Hepatitis C and hepatocellular carcinoma (Homo sapiens)

From WikiPathways

Revision as of 20:39, 6 June 2016 by Khanspers (Talk | contribs)
Jump to: navigation, search
1Cell MigrationCell Growth and SurvivalCASP3Cell MigrationCDKN1ANFKB1Cytoskeleton ActivationSTAT3PTGS2PODXLCCND1NFKB1 SignalingMYCMMP1AngiogenesisCCND1RAC1JAK1CASP9IL8BIRC3Cell Cycle ProgressionHIF1AUCHL1SOS1VEGFACOL4A2FASLGMIR744DNA RepairPTPN11CTTNE2F2MIR34ACell ProliferationMYOFBCL2L1VEGFATGFB1SMAD3ApoptosisBRCA1IL6RGRB2BIRC5AKT1MAPK SignalingCD44IL6VAV2PI3K SignalingCXCR1RRM2WNT SignalingMAPK14FRZBMAPK3TP53LEF1HNF1AMYCJUNCCND1MYCMAPK SignalingMYCCell ProliferationCell ProliferationAngiogenesisApoptosisCASP9CASP7MIR34AMIR155MIR34AMIR155MIR34AMIR155MIR24-1MIR24-2MIR92A1MIR92A2BIRC3BCL2L1ApoptosisNOS2AngiogenesisMIR34AMAPK SignalingMAPK8JUNCCND1IL8MMP1SMAD4CDKN1ATGFBR1MIR24-1MIR24-2MIR744MAPK SignalingApoptosisMIR155AngiogenesisTNFSS10Cell ProliferationCell Proliferation


Description

Pathway model based on hub miRNAs and their putative targets from network analysis.

- From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carcinoma) samples, a protein-protein network was constructed using STRING (http://string-db.org/) and GeneMANIA (http://genemania.org/).

- After topological analysis and network visualization in Cytoscape, the top hub genes were identified.

- miRNAs related to hub genes were identified using miRTarBase server and combined with the PPI network to constructed a miRNA-Hubgene network.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Poortahmasebi V, Poorebrahim M, Najafi S, Jazayeri SM, Alavian SM, Arab SS, Ghavami S, Alavian SE, Rezaei Moghadam A, Amiri M; ''How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study.''; Hepat Mon, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135169view00:57, 7 August 2024EweitzClear cache to fix board height
135168view00:55, 7 August 2024EweitzEconomize layout
135167view00:49, 7 August 2024EweitzIncrease font size
128258view00:16, 30 January 2024EweitzStandardize case
116732view10:58, 11 May 2021EweitzModified title
111190view07:11, 23 July 2020EgonwMade a few more pathway nodes clickable
107467view18:45, 10 October 2019KhanspersModified description
106591view19:33, 10 September 2019KhanspersModified description
105615view04:56, 10 August 2019KhanspersModified description
103011view15:22, 31 January 2019Mkutmonupdated outdated Ensembl identifier (MIR34A)
102150view18:57, 4 December 2018Khanspersupdated mirna identifiers
97632view10:53, 31 May 2018AMTanOntology Term : 'hepatocellular carcinoma' added !
88640view14:54, 12 August 2016JmeliusOntology Term : 'disease pathway' added !
85722view23:14, 6 June 2016KhanspersModified description
85720view20:53, 6 June 2016KhanspersAdded one final interaction
85719view20:49, 6 June 2016KhanspersModified description
85718view20:48, 6 June 2016KhanspersModified description
85714view20:39, 6 June 2016KhanspersModified description
85713view20:39, 6 June 2016KhanspersModified description
85700view18:34, 6 June 2016KhanspersOntology Term : 'hepatocyte' added !
85699view18:33, 6 June 2016KhanspersOntology Term : 'carcinoma' added !
85698view18:32, 6 June 2016KhanspersOntology Term : 'hepatitis' added !
85697view18:31, 6 June 2016KhanspersModified description
85696view18:28, 6 June 2016Khanspersupdate
85566view22:54, 31 May 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AngiogenesisPathwayWP1539 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
BCL2L1GeneProductENSG00000171552 (Ensembl)
BIRC3GeneProductENSG00000023445 (Ensembl)
BIRC5GeneProductENSG00000089685 (Ensembl)
BRCA1GeneProductENSG00000012048 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CD44GeneProductENSG00000026508 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
COL4A2GeneProductENSG00000134871 (Ensembl)
CTTNGeneProductENSG00000085733 (Ensembl)
CXCR1GeneProductENSG00000163464 (Ensembl)
Cell Cycle ProgressionPathwayWP45 (WikiPathways)
Cell MigrationPathway
Cell ProliferationPathway
Cytoskeleton ActivationPathway
DNA RepairPathwayWP707 (WikiPathways)
E2F2GeneProductENSG00000007968 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FRZBGeneProductENSG00000162998 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
HIF1AGeneProductENSG00000100644 (Ensembl)
HNF1AGeneProductENSG00000135100 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL6RGeneProductENSG00000160712 (Ensembl)
IL8GeneProductENSG00000169429 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
LEF1GeneProductENSG00000138795 (Ensembl)
MAPK SignalingPathwayWP382 (WikiPathways)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MIR155GeneProductENSG00000207795 (Ensembl)
MIR24-1GeneProduct407012 (Entrez Gene)
MIR24-2GeneProductENSG00000209707 (Ensembl)
MIR34AGeneProductENSG00000207865 (Ensembl)
MIR744GeneProductENSG00000211589 (Ensembl)
MIR92A1GeneProductENSG00000207968 (Ensembl)
MIR92A2GeneProductENSG00000208034 (Ensembl)
MMP1GeneProductENSG00000196611 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
MYOFGeneProductENSG00000138119 (Ensembl)
NFKB1 SignalingPathway
NFKB1GeneProductENSG00000109320 (Ensembl)
NOS2GeneProductENSG00000007171 (Ensembl)
PI3K SignalingPathway
PODXLGeneProductENSG00000128567 (Ensembl)
PTGS2GeneProductENSG00000073756 (Ensembl)
PTPN11GeneProductENSG00000179295 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
RRM2GeneProductENSG00000171848 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TNFSS10GeneProductENSG00000117560 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
UCHL1GeneProductENSG00000154277 (Ensembl)
VAV2GeneProductENSG00000160293 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)
WNT SignalingPathwayWP428 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3646"
Personal tools