV83 (Uniprot-TrEMBL)
IGLV8-61(1-?) ProteinQ5NV62 (Uniprot-TrEMBL)
IP3 receptor homotetramerComplexR-HSA-169686 (Reactome)
ITPR:I(1,4,5)P3 tetramerComplexR-HSA-169696 (Reactome)
Ig heavy chain V-I region EU ProteinP01742 (Uniprot-TrEMBL)
Ig heavy chain V-I region HG3 ProteinP01743 (Uniprot-TrEMBL)
Ig heavy chain V-I region Mot ProteinP06326 (Uniprot-TrEMBL)
Ig heavy chain V-I region ND ProteinP01744 (Uniprot-TrEMBL)
Ig heavy chain V-I region SIE ProteinP01761 (Uniprot-TrEMBL)
Ig heavy chain V-I region WOL ProteinP01760 (Uniprot-TrEMBL)
Ig heavy chain V-II region ARH-77 ProteinP06331 (Uniprot-TrEMBL)
Ig heavy chain V-II region COR ProteinP01815 (Uniprot-TrEMBL)
Ig heavy chain V-II region DAW ProteinP01816 (Uniprot-TrEMBL)
Ig heavy chain V-II region HE ProteinP01818 (Uniprot-TrEMBL)
Ig heavy chain V-II region MCE ProteinP01817 (Uniprot-TrEMBL)
Ig heavy chain V-II region NEWM ProteinP01825 (Uniprot-TrEMBL)
Ig heavy chain V-II region OU ProteinP01814 (Uniprot-TrEMBL)
Ig heavy chain V-II region SESS ProteinP04438 (Uniprot-TrEMBL)
Ig heavy chain V-II region WAH ProteinP01824 (Uniprot-TrEMBL)
Ig heavy chain V-III region BRO ProteinP01766 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUR ProteinP01773 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUT ProteinP01767 (Uniprot-TrEMBL)
Ig heavy chain V-III region CAM ProteinP01768 (Uniprot-TrEMBL)
Ig heavy chain V-III region DOB ProteinP01782 (Uniprot-TrEMBL)
Ig heavy chain V-III region GA ProteinP01769 (Uniprot-TrEMBL)
Ig heavy chain V-III region GAL ProteinP01781 (Uniprot-TrEMBL)
Ig heavy chain V-III region HIL ProteinP01771 (Uniprot-TrEMBL)
Ig heavy chain V-III region JON ProteinP01780 (Uniprot-TrEMBL)
Ig heavy chain V-III region KOL ProteinP01772 (Uniprot-TrEMBL)
Ig heavy chain V-III region LAY ProteinP01775 (Uniprot-TrEMBL)
Ig heavy chain V-III region NIE ProteinP01770 (Uniprot-TrEMBL)
Ig heavy chain V-III region POM ProteinP01774 (Uniprot-TrEMBL)
Ig heavy chain V-III region TEI ProteinP01777 (Uniprot-TrEMBL)
Ig heavy chain V-III region TIL ProteinP01765 (Uniprot-TrEMBL)
Ig heavy chain V-III region TRO ProteinP01762 (Uniprot-TrEMBL)
Ig heavy chain V-III region TUR ProteinP01779 (Uniprot-TrEMBL)
Ig heavy chain V-III region WAS ProteinP01776 (Uniprot-TrEMBL)
Ig heavy chain V-III region WEA ProteinP01763 (Uniprot-TrEMBL)
Ig heavy chain V-III region ZAP ProteinP01778 (Uniprot-TrEMBL)
Ig kappa chain V region EV15 ProteinP06315 (Uniprot-TrEMBL)
Ig kappa chain V-I region AG ProteinP01593 (Uniprot-TrEMBL)
Ig kappa chain V-I region AU ProteinP01594 (Uniprot-TrEMBL)
Ig kappa chain V-I region BAN ProteinP04430 (Uniprot-TrEMBL)
Ig kappa chain V-I region Bi ProteinP01595 (Uniprot-TrEMBL)
