ERK pathway in Huntington's disease (Homo sapiens)

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1Downstream TargetsReceptorsSignal TransducersLigandsDownstream KinasesApoptotic MoleculesTranscription FactorsCREBCaspase-3ERKmGluREGFRRAF1ELK1EGFRASMEKBDNFMSK1TrkBCaspase-7Glu


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bodai L, Marsh JL; ''A novel target for Huntington's disease: ERK at the crossroads of signaling. The ERK signaling pathway is implicated in Huntington's disease and its upregulation ameliorates pathology.''; Bioessays, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141601view02:08, 20 November 2025EweitzRefine elbows
141600view02:07, 20 November 2025EweitzTailor node width
141599view02:06, 20 November 2025EweitzEnlarge text
141598view02:05, 20 November 2025EweitzEconomize layout
137219view08:59, 1 March 2025EgonwModified description
129064view02:18, 10 March 2024EweitzModified description
128359view21:17, 2 February 2024Ash iyerFixed interation of HTT
128350view07:02, 2 February 2024KhanspersAdded xrefs, updated HTT, added interaction from HTT to ERK
120593view20:48, 17 December 2021EweitzUse gene symbols
120592view20:42, 17 December 2021EweitzTighten graphics, fix case
117714view12:28, 22 May 2021EweitzModified title
108057view09:40, 27 November 2019NirupamaWe added the disease-causing mutation in HTT that inhibits BDNF and EGF, and activates Glutamate.
106752view13:23, 17 September 2019MaintBotHMDB identifier normalization
106395view21:29, 28 August 2019KhanspersModified description
105575view06:30, 9 August 2019KhanspersModified description
97672view11:12, 1 June 2018AMTanOntology Term : 'Huntington's disease' added !
89748view23:55, 29 September 2016KhanspersModified title
89643view23:38, 22 September 2016Khanspersupdated xrefs
88611view23:04, 11 August 2016AAR&CoOntology Term : 'Huntington disease pathway' added !
88596view19:45, 11 August 2016Mkutmonfix unconnected lines
87413view11:30, 22 July 2016MkutmonOntology Term : 'disease pathway' added !
87412view11:30, 22 July 2016MkutmonOntology Term : 'signaling pathway' added !
87203view13:50, 19 July 2016AAR&CoModified description
87202view13:43, 19 July 2016AAR&CoModified title
87201view13:43, 19 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BDNFGeneProductENSG00000176697 (Ensembl)
CREBGeneProductENSG00000118260 (Ensembl)
Caspase-3ProteinA0A087WU32 (Uniprot-TrEMBL)
Caspase-7ProteinA0A0A0MRL7 (Uniprot-TrEMBL)
EGFGeneProductENSG00000138798 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
ERKGeneProduct495678 (NCBI Protein)
GluMetaboliteHMDB03423 (HMDB)
MEKGeneProduct578833395 (NCBI Protein)
MSK1GeneProduct32528295 (NCBI Protein)
RAF1GeneProductENSG00000132155 (Ensembl)
RASGeneProduct190938 (NCBI Protein)
TrkBGeneProduct913718 (NCBI Protein)
mGluRGeneProduct493799375 (NCBI Protein)

Annotated Interactions

No annotated interactions

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