ERK pathway in Huntington's disease (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Bodai L, Marsh JL; ''A novel target for Huntington's disease: ERK at the crossroads of signaling. The ERK signaling pathway is implicated in Huntington's disease and its upregulation ameliorates pathology.''; Bioessays, 2012 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	129064	view	02:18, 10 March 2024	Eweitz	Modified description
	128359	view	21:17, 2 February 2024	Ash iyer	Fixed interation of HTT
	128350	view	07:02, 2 February 2024	Khanspers	Added xrefs, updated HTT, added interaction from HTT to ERK
	120593	view	20:48, 17 December 2021	Eweitz	Use gene symbols
	120592	view	20:42, 17 December 2021	Eweitz	Tighten graphics, fix case
	117714	view	12:28, 22 May 2021	Eweitz	Modified title
	108057	view	09:40, 27 November 2019	Nirupama	We added the disease-causing mutation in HTT that inhibits BDNF and EGF, and activates Glutamate.
	106752	view	13:23, 17 September 2019	MaintBot	HMDB identifier normalization
	106395	view	21:29, 28 August 2019	Khanspers	Modified description
	105575	view	06:30, 9 August 2019	Khanspers	Modified description
	97672	view	11:12, 1 June 2018	AMTan	Ontology Term : 'Huntington's disease' added !
	89748	view	23:55, 29 September 2016	Khanspers	Modified title
	89643	view	23:38, 22 September 2016	Khanspers	updated xrefs
	88611	view	23:04, 11 August 2016	AAR&Co	Ontology Term : 'Huntington disease pathway' added !
	88596	view	19:45, 11 August 2016	Mkutmon	fix unconnected lines
	87413	view	11:30, 22 July 2016	Mkutmon	Ontology Term : 'disease pathway' added !
	87412	view	11:30, 22 July 2016	Mkutmon	Ontology Term : 'signaling pathway' added !
	87203	view	13:50, 19 July 2016	AAR&Co	Modified description
	87202	view	13:43, 19 July 2016	AAR&Co	Modified title
	87201	view	13:43, 19 July 2016	AAR&Co	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
BDNF	GeneProduct	ENSG00000176697 (Ensembl)
CREB	GeneProduct	ENSG00000118260 (Ensembl)
Caspase-3	Protein	A0A087WU32 (Uniprot-TrEMBL)
Caspase-7	Protein	A0A0A0MRL7 (Uniprot-TrEMBL)
EGF	GeneProduct	ENSG00000138798 (Ensembl)
EGFR	GeneProduct	ENSG00000146648 (Ensembl)
ELK1	GeneProduct	ENSG00000126767 (Ensembl)
ERK	GeneProduct	495678 (NCBI Protein)
Glu	Metabolite	HMDB03423 (HMDB)
MEK	GeneProduct	578833395 (NCBI Protein)
MSK1	GeneProduct	32528295 (NCBI Protein)
RAF1	GeneProduct	ENSG00000132155 (Ensembl)
RAS	GeneProduct	190938 (NCBI Protein)
TrkB	GeneProduct	913718 (NCBI Protein)
mGluR	GeneProduct	493799375 (NCBI Protein)

Annotated Interactions

No annotated interactions