Ig kappa chain V-I region CAR ProteinP01596 (Uniprot-TrEMBL)
Ig kappa chain V-I region DEE ProteinP01597 (Uniprot-TrEMBL)
Ig kappa chain V-I region Daudi ProteinP04432 (Uniprot-TrEMBL)
Ig kappa chain V-I region EU ProteinP01598 (Uniprot-TrEMBL)
Ig kappa chain V-I region Gal ProteinP01599 (Uniprot-TrEMBL)
Ig kappa chain V-I region HK101 ProteinP01601 (Uniprot-TrEMBL)
Ig kappa chain V-I region Hau ProteinP01600 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ka ProteinP01603 (Uniprot-TrEMBL)
Ig kappa chain V-I region Kue ProteinP01604 (Uniprot-TrEMBL)
Ig kappa chain V-I region Lay ProteinP01605 (Uniprot-TrEMBL)
Ig kappa chain V-I region Mev ProteinP01612 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ni ProteinP01613 (Uniprot-TrEMBL)
Ig kappa chain V-I region OU ProteinP01606 (Uniprot-TrEMBL)
Ig kappa chain V-I region Rei ProteinP01607 (Uniprot-TrEMBL)
Ig kappa chain V-I region Roy ProteinP01608 (Uniprot-TrEMBL)
Ig kappa chain V-I region Scw ProteinP01609 (Uniprot-TrEMBL)
Ig kappa chain V-I region WAT ProteinP80362 (Uniprot-TrEMBL)
Ig kappa chain V-I region WEA ProteinP01610 (Uniprot-TrEMBL)
Ig kappa chain V-I region Walker ProteinP04431 (Uniprot-TrEMBL)
Ig kappa chain V-I region Wes ProteinP01611 (Uniprot-TrEMBL)
Ig kappa chain V-II region Cum ProteinP01614 (Uniprot-TrEMBL)
Ig kappa chain V-II region FR ProteinP01615 (Uniprot-TrEMBL)
Ig kappa chain V-II region GM607 ProteinP06309 (Uniprot-TrEMBL)
Ig kappa chain V-II region MIL ProteinP01616 (Uniprot-TrEMBL)
Ig kappa chain V-II region RPMI 6410 ProteinP06310 (Uniprot-TrEMBL)
Ig kappa chain V-II region TEW ProteinP01617 (Uniprot-TrEMBL)
Ig kappa chain V-III region B6 ProteinP01619 (Uniprot-TrEMBL)
Ig kappa chain V-III region CLL ProteinP04207 (Uniprot-TrEMBL)
Ig kappa chain V-III region GOL ProteinP04206 (Uniprot-TrEMBL)
Ig kappa chain V-III region HAH ProteinP18135 (Uniprot-TrEMBL)
Ig kappa chain V-III region HIC ProteinP18136 (Uniprot-TrEMBL)
Ig kappa chain V-III region IARC/BL41 ProteinP06311 (Uniprot-TrEMBL)
Ig kappa chain V-III region NG9 ProteinP01621 (Uniprot-TrEMBL)
Ig kappa chain V-III region POM ProteinP01624 (Uniprot-TrEMBL)
Ig kappa chain V-III region SIE ProteinP01620 (Uniprot-TrEMBL)
Ig kappa chain V-III region Ti ProteinP01622 (Uniprot-TrEMBL)
Ig kappa chain V-III region VG ProteinP04433 (Uniprot-TrEMBL)
Ig kappa chain V-III region VH ProteinP04434 (Uniprot-TrEMBL)
Ig kappa chain V-III region WOL ProteinP01623 (Uniprot-TrEMBL)
Ig kappa chain V-IV region B17 ProteinP06314 (Uniprot-TrEMBL)
Ig kappa chain V-IV region JI ProteinP06313 (Uniprot-TrEMBL)
Ig kappa chain V-IV region Len ProteinP01625 (Uniprot-TrEMBL)
