Hfe effect on hepcidin production (Mus musculus)
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Description
Hfe, the mouse equivalent of the human hemochromatosis gene, is known to promote expression of hepcidin, a gene product that inhibits iron absorption, but it is not fully clear how it does this. Hfe, as well as Tmprss6, another gene product, are used in the regulation of systemic iron homeostasis. Evidence obtained from gene testing on mice seems to indicate that Hfe inhibits Tmprss6, which is known to be an inhibitor of Hjv, a gene product that augments BMP/SMAD signaling for the production of hepcidin. Alternatively, Hfe may promote Bmp/Smad signaling by HJV, or by promoting signaling at a point past where Tmprss6 inhibits HJV.
Quality Tags
Ontology Terms
Saving...Bibliography
- Karin E. Finberg, Rebecca L. Wittlesey, Nancy C. Andrews; ''Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice''; NIH, 2011 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| Bmp6 | GeneProduct | ENSMUSG00000039004 (Ensembl)  | |
| HJV (hemojuvelin) | GeneProduct | ENSMUST00000049208 (Ensembl) | |
| Hamp | GeneProduct | ENSMUSG00000050440 (Ensembl) | Hepcidin. Inhibits iron absorbtion |
| Hfe | GeneProduct | ENSMUSG00000006611 (Ensembl) | |
| Id1 | GeneProduct | ENSMUSG00000042745 (Ensembl) | |
| Smad7 | GeneProduct | ENSMUSG00000025880 (Ensembl) | |
| Tmprss6 | GeneProduct | ENSMUSG00000016942 (Ensembl) |
Annotated Interactions
No annotated interactions