Ig kappa chain V-IV region STH ProteinP83593 (Uniprot-TrEMBL)
Ig lambda chain V region 4A ProteinP04211 (Uniprot-TrEMBL)
Ig lambda chain V-I region BL2 ProteinP06316 (Uniprot-TrEMBL)
Ig lambda chain V-I region EPS ProteinP06888 (Uniprot-TrEMBL)
Ig lambda chain V-I region HA ProteinP01700 (Uniprot-TrEMBL)
Ig lambda chain V-I region MEM ProteinP06887 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEW ProteinP01701 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEWM ProteinP01703 (Uniprot-TrEMBL)
Ig lambda chain V-I region NIG-64 ProteinP01702 (Uniprot-TrEMBL)
Ig lambda chain V-I region VOR ProteinP01699 (Uniprot-TrEMBL)
Ig lambda chain V-I region WAH ProteinP04208 (Uniprot-TrEMBL)
Ig lambda chain V-II region BO ProteinP01710 (Uniprot-TrEMBL)
Ig lambda chain V-II region BOH ProteinP01706 (Uniprot-TrEMBL)
Ig lambda chain V-II region BUR ProteinP01708 (Uniprot-TrEMBL)
Ig lambda chain V-II region MGC ProteinP01709 (Uniprot-TrEMBL)
Ig lambda chain V-II region NEI ProteinP01705 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-58 ProteinP01713 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-84 ProteinP04209 (Uniprot-TrEMBL)
Ig lambda chain V-II region TOG ProteinP01704 (Uniprot-TrEMBL)
Ig lambda chain V-II region TRO ProteinP01707 (Uniprot-TrEMBL)
Ig lambda chain V-II region VIL ProteinP01711 (Uniprot-TrEMBL)
Ig lambda chain V-II region WIN ProteinP01712 (Uniprot-TrEMBL)
Ig lambda chain V-III region LOI ProteinP80748 (Uniprot-TrEMBL)
Ig lambda chain V-III region SH ProteinP01714 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Bau ProteinP01715 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Hil ProteinP01717 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Kern ProteinP01718 (Uniprot-TrEMBL)
Ig lambda chain V-IV region MOL ProteinP06889 (Uniprot-TrEMBL)
Ig lambda chain V-IV region X ProteinP01716 (Uniprot-TrEMBL)
Ig lambda chain V-V region DEL ProteinP01719 (Uniprot-TrEMBL)
Ig lambda chain V-VI region AR ProteinP01721 (Uniprot-TrEMBL)
Ig lambda chain V-VI region EB4 ProteinP06319 (Uniprot-TrEMBL)
Ig lambda chain V-VI region NIG-48 ProteinP01722 (Uniprot-TrEMBL)
Ig lambda chain V-VI region SUT ProteinP06317 (Uniprot-TrEMBL)
Ig lambda chain V-VI region WLT ProteinP06318 (Uniprot-TrEMBL)
Ig lambda chain V-VII region MOT ProteinP01720 (Uniprot-TrEMBL)
IgG-Ag:FCGRIA:CD3G homodimerComplexR-HSA-2029132 (Reactome)
IgG-Ag:FCGRIIAComplexR-HSA-1861689 (Reactome)
IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersComplexR-HSA-2029163 (Reactome)
IgH heavy chain V-III region VH26 precursor ProteinP01764 (Uniprot-TrEMBL)
LIMK1Protein397785 (Reactome)
Mother filament:ARP2/3:actin:GDPComplexR-HSA-2197686 (Reactome)
Mother

filament:branching complex:daughter

filament		ComplexR-HSA-1861699 (Reactome)
Mother

filament:branching

complex		ComplexR-HSA-2029140 (Reactome)
Myosin-Actin filamentsComplexR-HSA-2029139 (Reactome)
Myosin-X dimerComplexR-HSA-1861665 (Reactome)
MyosinComplexR-HSA-2029109 (Reactome)
PAMetabolite1602448 (Reactome)
PAK1 dimerComplexR-HSA-445002 (Reactome)
PAK1Protein162629 (Reactome)
PCMetabolite429802 (Reactome)
PI(3,4)P2Metabolite202247 (Reactome)
PI(3,4,5)P3 MetaboliteCHEBI:16618 (ChEBI)
PI(3,4,5)P3MetaboliteCHEBI:16618 (ChEBI)
PI(4,5)P2Metabolite179856 (Reactome)
PI3K:p-6Y-SYKComplexR-HSA-2029149 (Reactome)
PI3KComplexR-HSA-74693 (Reactome)
PKC-delta/epsilonComplexR-HSA-198276 (Reactome)
PLA2G6Protein201596 (Reactome)
PLC gamma1,2ComplexR-HSA-1169089 (Reactome)
PLDComplexR-HSA-2029102 (Reactome)
Phosphatidate phosphataseComplexR-HSA-2029101 (Reactome)
PhosphatidylcholineMetabolite428980 (Reactome)
Phospho-PKC-delta/epsilonComplexR-HSA-198265 (Reactome)
PiMetabolite29372 (Reactome)
RAC1/CDC42:PAK dimerComplexR-HSA-2029159 (Reactome)
RAC1/CDC42:p-S144,T423-PAKComplexR-HSA-2029155 (Reactome)
RAC1:GDPComplexR-HSA-5674631 (Reactome)
RAC1:GTPComplexR-HSA-442641 (Reactome)
SH3 domain proteinsComplexR-HSA-2197679 (Reactome)
SYK ProteinP43405 (Uniprot-TrEMBL)
SYKProteinP43405 (Uniprot-TrEMBL)
Src family kinases (SFKs)ComplexR-HSA-1861597 (Reactome)
Src-kinasesComplexR-HSA-2197681 (Reactome)
VAV1 ProteinP15498 (Uniprot-TrEMBL)
VAV1,2,3ComplexR-HSA-430172 (Reactome)
VAV2 ProteinP52735 (Uniprot-TrEMBL)
VAV3 ProteinQ9UKW4 (Uniprot-TrEMBL)
WASP/N-WASPComplexR-HSA-201892 (Reactome)
WAVE Regulatory ComplexComplexR-HSA-2029154 (Reactome)
WIP family proteinsComplexR-HSA-2197678 (Reactome)
WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2029147 (Reactome)
cholineMetabolite2263486 (Reactome)
clustered IgG-Ag:FCGRsComplexR-HSA-2029146 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKComplexR-HSA-2029129 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGComplexR-HSA-2029137 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVComplexR-HSA-2029133 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGComplexR-HSA-2029156 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVComplexR-HSA-2029131 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKComplexR-HSA-2029158 (Reactome)
clustered IgG-Ag:p-FCGRsComplexR-HSA-2029128 (Reactome)
clustered IgG-Ag:p-FCGRsComplexR-HSA-2029151 (Reactome)
p-4Y-PLCG1Protein167679 (Reactome)
p-6Y-CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
p-6Y-SYK ProteinP43405 (Uniprot-TrEMBL)
p-PLCGComplexR-HSA-2029095 (Reactome)
p-S144,T423-PAK1Protein399819 (Reactome)
p-T,Y MAPK dimersComplexR-HSA-1268261 (Reactome)
p-T508-LIMK1Protein399816 (Reactome)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2029148 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2130182 (Reactome)
p-Y160,Y171-CD3G ProteinP09693 (Uniprot-TrEMBL)
p-Y172-VAV2 ProteinP52735 (Uniprot-TrEMBL)
p-Y173-VAV3 ProteinQ9UKW4 (Uniprot-TrEMBL)
p-Y174-VAV1 ProteinP15498 (Uniprot-TrEMBL)
p-Y288,Y304-FCGR2A ProteinP12318 (Uniprot-TrEMBL)
pCofilin: Active LIMK-1ComplexR-HSA-399878 (Reactome)
pLIMK dimer:HSP-90ComplexR-HSA-419632 (Reactome)

Annotated Interactions

View all...
Source  ↓Target  ↓Type  ↓Database reference  ↓Comment  ↓
167686 (Reactome)
169680 (Reactome)
169683 (Reactome)
1861595 (Reactome)
1861621 (Reactome)
198314 (Reactome)
2-LysophosphatidylcholineArrow2029475 (Reactome)
2029268 (Reactome)
2029270 (Reactome)
2029271 (Reactome)
2029272 (Reactome)
2029273 (Reactome)
2029445 (Reactome)
2029449 (Reactome)
2029451 (Reactome)
2029452 (Reactome)
2029453 (Reactome)
2029454 (Reactome)
2029455 (Reactome)
2029456 (Reactome)
2029457 (Reactome)
2029458 (Reactome)
2029459 (Reactome)
2029460 (Reactome)
2029465 (Reactome)
2029466 (Reactome)
2029467 (Reactome)
2029468 (Reactome)
2029469 (Reactome)
2029471 (Reactome)
2029473 (Reactome)
2029475 (Reactome)
2029476 (Reactome)
2130194 (Reactome)
2197690 (Reactome)
2197691 (Reactome)
2197697 (Reactome)
2197698 (Reactome)
399950 (Reactome)
419644 (Reactome)
419645 (Reactome)
442586 (Reactome)
442592 (Reactome)
ABL1mim-catalysis2130194 (Reactome)
ADPArrow198314 (Reactome)
ADPArrow2029268 (Reactome)
ADPArrow2029271 (Reactome)
ADPArrow2029449 (Reactome)
ADPArrow2029453 (Reactome)
ADPArrow2029454 (Reactome)
ADPArrow2029459 (Reactome)
ADPArrow2029460 (Reactome)
ADPArrow2029469 (Reactome)
ADPArrow2130194 (Reactome)
ADPArrow2197698 (Reactome)
ADPArrow399950 (Reactome)
ADPArrow419644 (Reactome)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerTBar169683 (Reactome)
ARAArrow2029475 (Reactome)
ARP2/3 complex (ATP bound)442592 (Reactome)
ATP1861595 (Reactome)
ATP198314 (Reactome)
ATP2029268 (Reactome)
ATP2029271 (Reactome)
ATP2029449 (Reactome)
ATP2029453 (Reactome)
ATP2029454 (Reactome)
ATP2029459 (Reactome)
ATP2029460 (Reactome)
ATP2029469 (Reactome)
ATP2029476 (Reactome)
ATP2130194 (Reactome)
ATP2197698 (Reactome)
ATP399950 (Reactome)
ATP419644 (Reactome)
Actin filament bound Myosin-XArrow1861595 (Reactome)
Actin:ADPArrow2029473 (Reactome)
Activated WAVE2 and WASP/N-WASP442592 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		2029466 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		Arrow442592 (Reactome)
Activated WAVE2 and WASP/N-WASPArrow2197690 (Reactome)
Active LIMK1399950 (Reactome)
Active LIMK1Arrow419644 (Reactome)
Active LIMK1mim-catalysis399950 (Reactome)
Antigen-antibody complex1861621 (Reactome)
Antigen-antibody complex2029455 (Reactome)
Antigen-antibody complex2029457 (Reactome)
BAIAP22029465 (Reactome)
CDC42:GDP2029445 (Reactome)
CDC42:GTP, RAC1:GTP2029456 (Reactome)
CDC42:GTP442586 (Reactome)
CDC42:GTP:WASP/N-WASP2197691 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins2197698 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsArrow2197691 (Reactome)
CDC42:GTP:WASP/N-WASPArrow442586 (Reactome)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsArrow2197698 (Reactome)
CDC42:GTPArrow2029445 (Reactome)
CFL1399950 (Reactome)
CRK:DOCK180:ELMO1,ELMO22197697 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		Arrow2197697 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		mim-catalysis2029467 (Reactome)
Ca2+169683 (Reactome)
Ca2+Arrow169683 (Reactome)
DAGsArrow167686 (Reactome)
DAGsArrow198314 (Reactome)
DAGsArrow2029468 (Reactome)
F-actin2029466 (Reactome)
FCGR2A1861621 (Reactome)
FCGRIA:CD3G homodimer2029455 (Reactome)
FCGRIIIA:CD3G/CD3Z dimers2029457 (Reactome)
G-actin2029473 (Reactome)
G-actin442592 (Reactome)
GDPArrow2029445 (Reactome)
GDPArrow2029451 (Reactome)
GDPArrow2029467 (Reactome)
GTP2029445 (Reactome)
GTP2029451 (Reactome)
GTP2029467 (Reactome)
H2O167686 (Reactome)
H2O2029468 (Reactome)
H2O2029471 (Reactome)
H2O2029475 (Reactome)
HSP90AA1,HSP90AB1419645 (Reactome)
HSP90AA1,HSP90AB1Arrow419644 (Reactome)
I(1,4,5)P3169680 (Reactome)
I(1,4,5)P3Arrow167686 (Reactome)
I(1,4,5)P3Arrow169683 (Reactome)
IP3 receptor homotetramer169680 (Reactome)
ITPR:I(1,4,5)P3 tetramerArrow169680 (Reactome)
ITPR:I(1,4,5)P3 tetramermim-catalysis169683 (Reactome)
IgG-Ag:FCGRIA:CD3G homodimerArrow2029455 (Reactome)
IgG-Ag:FCGRIIAArrow1861621 (Reactome)
IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersArrow2029457 (Reactome)
LIMK12029460 (Reactome)
Mother filament:ARP2/3:actin:GDP2029473 (Reactome)
Mother filament:ARP2/3:actin:GDPArrow2197690 (Reactome)
Mother

filament:branching

complex		2197690 (Reactome)
Mother

filament:branching complex:daughter

filament		1861595 (Reactome)
Mother

filament:branching complex:daughter

filament		2029476 (Reactome)
Mother

filament:branching complex:daughter

filament		Arrow2029473 (Reactome)
Mother

filament:branching

complex		Arrow2029466 (Reactome)
Myosin-Actin filamentsArrow2029476 (Reactome)
Myosin-X dimer1861595 (Reactome)
Myosin-X dimermim-catalysis1861595 (Reactome)
Myosin2029476 (Reactome)
PA2029468 (Reactome)
PAArrow2029471 (Reactome)
PAK1 dimer2029456 (Reactome)
PAK1mim-catalysis2029454 (Reactome)
PC2029471 (Reactome)
PI(3,4)P21861595 (Reactome)
PI(3,4,5)P32029268 (Reactome)
PI(3,4,5)P32029458 (Reactome)
PI(3,4,5)P32029465 (Reactome)
PI(3,4,5)P3Arrow2029271 (Reactome)
PI(3,4,5)P3Arrow2029272 (Reactome)
PI(4,5)P2167686 (Reactome)
PI(4,5)P22029271 (Reactome)
PI(4,5)P2442586 (Reactome)
PI3K2029273 (Reactome)
PI3K:p-6Y-SYKArrow2029273 (Reactome)
PI3K:p-6Y-SYKmim-catalysis2029271 (Reactome)
PKC-delta/epsilon198314 (Reactome)
PKC-delta/epsilonmim-catalysis198314 (Reactome)
PLA2G6mim-catalysis2029475 (Reactome)
PLC gamma1,22029270 (Reactome)
PLDmim-catalysis2029471 (Reactome)
Phosphatidate phosphatasemim-catalysis2029468 (Reactome)
Phosphatidylcholine2029475 (Reactome)
Phospho-PKC-delta/epsilonArrow198314 (Reactome)
PiArrow1861595 (Reactome)
PiArrow2029468 (Reactome)
PiArrow2029473 (Reactome)
PiArrow2029476 (Reactome)
RAC1/CDC42:PAK dimer2029454 (Reactome)
RAC1/CDC42:PAK dimerArrow2029456 (Reactome)
RAC1/CDC42:p-S144,T423-PAKArrow2029454 (Reactome)
RAC1:GDP2029451 (Reactome)
RAC1:GDP2029467 (Reactome)
RAC1:GTP2029465 (Reactome)
RAC1:GTPArrow2029451 (Reactome)
RAC1:GTPArrow2029467 (Reactome)
SH3 domain proteins2197691 (Reactome)
SYK2029452 (Reactome)
Src family kinases (SFKs)mim-catalysis2029459 (Reactome)
Src-kinasesmim-catalysis2197698 (Reactome)
VAV1,2,32029458 (Reactome)
WASP/N-WASP442586 (Reactome)
WAVE Regulatory Complex2029465 (Reactome)
WIP family proteins2197691 (Reactome)
WRC:IRSp53/58:RAC1:GTP:PIP32130194 (Reactome)
WRC:IRSp53/58:RAC1:GTP:PIP3Arrow2029465 (Reactome)
cholineArrow2029471 (Reactome)
clustered IgG-Ag:FCGRs2029459 (Reactome)
clustered IgG-Ag:p-FCGRs2029452 (Reactome)
clustered IgG-Ag:p-FCGRs2029476 (Reactome)
clustered IgG-Ag:p-FCGRs:SYK2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKArrow2029452 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKmim-catalysis2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK2029270 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK2029273 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK2029458 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK2197697 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGArrow2029270 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGmim-catalysis2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV2029453 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVArrow2029458 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG2029272 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGArrow2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVArrow2029453 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVmim-catalysis2029451 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKArrow2029272 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKArrow2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKmim-catalysis2029453 (Reactome)
clustered IgG-Ag:p-FCGRsArrow2029459 (Reactome)
clustered IgG-Ag:p-FCGRsArrow2029476 (Reactome)
p-4Y-PLCG1mim-catalysis167686 (Reactome)
p-PLCGArrow2029272 (Reactome)
p-S144,T423-PAK1Arrow2029454 (Reactome)
p-S144,T423-PAK1mim-catalysis2029460 (Reactome)
p-T,Y MAPK dimersmim-catalysis2029469 (Reactome)
p-T508-LIMK1419645 (Reactome)
p-T508-LIMK1Arrow2029460 (Reactome)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3Arrow2029469 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP32029469 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3Arrow2130194 (Reactome)
pCofilin: Active LIMK-1Arrow399950 (Reactome)
pLIMK dimer:HSP-90419644 (Reactome)
pLIMK dimer:HSP-90Arrow419645 (Reactome)
pLIMK dimer:HSP-90mim-catalysis419644 (Reactome)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2719"
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